Health
Why microdosing Ozempic could become as common as taking a multivitamin
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They may have gained popularity for diabetes and weight loss, but GLP-1 medications like Ozempic and Wegovy have been linked to ever-expanding health benefits.
In fact, some doctors — including Dr. Terry Dubrow, a plastic surgeon and TV personality based in Newport Beach, California — recommend that everyone takes a low daily dose, even if they don’t need to lose weight.
Dubrow spoke on camera with Fox News Digital about the benefits of “microdosing” these medications. (See the video at the top of this article.)
How GLP-1s work
GLP-1 receptor agonists work by mimicking a hormone called glucagon-like peptide-1, which is released from the gut after eating.
The drugs help to regulate blood sugar, slow down emptying of the stomach and diminish appetite, and have also been shown to reduce the risk of heart disease.
Dr. Terry Dubrow, a plastic surgeon and TV personality based in Newport Beach, California, recommends that everyone takes a low daily dose of a GLP-1, even if they don’t need to lose weight. (Terry Dubrow)
“Sugar’s the enemy, and these drugs affect sugar in your blood,” Dubrow told Fox News Digital. “They affect the way insulin reacts.”
GLP-1s help insulin move the glucose (sugar) out of the bloodstream and into the body’s cells, where it can be used for energy or stored, the doctor said. The drugs also help to prevent the inflammation and damage sugar can cause in the blood vessels, nerves and organs.
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“I don’t think anyone would argue that if there was a way to manipulate the amount of sugar and inflammation your body’s exposed to, that is something we want to lean into. And that’s exactly what these drugs do,” Dubrow added.
In addition to regulating blood sugar and triggering weight loss, GLP-1s have also been approved to reduce the risk of cardiovascular events and kidney disease in certain patients.
“I have never seen a drug in the history of medicine be on such a rapid path to approval.”
“Even if you’re not overweight, being on these GLP-1 drugs … helps to minimize and prevent a repeat recurrent heart attack,” Dubrow said.
Semaglutide was also recently approved for MASH (metabolic dysfunction-associated steatohepatitis), an inflammatory form of fatty liver disease.
Dubrow spoke on camera with Fox News Digital about the benefits of GLP-1 medications. (Fox News Digital)
GLP-1s are also being studied for potential cognitive benefits in Parkinson’s patients.
“I have never seen a drug in the history of medicine be on such a rapid path to approval,” Dubrow said.
The case for microdosing
Along with other experts, Dubrow is an advocate for microdosing, which is where people take low, steady doses of GLP-1s every day, even if they don’t need them for diabetes or obesity.
While patients with diabetes take doses that increase every four weeks, microdosing entails using a low-level dose that doesn’t go up.
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A younger population on TikTok has zeroed in on microdosing, Dubrow pointed out — and he thinks everyone should be doing it.
“I am obsessed with the concept of microdosing,” he said. “I think maybe half the starting dose for diabetes is the way to go — and you probably don’t need it every seven days, it’s probably every 10 days, just to sort of modulate the amount of sugar in the blood.”
“Even if you’re not overweight, being on these GLP-1 drugs … helps to minimize and prevent a repeat recurrent heart attack,” Dubrow said. (iStock)
The doctor noted that there are still a lot of unknowns with GLP-1 medications.
“We are just figuring out now how to use these drugs for different indications, for different reasons,” he said. “We’re learning as we’re using it.”
“I am obsessed with the concept of microdosing.”
As with other drugs, like Botox, Dubrow said there is a bit of “human experimentation” at play.
“We’re figuring it out, and we’re teaching the medical profession how to do it. The patients are telling us how to use these drugs.”
Potential risks
GLP-1 medications have been linked to several potential risks. The most prevalent is gastrointestinal issues, such as nausea and vomiting.
Others have reported an increased risk of pancreatitis, muscle loss and thyroid tumors.
“I read every study that comes out on these drugs, and I can tell you, it’s very clear they don’t cause pancreatitas,” Dubrow said.
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“In fact, if you really look at the populations who have been using it, pancreatitis is less in those populations.”
Dubrow confirmed, however, that the drug has been linked to an increased risk of the very rare medullary cancer of the thyroid.
Those who experience severe side effects from GLP-1s should talk to a doctor, Dubrow advised. (iStock)
“If you have a family history of that, that’s a contraindication to you using these drugs,” he said.
Regarding the digestive side effects, the doctor said the medications do slow down the GI tract, but it’s been shown that the body adjusts to that over time.
“These particular drugs are natural hormones that occur in our small intestine, and you get used to the side effects. They go away.”
The severity of side effects is linked to the dose amount, Dubrow noted.
“The low dose, particularly the microdose, really has a low propensity toward the constipation, the nausea, the potential diarrhea, the GERD (reflux),” he said. “I think those side effects are less significant for people who microdose.”
To counteract the risk of muscle loss, Dubrow recommends increasing protein intake and incorporating resistance training as a core component of an exercise routine.
Those who do experience severe side effects should talk to a doctor, he advised.
Off-label use of GLP-1s, such as for microdosing, is common, Dubrow said — “but finding a doctor willing to prescribe can be difficult.” (iStock)
Drugmakers weigh in
When contacted by Fox News Digital, manufacturers of GLP-1 medications warned against microdosing the products.
“Lilly does not have any data on the benefits or risks of microdosing of Zepbound and Mounjaro,” said a spokesperson for Eli Lilly, maker of the GLP-1 drugs Mounjaro and Zepbounda. “Both autoinjectors and Zepbound vials are approved for single-use only — dose-splitting or ‘microdosing’ is not contemplated by the FDA label. As such, off-label use of Zepbound and Mounjaro may pose patient safety risks.”
“Off-label use of Zepbound and Mounjaro may pose patient safety risks.”
Novo Nordisk, maker of Ozempic and Wegovy, said it does not condone “misuse” of its products.
“It’s important to understand that for Wegovy, only the marked doses on the single-use, fixed-dose pens (0.25, 0.5, 1.0, 1.7 and 2.4 mg) are approved for use and represent an authentic FDA-approved medicine,” a spokesperson told Fox News Digital. “The starting dose of Wegovy® is 0.25 mg once a week, and the dose will gradually increase every four weeks. Patients should work with their healthcare professional to select either 1.7 mg or 2.4 mg for the maintenance dose.”
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“It is also important to note that the authentic Wegovy injectable pen is designed as a single-use pen, the dose is already set, and should not be altered or tampered with, and the pen must be disposed after one use.”
“Ozempic is a multi-use pen with one pen and multiple needles,” the spokesperson added.
Accessing GLP-1s
Dubrow said he’s not concerned about supply issues amid the growing popularity of GLP-1s, as major drug companies have the resources to “scale up” to meet the demand.
Off-label use of GLP-1s, such as for microdosing, is common, Dubrow said — “but finding a doctor willing to prescribe can be difficult.”
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The doctor cautioned against buying these drugs from online marketplaces, which he referred to as the “wild wild west.”
“It’s hard to find these drugs online from compounding pharmacies, because essentially they’re going rogue — it’s illegal. They’re not allow to do it,” he warned.
“These drugs are natural hormones that occur in our small intestine, and you get used to the side effects.”
“So if you’re getting it from rogue pharmacies that aren’t allowed to do it or are willing to bend the rules, what is it? You don’t know what you’re getting.”
“It may be an adulterated, weird version that has side effects or that’s not effective.”
Looking ahead
There are several next-generation drugs in development that combine multiple hormone pathways, Dubrow said.
“I predict within five years, we’ll have a pill … designed to manipulate hunger and insulin resistance,” he predicted.
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Overall, Dubrow said, GLP-1s are “here to stay.”
“They’re just going to get better, and we’re going to learn how to use them in a more appropriate and clinically effective way,” he said. “So fasten your seatbelt. If you’re not on them now, you will be later.”
Health
Holiday heart attacks rise as doctors share hidden triggers, prevention tips
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The holidays are known to be a source of stress, between traveling, preparing for family gatherings and indulging in lots of food and drinks.
The uptick of activity can actually put a strain on the heart, a phenomenon known as “holiday heart syndrome.”
Cardiothoracic surgeon Dr. Jeremy London addressed this elevated risk in a recent Instagram post, sharing how heart attacks consistently rise around the holidays.
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“Every year, like clockwork, we see a spike in heart attacks around Christmas and New Year’s,” the South Carolina-based surgeon said. “In fact, Christmas Eve is the highest-risk day of the year.”
This is due to a shift in behavior, specifically drinking and eating too much, moving less and being stressed out, according to London. “Emotional stress, financial stress, the increased pace of the holidays, increased obligations,” he listed.
Cold weather also causes vasoconstriction (narrowing of blood vessels), according to London, which increases the risk of plaque rupture and the potential for heart attack.
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Dr. Glenn Hirsch, chief of the division of cardiology at National Jewish Health in New York, noted in an interview with Fox News Digital that holiday heart syndrome typically refers to the onset of an abnormal heart rhythm, or atrial fibrillation.
This can happen after an episode of binge-drinking alcohol, Hirsch said, which can be exacerbated by holiday celebrations.
Binge-drinking at any time can drive atrial fibrillation, a cardiologist cautioned. (iStock)
“It’s often a combination of overdoing the alcohol intake along with high salt intake and large meals that can trigger it,” he said. “Adding travel, stress and less sleep, and it lowers the threshold to go into that rhythm.”
The biggest risk related to atrial fibrillation, according to Hirsch, is stroke and other complications from blood clots. Untreated atrial fibrillation can lead to heart failure after a long period of time.
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“The risk of atrial fibrillation increases with age, but also underlying cardiovascular disease risk factors increase the risk, such as high blood pressure, obesity, diabetes, sleep apnea and chronic kidney disease,” he added.
Christmas Eve is the “highest risk day of the year” for heart attacks, according to one cardiologist. (iStock)
Preventing a holiday heart event
Holiday heart syndrome is preventable, as Hirsch reminds people that “moderation is key” when celebrating.
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The expert recommends avoiding binge-drinking, overeating (especially salty foods) and dehydration, while managing stress levels and prioritizing adequate sleep.
“Don’t forget to exercise,” he added. “Even getting in at least 5,000 to 10,000 steps during the holiday can help lower risk, [while] also burning some of the additional calories we are often consuming around the holidays.”
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London agreed, stating in his video that “movement is medicine” and encouraging people to get out and move every day.
The various stresses of the holidays can have physical consequences on the body, doctors warn. (iStock)
It’s also important to stay on schedule with any prescribed medications, London emphasized. He encourages setting reminder alerts, even during the holiday break.
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“Prioritize sleep and mindfulness,” he added. “Take care of yourself during this stressful time.”
London also warned that many people delay having certain health concerns checked out until after the holidays, further worsening these conditions.
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“Don’t ignore your symptoms,” he advised. “If you don’t feel right, respond.”
Health
‘Aggressive’ new flu variant sweeps globe as doctors warn of severe symptoms
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Flu season is among us, and a new strain has emerged as a major threat.
Influenza A H3N2, or the subclade K variant, has been detected as the culprit in rising global cases, including in the U.S.
In an interview with Fox News Digital, Dr. Neil Maniar, professor of public health practice at Boston’s Northeastern University, shared details on the early severity of this emerging strain.
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“It’s becoming evident that this is a pretty severe variant of the flu,” he said. “Certainly in other parts of the world where this variant has been prevalent, it’s caused some severe illness, and we’re seeing an aggressive flu season already.”
Influenza A H3N2, or the subclade K variant, has been detected as the culprit in rising global cases. (iStock)
The variant seems to differ from prior strains of the flu, with heightened versions of typical symptoms like fever, chills, headache, fatigue, cough, sore throat and runny nose.
Subclade K is the “perfect storm” for an aggressive flu season, Maniar suggested, as vaccination rates overall are down and this year’s flu vaccine does not address this specific strain.
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“The vaccine is very important to get, but because it’s not perfectly aligned with this variant, I think that’s also contributing to some degree to the severity of cases we’re seeing,” he said. “We’re going in [to this flu season] with lower vaccination rates and a variant that in itself seems to be more aggressive.”
“There’s a lot of concern that this could be a particularly difficult flu season, both in terms of the total number of cases [and] the severity of those cases.”
Staying indoors during the colder months increases the risk of exposure to winter illness. (iStock)
Because subclade K is “quite different” from prior variants, Maniar said there is less natural immunity at the community level, further increasing the risk of spread and severity.
Those who are unvaccinated are also at risk of experiencing more severe symptoms, as well as a higher risk of hospitalization, the doctor emphasized.
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In addition to getting vaccinated, the doctor recommends washing hands frequently and properly. While the flu can spread via airborne transmission, a variety of other illnesses, like norovirus, can stick to surfaces for up to two weeks, he added.
The holiday season also boosts the risk of infection, as gatherings, large events, and packed planes, trains and buses can expose people to others who are sick.
The flu vaccine can help to prevent hospitalization and reduce severe symptoms, doctors agree. (iStock)
Those who are not feeling well or exhibiting symptoms should “please stay home,” Maniar advised — “especially if you think you are in that contagious period of the flu or any of these other illnesses that we’re seeing … whether it’s norovirus or COVID or RSV.”
“If you’re not feeling well, stay home. That’s a great way to recover faster and to ensure that you’re not going to get others around you sick.”
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For those who are unsure of their health status or diagnosis, Maniar recommends seeing a healthcare provider to get tested. Some providers may be able to prescribe medication to reduce the severity and duration of the illness.
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“It’s important that everyone stays vigilant and tries to take care of themselves and their families,” he added.
Health
Are you too old to shovel snow? Experts reveal the hidden heart risks
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As snow blanketed parts of the U.S. this week, heart health experts have shared warnings of the physical strain shoveling can take — particularly for older adults.
A 2025 Mayo Clinic review found that just 10 minutes of heavy snow shoveling can push the heart to about 97% of its maximum rate. Exposure to cold air was also found to increase blood pressure and reduce coronary blood flow.
While there isn’t an official age that’s “too old” to shovel, some cardiologists recommend that individuals over 45 should exercise more caution to lower their chances of a cardiac event.
When to take caution
“While there’s no strict age cutoff, generally above the age of mid 40s and above, we tend to be a little more cautious — particularly in people who are less active [without] regular exercise,” Dr. Navjot Kaur Sobti, M.D., an interventional cardiologist at Northwell’s Northern Westchester Hospital in Mount Kisco, New York, told Fox News Digital.
Heart health experts have shared warnings of the physical strain shoveling can take — particularly for older adults. (iStock)
“Certainly in people who are above the age of 65 — and who have risk factors for heart disease, such as high blood pressure, high cholesterol, diabetes, obesity or sedentary lifestyle — we recommend being very, very cautious about shoveling snow,” she advised.
Dr. John Osborne, M.D., a practicing Texas cardiologist and volunteer for the American Heart Association, shared similar guidance for people older than 45, especially males over 65.
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“Unless you are in good cardiovascular shape and conditioned, it may be a good idea to ask someone for help,” he said in an interview with Fox News Digital.
The impact of snow removal is especially concerning for those with existing cardiovascular risks and a history of heart attack or stroke, according to the cardiologist. “People with these characteristics and those who have had bypass surgery or coronary angioplasty simply should not be shoveling snow in any conditions,” he said.
Just 10 minutes of heavy snow shoveling can push the heart to about 97% of its maximum rate, a 2025 Mayo Clinic review found. (iStock)
Osbourne said he often sees cardiac episodes in people who are typically sedentary and sit at a computer most of the day with little or no exercise. “Then once or twice a year, they go out and try to shovel the driveway after a heavy snowfall, and that unexpected exertion can unfortunately lead to tragedy.”
Hidden strain
The stress that is placed on one’s heart while shoveling snow is similar to what occurs during a cardiac stress test, Sobti pointed out, and may even exceed it.
Cold temperatures can cause blood vessels to constrict and blood pressure to spike — which, coupled with existing hypertension and the exertion of lifting snow, can significantly tax the heart, she warned.
“It’s almost like an at-risk person is putting themselves through an unsupervised maximal exertion stress test without a cardiologist actively monitoring them,” Sobti told Fox News Digital.
The stress that is placed on one’s heart while shoveling snow is similar to what occurs during a cardiac stress test. (iStock)
In addition to the exertion of shoveling, frigid temperatures can also strain the heart. Recent research has shown that cold exposure accounts for nearly twice as many cardiovascular deaths as heat exposure, including heat exhaustion.
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That study, published in the Annals of Internal Medicine last month, also found that those over age 65 had higher rates of temperature-related deaths.
“So the risk is very, very high,” Sobti cautioned. “It’s really that sudden rise in blood pressure coupled with the physical stress of snow shoveling itself.”
Safer shoveling tips
The cardiologist said it’s ideal to have someone else help with snow removal — but if you do choose to use a shovel, she recommends pacing yourself and using a “pushing or sweeping” motion instead of heavy lifting.
Recent research has shown that cold exposure accounts for nearly twice as many cardiovascular deaths as heat exposure. (iStock)
To protect against the cold, Sobti also recommends covering your mouth, nose and extremities, wearing a hat and gloves, and using extra caution in windy conditions.
Using an automated snow blower can still raise the heart rate — up to 120 beats per minute, compared to 170 while shoveling, the American Heart Association states on its website.
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It is also important to be aware of any symptoms of a potential cardiac issue while shoveling, Sobti emphasized.
If a person starts to experience warning signs such as chest pain, shortness of breath, a racing heart or palpitations, those should not be ignored.
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Even if the symptoms resolve after a few minutes, a person “could still be experiencing symptoms of a heart attack” and should call 911 for evaluation, Sobti said.
“It’s better really to be safe than sorry.”
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