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New Ozempic-alternative diabetes pill burns fat without muscle loss, study suggests

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New Ozempic-alternative diabetes pill burns fat without muscle loss, study suggests

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Scientists in Sweden have created a new pill designed to help the body burn fat and control blood sugar in a different way than popular GLP-1 drugs, like Ozempic.

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While injectable GLP-1s work by suppressing appetite, this new treatment boosts metabolism in the muscles.

A study led by researchers at Karolinska Institutet and Stockholm University included both an early animal study and a human clinical trial with 48 healthy adults and 25 people with type 2 diabetes, according to a press release.

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The new oral medication was found to successfully control blood glucose, boost fat burning and retain muscle mass in animals, while getting high marks for tolerability and safety in humans.

It was also found to have fewer side effects than GLP-1s like semaglutides and tirzepatides, which are known to cause appetite loss, gastrointestinal distress and muscle wasting, the researchers noted.

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While injectable GLP-1s work by suppressing appetite, this new treatment boosts metabolism in the muscles. (iStock)

The experimental medication uses a new form of beta-2 agonist that benefits muscle function while also avoiding overstimulation of the heart, which has been identified as a potential safety concern of older versions.

The findings were published this week in the journal Cell.

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Because the new oral drug acts via a different mechanism than appetite-suppressing medications, it could be used alone or in combination with GLP-1s, the researchers noted.

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“Our results point to a future where we can improve metabolic health without losing muscle mass,” said Tore Bengtsson, professor at the Department of Molecular Bioscience at Wenner-Gren Institute, Stockholm University, in the release. “Muscles are important in both type 2 diabetes and obesity, and muscle mass is also directly correlated with life expectancy.”

“Muscles are important in both type 2 diabetes and obesity, and muscle mass is also directly correlated with life expectancy.” (iStock)

This medication has the potential to be of “great importance” for patients with type 2 diabetes and obesity, according to Shane C. Wright, assistant professor at the Department of Physiology and Pharmacology at Karolinska Institutet.

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“Our substance appears to promote healthy weight loss and, in addition, patients do not have to take injections,” he added.

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Dr. Trey Wickham, interim chief of the Division of Endocrinology, Diabetes & Metabolism at VCU Health in Richmond, Virginia, was not involved in the study but shared his reaction to the publication in the journal Cell.

“Our results point to a future where we can improve metabolic health without losing muscle mass.”

“This compound’s mechanism of action could address some specific metabolic concerns with previous weight reduction therapies, such as the loss of both muscle and fat tissue,” Wickham told Fox News Digital.  

“Although the reported preliminary results are interesting, rigorous testing involving larger longitudinal trials are necessary to ensure human long-term safety and understand the potential role of this compound in the comprehensive, evidence-based treatment of obesity and diabetes.”

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The study had some limitations, the researchers noted, chiefly that the preclinical studies in mice fail to capture the “complex nature of these diseases” in humans.

Structural studies are needed to understand exactly how the drug works.

“This compound’s mechanism of action could address some specific metabolic concerns with previous weight reduction therapies, such as the loss of both muscle and fat tissue,” a doctor said. (iStock)

“Our phase 1 data show that compound 15 is well-tolerated; however, conclusive clinical efficacy data (on how the drug controls glucose metabolism) are currently still lacking.”

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Looking ahead, the company that developed the drug, Atrogi AB, plans to conduct a larger phase 2 clinical trial with a larger, more diverse population, including people with obesity.

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The study was supported in part by the Swedish Research Council, the Swedish Society for Medical Research and the Novo Nordisk Foundation.

Uppsala University, University of Copenhagen, Monash University and University of Queensland all collaborated with the lead researchers.

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Can Pickles Help You Lose Weight? Discover the Perks of Fermented Foods

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Can Pickles Help You Lose Weight? Discover the Perks of Fermented Foods


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Cellphone health risks are focus of new government study: ‘Very concerned’

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Cellphone health risks are focus of new government study: ‘Very concerned’

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The Department of Health and Human Services (HHS) is launching a study on whether radiation from cellphones could harm Americans’ health.

“The FDA removed web pages with old conclusions about cellphone radiation while HHS undertakes a study on electromagnetic radiation and health research to identify gaps in knowledge, including on new technologies, to ensure safety and efficacy,” HHS spokesperson Andrew Nixon said in a statement to Fox News Digital.

The study is part of a strategy report released last year by President Donald Trump’s MAHA Commission, Nixon added.

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The report urges officials to address electromagnetic radiation (EMR) exposure stemming from the widespread use of cellphones, Wi-Fi routers, cell towers and wearable, such as smartwatches.

In 2018, the National Institutes of Health did a study concluding there is “clear evidence” that high exposure to radio frequency radiation (RFR) was associated with cancer in male rats.

The HHS has launched a cellphone radiation study to investigate whether electromagnetic radiation is harmful to people’s health. (iStock)

“In our studies, rats and mice received RFR across their whole bodies. By contrast, people are mostly exposed in specific local tissues close to where they hold the phone,” said senior scientist John Bucher at the time.

Bucher added, “The exposure levels and durations in our studies were greater than what people experience.”

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The study did not investigate the RFR that is used for Wi-Fi or 5G networks.

HHS Secretary Robert F. Kennedy Jr. told USA TODAY on Friday that “electromagnetic radiation is a major health concern,” adding that he is “very concerned about it.”

A spokesperson for CTIA, the mobile carrier industry trade group, told Fox News Digital there is no credible evidence linking wireless devices to health problems.

“The FDA removed web pages with old conclusions about cellphone radiation while HHS undertakes a study on electromagnetic radiation and health research to identify gaps in knowledge, including on new technologies, to ensure safety and efficacy,” said an HHS spokesperson. (iStock)

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“Radiofrequency energy from Wi-Fi and Bluetooth devices, mobile phones and wireless infrastructure has not been shown to cause health problems, according to the consensus of the international scientific community and independent expert organizations around the world,” said the spokesperson.

The World Health Organization has noted on its website that research shows “no adverse health effect has been causally linked with exposure to wireless technologies.”

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In the U.S., cellphones must comply with Federal Communications Commission (FCC) limits on radiofrequency (RF) exposure.

The FCC uses a metric called specific absorption rate (SAR), which tracks how much RF energy the body absorbs. To be sold in the U.S., mobile phones and similar wireless devices must be tested and certified to ensure that they do not exceed 1.6 W/kg (watts per kilogram), averaging over 1 gram of tissue.

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In the U.S., cellphones must comply with Federal Communications Commission (FCC) limits on radiofrequency (RF) exposure. (iStock)

The FCC states on its website that there is “no scientific evidence currently establishing a definitive link between wireless device use and cancer or other illnesses.”

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However, the agency does share ways that Americans can reduce exposure — such as shortening the amount of time spent on wireless devices, putting a phone on speaker or using an earpiece “to reduce proximity to the head and thus head exposure.”

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The FCC also recommends increasing the distance between wireless devices and the body, and texting instead of talking when possible.

Fox News Digital reached out to HHS and NIH for additional comment, as well as several major cellphone carriers.

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Dozens sickened as potentially deadly fungus spreads in southern state

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Dozens sickened as potentially deadly fungus spreads in southern state

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A potentially deadly fungus has been spreading throughout Tennessee, health officials have warned.

Over 35 cases of histoplasmosis, a lung infection caused by exposure to the fungus Histoplasma capsulatum, have been confirmed in a three-month period in the Murray and Williamson County area, according to numbers presented on Jan. 12 by the Tennessee Department of Health.

A family has also spoken out with claims that one woman died after contracting histoplasmosis, with a positive test result returned two days after her death, according to a local report.

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However, during a briefing at the Williamson County Board of Commissioners, state epidemiologists said an investigation is underway and that the infection has not yet been confirmed as the direct cause of any fatalities.

They also noted that the average age of those infected is 50.

Histoplasmosis is a lung infection caused by exposure to the fungus Histoplasma capsulatum. (iStock)

The fungus comes from soil that is contaminated with bird or bat droppings, according to state officials. People are exposed when they breathe in the fungal spores. A single common source has not been identified in the Tennessee outbreak.

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In most cases, people don’t get sick, but there is the potential for histoplasmosis to cause respiratory symptoms, ranging from mild to life-threatening, per the CDC. 

Symptoms of histoplasmosis — which can include fever, cough, extreme fatigue, headache, body aches, chills and chest pain — typically emerge within three to 17 days after exposure to the fungus.

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Because these symptoms are similar to the cold and flu, the condition is often missed or misdiagnosed.

People with weak immune systems are at a higher risk of developing severe illness, which can lead to a long-term lung infection or, in rare cases, meningitis, per the CDC.

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While most people do not require treatment, there are antifungal medications for severe cases. Some of the Tennessee patients have been hospitalized and some are “critically ill,” the state officials confirmed during the briefing.

State officials confirmed there have been 35 cases over a three-month period in the Murray and Williamson County area. (iStock)

Healthcare providers can confirm the infection by testing blood or urine samples in a lab. Other possible means of testing may include respiratory fluid, X-rays, CT scans or a tissue biopsy.

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To prevent infection, health officials recommend limiting activities where soil is disturbed and to consider wearing masks during “high-risk” outdoor activities.

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Healthcare providers can confirm the infection by testing blood or urine samples in a lab. Other possible means of testing may include respiratory fluid, X-rays, CT scans or a tissue biopsy. (iStock)

Before this outbreak, histoplasmosis was a “reportable disease” in only 14 states (Arkansas, Delaware, Illinois, Indiana, Kansas, Kentucky, Louisiana, Michigan, Minnesota, Nebraska, Pennsylvania, Rhode Island, Wisconsin and Washington), according to the CDC.

The infection does not spread between humans and cannot be transmitted from humans to animals.

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Anyone who experiences symptoms and believes they have been exposed to the Histoplasma fungus should contact a doctor for testing, especially if antibiotics are not helping.

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