Health
New brain therapy allows paralyzed patients to walk again: 'I feel my legs'
New research suggests that paralyzed patients could regain some degree of movement — perhaps even walk again.
In a study led by EPFL (Swiss Federal Technology Institute of Lausanne) and Lausanne University Hospital in Switzerland, two people with spinal cord injuries received deep brain stimulation (DBS) therapy.
The therapy was applied to an “unexpected” part of the brain called the lateral hypothalamus, which has previously been associated with functions like eating and arousing from sleep.
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After the stimulation, the patients were able to walk without assistance and even climb stairs, according to a press release from Lausanne University Hospital.
The findings were published in the journal Nature Medicine.
One of the participants in the study was 54-year-old Wolfgang Jäger from Kappel, Austria, who experienced a spinal cord injury in 2006 that left him in a wheelchair.
The clinical trial participant, Wolfgang Jäger, gets out of his wheelchair and climbs up and down the steps using the deep brain stimulation of the lateral hypothalamus. (.NeuroRestore / EPFL)
After having electrodes implanted in the targeted area of his brain and receiving deep brain stimulation, he regained some lower-body mobility.
“Last year on vacation, it was no problem to walk a couple of steps down and back to the sea using the stimulation,” Jäger said in the release.
“I can also reach things in my cupboards in the kitchen.”
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Study author Jocelyne Bloch, neurosurgeon and professor at the Lausanne University Hospital, UNIL and EPFL, shared the immediate effects of the therapy.
“Once the electrode was in place and we performed the stimulation, the first patient immediately said, ‘I feel my legs,’” she said in the release.
The therapy was applied to an “unexpected” part of the brain called the lateral hypothalamus, which has previously been associated with functions like eating and arousing from sleep. (.NeuroRestore / EPFL)
“When we increased the stimulation, she said, ‘I feel the urge to walk!’ This real-time feedback confirmed we had targeted the correct region, even if this region had never been associated with the control of the legs in humans.”
“At this moment, I knew we were witnessing an important discovery of the anatomical organization of brain functions,” added Bloch.
“When we increased the stimulation, she said, ‘I feel the urge to walk!’”
The participants also reported “long-term improvement” in mobility even when the stimulation wasn’t actively being applied.
“This research highlights the unexpected role of the lateral hypothalamus, a brain region not previously associated with locomotion in humans,” lead researcher Dr. Grégoire Courtine, professor of neuroscience at EPFL and Lausanne University Hospital and co-director of the .NeuroRestore center, told Fox News Digital.
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“Our findings show that this approach not only enhances motor abilities during stimulation, but also induces a reorganization of nerve fibers, leading to lasting improvements even in the absence of stimulation.”
DBS has traditionally been used to control tremors in people with movement disorders like Parkinson’s disease, the researchers noted.
A visual representation of deep brain stimulation of the lateral hypothalamus is shown. (.NeuroRestore / EPFL)
The concept of applying it to the lateral hypothalamus is unchartered territory.
Looking ahead, the researchers hope to combine DBS with spinal implants to enable further recovery from paralysis.
“Integrating our two approaches — brain and spinal stimulation — will offer a more comprehensive recovery strategy for patients with spinal cord injuries,” added Courtine.
‘Pushing science forward’
Dr. Ann Murray, director of the Comprehensive Movement Disorder Clinic at WVU Rockefeller Neuroscience Institute in West Virginia, said the study’s results are “surprising and exciting.”
“The targeted location of the brain they were stimulating, the hypothalamus, has not historically been known to be involved in the mechanism of gait,” Murray, who was not involved in the study, told Fox News Digital.
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“As we continue to better understand the brain networks, it will continue to enable us to modulate areas that aren’t working correctly,” she went on.
“The brain communicates via electrical signaling, and technologies like deep brain stimulation therapy help us interface with the brain circuitry to improve and/or restore more normal connectivity.”
“The brain communicates via electrical signaling, and technologies like deep brain stimulation therapy help us interface with the brain circuitry to improve and/or restore more normal connectivity,” a neurologist said. (.NeuroRestore / EPFL)
The potential for advancements in these types of technologies is “truly endless,” Murray said.
“I have the utmost hope that technologies like deep brain stimulation and other neuromodulation therapies will continue to advance the science in restoration of brain health for patients suffering neurologic injury.”
Potential limitations
The researchers acknowledged that there are some limitations of the research.
“This is precision medicine at its finest.”
“This therapy is only beneficial for patients with incomplete injuries, where functional neural circuits remain but are not fully utilized,” Courtine told Fox News Digital.
“For complete spinal cord injuries, only localized epidural electrical stimulation or a brain-spine interface bridge may assist in restoring functional movements.”
After having electrodes implanted in the targeted area of his brain and receiving deep brain stimulation, a clinical trial participant was able to climb the stairs. (.NeuroRestore / EPFL)
He also pointed out that this study is an “early-stage safety and feasibility trial,” conducted without a control group.
“For this therapy to become widely accessible, larger pivotal studies will need to be completed and thoroughly evaluated [before approval],” Courtine said.
“This process may take several years before the therapy becomes available to patients.”
Murray also emphasized that caution must be taken with this type of stimulation.
“Anytime we are investigating brain therapies, a tremendous degree of safety and precision has to be applied,” she cautioned.
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“The brain is the most precise, complicated organ in the body, which requires any treatment or innovation to appreciate not just the intended effects, but the potential unintended effects of interfering with certain networks.”
Every step of the process must be carefully executed by a comprehensive team, Murray said.
“Anytime we are investigating brain therapies, a tremendous degree of safety and precision has to be applied,” a neurologist cautioned. (iStock)
“This is precision medicine at its finest — any misstep in any one of those stages can result in suboptimal outcomes.”
The goal, she said, is to standardize this process so that more patients have access to this “life-changing therapy.”
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Added Murray, “This should give hope to millions of patients across the world suffering from neurologic conditions, as this is pushing the technology, pushing the science forward, to expand treatment to people that have never had any other options.”
Health
Deadly Legionnaires’ disease outbreak sparks concern in major US city: Know the symptoms
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Amid warnings of a Legionnaires’ disease outbreak on Manhattan’s Upper East Side, health experts say that early recognition of symptoms can mean the difference between a quick recovery and life-threatening complications, especially for high-risk groups.
New York City health officials are urging anyone who has visited the east side of Central Park or Manhattan’s Upper East Side since late June to watch for symptoms.
As of July 6, the New York City Health Department had confirmed 23 cases and 17 hospitalizations associated with the respiratory infection. No deaths have been reported.
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Officials are investigating contaminated cooling towers as the likely source. They have emphasized that the illness is not spread person-to-person and is not linked to the city’s drinking water.
Health experts say that early recognition of symptoms can mean the difference between a quick recovery and life-threatening complications, especially for high-risk groups. (iStock)
“Legionnaires’ disease is deadly but can be effectively treated if diagnosed early,” said NYC Health Commissioner Dr. Alister Martin in a press release. “New Yorkers at higher risk, including anyone who is 50 and older, those who smoke or people with chronic lung conditions should be especially mindful of their symptoms and seek care as soon as symptoms begin.”
What is Legionnaires’?
Legionnaires’ disease is a type of pneumonia caused by Legionella bacteria.
The bacteria is usually found in lakes, streams and other freshwater environments, but can grow in any area where water sits for a long time, according to the CDC.
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That can include shower heads, sink faucets, hot tubs, water features/fountains, plumbing systems and other water systems.
When people swallow or breathe in droplets of water that contain Legionella, they can potentially become ill.
Although human transmission is possible in rare cases, the disease is not typically transmitted among people, per the Centers for Disease Control and Prevention.
Symptoms of infection
Infections can lead to severe pneumonia in older people and those with compromised immune systems, according to Dr. Andrew Handel, a pediatric infectious diseases expert at Stony Brook Children’s Hospital on Long Island, New York.
Symptoms of Legionnaires’ disease usually show up between two and 14 days after exposure.
New York City health officials are urging anyone who has visited the east side of Central Park or Manhattan’s Upper East Side since late June to watch for symptoms. (iStock)
“Legionella infections cause symptoms that are similar to other forms of pneumonia — fever, coughing, difficulty breathing, shortness of breath and chest pain,” Handel previously told Fox News Digital.
“Legionnaires’ disease is deadly but can be effectively treated if diagnosed early.”
The signs are similar to other types of pneumonia, and include the following:
- Cough
- Fever
- Shortness of breath
- Muscle aches and headaches
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Some patients may also experience nausea, diarrhea and confusion, the CDC noted.
Diagnosis, treatment and prevention
A medical professional can diagnose the infection with laboratory tests and chest X-rays.
The condition is typically treated with antibiotics. In cases of severe infection, hospitalization may be required for breathing support and IV hydration.
Around 10% of people who contract Legionnaires’ disease will die from those complications — and the mortality risk rises to 25% for those who get Legionnaires’ while staying in a healthcare facility, according to the CDC.
The bacteria is usually found in lakes, streams and other freshwater environments, but can grow in any area where water sits for a long time, according to the CDC. (iStock)
“Treatment needs to be early and aggressive,” Dr. Nathan Goodyear, an Arizona-based integrative medicine expert, previously told Fox News Digital. “Legionella infection is an intracellular infection that requires antibiotic treatment.”
Antibiotics that are appropriate for Legionella infection include Levofloxacin and Azithromycin.
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“Therapy can be prescribed orally in healthy individuals… but intravenous antibiotics often prove to be the initial option for treatment secondary to the pathogenicity of the disease,” Goodyear said.
Currently, there are no vaccines for Legionnaires’ disease.
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The best strategy to prevent infection is to reduce the growth and spread of the Legionella bacteria. The CDC recommends that building owners and managers use a water management program to reduce the risk.
“New Yorkers at higher risk, including anyone who is 50 and older, those who smoke or people with chronic lung conditions should be especially mindful of their symptoms and seek care as soon as symptoms begin,” city officials stated. (iStock)
To prevent serious illness from Legionnaires’, Goodyear recommends that all smokers kick the habit, and also emphasizes the need to “aggressively support” chronic pulmonary disease.
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“Increasing immune support (vitamin D3, vitamin C, Zinc) is required to counter the immune dysfunction associated with advancing age.”
Obesity is another foundational risk factor for all chronic inflammatory diseases, the doctor added.
Health
Katie Couric couldn’t remember the year or the president during frightening brain episode
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Journalist Katie Couric is sharing a scary medical episode that she experienced on June 27.
In a post on Substack titled “The Day I’ll Never Remember,” she detailed a sudden episode that left her unable to recall the current month, year and president.
“I thought it was 2024. And I believed Joe Biden was president,” she wrote.
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The event occurred while Couric was attending the Aspen Ideas Festival in Colorado, during which she participated in two public panels — one on AI and one on journalism — both of which she cannot remember at all.
“I have no idea what we talked about, or of what occurred when the panels ended,” she said.
Journalist Katie Couric is sharing a scary medical episode that she experienced on June 27. (Getty Images)
John Molner — Couric’s husband, who was in attendance at the festival and the two panels — also shared his account.
After the event, someone told Molner that Katie wasn’t feeling well. When he reached her, an EMT and a doctor were tending to her. “I could tell something was off,” he wrote. “It could have been altitude sickness, but Katie was definitely not all there.”
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At the hospital, when Couric struggled to recall the year, the president and her grandchildren’s names, doctors began checking for a stroke.
An MRI revealed no signs of stroke, which was a relief, but “Katie’s ‘fog’ became a lot more apparent,” Molner wrote.
John Molner, Couric’s husband, who was in attendance at the festival and the two panels, also shared his account. (Getty Images)
“She repeatedly asked me the same questions: ‘What was I doing before we got to the hospital?’ ‘Why am I at the hospital?’”
Couric was ultimately diagnosed with transient global amnesia, a sudden, temporary episode of memory loss that prevents a person from forming new memories and may also erase some recent memories, according to Mayo Clinic.
“The cause seems to be as mysterious as the brain itself.”
It is not caused by a stroke, seizure or head injury, and it usually resolves completely within 24 hours.
“[It’s] just a very weird neural episode that’s pretty uncommon and, at least in most cases, is a ‘one and done’ experience,” Molner said.
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Couric said she finally began feeling “like herself” again around 9 p.m. and went to sleep at 2 a.m.
As TGA leaves a “permanent gap in memory” for the duration of the episode and for hours beforehand, Couric said that from around noon on that day until at least 7 p.m. will remain a “big, black hole.”
As TGA leaves a “permanent gap in memory” for the duration of the episode and for hours beforehand, Couric said that from around noon on that day until at least 7 p.m. will remain a “big, black hole.” (Getty Images)
Data shows that approximately three to eight people per 100,000 will have an episode of transient global amnesia, with people 50 years of age and older at higher risk.
The specific cause of TGA is not known, but some experts believe it stems from a “temporary dysfunction in the brain’s hippocampus — the area responsible for creating new memories,” Couric shared.
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“Doctors believe this is driven by brief interruptions in blood or oxygen flow, or microscopic spasm in the blood vessels.”
Episodes could potentially be triggered by intense physical exertion, emotional distress, extreme temperature changes or migraines, experts say.
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Approximately 15% of patients will have a recurrence 10 years later.
“Why did this happen to me? Was the altitude an issue? Was I dehydrated? Tired? Stressed? The literature doesn’t seem to indicate that these are contributing factors, but the cause seems to be as mysterious as the brain itself,” Couric wrote.
Anyone who experiences sudden memory loss, confusion, difficulty speaking, weakness, numbness, vision changes, severe headache or other stroke-like symptoms should seek immediate medical attention or call 911, doctors advise. (iStock)
“All I know is that those hours will be forever lost. Someone described it as my brain failing to hit the ‘record button.’”
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“While this was a freaky occurrence, it could have been much more serious. So ultimately, I’m relieved — even though several hours of a Saturday in June will always be missing for me.”
Anyone who experiences sudden memory loss, confusion, difficulty speaking, weakness, numbness, vision changes, severe headache or other stroke-like symptoms should seek immediate medical attention or call 911, doctors advise.
Health
One walking habit could signal a healthier brain after 80, scientists say
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Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers.
That’s according to a recent study led by Stony Brook Medicine in New York, which evaluated the cognitive function of 4,000 adults 80 and over who participated in multiple aging and longevity studies over several years.
Among this group, 6% to 10% were classified as super movers, which means they walk at a much faster pace than others of the same age and gender — at speeds comparable to people three decades younger.
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The super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed.
The findings were published in the journal Neurology on June 16.
Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers. (iStock)
“The study reinforces that mobility and brain health are closely connected,” lead study author Dr. Joe Verghese, MD, neurologist at Stony Brook Medicine, told Fox News Digital. “This suggests that preserving mobility may be an important marker of healthy brain aging and resilience.”
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The most intriguing finding, according to Verghese, was that super movers maintained cognitive function despite having similar dementia-related brain changes as their peers.
In postmortem brain analysis, there was no difference in dementia-related pathologies between the super movers and the slower walkers, the study stated.
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“This suggests they may possess resilience mechanisms that help preserve brain function even in the presence of age-related changes,” he said. “Understanding these resilience factors could lead to new strategies for promoting healthy brain aging.”
As the study was observational, there were some limitations, and it does not prove that walking faster prevents dementia, the researchers noted.
Super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed. (iStock)
“Other factors, such as cardiovascular health, physical fitness or genetics, may also contribute to both faster walking and better cognitive outcomes,” Verghese said.
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This study adds to growing evidence that what’s good for the heart and muscles also benefits the brain, he noted, adding that “staying physically active remains one of the most effective, evidence-based ways to support healthy aging.”
“Walking speed is best viewed as a marker of overall health, not a treatment.”
“The broader message is that physical activity is important at any age,” Verghese said. “Walking is an easy step-up point because you don’t need any special equipment. You can do it inside or outdoors, and you can do it on a regular basis. You can walk with a dog, you can walk with a friend.”
Any activity is beneficial if it’s done regularly and with the right intensity, he added.
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Rather than just trying to walk faster, the neurologist recommends that seniors focus on maintaining mobility through regular physical activity, strength training, balance exercises and good cardiovascular health.
“Walking speed is best viewed as a marker of overall health, not a treatment,” Verghese noted.
Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking.
Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking. (iStock)
This can be achieved by walking 30 minutes a day, five days a week, or about 20 to 25 minutes most days. Another option is to engage in shorter sessions that add up over the day.
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“You have to do it within your health limitations and medical conditions,” Verghese advised. “So if there are any medical concerns, I would get your physician to clear you before starting exercise.” The good thing about walking, he added, is that you can start at a slow pace and then gradually build up to a brisker pace.
“And then adding on strength and balance training, whatever age you are, I think is also important.”
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