Health
New Ozempic-alternative diabetes pill burns fat without muscle loss, study suggests
GLP-1 weight loss pill in development
Fox News senior medical analyst Dr. Marc Siegel discusses advancements in weight loss drugs, safety concerns surrounding nicotine patches and his interview with FDA Commissioner Dr. Marty Makary on vaccine protocol.
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Scientists in Sweden have created a new pill designed to help the body burn fat and control blood sugar in a different way than popular GLP-1 drugs, like Ozempic.
While injectable GLP-1s work by suppressing appetite, this new treatment boosts metabolism in the muscles.
A study led by researchers at Karolinska Institutet and Stockholm University included both an early animal study and a human clinical trial with 48 healthy adults and 25 people with type 2 diabetes, according to a press release.
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The new oral medication was found to successfully control blood glucose, boost fat burning and retain muscle mass in animals, while getting high marks for tolerability and safety in humans.
It was also found to have fewer side effects than GLP-1s like semaglutides and tirzepatides, which are known to cause appetite loss, gastrointestinal distress and muscle wasting, the researchers noted.
While injectable GLP-1s work by suppressing appetite, this new treatment boosts metabolism in the muscles. (iStock)
The experimental medication uses a new form of beta-2 agonist that benefits muscle function while also avoiding overstimulation of the heart, which has been identified as a potential safety concern of older versions.
The findings were published this week in the journal Cell.
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Because the new oral drug acts via a different mechanism than appetite-suppressing medications, it could be used alone or in combination with GLP-1s, the researchers noted.
“Our results point to a future where we can improve metabolic health without losing muscle mass,” said Tore Bengtsson, professor at the Department of Molecular Bioscience at Wenner-Gren Institute, Stockholm University, in the release. “Muscles are important in both type 2 diabetes and obesity, and muscle mass is also directly correlated with life expectancy.”
“Muscles are important in both type 2 diabetes and obesity, and muscle mass is also directly correlated with life expectancy.” (iStock)
This medication has the potential to be of “great importance” for patients with type 2 diabetes and obesity, according to Shane C. Wright, assistant professor at the Department of Physiology and Pharmacology at Karolinska Institutet.
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“Our substance appears to promote healthy weight loss and, in addition, patients do not have to take injections,” he added.
Dr. Trey Wickham, interim chief of the Division of Endocrinology, Diabetes & Metabolism at VCU Health in Richmond, Virginia, was not involved in the study but shared his reaction to the publication in the journal Cell.
“Our results point to a future where we can improve metabolic health without losing muscle mass.”
“This compound’s mechanism of action could address some specific metabolic concerns with previous weight reduction therapies, such as the loss of both muscle and fat tissue,” Wickham told Fox News Digital.
“Although the reported preliminary results are interesting, rigorous testing involving larger longitudinal trials are necessary to ensure human long-term safety and understand the potential role of this compound in the comprehensive, evidence-based treatment of obesity and diabetes.”
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The study had some limitations, the researchers noted, chiefly that the preclinical studies in mice fail to capture the “complex nature of these diseases” in humans.
Structural studies are needed to understand exactly how the drug works.
“This compound’s mechanism of action could address some specific metabolic concerns with previous weight reduction therapies, such as the loss of both muscle and fat tissue,” a doctor said. (iStock)
“Our phase 1 data show that compound 15 is well-tolerated; however, conclusive clinical efficacy data (on how the drug controls glucose metabolism) are currently still lacking.”
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Looking ahead, the company that developed the drug, Atrogi AB, plans to conduct a larger phase 2 clinical trial with a larger, more diverse population, including people with obesity.
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The study was supported in part by the Swedish Research Council, the Swedish Society for Medical Research and the Novo Nordisk Foundation.
Uppsala University, University of Copenhagen, Monash University and University of Queensland all collaborated with the lead researchers.
Ants can be a nuisance. Just ask officials at a hospital in Canada who are dealing with an “appearance of ants within the operating room” that has forced them to indefinitely suspend some surgeries there.
The ants appeared recently at Carman Memorial Hospital in Carman Manitoba, according to a statement from Southern Health-Santé Sud, the provincial authority that oversees the hospital.
It was not clear when the hospital would resume operations, but Southern Health said on Friday that a “limited number of elective surgeries” had been postponed and that the hospital was working with patients to reschedule them. Portage Online, a local news website, reported that 16 operations had been postponed, citing information from Southern Health.
It’s not the first time ants have disrupted operations at the hospital. The insects appeared there in August 2024, but “the issue resolved within a few weeks,” Southern Health said. They returned last summer. But with their reappearance this week, the hospital said it was taking more drastic measures. The hospital serves the area around Carman, a town with a population of around 3,000 residents about 47 miles southwest of Winnipeg.
“Any factor that could impact the safety or integrity of the operating room environment requires the suspension of surgical activity until the issue can be resolved,” Southern Health said. “The safety of patients, staff and physicians is paramount.”
The hospital is working with exterminators “to identify the source of the ants and implement additional measures and support a long-term resolution.” Southern Health told Portage Online that exterminators had “surveyed and cleaned drains, opened walls and sealed cracks.”
“Several methods have been used to bait the ants in an effort to find where they are originating from,” the authority said.
In a separate statement to the CBC, Southern Health said that it believed that an ant colony had made its home near the hospital and that they appeared to be “simply seeking food sources inside buildings as ants are known to do.”
The hospital also told the CBC that the ant problem at the hospital did not amount to an “infestation.”
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The U.S. government is moving to evacuate American passengers from a cruise ship linked to a deadly hantavirus outbreak, with plans to transport them to a military base in Nebraska for quarantine and monitoring, federal health officials said Friday.
The Centers for Disease Control and Prevention said the risk to the American public remains extremely low as officials move forward with a medical repatriation flight for passengers aboard the M/V Hondius.
President Donald Trump said earlier Friday that the situation appears to be under control, pointing to the virus being difficult to transmit.
“We have very good people looking at it. It seems to be okay. They know the virus very well. They’ve worked with it for a long time. They know it very well. Not easy to pass on. So we hope that’s true,” he said.
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Health workers in protective gear evacuate patients from the MV Hondius cruise ship at a port in Praia, Cape Verde, on May 6, 2026. (Misper Apawu/AP)
“We seem to have things under very good control. They know that virus very well. It’s been around a long time. Not easily transferable, unlike COVID. But we’ll see. We have very good people studying it very closely.”
The outbreak has escalated over several weeks, beginning with a passenger who became sick in early April and later resulting in at least three deaths, according to the World Health Organization.
Cases are now reported across multiple countries after passengers disembarked in Africa and Europe, prompting health officials to trace contacts globally.
Authorities in Cape Verde at one point blocked passengers from leaving the ship, underscoring concerns about containment.
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An ambulance evacuates patients from the MV Hondius cruise ship to the airport in Praia, Cape Verde, on May 6, 2026. (Misper Apawu/AP)
Hantavirus is a rare but potentially deadly disease typically spread through contact with infected rodents or their droppings, according to the CDC. While most strains do not spread between people, health officials say the Andes virus — identified in some cases linked to the cruise ship — is the only known strain capable of limited person-to-person transmission.
The vessel is expected to dock in Spain’s Canary Islands, where international teams are coordinating next steps for passengers and crew.
A CDC team has been deployed to the Canary Islands to assess potential exposure among American passengers and determine monitoring needs.
Returning passengers are expected to be flown on a U.S. government medical repatriation flight to Offutt Air Force Base in Omaha, Nebraska.
Health workers in protective gear evacuate patients from the MV Hondius cruise ship into an ambulance at a port in Praia, Cape Verde, on May 6, 2026. (Misper Apawu/AP)
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They will then be transported to the National Quarantine Center at the University of Nebraska Medical Center for further monitoring.
Additional CDC personnel will be stationed at Offutt Air Force Base to support health assessments.
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From tracking sleep and steps to monitoring heart rate, temperature and stress levels, wearable devices like smartwatches and rings are growing in popularity as wellness tools.
Fox News’ Brian Kilmeade recently used one of these — an Oura ring — to track his metrics from the early morning hours through a demanding work schedule and reported the results live on “Fox & Friends.”
“I just got four hours and one minute [of sleep], but I have some REM sleep, 14%, over 20% of deep sleep. Feeling pretty good, I feel pretty fresh,” Kilmeade shared during his first early morning update, reviewing the stats from his ring.
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Throughout the day, the wearable tracked his physiological responses to various environments, from the stress of a live television broadcast to the physical exertion of a workout.
Wearable devices are changing cardiology’s landscape, helping detect conditions like atrial fibrillation early, a cardiologist said. (iStock)
Kilmeade observed the data in real time, noting, “You see the stress level spike just a little bit … as I make my way over to radio, my activity is going to pick up.”
By the end of his day, which included a trip to West Point and hours spent in a car, the device provided a summary of Kilmeade’s activity levels and heart rate stability.
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Dr. Craig Basman, a New Jersey cardiologist, joined the program to interpret the data and discuss the clinical implications of such technology.
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Basman immediately addressed Kilmeade’s limited rest. “Well, I don’t think you have to be a cardiologist to diagnose him with suboptimal sleep,” he said.
The cardiologist urged users to treat the data as a catalyst for lifestyle changes. (iStock)
However, the doctor highlighted the broader potential of these tools, explaining that “these wearable devices are changing the landscape of cardiology” and that “the future is bright, not just for preventative care … but also screening and detection of actual cardiovascular pathology.”
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The cardiologist urged users to treat the data as a catalyst for lifestyle changes, noting that he wouldn’t recommend detection tools unless you’re “going to do something about it.”
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Regarding the accuracy of the technology, Basman said there is “robust data” to suggest that the numbers are “incredibly accurate” for a lot of the metrics people are viewing, specifically data like resting heart rate and heart rate variability.
Wearable health tech like watches and rings can track sleep, heart rate and stress. (iStock)
He also mentioned that some devices can detect serious conditions like atrial fibrillation, which affects millions and can often go undetected during a standard physical exam.
For younger individuals, wearables can serve as a “great primary prevention tool,” according to the doctor, given that plaque can begin to develop in the arteries as early as the 20s and 30s.
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For the older population, the devices act more as a “screening tool for actual existing cardiac pathology,” he added.
Anyone concerned about wearable health data should consult a doctor for medical guidance.
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