Connect with us

Health

Some cancer patients could avoid surgery with innovative new therapy

Published

on

Some cancer patients could avoid surgery with innovative new therapy

NEWYou can now listen to Fox News articles!

An experimental drug has shown promise in fighting a hard-to-treat form of bladder cancer known as BCG-unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC).

BCG (Bacillus Calmette-Guérin) is an immunotherapy drug that is often the first-line treatment for certain early-stage bladder cancers.

The new drug, TAR-200 — which was evaluated in a trial sponsored and conducted by Janssen Research & Development, LLC, a subsidiary of Johnson & Johnson — may offer a less invasive alternative to bladder removal surgery.

KILLER CONDITION LANDS IN TOP 10 LEADING CAUSES OF DEATH AS GLOBAL CASES SURGE

Advertisement

TAR-200 is a small, drug-releasing device placed directly into the bladder through a simple outpatient procedure, without general anesthesia, according to the study press release. 

Once inserted, it slowly releases the chemotherapy drug gemcitabine over several weeks.

Researchers say the new bladder-inserted device could spare patients from losing their bladder entirely. (iStock)

“Traditionally, these patients have had very limited treatment options. This new therapy is the most effective one reported to date for the most common form of bladder cancer,” said study lead Sia Daneshmand, M.D., director of urologic oncology with Keck Medicine of USC, in a press release. 

“The findings of the clinical trial are a breakthrough in how certain types of bladder cancer might be treated, leading to improved outcomes and saved lives.”

Advertisement

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

Bladder cancer is the fourth most common cancer in men and the 11th most common cancer in women.

According to the Urology Care Foundation, non-muscle-invasive bladder cancer is found in the tissue that lines the inner surface of the bladder. 

“Bladder cancer is one of the 10 most common cancers worldwide, yet treatment options have remained largely unchanged for over 40 years.”

High-risk NMIBC carries a greater chance of coming back after treatment. This study aimed to find an option for patients whose cancer recurred even after standard therapy.

Advertisement

“The standard treatment plan for these patients was surgery to remove the bladder and surrounding tissue and organs, which has many health risks and may negatively impact patients’ quality of life,” said Daneshmand.

This new therapy could eventually allow some patients to avoid that procedure.

Trial results showed that many patients stayed cancer-free for more than two years. (iStock)

All participants in the study had high-risk NMIBC that did not respond to the standard immunotherapy drug BCG. The study was split into multiple groups who tested different combinations of drugs and treatment methods.

In one group, patients received TAR-200 once every three weeks for about six months, followed by maintenance treatments every 12 weeks for up to two years.

Advertisement

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

Among 85 patients in this group, 82.4% showed no detectable signs of cancer after treatment. In that group, 52.9% remained cancer-free at one year, and many stayed cancer-free for more than two years without needing additional therapy.

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

In another group of patients with a less aggressive type of early-stage bladder cancer, early disease-free survival rates were 85.3% at six months and 81.1% at nine months. Overall, 94% were able to keep their bladders.

The clinical trial results were published earlier this year in the Journal of Clinical Oncology.

Advertisement

The TAR-200 device delivers gemcitabine directly to the bladder, keeping the drug where it’s needed most. (iStock)

The researchers emphasized that this is still mid-stage (Phase 2b) data. Longer-term, larger trials and regulatory reviews are still needed before the treatment could become standard care. 

“Because the study didn’t include a traditional comparison (no randomized control arm), we can’t definitively say how TAR-200 stacks up against other treatments in a fair head-to-head way,” the researchers wrote. 

CLICK HERE FOR MORE HEALTH STORIES

Patients in this study are a specific subset (BCG-unresponsive and eligible for bladder preservation) and may not represent all bladder-cancer cases.

Advertisement

“Also, follow-up time remains relatively short and the number of patients modest, meaning we don’t yet know how long the benefits will last or how they apply to larger, more diverse groups of people,” the researchers added.

Health

Tobacco and nicotine ban sparks backlash from business owners in coastal town

Published

on

Tobacco and nicotine ban sparks backlash from business owners in coastal town

NEWYou can now listen to Fox News articles!

Officials in Tiburon, California, have moved to prohibit the sale of all tobacco.

On Wednesday, the town council unanimously passed an ordinance that would ban the sale of cigarettes, cigars, vapes, e-cigarettes and all other nicotine products.

Tiburon Mayor Holli Thier told Fox News Digital in a statement that she is “pleased to have sponsored” and “voted to save lives and save our environment.”

SMOKING BANNED FOR ENTIRE GENERATION UNDER SWEEPING NEW NATIONAL LAW

Advertisement

“With local youth in Marin County vaping at twice the national average, it is critical that we take all efforts to reduce teen addiction,” she added. “By banning all tobacco sales here in Tiburon, we are preventing youth from getting addicted and protecting our environment.”

Cigarettes are the biggest source of single-use plastic finding its way into rivers, bays and oceans in the world, Thier said.

Officials in Tiburon, California, have moved forward to prohibit the sale of tobacco products in the Bay Area. (iStock)

An anti-tobacco group of high school students from across Marin County, the Youth Advocacy Committee (YAC), were present at a few town council meetings to advocate for the ordinance.

Advertisement

Diana Garcia, a YAC student, reiterated her strong support for the ban. 

“I urge you to keep supporting this amendment to protect the health and future of our youth. You have a chance to set an example for communities to follow,” she said at the Nov. 5 meeting.

In 2022, nearly 50 million U.S. adults reported the use of any tobacco product, according to the Centers for Disease Control and Prevention.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

The CDC also reports that smoking and secondhand smoke exposure cause over 480,000 deaths each year, with “smoking harm[ing] nearly every organ of the body and caus[ing] many diseases.”

Advertisement

The new anti-tobacco ordinance is set to take effect in December. (iStock)

The 2023 County Health Rankings & Roadmaps report by the University of Wisconsin School of Medicine ranked Marin County as the healthiest California county.

“We remain committed to doing the hard work and changing the outcomes so all in Marin can thrive and live healthy lives,” said Niccore Tyler, Marin County’s health and human services’ chief strategy officer, at the time.

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

The California Fuels & Convenience Alliance penned an opposition letter to the town council.

Advertisement

“We believe this complete prohibition sends a discouraging message to small businesses and entrepreneurs. Small businesses, including convenience stores and gas stations, are essential to communities and provide residents with convenient access to everyday necessities,” it read.

Nearly 50 million U.S. adults reported the use of any tobacco product in 2022.  (iStock)

“Complete prohibitions on product categories, rather than reasonable regulation, send a message that small businesses may face unpredictable restrictions, creating uncertainty that discourages entrepreneurship and investment in Tiburon,” the letter continued.

CLICK HERE FOR MORE HEALTH STORIES

The ordinance is set to take effect in December.

Advertisement

Continue Reading

Health

What a Dietitian Really Eats in a Day To Beat Menopause Weight Gain

Published

on

What a Dietitian Really Eats in a Day To Beat Menopause Weight Gain


Advertisement


How To Lose Weight During Menopause, According to a Dietitian | Woman’s World




















Advertisement











Advertisement




Use left and right arrow keys to navigate between menu items.


Use escape to exit the menu.

Advertisement

Continue Reading

Health

Killer condition lands in top 10 leading causes of death as global cases surge

Published

on

Killer condition lands in top 10 leading causes of death as global cases surge

NEWYou can now listen to Fox News articles!

Chronic kidney disease has been named the ninth leading cause of global death.

Record numbers of men and women are currently estimated to have reduced kidney function, according to new research following a study published in the journal The Lancet.

Researchers at NYU Langone Health, the University of Glasgow, and the Institute for Health Metrics and Evaluation (IHME) at the University of Washington analyzed the rise of kidney disease worldwide.

CUTTING OUT ALCOHOL AND MEDICATING SOONER COULD PREVENT ‘SILENT KILLER,’ EXPERTS SAY

Advertisement

They examined 2,230 published papers and health datasets from 133 countries, searching for diagnoses, mortality and the toll of disability from the disease.

From 1990 to 2023, cases rose from 378 million to 788 million, landing the disease in the top 10 of most deadly diseases in the world for the first time.

The largest risk factors for kidney disease include high blood sugar, high blood pressure and high body mass index (BMI). (iStock)

The research, conducted as part of the Global Burden of Disease 2023 study, also revealed that about 14% of the world’s adult population has chronic kidney disease. About 1.5 million people died from kidney disease in 2023, an increase of more than 6% since 1993.

Most people in the study were in early stages of the disease, which can be improved with drugs and lifestyle changes before dialysis or surgery becomes necessary, the researchers noted.

Advertisement

The research, which was presented last week at the American Society of Nephrology’s annual Kidney Week conference, marks “the most comprehensive estimate of the condition in nearly a decade,” according to the authors.

DIABETES STUDY REVEALS DIAGNOSIS GAP AFFECTING MILLIONS OF PEOPLE

Chronic kidney disease causes the kidneys to lose the ability to filter waste and excess fluid from the blood, NYU Langone detailed.

Mild cases may not show any symptoms, but those in the most advanced stages can require dialysis, kidney replacement therapy or an organ transplant. 

Chronic kidney disease causes the kidneys to lose the ability to filter waste and excess fluid from the blood. (iStock)

Advertisement

Impaired kidney function was also identified as a key risk factor for heart disease, contributing to about 12% of global cardiovascular mortality. 

The largest risk factors for kidney disease, based on the study findings, include high blood sugar, high blood pressure and high body mass index (BMI).

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

Study co-senior author Josef Coresh, M.D., Ph.D., director of NYU Langone’s Optimal Aging Institute, said these results classify chronic kidney disease as “common, deadly and getting worse as a major public health issue.”

“These findings support efforts to recognize the condition alongside cancer, heart disease and mental health concerns as a major priority for policymakers around the world,” he said in a statement.

Advertisement

Kidney disease may show no symptoms, yet can ultimately require dialysis or organ transplantation. (iStock)

Study co-lead author Morgan Grams, M.D., Ph.D., the Susan and Morris Mark Professor of Medicine at the NYU Grossman School of Medicine, also commented that chronic kidney disease is “underdiagnosed and undertreated.”

“Our report underscores the need for more urine testing to catch it early and the need to ensure that patients can afford and access therapy once they are diagnosed,” she wrote.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

New medications have recently become available that can slow disease progression and reduce the risk of heart attack, stroke and heart failure, although it may take time to see the global impact, Grams added.

Advertisement

A doctor urged physicians to be more aware of kidney function and the impact of certain medications. (iStock)

Fox News senior medical analyst Dr. Marc Siegel commented on the “dramatic increase” in an interview with Fox News Digital, agreeing that kidney disease is “vastly underestimated and underdiagnosed,” in part due to lack of symptoms in early stages.

“The kidneys are filters of waste and managers of electrolytes and acid/base balance,” said Siegel, who was not involved in the study. “They are very sensitive to changes in blood pressure and blood flow, and can lead to loss of protein and electrolytes when damaged.”

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

“High blood pressure, obesity, heart disease, diabetes and low blood pressure all impact basic kidney function, so there is a high degree of secondary kidney disease and failure in addition to primary damage to the kidneys themselves,” the doctor added.

Advertisement

CLICK HERE FOR MORE HEALTH STORIES

Siegel urged physicians to be more aware of kidney function and the impact of certain medications.

This study was funded by the National Institutes of Health, the Gates Foundation and the National Kidney Foundation.

Continue Reading

Trending