Health
Stroke, dementia and depression share these 17 preventable risk factors
Three of the most common aging-related diseases share many of the same risk factors — and they can all be reduced through lifestyle changes.
That’s according to a new study from Mass General Brigham (MGB), which identified 17 common risk factors all linked to stroke, dementia and late-life depression.
The researchers combed through previously published studies of risk factors associated with those three conditions, then determined which ones can be controlled through healthy behaviors.
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They also predicted the impact each risk factor had on quality of life and mortality, according to a press release from MGB.
“The suggestion that reduced activity may be a symptom rather than a cause of brain disease challenges how we interpret early signs.” (iStock)
The 17 risk factors that are shared by at least two of the diseases include blood pressure, kidney disease, fasting plasma glucose, total cholesterol, alcohol use, diet, hearing loss, pain, physical activity, purpose in life, sleep, smoking, social engagement and stress, the researchers listed.
The findings were published in the Journal of Neurology, Neurosurgery, and Psychiatry.
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Senior author Sanjula Singh, MD, PhD, principal investigator at the Brain Care Labs at Massachusetts General Hospital, described the discovery as “hopeful.”
“This means there are real opportunities for prevention. Whether it’s managing your blood pressure, staying physically active, eating well or maintaining social connections, small changes in your daily routine can help you take better care of your brain over time,” she told Fox News Digital.
“Small changes in your daily routine can help you take better care of your brain over time.”
Brian Snelling, MD, of the Miami Neuroscience Institute, part of Baptist Health South Florida, was not involved in the study but shared his input on the findings.
“The influence of factors like chronic pain and a sense of purpose on brain health was notable and often overlooked in neurological care,” he told Fox News Digital.
“Also, the suggestion that reduced activity may be a symptom rather than a cause of brain disease challenges how we interpret early signs.”
Total cholesterol was one of the modifiable risk factors shared by at least two of the three cognitive disorders. (iStock)
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News senior medical analyst, said he agrees with the findings of the study.
“These factors are all well-proven to decrease inflammation in the body and thereby the risk of stroke, dementia and late-life depression,” he told Fox News Digital.
Incremental changes
To keep from becoming overwhelmed, the researchers recommend regarding the 17 factors as a “menu of options.”
“You don’t have to address them all at once — starting with one to three small, realistic changes can already make a meaningful difference,” said Singh. “These findings might help people consider which of these 17 risk factors could be a starting point to take better care of their brains.”
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Singling out one area to start with, Singh recommended measuring blood pressure and taking steps to keep it at a healthy level.
“There are many ways to control your blood pressure — reducing salt intake, increasing physical activity, eating more fruits and vegetables, managing stress and taking medication when prescribed,” she advised.
Singling out one area to start with, the lead study author (not pictured) recommended measuring blood pressure and taking steps to keep it at a healthy level. (iStock)
Other important areas to focus on include sleep, social connections, blood sugar and physical activity, according to the researcher.
“The most important thing is to start somewhere — even small improvements can make a meaningful difference for your brain health,” she said.
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Many of the factors are interconnected, Singh noted.
“Progress in one area often supports progress in others,” she said. “For example, becoming more active may help to improve sleep or lower blood pressure.”
Managing blood pressure and kidney health, as well as staying mentally and socially engaged, are key strategies to protect the brain, according to Snelling.
“Proactive brain care should start well before symptoms appear,” he said.
Limitations of the study
Like any study, Singh noted, this one had several limitations.
“We focused on modifiable risk factors that overlapped with at least two out of the three conditions — as a result, we may have excluded important risk factors that are specific to just one condition, particularly certain psychological or behavioral factors related to late-life depression,” she told Fox News Digital.
Maintaining social connections is one of the most important strategies for protecting brain health, according to experts. (iStock)
The researchers also relied only on existing meta-analyses, which meant some potentially important factors in smaller studies may have been missed.
“Additionally, the strength of evidence varied across risk factors and conditions, and we couldn’t establish causality — only associations,” Singh said. “Still, we hope this work offers a useful starting point for prevention-focused research.”
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Snelling agreed that while the large review shows strong associations, it doesn’t confirm cause and effect.
“It also highlights the need for more high-quality data, especially around late-life depression.”
“Proactive brain care should start well before symptoms appear.”
Overall, experts agreed the study emphasizes that lifestyle changes can be instrumental in promoting health and longevity.
“Diet, exercise, sleep and having a purpose in life aren’t just good for brain health — they are also critical in preventing numerous chronic diseases,” family physician Dr. Brintha Vasagar, based in Milwaukee, Wisconsin, told Fox News Digital.
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“Your family medicine physician can help you identify which changes would have the most impact on your health.”
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Health
James Van Der Beek’s death highlights alarming colon cancer rise in younger adults
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Following actor James Van Der Beek’s death after a 2½-year battle with colon cancer, experts are warning of the disease’s prevalence among younger people.
The “Dawson’s Creek” star announced his stage 3 colon cancer diagnosis in November 2024, although he was officially diagnosed in August 2023 after a colonoscopy.
In an August 2025 feature with Healthline, Van Der Beek revealed the first warning sign of colon cancer was a change in bowel movements, which he chalked up to an effect of drinking coffee.
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“Before my diagnosis, I didn’t know much about colorectal cancer,” the actor said. “I didn’t even realize the screening age [had] dropped to 45; I thought it was still 50.”
Following actor James Van Der Beek’s death after a 2½-year battle with colon cancer, experts are warning of the disease’s prevalence among younger people. (Ray Tamarra/GC Images)
Risk on the rise
Recent research has shown an alarming rise in colorectal cancer (CRC) cases among younger individuals.
The American Cancer Society published evidence in January that colorectal cancer is now officially the leading cause of cancer-related death among men and women 50 and younger.
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This is a significant increase from the 1990s, when it was the fifth deadliest.
While overall cancer deaths have been on the decline for this age group since 1990, dropping by about 44% combined, CRC is the only major cancer that has seen a spike in mortality for those under 50 during that time period, the researchers noted.
Colorectal cancer is now officially the leading cause of cancer-related death among men and women 50 and younger. (iStock)
Dr. Aparna Parikh, medical director of the Center for Young Adult Colorectal Cancer at the Mass General Cancer Center, who is not affiliated with the ACS, shared that experts don’t “entirely understand why” cases are on the rise.
“But it seems to be an interplay of a person’s risk factors, overall makeup and early exposures,” she previously told Fox News Digital. “The exposures include dietary exposures, environmental exposures and possible antibiotic exposures, as well as lifestyle factors in the right host.”
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Another recent ACS study discovered that drinking heavily and consistently over an adult’s lifetime could lead to a higher risk of colorectal cancer.
Other primary risk factors include family history, obesity, smoking, a diet high in red and processed meats, inflammatory bowel disease, and a personal history or family history of polyps.
In a Thursday appearance on “America’s Newsroom,” Fox News senior medical analyst Dr. Marc Siegel commented on the rise of CRC among younger individuals.
“There is a genetic issue, but there’s also ultraprocessed foods — a new study out of Mass General shows a high diet in that… [you’re] 45% more likely to have colon cancer,” he said.
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There is also a 30% increase in risk with a diet higher in processed meats, like hot dogs, and a 20% increase with diets higher in red meat, according to Siegel.
“These are the villains here,” he said. “That, plus genetics. And I’m urging everyone out there — change the age for screening to 45, or even below if you have risk factors. That’s really key.”
Recognizing red flags
While there may be no symptoms of CRC before diagnosis, especially in the early stages, certain symptoms should not be overlooked, experts say.
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Dr. Eitan Friedman, Ph.D., an oncologist and founder of The Suzanne Levy-Gertner Oncogenetics Unit at the Sheba Medical Center in Israel, confirmed that changes in bowel habits are the primary red flag that should raise the suspicion of colorectal cancer.
Abdominal discomfort and stomach pain, including cramps, bloating and gas, may be sneaky signs of colorectal cancer. (iStock)
Other symptoms include fatigue as a result of anemia, a change in bowel movements, stomach pain or abdominal discomfort, rectal bleeding or blood in stool, weakness and unexplained weight loss, Friedman, who did not treat Van Der Beek, told Fox News Digital.
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Dr. Erica Barnell, Ph.D., a physician-scientist at Washington University School of Medicine — and co-founder and chief medical officer at Geneoscopy — noted that the actor’s experience of having no “glaring” signs is common.
“Many colorectal cancers develop silently, without obvious symptoms,” Barnell, who also did not treat Van Der Beek, told Fox News Digital. “By the time symptoms appear, the disease may already be advanced.”
Family history and lifestyle habits such as smoking and drinking can increase CRC risk. (iStock)
The key to getting ahead of colorectal cancer is early detection, according to experts.
“Colonoscopy at age 45 onwards, at five- to 10-year intervals, has been shown to lead to early detection of polyps that have the potential to become malignant, and to allow for their removal as an effective means of minimizing the risk of malignant transformation,” Friedman said.
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Unfortunately, Barnell noted, “screening compliance in the U.S. remains below national targets, and gaps are widest in rural, low-income and minority communities.”
“Most people don’t like talking about bowel habits, but paying attention to changes can save your life,” the doctor said. “Screening gives us the chance to find problems early — often before you feel sick — and that can make all the difference.”
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Siegel also pushed for colonoscopies as the best method to screen for CRC, especially if a polyp is detected and removed before turning into cancer.
Fox News Digital’s Christina Dugan Ramirez contributed to this report.
Health
Common sleep aid could be quietly interfering with your rest, study suggests
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Think your sound machine is helping you sleep? It might be doing the opposite.
A new study from the University of Pennsylvania Perelman School of Medicine found that listening to pink noise at bedtime could disturb REM sleep (dream sleep) and sleep recovery.
The research, published in the journal Sleep, found that earplugs were significantly more effective at blocking out traffic noise during sleep.
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The researchers observed 25 healthy adults between the ages of 21 and 41, in an eight-hour, seven-night sleep lab simulation, according to a Penn Medicine press release.
The participants said they did not previously use noise to help them sleep, and did not have any sleep disorders.
Pink noise could disrupt REM sleep, according to Penn Medicine research. (iStock)
During the experiment, the participants slept under different sound exposures, including aircraft noise, pink noise, aircraft noise with pink noise, and aircraft noise with earplugs. The participants completed tests and surveys each morning to gauge sleep quality, alertness and other health effects.
Exposure to aircraft noise was associated with about 23 fewer minutes spent in the deepest stage of sleep compared to no noise, the study found.
Earplugs prevented this decline in deep sleep “to a large extent,” the release stated.
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Pink noise at 50 decibels, which sounds similar to “moderate rainfall,” was associated with almost a 19-minute decrease in REM sleep.
Aircraft noise and pink noise combined led to “significantly shorter” REM and deep sleep compared to noise-free nights. Time spent awake was also 15 minutes longer with this combination, which was not observed with solo aircraft or pink noise.
Earplugs were found to improve sleep quality among study participants. (iStock)
Participants said their sleep felt “lighter,” the overall quality was worse, and they reported waking up more frequently when exposed to aircraft or pink noise compared to no noise, unless they used earplugs.
Lead study author Mathias Basner, M.D., Ph.D., professor of sleep and chronobiology in psychiatry, noted that REM sleep is important for “memory consolidation, emotional regulation and brain development.”
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“Our findings suggest that playing pink noise and other types of broadband noise during sleep could be harmful — especially for children whose brains are still developing and who spend much more time in REM sleep than adults,” he wrote in the release.
Basner noted it’s common for parents to place sound machines near their newborns or toddlers, with a “good intention” of helping them fall and stay asleep.
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There were some positive effects of pink noise, he said, including that it mitigated some deep sleep reduction and sleep fragmentation caused by “intermittent” environmental noise.
“If low amounts of deep sleep and sleep fragmentations are someone’s main sleep issues, pink noise could be overall beneficial for them,” he said.
Importance of sound sleep
Individuals cycle through periods of deep sleep and REM sleep multiple times throughout the night, according to Penn Medicine. Deep sleep is important for physical restoration, memory consolidation and the clearing of toxins in the brain.
“Deep and REM sleep complement each other and collectively guarantee that we wake up restored in the morning, ready for the next day,” the release stated.
Pink noise introduces a “constant stimulus” for the brain to process, a sleep doctor said. (iStock)
Dr. William Lu, a San Francisco sleep expert and medical director of Dreem Health, said these findings are a “significant pivot” from the sound machine trend.
“While pink noise might mask external disruptions, it introduces a constant stimulus that the brain still has to process,” he told Fox News Digital. “The most concerning finding is that we may be unknowingly sacrificing segments of our REM sleep.”
Differences between ambient noises
Different types of noise could potentially have different impacts on sleep, Lu acknowledged.
White noise translates as “equal energy across all frequencies” and sounds like harsh radio static, the sleep expert said. Brown noise emphasizes lower frequencies, resulting in a “deep, bass-heavy rumble” like distant thunder or a heavy waterfall.
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While pink noise also has more energy at lower frequencies, but not as deep as brown, it creates a “perceptually balanced” sound like steady rainfall or wind.
“The study suggests that pink noise acts as a continuous auditory load that specifically fragments and reduces REM sleep,” Lu summarized.
Based on this type of research and data, the expert said he does not recommend using a sound machine as a “first-line” sleep aid in his own practice.
It’s common for parents to place sound machines near their newborns or toddlers while they sleep, with “good intention,” the researcher said. (iStock)
More research needed
The researchers concluded that the impact of pink noise and other audio sleep aids needs to be studied more thoroughly.
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“Overall, our results caution against the use of broadband noise, especially for newborns and toddlers, and indicate that we need more research in vulnerable populations on long-term use, on the different colors of broadband noise, and on safe broadband noise levels in relation to sleep,” Basner said.
In an interview with Fox News Digital, the researcher noted that the study, funded by the FAA, does have limitations — including that it did not investigate the effect on sleep when pink noise is used for longer periods of time.
The study was “relatively small,” and more research is necessary to weigh long-term impacts, the researchers said. (iStock)
The study was also relatively small, Basner said, and the researchers haven’t yet examined differences between individuals.
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“Until we have more research, I would recommend that if somebody wants to use pink noise, they should do it at the lowest sound level that still works for them — and if falling asleep is the main problem, put the machine/app on a timer so that it shuts off after the subject falls asleep,” he advised.
“Also, I would probably discourage general use [for] newborns and toddlers until we have more information.”
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