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Men’s brains shrink faster than women’s; researchers explore Alzheimer’s connection

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Men’s brains shrink faster than women’s; researchers explore Alzheimer’s connection

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A new study may challenge what we thought we knew about brain aging. 

Scientists have discovered that men’s brains shrink faster than women’s as they grow older, even though women are more likely to develop Alzheimer’s disease.

The research, published in the Proceedings of the National Academy of Sciences, analyzed more than 12,000 brain scans from nearly 5,000 healthy people between the ages of 17 and 95. Each participant had at least two MRI scans taken over time, allowing scientists to gauge how their brains changed as they aged.

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Researcher Anne Ravndal of the University of Oslo in Norway said her team wanted to test whether the higher Alzheimer’s rate in women could be linked to gender differences in the brain.

“Women are diagnosed with Alzheimer’s disease more often than men, and since aging is the main risk factor, we wanted to test whether men’s and women’s brains change differently with age,” she told Fox News Digital.

A new study shows women’s brains don’t shrink as quickly as men’s in old age, although women still have higher rates of Alzheimer’s diagnoses. (iStock)

Men showed a faster rate of brain shrinkage across more regions than women. Areas related to memory, emotion and sensory processing — like the hippocampus and parahippocampal regions — were especially affected, the study found.

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Women’s brains, by contrast, appeared to maintain their size in more areas, though they did show slightly more enlargement in the brain’s fluid-filled spaces, known as ventricles.

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“Our findings show that men experience greater structural brain decline across more regions, meaning that normal brain aging doesn’t explain the sex difference in Alzheimer’s rates,” Ravndal said.

One hypothesis is that women get more checkups than men and are diagnosed more often with Alzheimer’s. (iStock)

Because women are still diagnosed with the disease nearly twice as often, researchers concluded that brain size changes alone can’t explain that gap.

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“The results instead point toward other possible explanations, such as differences in longevity, diagnostic patterns or biological factors,” said Ravndal.

For example, women tend to live longer, which increases the window of time during which Alzheimer’s can develop. Shifts in estrogen during menopause could also affect how brain cells age, experts say.

One potential reason for the higher rate of Alzheimer’s in women could be changes in estrogen and other hormones as they age. (iStock)

Some researchers have noted that women may simply be diagnosed more often because they’re more likely to seek medical help when memory problems appear.

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One limitation of the study is that it only looked at healthy people, not those who were already showing signs of dementia, Ravndal acknowledged. The participants were also generally well-educated and came from multiple study sites.

Ravndal emphasized that the work isn’t meant to guide individual health decisions.

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“The study is not about making direct recommendations for individuals — rather, it helps refine scientific understanding by showing that normal brain aging does not account for women’s higher prevalence of Alzheimer’s disease,” she said.

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The researcher added that “future work needs to identify the mechanisms that do.”

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5 Surprising Ozempic Side Effects Doctors Are Finally Revealing (Like Back Pain and Hair Loss)

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5 Surprising Ozempic Side Effects Doctors Are Finally Revealing (Like Back Pain and Hair Loss)


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Relationship coach blames Oprah for pushing family estrangement ‘for decades’

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Relationship coach blames Oprah for pushing family estrangement ‘for decades’

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Oprah Winfrey is shining a light on family estrangement, which she calls “one of the fastest-growing cultural shifts of our time” — but one expert says the media mogul helped fuel that very culture.

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“A Cornell University study now shows that almost one-third of Americans are actively estranged from a family member,” Winfrey said on a recent episode of “The Oprah Podcast,” referring to adult children going “no-contact” with parents, siblings or entire family systems.

Winfrey said the trend is a “silent epidemic” that can be especially relevant during the holidays.

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But family and relationship coach Tania Khazaal, who focuses on fighting “cutoff culture,” took to social media to criticize Winfrey for acting as if the estrangement crisis appeared “out of thin air.”

“Now Oprah is shocked by the aftermath of estrangement, after being one of the biggest voices pushing it for decades,” Canada-based Khazaal said in an Instagram video, which drew more than 27,000 likes and 3,000 comments.

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Oprah Winfrey recently discussed what she called a “silent epidemic” of family estrangement on her podcast. (Theo Wargo/Getty Images)

Khazaal claimed that Winfrey’s messaging started in the 1990s and has contributed to a cultural shift where walking away became the first resort, not the last.

According to the relationship coach, millennials, some of whom grew up watching Oprah, are the leading demographic cutting off family members — and even if it wasn’t intentional, “the effect has absolutely been harmful,” Khazaal told Fox News Digital.

FAMILY BREAKUPS OVER POLITICS MAY HURT MORE THAN YOU THINK, EXPERT SAYS

The coach, who has her own history with estrangement, questioned why Winfrey is now treating the issue as a surprising crisis.

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“Now she hosts a discussion with estranged parents and estranged kids, speaking on estrangement like it’s some hidden, sudden, heartbreaking epidemic that she had no hand in,” she said in her video.

Nearly one-third of Americans are estranged from a family member, research shows. (iStock)

Khazaal said she believes discussions about estrangement are necessary, but insists that people shouldn’t “rewrite history.”

“Estrangement isn’t entertainment or a trending conversation piece,” she added. “It’s real families, real grief, parents dying without hearing their child’s voice.”

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Winfrey reportedly responded in the comments, writing, “Happy to have a conversation about it — but not on a reel. Will have my producer contact you if you’re interested.” But the comment was later deleted due to the backlash it received, Khazaal told Fox News Digital.

“I would still be open to that discussion,” Khazaal said. “The first thing I’d want her to understand is simple: Setting aside cases of abuse or danger, the family unit is the most sacred structure we have.” 

Experts emphasize that estrangement should be a last resort. (iStock)

“When children lose their sense of belonging at home, they search for it in the outside world,” she added. “That’s contributing to the emotional fragility we’re seeing today.”

Her critique ignited a debate online, with some social media users saying Khazaal is voicing a long-overdue concern.

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“The first time I heard, ‘You can love them from a distance’ was from Oprah … in the ’90s,” one woman said.

My son estranged himself from us for five years,” one mother commented. “The pain, hurt and damage never goes away.”

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Others, however, argued that Winfrey’s podcast episode was empathetic and that estrangement shouldn’t be oversimplified.

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Mental health experts say the conversation around estrangement is more complex than any single celebrity influence, and reflects broader cultural shifts.

Experts say today’s focus on boundaries and emotional well-being has reshaped family expectations. (iStock)

In the episode with Winfrey, Joshua Coleman, a California-based psychologist, said, “The old days of ‘honor thy mother and thy father,’ ‘respect thy elders’ and ‘family is forever’ has given way to much more of an emphasis on personal happiness, personal growth, my identity, my political beliefs, my mental health.” 

Coleman noted that therapists sometimes become “detachment brokers” by unintentionally green-lighting estrangement.

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Jillian Amodio, a licensed master’s social worker at the Maryland-based Waypoint Wellness Center, told Fox News Digital that while public figures like Winfrey help normalize these conversations, estrangement might just be a more openly discussed topic now.

“Estrangement used to be handled privately and quietly,” she said.

Winfrey’s take on family estrangement is prompting a broader discussion amid the holiday season. (iStock)

But even strained relationships can be fixed with the right support, experts say.

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Susan Foosness, a North Carolina-based clinical director of patient programs at Rula Health, said families can strengthen their relationships by working with a mental health professional to improve communication, learn healthier conflict-resolution skills, and build trust and empathy through quality time together.

“No family is perfect,” Foosness told Fox News Digital.

Khazaal agreed, saying, “Parents need to learn how to listen without slipping into justification, and children need help speaking about their pain without defaulting to blame or avoidance.”

Fox News Digital reached out to Winfrey for comment.

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Major measles outbreak leads to hundreds quarantined in US county, officials say

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Major measles outbreak leads to hundreds quarantined in US county, officials say

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South Carolina is facing a major measles outbreak, resulting in the quarantine of hundreds of residents.

The South Carolina Department of Health (DPH) reported in a media briefing on Wednesday that the current number of measles cases has reached 111 as part of the current Spartanburg County outbreak.

DPH first reported a measles outbreak in the Upstate region on Oct. 2.

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The health department confirmed that 254 people are currently in quarantine and 16 are in isolation to prevent further spread.

The health department confirmed that 254 people are currently in quarantine in the upstate region. (Getty Images)

“This significant jump in cases is unfortunate,” a DPH spokesperson commented on the outbreak.

Public exposure was identified at Inman Intermediate School, with 43 of their students in quarantine.

“This significant jump in cases is unfortunate.”

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Eight other intermediate and middle schools in the area are also reportedly undergoing quarantine. The DPH said multiple students have had to quarantine twice due to repeat exposure.

“Vaccination continues to be the best way to prevent the disruption that measles is causing to people’s education, to employment and other factors in people’s lives and our communities,” the spokesperson said.

“This significant jump in cases is unfortunate,” a DPH spokesperson commented on the current outbreak. (iStock)

Out of the 111 confirmed cases, 105 were unvaccinated. Receiving a vaccination within 72 hours has been shown to prevent measles infection, the DPH spokesperson noted. 

Some cases are related to travel exposure, while others are from an unknown source, suggesting that measles is circulating in the community, the DPH noted.

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Connecticut has also reported its first measles case in four years, according to the Connecticut Department of Public Health.

The department confirmed on Thursday that an unvaccinated child in Fairfield County, under the age of 10, was diagnosed with measles after recently traveling internationally.

“Vaccination continues to be the best way to prevent the disruption that measles is causing,” a DPH spokesperson said. (iStock)

The child began to show symptoms several days later, including a runny nose, cough, congestion, fever and a rash starting at the head and spreading to the rest of the body.

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The Connecticut DPH noted that measles is “highly contagious” and can spread quickly through the air via coughing or sneezing. The CDC has estimated that nine out of 10 unvaccinated individuals who encounter an infected person will develop the measles virus.

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According to the International Vaccine Access Center, more than 1,800 cases of measles have been reported in 2025, which is the most since the U.S. declared the virus eliminated in 2000. It is also the most cases recorded in three decades.

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“The single best way to protect your children and yourself from measles is to be vaccinated,” DPH Commissioner Manisha Juthani, M.D., wrote in a statement. “One dose of measles vaccine is about 93% effective, while two doses are about 97% effective.”

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