Nebraska
Nebraska Medicine researchers making strides in Alzheimer’s treament
OMAHA, Neb. (WOWT) – Nebraska Medicine and UNMC have been leaders in health and research for decades, and now, the institution is touting its accomplishments when it comes to reducing and reversing the effects and severity of Alzheimer’s.
Inside the walls of the Durham Research Center on UNMC’s campus, research is being done and breakthroughs are being made that could eventually change the lives of millions.
“I think if one has to look at all medical science, medical research, medical investigations, medical therapeutics and pick one that they would like to have a major impact on, it would be neurodegenerative diseases,” said Dr. Howard Gendelman, a UNMC professor of Pharmacology and Internal Medicine.
Dr. Gendelman has dedicated more than two decades to neurodegenerative research, namely, Alzheimer’s.
“So why Alzheimer’s? Alzheimer’s disease is not simply a disease that affects a single person. It affects a family and it affects a community,” Dr. Gendelman said.
The research started with a simple thought: When you scrape your elbow, your immune system responds with redness, swelling, and some pain. After that, your body starts to make repairs to the affected area.
“We reasoned, why can’t we take this simple repair mechanism that is operative on a day-to-day basis in millions of people and look at ways we can harness that to repair the brain in the face of neurodegenerative disease?” said Dr. Gendelman.
So, that’s exactly what the doctor and his team started working towards.
But there were two major obstacles.
The first was simply identifying, isolating, and studying which cells are involved in repairing injuries, like that scraped elbow. After identifying the cells, the next obstacle was figuring out how to get them to respond specifically to the brain.
They found the answer in genetic engineering. Simply put, they’re training the cells to learn a new function, like teaching a dog a new trick.
“We were able to change the repertoire of these immunological cells,” Dr. Gendelman said. “We’re able to get these cells into the area of the brain, have them grow in that area of the brain and ultimately repair the damage that has occurred and improve cognitive function and improve the neurological manifestations of the disease and clear the cause, these plaques that form as Alzheimer’s evolves over time.”
This process is what sets UNMC’s research apart from other Alzheimer’s research and therapies, Gendelman says.
The cellular therapy was then tested, and it did what they hoped and hypothesized that it would do. Dr. Gendelman and his team tested it on mice with the disease and reported that infected mice saw improvements in cognitive function, like learning and memory.
Now, Gendelman says they have the tools, research, and resources to test the therapy in humans, but need to wait for approval from overarching health organizations like NIH and FDA.
It will take time, but they hope to begin human testing in the next two to three years.
“Our biggest reflection of why we do what we do is to say that we’ve made a difference, we’ve made this world better than before we were here before we were involved,” Dr. Gendelman said.
Copyright 2024 WOWT. All rights reserved.
Nebraska
33 Nebraska senators urge Board of Regents to delay vote on $800M acquisition of Nebraska Medicine
LINCOLN, Neb. (KOLN) – Thirty-two Nebraska state senators joined Sen. Brad von Gillern’s letter calling on the Nebraska Board of Regents to delay a vote on the proposed $800 million acquisition of Nebraska Medicine.
The letter, dated Thursday and bearing a total of 33 signatures from state senators, shared concerns about the proposed acquisition, including the lack of transparency to the public and the Legislature.
According to the letter, the regents’ Jan. 9 meeting agenda item summary indicates that the Board has “negotiated the final agreement over a series of meetings in the past 18 months”.
The regents will consider a proposal in which Clarkson Regional Health Services would give up its 50% membership in Nebraska Medicine. The deal would give full control of the health system to the University of Nebraska.
However, the letter said the public and Legislature have had little time to understand the proposal, its impact and any financial implications of the transaction.
“The University of Nebraska and Nebraska Medicine are two institutions of tremendous significance to our state, and any major changes to the existing structures must be carefully considered,” the letter stated.
Senators are asking the Board to delay the vote to “ensure all viable alternatives have been considered and until all stakeholders understand the impact of the proposal for the state” and the two institutions.
The Board of Regents meeting, previously set for Friday, will now be held Thursday, Jan. 15 at 9 a.m.
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Copyright 2026 KOLN. All rights reserved.
Nebraska
Pillen labels actions “destructive partisanship” as senator responds
Nebraska
Pillen: Nebraska senator tears down historical exhibits by PragerU from Capitol walls
LINCOLN, Neb. (KOLN) – Parts of a temporary historical exhibit inside the Nebraska State Capitol were torn down by a state senator, Gov. Pillen alleges.
Gov. Pillen said Wednesday on social media that several displays of historical figures, key events in the American Revolution and portraits of those who signed the Declaration of Independence were “ripped off the walls” by state Sen. Machaela Cavanaugh of Omaha.
A 40-second video shared by Pillen appears to show Sen. Cavanaugh taking down several displays and a photo showed the items on the floor of her office.
The displays featuring material made by the controversial conservative group PragerU were put up in the state Capitol as part of the United States’ 250th anniversary.
“Celebrating America during our 250th year should be a moment of unity and patriotism, not divisiveness and destructive partisanship. I am disappointed in this shameful and selfish bad example,” Pillen wrote.
Cavanaugh told 10/11 that senators are prohibited from putting items on the walls in the hallway outside their offices. She said the posters line the entire hallway around the first floor, but she only took down the ones outside her office.
“When I walked in this morning and saw these poster boards lining the hallway of my office, I thought well I’m not allowed to have things lining the hall of my office… I tried to take them down as gently as I could and not damage any of them, and I stacked them inside of my office and I let the state patrol know that they were there,” Cavanaugh said.
PragerU has previously faced criticism for making content that historians, researchers and scholars have considered inaccurate or misleading. Some parents and educators have also spoken out against the nonprofit, saying its content spreads misinformation and is being used for “indoctrinating children.”
The Founders Museum exhibit in particular has been criticized by The American Historical Association for blurring the line between reality and fiction, according to NPR.
The exhibit is supposed to remain on display during public building hours through the summer.
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Copyright 2026 KOLN. All rights reserved.
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