Health
New antibiotic kills deadly, drug-resistant bacteria in ‘scientific breakthrough’
Scientists in Switzerland have announced the discovery of a new class of antibiotics shown to be effective against deadly, drug-resistant bacteria.
The antibiotic, called zosurabalpin, works by blocking a bacterial molecule called lipopolysaccharide (LPS), which is responsible for creating the outer membrane that protects a harmful bacteria, Acinetobacter baumannii.
Acinetobacter is a “gram-negative” bacteria, which means it is resistant to most antibiotics and other drugs.
It can cause infections in the blood, lungs, urinary tract and other parts of the body, according to the Centers for Disease Control and Prevention (CDC).
In animal studies, zosurabalpin successfully killed drug-resistant strains of Acinetobacter.
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The research, conducted at Roche Pharma Research & Early Development in Switzerland, was published in the journal Nature on Jan. 3.
Scientists in Switzerland have announced the discovery of a new class of antibiotics that shown to be effective against deadly, drug-resistant bacteria. (iStock)
“This new class of antibiotics prevents bacteria from creating their outer membrane, which provide structure to the bacteria and help them survive in harsh environments and cause infection,” Kenneth Bradley, the Switzerland-based global head of infectious disease discovery at Roche, told Fox News Digital via email.
Without the ability to transport LPS — the bacteria die.
“The new molecule overcomes the existing drug-resistance mechanisms that the currently available antibiotics are failing to address,” Bradley said.
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This is the first time in over 50 years that a new class of antibiotic has been identified to treat infections by gram-negative bacteria, he noted.
Zosurabalpin specifically targets Acinetobacter.
“The specificity of zosurabalpin is due to the unique way in which it binds to the drug target in these bacteria,” Bradley said.
The antibiotic, called zosurabalpin, works by blocking a bacterial molecule called lipopolysaccharide (LPS), which is responsible for creating the outer membrane that protects harmful bacteria, Acinetobacter baumannii (not pictured). (iStock)
The hope is that this finding could help eventually to fight other drug-resistant bacteria.
“Discovery of the mode of action of zosurabalpin in Acinetobacter may enable the identification of other drugs that work in the same way in other antibiotic-resistant bacteria,” Bradley told Fox News Digital.
Zosurabalpin is currently in a phase 1 clinical trial, which will evaluate the “safety, tolerability and pharmacokinetics” of the molecule, according to the researcher.
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“These data, as well as data from future pivotal phase 3 clinical studies, would be needed to determine the safety and efficacy profile of the molecule,” he added.
The discovery of zosurabalpin, which Bradley calls a “scientific breakthrough,” will help researchers learn more about the construction of bacterial membranes, knowledge that could enable new drugs to kill bacteria.
The finding is especially significant, given that resistance to antibiotics has been on the rise in various gram-negative bacteria for several decades, he said.
Acinetobacter infections are most commonly seen in hospital patients, mainly affecting those who are on ventilators, have surgical wounds, are in intensive care units or have catheters, according to the CDC. (iStock)
“Any new antibiotic class that has the ability to treat infections caused by multi-drug-resistant bacteria such as carbapenem-resistant Acinetobacter baumannii (CRAB) would be a significant breakthrough,” he added.
Michael Lobritz, the Switzerland-based head of infectious diseases at Roche, referred in a press release to antimicrobial resistance as a “silent pandemic.”
“Over the next 30 years, it is projected to claim more lives than those taken by cancer today, according to the report of the economist Jim O’Neill,” Lobritz said.
Over the next 30 years, antimicrobial resistance is “projected to claim more lives than those taken by cancer today,” an expert said.
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, agreed that the growing resistance of gram-negative bacteria is a “huge problem.”
“Our last line of defense for decades now in the hospital has been the carbapenem drugs, specifically Imipenem and Mirapenem,” he told Fox News Digital.
The research was done at Roche Pharma Research & Early Development in Switzerland. (iStock)
“But now there is an increase of carbapenem-resistant strains — including carbapenem-resistant Acinobacter baumannii, or CRAB — which are very difficult to treat.”
Siegel also acknowledged the importance of the newly discovered zosurabalpin.
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“It interferes with a lipid transport mechanism at the surface of the bacteria,” he said. “This is very important, as there are now millions of deaths a year worldwide due to antibiotic resistance.”
Zosurabalpin has only been tested in animals so far, Siegel noted, with human trials underway.
What to know about Acinetobacter
Acinetobacter infections are most commonly seen in hospital patients, mainly affecting those who are on ventilators, have surgical wounds, are in intensive care units or have catheters, according to the CDC.
Those with lung disease, diabetes or weakened immune systems are at a higher risk of infection. (iStock)
Those with lung disease, diabetes or weakened immune systems are at a higher risk of infection.
The bacteria can spread from person to person or via contact with contaminated surfaces.
Acinetobacter baumannii, along with other gram-negative bacteria, is tracked by the CDC as part of its Emerging Infections Program.
Looking ahead, Siegel said he expects that artificial intelligence will help speed up the process of developing new antibiotics and make it “more effective and streamlined.”
For more Health articles, visit www.foxnews.com/health.
A look back at the medical miracles of 2025
Fox News senior medical analyst Dr. Marc Siegel joins ‘Fox & Friends’ to highlight 2025 breakthroughs, from a pineapple-derived burn cream to a newly approved heart procedure.
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America has been at the forefront of medical innovation since the nation’s founding in 1776.
From groundbreaking surgeries to cancer breakthroughs, U.S. physicians have helped transform nearly every field of medicine.
As America marks its 250th anniversary, experts are highlighting some of the most influential medical innovations in the nation’s history.
No. 1: Orthopedic care
John Uribe, MD, orthopedic surgeon and system chief executive at Baptist Health Orthopedic Care in Florida, said he believes the greatest breakthrough in orthopedics is the evolution of joint replacement surgery, particularly of the hip and knee.
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“A generation ago, severe arthritis or joint damage often meant a lifetime of pain, limited mobility and loss of independence,” he told Fox News Digital.
“Today, orthopedic surgeons can replace a damaged joint with highly durable implants, use advanced imaging and navigation, and increasingly rely on robotic-assisted technology to personalize implant positioning and improve precision.”
“The future of orthopedics will be less one-size-fits-all and more focused on matching the right procedure, implant, recovery plan and technology to the individual patient,” a doctor said. (iStock)
Today, patients can walk the same day after joint replacement, return home sooner and recover with less disruption than in the past, according to Uribe.
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“Hip and knee replacements, arthroscopic procedures, advanced fracture care and spine treatments have allowed patients to stay active longer and maintain independence as they age,” the doctor said. “The biggest impact is that orthopedic care can give people back parts of their lives they thought they had lost.”
“For many patients, the goal is no longer just to relieve pain; it is to restore movement, independence and quality of life.”
No. 2: Mental health treatment
For most of America’s 250 years, mental illness was largely treated indirectly with medication, or not at all when medication was ineffective, according to Dr. Russ Voltin, a West Virginia-based practicing psychiatrist and medical consultant at BrainsWay.
The biggest breakthrough, Voltin told Fox News Digital, has been neuromodulation therapies like deep transcranial magnetic stimulation (TMS), which are “clinically proven to non-invasively target the brain circuits involved in conditions such as depression and OCD, helping rebalance neural activity at its source.”
“Mental health is brain health, and for the first time, we have treatments designed to address it that way.”
For most of America’s 250 years, mental illness was largely treated indirectly with medication, or not at all when medication was ineffective. (iStock)
A generation ago, a patient who didn’t respond to medication had very limited options, he said.
“Today, a clinician can offer noninvasive brain stimulation in an outpatient chair – no anesthesia, no sedation, none of the prominent side effects of medication, and all with limited lifestyle interruption.”
The FDA recently expanded clearance for an accelerated Deep TMS protocol that shortens the initial phase of depression treatment from about four weeks of daily visits to just six treatment days.
“Mental health is brain health, and for the first time, we have treatments designed to address it that way.”
“For someone in a depressive crisis, this is the difference between waiting and getting better,” the expert said.
In clinical trials, roughly 78% of patients reached remission and more than 80% were still in remission a full year later.
“The biggest shift is that for people who once cycled through medication after medication with no relief, durable recovery is now a realistic goal rather than a hope.” (iStock)
“As a clinician, that last figure is the one that matters most: People going back to work, repairing relationships and re-entering their own lives, not just scoring better on a questionnaire,” Voltin said.
“The biggest shift is that for people who once cycled through medication after medication with no relief, durable recovery is now a realistic goal rather than a hope.”
No. 3: Cancer care
Cancer care has advanced dramatically over the past 250 years, with breakthroughs in prevention, screening, diagnosis and treatment transforming patient outcomes.
Leonard Kalman, MD, acting system chief executive at Baptist Health Cancer Care and acting executive medical director at Baptist Health Herbert Wertheim Cancer Institute in South Florida, said one of the most important breakthroughs in oncology is the understanding that “at its core,” cancer is a genetic disease.
Today, physicians can cure certain leukemias and lymphomas that were “once far more difficult to treat,” an expert noted. (iStock)
“Cancer can be driven by inherited germline mutations or by somatic mutations that occur in normal tissue and lead cells to become malignant,” he told Fox News Digital. “That discovery has transformed how we understand, diagnose and treat cancer.”
Today, physicians can cure certain leukemias and lymphomas that were “once far more difficult to treat,” the doctor noted.
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“We can also extend life while preserving quality of life for many patients with metastatic cancers — including diseases such as lung cancer, melanoma and prostate cancer, where treatment options were much more limited a generation ago,” Kalman said.
Many of those advances have shifted cancer care toward more individualized treatment, allowing physicians to tailor therapies based on a patient’s specific disease.
“For many patients, the goal is no longer just to relieve pain; it is to restore movement, independence and quality of life.”
“Advances in targeted therapies, immunotherapy, molecular testing and supportive care allow physicians to better personalize treatment, manage side effects and help patients live longer with a better quality of life, even when cancer has spread beyond the primary tumor,” the doctor said.
No. 4: Cardiovascular care
Tom Nguyen, MD, system chief executive at Baptist Health Heart & Vascular Care and chief medical executive at Baptist Health Miami Cardiac & Vascular Institute in South Florida, highlighted the ability to diagnose heart disease earlier and treat “even the most complex conditions” with safer, more precise and less invasive therapies.
“Cardiovascular disease remains the leading cause of death worldwide, but patients who once might have died in their 40s or 50s are now routinely living into their 80s and 90s with an excellent quality of life,” he told Fox News Digital.
Although cardiovascular disease is the leading cause of death worldwide, patients who once might have died in their 40s or 50s are now “routinely living into their 80s and 90s with an excellent quality of life,” the doctor said. (iStock)
Procedures like open-heart surgery, coronary artery bypass surgery, coronary stents, catheter-based valve replacement, advanced imaging and robotic heart surgery have “completely transformed what is possible,” according to Nguyen.
“Robotic heart surgery is a powerful example of how far the field has come,” he said. “For appropriately selected patients, surgeons can now perform highly complex heart procedures through much smaller incisions using robotic technology that provides exceptional visualization, precision and control.”
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The biggest achievement, Nguyen said, is not only helping people live longer, but also helping them “live better.”
“Today, heart and vascular specialists can perform procedures that would have seemed almost unimaginable just one generation ago,” he said. “Patients are surviving heart attacks, valve disease, rhythm disorders and complex vascular conditions at rates that would have been difficult to imagine decades ago.”
“Many complex cardiac operations that once required opening the chest can now be performed through small incisions, or robotically – allowing patients to recover much faster with less pain and disruption to their lives,” a doctor said. (iStock)
Success isn’t measured only by survival, Nguyen added. “Our ultimate goal is to help patients feel better and return to the lives they enjoy.”
No. 5: Neurology
Michael McDermott, MD, system chief executive of Baptist Health Brain & Spine Care and chief medical executive at Baptist Health Miami Neuroscience Institute, said the ability to safely operate on the brain is the greatest advancement in American neuroscience.
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“Less than a century ago, a craniotomy was an extraordinarily risky operation, and survival itself was far from guaranteed,” he told Fox News Digital. “Today, advances in anesthesia, electrocautery, imaging, surgical navigation, brain mapping and intraoperative neurophysiologic monitoring have transformed brain surgery into a highly precise and much safer procedure.”
The ability to treat acute stroke in real time has been “equally transformative,” McDermott noted.
The growth of artificial intelligence is “beginning to transform spine surgery,” a neurologist said, by helping physicians identify which patients are “most likely to benefit from complex corrective procedures and by allowing implants to be precisely modeled before surgery.” (iStock)
“Using advanced imaging and mechanical thrombectomy, physicians can now remove a clot from the brain and restore blood flow before permanent damage occurs in many eligible patients,” he said. “At the same time, innovations such as high-intensity focused ultrasound for essential tremor demonstrate how neuroscience has become increasingly precise and less invasive.”
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Today, neuro experts can accomplish tasks that “would have been difficult to imagine just one generation ago,” McDermott noted.
“We can remove blood clots from the brain during an active stroke, implant deep brain stimulation devices for Parkinson’s disease, and perform highly sophisticated brain and spine surgery using advanced imaging, navigation and artificial intelligence,” he said.
Medical advancements have improved quality of life in patients with brain tumors and spinal complications. (iStock)
Advances like image-guided surgery, intra-operative brain mapping, neurophysiologic monitoring and radio-surgery allow surgeons to remove tumors more safely while protecting areas of the brain responsible for movement, speech and other critical functions, he said.
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Beyond brain tumors, other advances across neuroscience, like corrective spine surgery, have allowed doctors to restore posture and mobility in patients with severe spinal deformities. Meanwhile, focused ultrasound can “significantly reduce tremors that interfere with everyday activities such as writing, eating or drinking,” McDermott noted.
“Increasingly, our goal isn’t simply to help patients survive – we’re helping them maintain their independence, preserve function and return to the lives they want to live.”
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Health
West Nile virus detected in southern state as health officials warn residents about mosquitoes
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Health officials in Nashville are urging residents to protect themselves from mosquito bites after West Nile virus was detected in mosquitoes for the first time this year.
The Metro Public Health Department (MPHD) announced the virus was found in a mosquito pool collected near Cass Street in North Nashville, marking the city’s first detection of West Nile virus in 2026 and the earliest positive mosquito sample of the season.
The detection comes after health officials reported elevated West Nile virus activity in mosquito pools during 2025, when one human case of the virus was confirmed.
“We can all play a role in reducing the presence of mosquitoes in our community, making our outdoor areas both more pleasant and safer from mosquito-borne diseases like West Nile virus,” Dr. Sanmi Areola, director of health at the Metro Public Health Department, said in a statement to Fox 17.
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A close-up shows mosquitoes feeding in Tehatta, India, on May 1, 2026. Health officials in Nashville recently detected West Nile virus in a mosquito pool, prompting residents to take precautions against mosquito bites. (Soumyabrata Roy/NurPhoto via Getty Images)
“As our team educates those in the area where West Nile virus was found, we hope the rest of our community does what they can to protect themselves and their families from mosquitoes this summer.”
According to the Centers for Disease Control and Prevention, West Nile virus is the leading mosquito-borne disease in the United States. Most people infected with the virus do not develop symptoms, but about one in five experience fever, headaches, body aches, vomiting, diarrhea or a rash. Fewer than 1% develop a serious neurological illness that can affect the brain or spinal cord, with older adults and people with weakened immune systems facing the greatest risk.
Public health officials routinely trap and test mosquitoes throughout the summer to monitor for West Nile virus activity. A positive mosquito sample does not necessarily mean people in the area will become infected, but it serves as an early warning that the virus is circulating locally.
In response to the positive test, MPHD said crews are distributing educational flyers in the affected neighborhood, increasing mosquito trapping, monitoring standing water and applying larvicide where needed to help reduce mosquito populations. The department said it does not spray insecticide to kill adult mosquitoes.
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The Aedes mosquito is a known vector for several viruses, including West Nile virus, yellow fever virus, dengue virus, chikungunya virus, and Zika virus. (Soumyabrata Roy/NurPhoto via Getty Images)
Residents can also request a free backyard inspection from the department’s Pest Management team to identify areas where mosquitoes may be breeding.
Health officials recommend eliminating standing water from bird baths, flowerpots, buckets, old tires, children’s toys and other outdoor containers where mosquitoes lay eggs. Trimming overgrown vegetation around homes can also help reduce mosquito activity.
A field sample of mosquitoes that could carry West Nile Virus is seen at offices of the Riverside County Department of Environmental Health on April 26, 2007, in Hemet, California. (David McNew/Getty Images)
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To help prevent mosquito bites, the health department recommends using EPA-approved insect repellents containing DEET, picaridin or oil of lemon eucalyptus, wearing long sleeves and pants outdoors during peak mosquito hours around dusk and dawn, and making sure window and door screens are in good repair.
Officials said reducing mosquito breeding around homes can help lower the risk of West Nile virus and other mosquito-borne illnesses throughout the community.
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