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Vitamin supplement may delay diabetes in select groups, researchers say

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Vitamin supplement may delay diabetes in select groups, researchers say

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High-dose vitamin D supplements could help reduce diabetes risk among certain groups, according to new research from Tufts University.

In a large clinical trial, researchers performed genetic testing of more than 2,000 U.S. adults with prediabetes after they received 4,000 units per day of vitamin D supplements, then compared them to a placebo group.

An earlier study showed no significant reduction in diabetes risk in the group receiving vitamin D supplementation, but when the researchers looked closer, they found a benefit for certain genetic groups.

High-dose vitamin D supplements could help reduce diabetes risk among certain groups, according to new research from Tufts University. (iStock)

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For the new study, the Tufts researchers compared participants who appeared to benefit from vitamin D supplementation to those who did not, then examined how outcomes differed across three common variants of the vitamin D receptor gene.

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People who had certain versions of a vitamin D-related gene (called AC or CC) were 19% less likely to get diabetes when they took vitamin D compared to people who took a placebo, according to a university press release.

Participants with another genetic variant (AA) showed no benefit from supplementation.

People who had certain versions of a vitamin D-related gene (called AC or CC) were 19% less likely to get diabetes when they took vitamin D compared to people who took a placebo. (iStock)

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Vitamin D seems to work by attaching to a specific “receiver” in the body called the vitamin D receptor, the researchers discovered. These receptors are found in many places, including the pancreas, the organ that makes insulin.

The findings were published last week in JAMA Network Open.

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“Our finding is an example of the emerging science of precision nutrition or precision medicine, in which an intervention can be tailored to the needs of individuals according to their genetic makeup and disease risk,” Bess Dawson-Hughes, the study’s lead author and a senior scientist at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, told Fox News Digital.

“Taking a vitamin D supplement daily is an easy, inexpensive and generally safe approach to reducing diabetes risk,” she added. “In principle, this could involve a single, relatively inexpensive genetic test.”

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“It is too early to make specific recommendations for the general population.”

There were some limitations to the study, the researchers noted, including that this was a secondary analysis rather than a primary randomized comparison.

“Like any other first observation, this finding needs to be replicated in a future study,” the researcher said.

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The study only included individuals with prediabetes, which could limit relevance to broader populations. The results seen in specific genetic groups need to be confirmed in more studies before doctors can use them in patient care.

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“I would not advise older adults to take a daily dose of 4,000 IU of vitamin D without first consulting with their doctors,” the researchers said. (iStock)

The authors emphasized that people should not start taking high doses of vitamin D as a diabetes prevention strategy based on this study.

“It is too early to make specific recommendations for the general population,” Dawson-Hughes said. 

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Current recommendations suggest that most adults get about 600 IU of vitamin D daily (ages 1–70) and 800 IU for those over 70. However, previous studies have shown that taking very high doses can be harmful for older adults.

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“There is some evidence, from my laboratory and others, that the relatively high blood levels of 25-hydroxyvitamin D needed to achieve the diabetes risk reduction have been associated with an increased risk of falling in older adults,” Dawson-Hughes noted.  

“I would not advise older adults to take a daily dose of 4,000 IU of vitamin D without first consulting with their doctors.”

Adults with prediabetes also have an increased risk of cardiovascular disease, the researcher noted. (iStock)

This new study raises another question, according to Dawson-Hughes: Would vitamin D supplementation in adults with the responsive genotypes lower the risk of developing prediabetes, the forerunner to Type 2 diabetes? 

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“This is important because prediabetes is not a benign condition,” she said. “Adults with prediabetes also have an increased risk of cardiovascular disease.”

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Weekly weightlifting sweet spot may be linked to longer life, study finds

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Weekly weightlifting sweet spot may be linked to longer life, study finds

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Sticking to a resistance or strength training routine for a certain amount of time may extend your life, according to a new study.

Research published in the British Journal of Sports Medicine analyzed whether workouts involving weightlifting and weight machines are linked to a lower risk of death over time.

The study followed more than 147,000 U.S. adults who participated in three large health studies spanning up to 30 years. More than 35,000 died during the study period.

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Participants reported their exercise habits, including the number of minutes per week spent on resistance training and on aerobic activity, like walking, biking or swimming.

Resistance training levels were then compared with later death from any cause, as well as from cardiovascular disease, cancer, respiratory disease and neurological disease, according to a press release.

Doing a moderate amount of resistance training was linked with a lower risk of death in a recent study. (iStock)

Doing a moderate amount of resistance training was linked with a lower risk of death, according to study results. This outcome persisted even after researchers adjusted for other factors like age, smoking, diet quality, alcohol intake, family history and aerobic activity.

The clearest benefit was seen at around 90 to 119 minutes per week of resistance training.

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People who stuck to this interval of training per week had a 13% lower risk of all-cause death, 19% lower risk of death from heart disease and 27% lower risk of death from neurological disease.

More than 120 minutes of resistance training per week did not appear to add extra benefit to the overall death risk, according to the findings.

The clearest benefit was seen at around 90 to 119 minutes per week of resistance training. (iStock)

A lower risk of cancer death was seen at even small amounts of resistance training — 30 to 59 minutes per week was associated with a 12% decreased risk.

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The lowest overall death risk was found in people who did both higher aerobic activity and moderate to high resistance training.

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The study shows only an association between resistance training and lower death risk, not a direct cause, the researchers noted.

Other limitations were that participants reported their own exercise habits, which may not have been completely accurate, and the study did not measure how intensely they exercised.

30 to 59 minutes per week of strength training was associated with a 12% decreased risk of cancer death.

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The authors reflected in the study that engaging in “sufficient aerobic or resistance training alone is linked to lower mortality, with a stronger effect from aerobic activity.”

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The lowest risk was seen among people who did high levels of both aerobic exercise and resistance training. However, for people already doing a very high amount of aerobic exercise (roughly five to six hours of jogging or 11 hours of brisk walking per week), adding resistance training did not appear to lower the risk any further, they noted.

The lowest overall death risk was found in people who did both higher aerobic activity and moderate to high resistance training. (iStock)

In a previous interview with Fox News Digital, Kenny Santucci, fitness trainer, gym owner and host of the “Strong New York” podcast, shared the importance of pairing general movement with a focus on muscle building.

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For a better fitness outcome, Santucci encourages gym-goers to add more strength training to their routines and to lift “a little bit heavier.”

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“Strength training should be the basis of what you do,” he said. “I don’t have anything against cycling … but if you’re telling me that’s the basis of your training, and your goal is aesthetics, then you are not really helping yourself get to that point any easier.”

“Hard doesn’t necessarily mean it’s a better workout.”

Santucci recommends working at about 60% to 80% of capacity, pushing to a point of fatigue with moderate intensity.

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“There’s a science behind muscle growth, and if there’s no external force pushing against the muscle tissue, and you’re not fueling yourself with protein, then you’re probably not going to build muscle,” he said.

“Hard doesn’t necessarily mean it’s a better workout … If you’re training at levels of intensity, then you’re reproducing good outcomes.”

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AI-designed ‘universal vaccine’ passes first human clinical trial, could prevent future pandemics

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AI-designed ‘universal vaccine’ passes first human clinical trial, could prevent future pandemics

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A vaccine created using artificial intelligence that could potentially provide broader protection against multiple coronaviruses and help prepare for future outbreaks has passed its first human clinical trial.

Researchers from the Universities of Cambridge and Southampton developed a “universal vaccine” designed to protect against multiple Sarbeco coronaviruses, which the university explained in a news release is “the large group of viruses that occur in nature, including SARS-CoV-2, which caused the COVID pandemic.”

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Traditional vaccines must constantly be updated as viruses mutate, and the process is “like a dog chasing its tail,” said University of Southampton professor Saul Faust, the trial’s chief investigator.

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“Viruses like Influenza, coronaviruses and the Ebola group are evolving continuously, and by the time vaccines are rolled out, they may be poorly matched — the current ‘reactive’ vaccine system struggles to keep pace,” Faust said.

Researchers have developed a vaccine using AI that has proven to be promising in “future-proofing” people against mutating infections. (iStock)

An antigen is the active ingredient in a vaccine meant to trigger an immune-system response and fight off infection. According to the release, the university scientists logged all the available genetic sequence data for Sarbeco coronaviruses and used AI used to design a “super-antigen” that contains the antigen features “common to this whole group of viruses – including ones that haven’t emerged yet.”

The trial of the vaccine proved safe and triggered an immune response in 39 healthy volunteers, marking “the first time that a vaccine whose active component was designed entirely by computer simulations has been tested in humans,” the release said.

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The trial vaccine was administered through a micro-fluid jet that delivers the immunization through the skin using a tiny, high-pressure stream of liquid and does not require a needle. The researchers said this method could make it “faster and easier to carry out in large numbers of people.”

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“This new class of universal vaccines are future-proofed,” Faust said. “They not only protect against many variants simultaneously, but potentially against related viruses that haven’t yet emerged and spilt over to humans. If we can develop and clinically advance this new class of vaccines before a virus outbreak begins, millions of lives could be saved, lockdowns avoided and the economy preserved.”

A new vaccine has been proven safe and capable of triggering immune responses against coronavirus in a limited human trial. (iStock)

Some experts have raised broad concerns about using AI in medicine, primarily when it comes to making clinical decisions, not developing vaccines. Certain groups of people may be underrepresented in the data AI relies on, resulting in biased outcomes, some said.

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AI also sometimes produces erroneous information, called “hallucinations,” and determining who is liable for medical failings in such situations is a complex matter.

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Others have expressed concern over patient privacy, as well as the need for human judgment that takes into account the scope of a patient’s health history, rather than a single dataset.

While traditional vaccines are reactive, a new AI-designed vaccine aims to protect against future coronavirus threats. (iStock)

The universal-vaccine researchers said that a larger trial involving “a wider and more diverse population” is needed. They published their findings in Journal of Infection.

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Former wrestler, actor reveals breast cancer diagnosis: ‘One in 750 men’

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Former wrestler, actor reveals breast cancer diagnosis: ‘One in 750 men’

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Former professional wrestler and actor Tyler Mane announced he has been diagnosed with breast cancer.

Known for his roles in “X-Men” and “Halloween,” Mane shared the news publicly to help raise awareness about a condition that is frequently overlooked in men.

“I have some bad news. I start chemo today,” Mane stated in a video posted to his social media channels. “One in 750 men will be diagnosed with breast cancer in their lifetime, and I’m one of them.”

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Because breast cancer is predominantly associated with women, many men are unaware that they are also at risk. However, according to Mayo Clinic, everyone is born with a small amount of breast tissue.

While women go on to develop more of this tissue during puberty, the biological foundation for the disease exists in everyone.

Known for his roles in X-Men and Halloween, Mane shared the news publicly to help raise awareness about a condition that is frequently overlooked in men. (Bobby Bank/Getty Images)

The most common symptom of male breast cancer is a hard, painless lump located directly behind or near the nipple, according to experts. Other signs can include skin dimpling, nipple retraction or discharge.

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Male breast cancer is rare, accounting for less than 1% of all cases globally. Because routine screenings like mammograms are not standard practice for men, the disease is often caught much later than it is in women.

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Mane highlighted this issue as a primary motivation for speaking out. “Because it’s rarely talked about, it’s usually found at later stages and has worse outcomes,” he said. “I want to change that.”

Experts say the most common symptom of male breast cancer is a hard, painless lump located directly behind or near the nipple. (Dimitrios Kambouris/Getty Images)

Medical data supports Mane’s concerns regarding late-stage detection. While male breast cancer can occur at any age, it is most frequently diagnosed in older men, according to Mayo Clinic.

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Men’s treatment plans generally mirror those for women, typically involving surgery to remove the breast tissue, followed by chemotherapy, radiation or hormone therapy depending on how far the cancer has progressed.

Treatment plans generally mirror those for women, typically involving surgery to remove the breast tissue, followed by chemotherapy, radiation or hormone therapy depending on how far the cancer has progressed. (Rune Hellestad/Corbis via Getty Images)

Mane said he is utilizing his platform to normalize conversations about male health and encourage early detection. He concluded his video by asking his followers to spread the word and help educate others.

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“Follow, like and share, and come along for my journey to kick this thing in the ass,” Mane said. “Send this to 10 of your friends and have them follow me, because people need to hear this.”

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