Rhode Island
3 Medical Breakthroughs in Rhode Island – Rhode Island Monthly
Pressure Point
Brown scientists have discovered a key driver of preeclampsia, which causes high blood pressure during pregnancy. By Dana Laverty
Researchers at Brown University have identified a protein in cerebrospinal fluid that’s a driver in preeclampsia, a dangerous pregnancy condition that affects between 5 to 8 percent of pregnancies and is a leading cause of maternal and fetal death.
Research led by Surendra Sharma and Sukanta Jash at Brown University and Kun Ping Lu and Xia Zhen Zhou at Western University in Canada found the protein, cis P-tau, in the blood and placentas of people with preeclampsia. They also found that depleting cis P-tau prevented mice from developing the condition.
“Our study identifies cis P-tau as a culprit and biomarker for preeclampsia,” says Sharma, who until recently was a Brown professor of pathology and laboratory medicine and professor of pediatrics. “It can be used for early diagnosis of the complication and is a crucial therapeutic target.” (Sharma is now a professor of obstetrics and gynecology at the University of Texas Medical Branch in Galveston.)
Preeclampsia is a complication that results in high blood pressure during pregnancy. Untreated, it can lead to serious complications for both the mother and baby, and often leads to preterm labor and birth.
The protein cis P-tau has mainly been associated with Alzheimer’s disease, traumatic brain injuries and stroke. Lu and Zhou discovered the association in 2015.
Screening tests for the cis P-tau biomarker, combined with therapies involving the cis P-tau antibody, could change the outlook for pregnant people with preeclampsia, Jash says. The root cause of preeclampsia has so far remained unknown, Sharma says, and without a known cause there has been no cure.
The team at Brown is currently working on developing a lab test that can detect preeclampsia.
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Bridging the Gap
Researchers from Brown University and Lifespan are partnering on a device that could restore function for individuals with a spinal cord injury. By Lauren Clem
In an unassuming building on Allens Avenue in Providence, research is underway that could change the future of spinal cord injury treatment.
The Intelligent Spine Interface, led by researchers from Brown University and surgeons from Rhode Island Hospital, aims to restore limb motor function, sensation, autonomic function and bladder control for individuals paralyzed following a spinal cord injury. According to principal investigator David Borton, an associate professor of engineering and brain science at Brown University and biomedical engineer with the Department of Veterans Affairs, no technology currently exists to bridge the gap created by such an injury.
“There’s no tool or a magic fix that we have for someone who has a complete spinal cord injury,” he says. “There’s nothing available to help them regain functions that they have lost.”
Working with Dr. Jared Fridley, director of the Spinal Outcomes Laboratory at Lifespan and an associate professor of neurosurgery at Brown, the team is creating a device that would carry signals across the injury site and restore the connection between brain and limbs. The device uses artificial intelligence to interpret signals from the spinal cord and adapt to the needs of the wearer over time.
“These devices enable the person’s spinal cord and nervous system to modulate over time to hopefully recover function,” Fridley says. “For most people, we’re talking about weeks to months of rehabilitation, plus the device, to see if there’s recovery of function.”
The study, funded by the Defense Advanced Research Projects Agency and the Department of Veterans Affairs at the Providence VA Medical Center, has the potential to restore movement to those with spinal cord injuries, including veterans paralyzed in combat situations. A clinical trial is underway at Lifespan’s Center for Innovative Neurotechnology for Neural Repair, where the researchers have enlisted two individuals to participate in phase one of the trial.
“This is a first in human clinical study for this type of technology,” Borton says. “No one’s ever done this before.”
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Vasectomy Victor
There may be a faster and easier way to perform a vasectomy. By Jamie Coelho
Imagine if men could get a vasectomy in five seconds. There may be a new, minimally invasive way to conduct the procedure in our near future. On the heels of its five-year anniversary, Providence-based Signati Medical earned FDA approval for clinical trials for a study of a minimally invasive surgical device to perform a sealed vasectomy procedure (SVP).
Signati Medical is a medical device company working to advance men’s health. Signati CEO William Prentice says the study kicked off this April with its first patient at Louisiana State University Medical Center, and they plan to have an additional seven people undergo the procedure by the end of the month. The device obstructs the vas deferens by sending a shock through the skin that seals the tubes, rather than a surgeon cutting and fusing.
Prentice wants to undergo SVP on live TV to gain support, but he must wait until the procedure is fully approved. “I agreed to do it,” he says. “We should be doing this for women. There’s no reason women need to go in for tubal ligations and have major surgery, take birth control pills or get IUDs. Men think because they have a vasectomy, they are not going to get an erection. It really shouldn’t be that way.”
Prentice says this is the first innovation in vasectomy in more than twenty years.
“About twenty years ago, one thing changed and that was that they went from scalpel to no scalpel,” he says. “This procedure takes about five seconds. Bipolar sealing in the body is the best sealing you can get.” signatimed.com
Rhode Island
Rhode Island Begins Notifying Residents Impacted by RIBridges Data Breach – Newport Buzz
Rhode Island Governor Dan McKee announced today that the state has begun mailing letters to individuals affected by a cyberattack on the RIBridges database. The letters, sent on January 10, confirm that personal data belonging to recipients—or individuals in their care—was accessed by cybercriminals.
In an effort to protect those impacted, the state is offering five years of free credit monitoring through Experian. Each letter contains an activation code and instructions for enrolling in the service. Affected individuals must sign up online or via phone by April 30, 2025, to take advantage of the offer.
“We understand the concerns this breach has caused for our residents,” Governor McKee said in a statement. “We appreciate everyone’s patience as these letters are delivered.”
The letters, bearing the official State seal in the upper left corner, may take several days to arrive. Individuals with questions can contact the RIBridges Data Breach Hotline at 833-918-6603. The hotline operates Monday through Friday from 9 a.m. to 9 p.m., and Saturday through Sunday from 11 a.m. to 8 p.m.
State officials emphasized that Deloitte, the company managing the RIBridges system, is still reviewing the breached files. Additional letters may be sent in the future if more affected individuals are identified.
Residents who have not received a letter and do not have an activation code cannot be enrolled in the free credit monitoring service at this time, officials clarified.
The breach, which exposed sensitive personal data, has sparked widespread concern. State leaders are urging residents to remain vigilant and take steps to monitor their credit and financial accounts.
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Rhode Island
Budget Breakdown: Is This $590K Rhode Island Home “Too California?” Not for Its Owners
While Lauren and Ryan Tracy were visiting his parents in Newport, Rhode Island, over the winter holidays in 2023, the couple’s then-toddler daughter, Renny, needed a car nap. Driving around Jamestown on the adjacent Conanicut Island, the San Diego family toured a dilapidated 1950s cottage for sale. Though the small home had “zero curb appeal” and a distinct cat-like smell, it did have an ocean view from the backyard, says Lauren. The price was also attractive: $265,000, a far cry from the overinflated California market they were used to. Having renovated several homes before with their design-build company, Shelter Residential, it was easy for the Tracys to imagine it as their next project: a summer home for their growing family (which now includes new baby Lottie and miniature bull terrier, Hank), located just 15 minutes away from the grandparents.
Rhode Island
R.I. Senate panel advances appointment of inaugural Life Science Hub CEO • Rhode Island Current
Almost a year after its inaugural meeting, the Rhode Island Life Science Hub has nearly cemented its hire of a full-time president and CEO, receiving the rubber stamp of the Rhode Island Senate Committee on Finance in a hearing Thursday.
The committee’s unanimous vote advances the appointment of Dr. Mark Turco to the full R.I. Senate, which has scheduled the final confirmation vote for Jan. 21, Greg Paré, a Senate spokesperson said in an email.
Finding a full-time president to lead the nascent life science agency and complement the work of its 15-member, volunteer board of directors, has been a priority since the board’s first meeting in January 2024. But finding that person took longer than expected, with the board finalizing a three-year contract with Turco in December.
The extra time ended up benefiting the search, said Neil Steinberg, chairman of the agency’s board of directors.
“One of the things we found is that, as we got delayed, the more qualified candidates we had because people knew what we’re about,” Steinberg said in remarks to lawmakers Thursday.
Turco’s confirmation by the Senate — required under the state budget article that created the agency — is the “seminal event” for the Life Science Hub, Steinberg said.
“We got a very smart person to head this and we’re excited about that,” Steinberg said. “He had the most breadth of experience to bring to the table. And, his wife was from Pawtucket.”
Turco, a Philadelphia native who relocated to Rhode Island 12 years ago, highlighted his 25 years of experience in the medical and research industry, starting as a cardiologist, with stints in academia, research and as CEO of two startup businesses. He was plucked from a pool of more than 300 candidates through a nationwide search, led by a professional consulting firm enlisted by the Hub board.
“We are here so we can impact lives,” Turco said. “We can improve health and well being in Rhode Island and beyond. We can also create jobs and grow our economy.”
Establishing Rhode Island as a hub for medical and scientific research and entrepreneurship, similar to Cambridge and Worcester in Massachusetts, has been a top priority for lawmakers and industry leaders. While the Ocean State doesn’t have the name recognition in life sciences that its Commonwealth counterpart enjoys, Turco insisted the foundational pieces — a skilled workforce, academic and health care institutions, and a spirit of innovation — were already in place.
“Rather than the state being a series of silos, we hope to be the conveners,” Turco said. “Innovation is a team sport and that’s how we will succeed in our efforts.”
Lawmakers peppered Turco with questions during the 45-minute hearing, seeking clarity on his short and long-term goals for the agency, and spending plans. The state’s fiscal 2024 budget allotted $45 million to the agency, part of which will cover Turco’s $400,000 annual salary.
“We’re spending taxpayer dollars here,” Sen. Lou DiPalma, Senate Finance chairman and a Middletown Democrat said. “We will need to see ‘Here’s the why.’”
Turco also pledged to seek additional funding, including establishing a venture fund to accept private investments and an incorporated 501(c)(3). But he will also be making an ask of lawmakers in the state budget that starts July 1, though he did not say how much.
Steinberg highlighted the accomplishments the agency has achieved so far. Chief among them: Inking agreements with project partners to open a first-of-its-kind state wet lab incubator space within the new state public health laboratory in the I-195 Redevelopment District. The $16 million, 30,000-square-foot incubator space is expected to open in December 2025.
If approved by the full Senate, Turco will serve a three-year term as Hub CEO, expiring Jan. 15, 2028.
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