Health
The U.S. Is Having Its Mildest Covid Winter Yet
This winter’s Covid wave in the United States has been the gentlest to date, in a welcome reprieve.
According to wastewater data aggregated by the Centers for Disease Control and Prevention, not only was there less Covid circulating over the holidays than in previous years, but there was also less virus in the wastewater than in all the summer waves the program has tracked.
The Covid hospitalization rate stayed around half of what it was last year, and deaths fell too. In late December, around 600 people were dying each week. Last winter at that time, it was around 2,000. (During the Omicron surge at the end of 2021, weekly deaths were topping 10,000.)
Although wastewater levels can’t tell us how many individual cases of Covid there are, the recent data reflects a significant lull in the virus’s five-year assault.
“This is definitely the mildest Covid winter,” said Michael Mina, an epidemiologist and chief science officer for eMed. “In terms of hospitalizations, in terms of spread.”
A new low
One possible reason for the lull is that the population is still carrying some immunity from a large, later-than-usual summer surge, said Peter Chin-Hong, an infectious disease specialist at the University of California, San Francisco. This year’s vaccine was also a good match for the circulating variant, and more people got it this year than last, according to C.D.C. data.
The virus also didn’t acquire the kind of mutations after the summer wave that would have allowed for significantly faster transmission or greater sickness, epidemiologists said.
That’s not unexpected several years into a new virus, said Aubree Gordon, an epidemiologist at the University of Michigan.
“You have two or three years of it being really bad,” she said. “Usually the first year is the worst — as far as incidence rates and severity goes — and then it settles out.”
Epidemiologists don’t know yet what a “baseline” Covid wave will look like, and there’s no guarantee that each winter will be milder than the last. But the chances of a new variant that can cause significant harm are much lower now, Mr. Mina said.
“Should we expect the variants to start to decline, in terms of how quickly they’re rising, and how aggressively?” he said. “The short answer is yes. The virus has grown up.”
Americans’ immune systems have become very familiar with the virus, said Mr. Mina, through vaccination and prior infections, and on average are more capable of recognizing and attacking it. That means we might have a lower viral load when we become ill, he said, or clear the virus faster, getting less sick and infecting fewer people in the process. Fewer infections also give the virus fewer opportunities to mutate.
Still other ways to get sick
That said, if it feels as if almost everyone you know has gotten sick this winter (or still is), you’re not wrong: It’s been another tough season for other respiratory viruses.
At its peak, the weekly flu hospitalization rate this year surpassed last winter’s high rate; hospitalizations for respiratory syncytial virus (R.S.V.) have similarly mirrored last year. (Norovirus, though not respiratory, is also notably high this year.)
Flu and Covid have had roughly the same death toll so far this season — around 8,000 to 9,000 people as of mid-January, according to C.D.C. estimates. Covid deaths since the start of last summer have totaled around 25,000. (Though getting one virus can theoretically lower an individual’s risk of getting another for a short time, it’s still very possible for multiple viruses to surge at once.)
The comparison with flu is useful because, like flu, Covid is here to stay. As with flu, there’ll be better and worse seasons. It might turn out that this winter was on the low side of our new baseline, Professor Gordon said.
But unlike with flu, there will probably be more waves outside of winter. While the timing of Covid’s winter surge has been relatively consistent — peaking in early January each year — its other waves have yet to fall into a clear pattern. A mild surge during the winter holidays could mean a worse one later this year, possibly even later this winter. And for people who are at higher risk, that will continue to translate into severe illness and death, as well as new cases of long Covid.
“There might be some good times, some bad times,” Dr. Chin-Hong said. “So whether or not we’ll get something later on? We have to have humility.”
But for now, there’s a measure of relief for Americans, as well as for the experts who’ve tracked the virus for five long years. “If I never saw a crazy variant for the rest of my life,” he said, “I’d be so excited.”
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Chronic back pain may have met its match with hormone treatment, scientists say
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A hormone traditionally used to treat bone loss may hold the key to stopping chronic back pain at its source, according to a new study.
Chronic back pain is often linked to the deterioration of spinal discs and vertebral end plates, which are the thin layers of tissue separating the discs from the vertebrae, according to medical sources.
When these break down, they become porous, allowing nerves that aren’t usually impacted to enter the spinal center, leading to frequent discomfort.
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Research led by Dr. Janet L. Crane at Johns Hopkins University found the parathyroid hormone (PTH) could prevent and even reverse the growth of pain-sensing nerves into damaged areas of the spine.
Parathyroid glands naturally produce PTH, which experts say plays a key role in regulating calcium levels and bone remodeling.
Research suggests a parathyroid hormone can prevent the growth of pain-sensing nerves into damaged areas of the spine. (iStock)
These findings could shift the focus of back pain treatment from managing symptoms to modifying the underlying issue, according to scientists.
“During spinal degeneration, pain-sensing nerves grow into regions where they normally do not exist. Our findings show that parathyroid hormone can reverse this process by activating natural signals that push these nerves away,” Crane said in a press release.
HIDDEN SIGNS YOUR BONES MAY BE WEAKER THAN YOU THINK, ACCORDING TO DOCTOR
Synthetic versions of PTH are already used to treat osteoporosis. Earlier research hinted that these treatments might also reduce bone-related pain, but the underlying biological mechanism was not well understood.
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Using animal models, the Johns Hopkins researchers found that one to two months of PTH treatment led to denser, more stable vertebral endplates.
More significantly, the treatment triggered bone-building cells, known as osteoblasts, to produce a protein called Slit3, the study detailed.
These findings could shift the focus of back pain treatment from managing symptoms to modifying the underlying issue, according to scientists. (iStock)
The study found that this protein repels growing nerve fibers, preventing them from infiltrating sensitive regions of the spine.
When the researchers removed Slit3 from mice, the hormone’s pain-relieving effects disappeared, confirming the protein’s critical role in the process.
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PTH is already approved by the Food and Drug Administration to treat osteoporosis. Some patients receiving the hormone for bone density have reported unexpected relief from back pain, a phenomenon this study could help explain.
This study lays a foundation for future clinical trials to explore the efficacy of PTH as a disease-modifying and pain-relieving treatment for spinal degeneration, the researchers say. (iStock)
“Our study suggests that PTH treatment of [lower back pain] during spinal degeneration may reduce aberrant innervation (abnormal nerve growth),” Crane concluded.
The doctor said this research lays the foundation for future clinical trials that will explore PTH’s effectiveness as a disease-modifying and pain-relieving treatment for spinal degeneration.
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Researchers noted several limitations, including the possibility that PTH treatment could affect the central nervous system in ways not fully explored in this study.
Because the study focused specifically on the Slit3 protein, further research is needed to determine how other genetic factors and bone-forming processes might influence spinal nerve growth and pain relief.
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The study was published in the journal Bone Research.
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