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New antibiotic kills deadly, drug-resistant bacteria in ‘scientific breakthrough’

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New antibiotic kills deadly, drug-resistant bacteria in ‘scientific breakthrough’

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Scientists in Switzerland have announced the discovery of a new class of antibiotics shown to be effective against deadly, drug-resistant bacteria.

The antibiotic, called zosurabalpin, works by blocking a bacterial molecule called lipopolysaccharide (LPS), which is responsible for creating the outer membrane that protects a harmful bacteria, Acinetobacter baumannii.

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Acinetobacter is a “gram-negative” bacteria, which means it is resistant to most antibiotics and other drugs

It can cause infections in the blood, lungs, urinary tract and other parts of the body, according to the Centers for Disease Control and Prevention (CDC).

In animal studies, zosurabalpin successfully killed drug-resistant strains of Acinetobacter.

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The research, conducted at Roche Pharma Research & Early Development in Switzerland, was published in the journal Nature on Jan. 3.

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Scientists in Switzerland have announced the discovery of a new class of antibiotics that shown to be effective against deadly, drug-resistant bacteria. (iStock)

“This new class of antibiotics prevents bacteria from creating their outer membrane, which provide structure to the bacteria and help them survive in harsh environments and cause infection,” Kenneth Bradley, the Switzerland-based global head of infectious disease discovery at Roche, told Fox News Digital via email.

Without the ability to transport LPS — the bacteria die.

“The new molecule overcomes the existing drug-resistance mechanisms that the currently available antibiotics are failing to address,” Bradley said.

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This is the first time in over 50 years that a new class of antibiotic has been identified to treat infections by gram-negative bacteria, he noted.

Zosurabalpin specifically targets Acinetobacter.

“The specificity of zosurabalpin is due to the unique way in which it binds to the drug target in these bacteria,” Bradley said. 

The antibiotic, called zosurabalpin, works by blocking a bacterial molecule called lipopolysaccharide (LPS), which is responsible for creating the outer membrane that protects harmful bacteria, Acinetobacter baumannii (not pictured).  (iStock)

The hope is that this finding could help eventually to fight other drug-resistant bacteria.

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“Discovery of the mode of action of zosurabalpin in Acinetobacter may enable the identification of other drugs that work in the same way in other antibiotic-resistant bacteria,” Bradley told Fox News Digital.

Zosurabalpin is currently in a phase 1 clinical trial, which will evaluate the “safety, tolerability and pharmacokinetics” of the molecule, according to the researcher.

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“These data, as well as data from future pivotal phase 3 clinical studies, would be needed to determine the safety and efficacy profile of the molecule,” he added.

The discovery of zosurabalpin, which Bradley calls a “scientific breakthrough,” will help researchers learn more about the construction of bacterial membranes, knowledge that could enable new drugs to kill bacteria.

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The finding is especially significant, given that resistance to antibiotics has been on the rise in various gram-negative bacteria for several decades, he said. 

Acinetobacter infections are most commonly seen in hospital patients, mainly affecting those who are on ventilators, have surgical wounds, are in intensive care units or have catheters, according to the CDC. (iStock)

“Any new antibiotic class that has the ability to treat infections caused by multi-drug-resistant bacteria such as carbapenem-resistant Acinetobacter baumannii (CRAB) would be a significant breakthrough,” he added. 

Michael Lobritz, the Switzerland-based head of infectious diseases at Roche, referred in a press release to antimicrobial resistance as a “silent pandemic.”

“Over the next 30 years, it is projected to claim more lives than those taken by cancer today, according to the report of the economist Jim O’Neill,” Lobritz said.

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Over the next 30 years, antimicrobial resistance is “projected to claim more lives than those taken by cancer today,” an expert said.

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, agreed that the growing resistance of gram-negative bacteria is a “huge problem.”

“Our last line of defense for decades now in the hospital has been the carbapenem drugs, specifically Imipenem and Mirapenem,” he told Fox News Digital. 

The research was done at Roche Pharma Research & Early Development in Switzerland. (iStock)

“But now there is an increase of carbapenem-resistant strains — including carbapenem-resistant Acinobacter baumannii, or CRAB — which are very difficult to treat.”

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Siegel also acknowledged the importance of the newly discovered zosurabalpin.

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“It interferes with a lipid transport mechanism at the surface of the bacteria,” he said. “This is very important, as there are now millions of deaths a year worldwide due to antibiotic resistance.”

Zosurabalpin has only been tested in animals so far, Siegel noted, with human trials underway. 

What to know about Acinetobacter

Acinetobacter infections are most commonly seen in hospital patients, mainly affecting those who are on ventilators, have surgical wounds, are in intensive care units or have catheters, according to the CDC.

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Those with lung disease, diabetes or weakened immune systems are at a higher risk of infection. (iStock)

Those with lung disease, diabetes or weakened immune systems are at a higher risk of infection.

The bacteria can spread from person to person or via contact with contaminated surfaces.

Acinetobacter baumannii, along with other gram-negative bacteria, is tracked by the CDC as part of its Emerging Infections Program.

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Looking ahead, Siegel said he expects that artificial intelligence will help speed up the process of developing new antibiotics and make it “more effective and streamlined.”

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Doctor reveals what 30 days without alcohol does to the brain and body amid Dry January

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Doctor reveals what 30 days without alcohol does to the brain and body amid Dry January

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After a season of bingeing and drinking, your body may feel like it needs a break from the party.

Dry January — a modern trend that challenges people to abstain from drinking for the first month of the year — has become a popular way to “detox” from the holidays and start the new year on a healthy note.

Research has linked alcohol to a variety of health conditions, ranging from hangovers to higher cancer risk.

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In a recent podcast episode of “The Dr. Mark Hyman Show,” Dr. Mark Hyman, chief medical officer of Function Health, shared how 30 days of not drinking alcohol can transform health.

Hyman, who is based in Massachusetts, called Dry January a “powerful way to see in real time how alcohol affects nearly every system of your body and how quickly those systems can recover.”

Dry January has become a popular way to “detox” from the holidays and start the new year on a healthy note. (iStock)

Alcohol’s toll on the brain and body

Hyman acknowledged that most people drink to feel happier and more comfortable in social situations. This effect is caused by the main ingredient in alcohol, called ethanol, which can also have toxic effects.

Instead of stimulating the brain, alcohol slows it down and loosens inhibitions. “You feel more relaxed, more social, more confident, maybe you feel a little euphoric,” Hyman said.

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Alcohol’s effect on the brain can also lead to poorer decisions and slower reflexes, the doctor cautioned.

Drinking alcohol can cause cognitive decline and brain fog, experts warn. (iStock)

Drinking also impacts the prefrontal cortex of the brain, which Hyman described as “the adult in the room,” responsible for judgment, planning and restraint. “It goes offline early in drinking, which explains why people feel freer or act impulsively when they drink,” he said.

Even moderate drinking can cause metabolic stress, inflammation, impaired detoxification and hormonal shifts, Hyman said, which can impact nearly every organ system in the body.

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Alcohol consumption has also been linked to an increased risk of cancer, metabolic dysfunction, gut microbiome disturbances and mitochondrial toxins.

It can also prevent the body from falling into REM sleep, which is the deep rest recovery period when the immune system cleans out the day’s toxins, according to Hyman.

Alcohol can impact deep rest and mental health, according to experts. (iStock)

Memory loss, cognitive decline, anxiety, sleep disruption, dementia and cardiovascular disease are all known risks of long-term alcohol use, as well as liver complications like fatty liver disease.

“Bottom line, alcohol taxes every major system in your body, especially your liver, your brain, your gut, your hormones,” Hyman said.

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The effects of 30 days with no alcohol

The first week after your last drink, the body begins to detoxify and reset, according to Hyman. Blood sugar and cortisol stress hormones level out, and the liver begins to process a “backlog of toxins.” The body also re-hydrates and re-energizes.

The first 30 days with no alcohol allows the body to balance itself out. (iStock)

The second week, the gut and brain will begin to re-balance, as hormones like serotonin and dopamine stabilize, gut inflammation drops and the microbiome begins to heal. Cravings for sugar and alcohol will wane and mental clarity returns, the doctor said.

Week three is marked by further decreases in inflammation, fatty liver and blood pressure. This can be noticeable in the skin, as puffiness and redness are reduced. Mood also begins to stabilize, with lower anxiety levels.

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In week four, the body experiences additional metabolic and immune benefits, Hyman shared, including more insulin sensitivity, which makes it easier to lose weight.

“You have a stronger immune response. You’re not getting sick as much. You have better deep sleep, balanced hormones, especially cortisol and testosterone,” he said. “And you see a big change in energy, confidence and focus.”

Abstaining from alcohol can help restore energy, according to experts. (iStock)

Dr. Pinchieh Chiang, a clinician at Circle Medical in San Francisco, said that Dry January isn’t a “detox,” but rather provides “feedback” from the body.

“It gives the body time to show people how it feels without alcohol. For many, that insight alone changes their relationship with drinking,” she said. “The biggest surprise isn’t what people give up, it’s how much better they feel.”

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The doctor confirmed that the first few days of not drinking may feel harder than expected, sometimes causing restlessness, cravings or disrupted sleep, but Dry January can ultimately change drinking habits for the remainder of the year.

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After a full year without alcohol, Chiang noted that health improvements are more profound. “We see sustained improvements in blood pressure, liver function and inflammation,” she said. “Those changes directly affect long-term heart disease and stroke risk.”

The risks of ‘all or nothing’

Some experts warn that adopting the Dry January trend could strengthen the urge to drink more in the other months, noting that some drinkers may find more success by slowly consuming fewer drinks per week.

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Thomas Stopka, Ph.D., an epidemiologist and professor in the public health and community medicine department at Tufts University School of Medicine in Massachusetts, shared in a Futurity report that for some people, “damp January” may be more suitable.

One expert warned that not all drinkers should quit “cold turkey,” as it could lead to severe withdrawals. (iStock)

“Dry January is well-intentioned, and it may work really well for the people who can stick to it, maybe even beyond January,” he said. “Other people may be more inclined to cut down on alcohol consumption rather than quit drinking completely for the month.”

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Stopka noted that successful harm-reduction approaches “aim to be judgment free.”

“Substance use disorder is a disease,” he said. “It takes time to treat the disease and to stay connected to the continuum of care — from prevention to treatment initiation to sustained therapy, whether through medication, self-help, or individual therapy or group support.”

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Those struggling with signs of alcohol use disorder should consult a medical professional for personalized guidance.

Fox News Digital reached out to several alcohol industry associations requesting comment.

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The Best Weight Loss Medications and Supplements in 2026

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