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BA.2 more severe for children, Hong Kong study finds, though serious outcomes uncommon

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BA.2 more severe for children, Hong Kong study finds, though serious outcomes uncommon
The findings are thought-about preliminary as a result of they arrive from a preprint, or a examine that has not been scrutinized by exterior researchers or revealed in a medical journal. They’ve additionally not been confirmed by different research, which makes them much less sure.

“I feel it is slightly onerous to know what that can appear like right here, the place in all probability a big fraction of our inhabitants has been uncovered in some unspecified time in the future earlier than both to Delta or BA.1,” mentioned Dr. Beth Thielen, a pediatric infectious illness specialist on the College of Minnesota in Minneapolis.

However Thielen notes that the examine presents an essential take a look at the uncooked energy of this variant in a weak inhabitants. It additionally highlights the urgency of Covid-19 vaccination for youths and the necessity for extra remedies for this age group.

“Proper now, we’re pretty restricted,” Thielen mentioned. “We may give remdesivir, however we do not have plenty of different drug remedy instruments.”

BA.2 hits a weak inhabitants

All through the pandemic, Hong Kong has applied strict Covid management measures together with common masking, stringent social distancing, contact tracing and enterprise and college closures. In consequence, this metropolis had low case ranges and comparatively little publicity to the SARS-CoV-2 virus by a lot of the pandemic.

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Not less than that was true till the extremely contagious BA.2 subvariant of the Omicron pressure hit town. Since then, Hong Kong has seen an alarming rise in circumstances and deaths, notably in its aged inhabitants, lots of whom had been reluctant to be vaccinated.

However youngsters weren’t spared from BA.2 both, and the brand new examine compares the outcomes for youngsters hospitalized with this variant to outcomes for youths hospitalized with earlier variants (between January 2020 and November 2021), parainfluenza or the flu. Knowledge on youngsters hospitalized with parainfluenza and influenza got here from medical data between January 2015 and December 2018.

In February 2022, throughout the peak of Hong Kong’s Omicron wave, which was largely brought on by BA.2, 1,147 youngsters have been hospitalized, and 4 died.

The kids who died have been 11 months, 3 years, 4 years and 9 years previous. Three had beforehand been in good well being, and the 9-year-old had muscular dystrophy. None was vaccinated towards Covid-19. Two youngsters died from encephalitis, or swelling of their brains.

These have been the primary youngsters to die of Covid-19 in Hong Kong throughout the pandemic.

When the researchers in contrast fatality charges, they discovered that youngsters hospitalized with BA.2 had seven instances larger odds of dying in contrast with these hospitalized with the flu, and greater than six instances larger odds of dying from BA.2 than from parainfluenza.

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The case fatality charges have been 0.35% for BA.2, 0.05% for influenza and 0.04% for parainfluenza, which causes croup.

As well as, the percentages that youngsters would should be admitted to the pediatric ICU have been 18 instances larger for BA.2 in contrast with earlier Covid-19 variants, greater than twice as excessive as for the flu and roughly on par with the dangers for youngsters hospitalized with parainfluenza.

China's zero-Covid policy is showing signs of strain. But ditching it now could be a disaster

No circumstances of febrile seizures have been recorded in Hong Kong throughout earlier variants. However youngsters with Omicron’s BA.2 subvariant had thrice the percentages of getting a seizure brought on by a fever in contrast with these with flu and greater than 4 instances larger odds in comparison with these with parainfluenza.

Children with BA.2 additionally had larger dangers of mind swelling than youngsters with parainfluenza however about the identical as these with the flu.

By way of respiratory problems, 5% of hospitalized youngsters contaminated with BA.2 developed croup, in contrast with 0.27% of kids with different Covid-19-causing variants, making the percentages of getting group about 11 instances larger for BA.2 than for earlier variants.

They have been about twice as more likely to have croup with BA.2 than youngsters hospitalized with the flu.

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The examine researchers, from the College of Hong Kong, concluded that “The intrinsic severity of Omicron BA.2 will not be delicate as evident by the fatality and extreme problems of the uninfected and unvaccinated youngsters.”

Put together however do not panic

Although the examine findings could seem scary, Dr. Claudia Hoyen, a pediatric infectious illness specialist at UH Rainbow Infants & Youngsters’s Hospital in Cleveland, says mother and father ought to keep in mind that “the probabilities of a kid dying from Omicron are very, very, very, very low,” she mentioned.

In keeping with knowledge from the US Facilities for Illness Management and Prevention, lower than 0.1% of Covid-19 deaths within the US have been in youngsters below the age of 12.

“I do not assume there’s any have to panic, seeing what we have seen from this examine,” Hoyen says.

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Nevertheless it is a sign that despite the fact that “we’re all in the midst of a giant sigh of aid right here, at the very least in the US, it is not over,” she mentioned. “We do have giant teams of weak inhabitants nonetheless on the market.

“For folks of smaller youngsters, they could have to take extra precautions than different households,” Hoyen mentioned.

Thielen agrees. The easiest way for households to guard infants and younger youngsters is to ensure everybody round them is updated on their vaccinations, together with boosters, she mentioned.

She famous that the pictures have been notably helpful for people who find themselves pregnant as a result of antibodies from the vaccines defend each the individual carrying the kid and the newborn for a time frame after beginning.

Breastfeeding can also be protecting as a result of antibodies cross to infants by breast milk.

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And Thielen says high-quality masks on all relations who can put on them are additionally a good suggestion.

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Russia launches Christmas Day attack on Ukraine’s energy system

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Russia launches Christmas Day attack on Ukraine’s energy system

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Russia has carried out a Christmas Day attack on Ukraine’s energy system, leaving more than half a million people without heating, water and electricity. 

Ukrainian President Volodymyr Zelenskyy said the attack, the 13th large-scale assault of 2024 on the country’s grid, was “deliberate” and not a coincidence. “What could be more inhuman?” he wrote on X.

About 50 of the 70 missiles fired in the attack were intercepted, along with a “significant” portion of the more than 100 attack drones deployed, he added.

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This year Ukrainians marked Christmas Day on December 25 for the second time, after switching to the western Gregorian calendar last year. The decision to stop celebrating Christmas on January 7 in line with the Orthodox calendar was made by Kyiv to break with Russian influence.

Oleh Syniehubov, governor of Ukraine’s eastern Kharkiv region, told Ukraine’s national television news that the attack had left more than 500,000 people without heating, water and electricity.

Temperatures across Ukraine are around freezing point.

Heating supplies were also cut in some areas of Ukraine’s Ivano-Frankivsk and Dnipropetrovsk regions, in the west and south of the country. 

Ukraine’s energy grid operator, Ukrenergo, urged consumers to limit consumption by not switching on multiple appliances at once, adding that the system was still recovering from the previous Russian attack on December 13.

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Ukraine’s largest private energy company, DTEK, said that its power stations had been damaged and one of its long-term employees killed.

Ukraine’s foreign minister, Andriy Sybiha, said on X that the attack reflects Russian President Vladimir Putin’s response to “those who spoke about illusionary ‘Christmas ceasefire’”.

Hungarian Prime Minister Viktor Orbán said last week that Zelenskyy had rejected his proposal for a ceasefire and prisoner exchange on the January 7 Orthodox Christmas.

Ukraine denied that such a proposal was ever on the table, asking Hungary to “refrain from manipulations” regarding the war. On Friday, Heorhii Tykhyi, spokesperson for Ukraine’s foreign ministry, described it as “PR, a move” by Orbán.

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American Airlines lifts ground stop that froze Christmas Eve travelers

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American Airlines lifts ground stop that froze Christmas Eve travelers

An American Airlines agent talks to a customer at O’Hare International Airport in Chicago, Ill., last week. On Tuesday, the airline issued a national halt to flights.

Kamil Krzacznski/AFP via Getty Images


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Kamil Krzacznski/AFP via Getty Images

American Airlines passengers across the U.S. endured a sudden disruption of service on Christmas Eve, as a “technical issue” forced the airline to request a nationwide ground stop of its operations.

“The ground stop has now been lifted,” the Federal Aviation Administration told NPR shortly after 8 a.m. ET.

On Facebook and X, passengers shared stories of boarding planes early on Christmas Eve — only to be left waiting on the tarmac. In some cases, they described being told the flight would return to its gate so everyone onboard could deplane.

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The ground stop lasted for about one hour, according to the airline.

 “We sincerely apologize to our customers for the inconvenience this morning,” the airline said.

In a statement sent to NPR, American says the widespread delays were caused by a “vendor technology issue” affecting systems that are needed for a flight to be “released” — one of the final key steps before a plane takes off from an airport.

Early circumstances around Tuesday’s outage seemed ominous, reminding travelers of a nightmare scenario that played out two years ago when computer problems fueled a meltdown for Southwest Airlines as it tried to cope with bad weather during the holidays.

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Southwest stranded millions of travelers — and was later ordered to pay a $140 million civil penalty.

Aviation industry veterans like George Hamlin, a consultant, notes that Southwest took the brunt of the blame for the meltdown — but, he adds, “now we’re finding out that it’s a larger, more endemic problem than that.”

Delayed American Airlines passengers who posted to social media Tuesday said pilots blamed the slowdown on a computer system that aims to ensure an optimal center of gravity by balancing planes’ cargo weight and other factors.

Winter weather also threatens to snarl Christmas Eve travel, including storms along the East and West Coasts of the U.S.

The FAA’s operations page shows nearly a dozen airports were deicing planes Tuesday morning, including at Philadelphia International, and Dulles International and Reagan National outside Washington, D.C.

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If you’re flying, the FAA recommends checking your airline’s flight status updates for potential delays. As of 9 a.m. ET, the FlightAware website’s “Misery Map” showed some 544 flights had been delayed and five canceled since 6 a.m. Nearly 120 of those delays were at Charlotte, N.C.’s, airport.

Nearly 12.7 million passengers are expected to fly on American Airlines this winter holiday season, comprising more than 118,000 flights, according to the airline. The most-traveled days in that span are both Fridays, ahead of and just after Christmas.

NPR’s Joel Rose contributed reporting.

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Private equity payouts fell 50% short in 2024

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Private equity payouts fell 50% short in 2024

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Private equity funds cashed out just half the value of investments they typically sell in 2024, the third consecutive year payouts to investors have fallen short because of a deal drought.

Buyout houses typically sell down 20 per cent of their investments in any given year, but industry executives forecast that cash payouts for the year would be about half that figure.

Cambridge Associates, a leading adviser to large institutions on their private equity investments, estimated that funds had fallen about $400bn short in payments to their investors over the past three years compared with historical averages.

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The data underline the increasing pressure on firms to find ways to return cash to investors, including by exiting more investments in the year ahead.

Firms have struggled to strike deals at attractive prices since early 2022, when rising interest rates caused financing costs to soar and corporate valuations to fall.

Dealmakers and their advisers expect that merger and acquisition activity will accelerate in 2025, potentially helping the industry work through what consultancy Bain & Co. has called a “towering backlog” of $3tn in ageing deals that must be sold in the years ahead.

Several large public offerings this year including food transport giant Lineage Logistics, aviation equipment specialist Standard Aero and dermatology group Galderma have provided private equity executives with confidence to take companies public, while Donald Trump’s election has added to Wall Street exuberance.

But Andrea Auerbach, global head of private investments at Cambridge Associates, cautioned that the industry’s issues could take years to work through.

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“There is an expectation that the wheels of the exit market will start to turn. But it doesn’t end in one year, it will take a couple of years,” Auerbach said.

Private equity firms have used novel tactics to return cash to investors while holdings have proved difficult to sell.

They have made increasing use of so-called continuation funds — where one fund sells a stake in one or more portfolio companies to another fund to another fund the firm manages — to engineer exits.

Jefferies forecasts that there will be $58bn of continuation fund deals in 2024, representing a record 14 per cent of all private equity exits. Such funds made up just 5 per cent of all exits in the boom year of 2021, Jefferies found.

But some private equity investors are sceptical that the industry will be able to sell assets at prices close to funds’ current valuations.

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“You have a huge amount of capital that has been invested on assumptions that are no longer valid,” a large industry investor told the Financial Times.

They warned that a record $1tn-plus in buyouts were struck in 2021, just before interest rates rose, and many deals are carried on firms’ books at overly optimistic valuations.

Goldman Sachs recently noted in a report that private equity asset sales, which had historically been done at a premium of at least 10 per cent to funds’ internal valuations, have in recent years been made at discounts of 10-15 per cent.

“[Private] equity in general is still over-marked, which is leading to this situation where assets are still stuck,” said Michael Brandmeyer of Goldman Sachs Asset Management in the report.

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