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Alzheimer’s scientists find key to halting brain decline before symptoms

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Alzheimer’s scientists find key to halting brain decline before symptoms

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Scientists may have found a way to stop Alzheimer’s damage before it starts — by “melting” the tiny protein clumps that are the early triggers of the disease.

Alzheimer’s has long been linked to harmful tau protein fibrils that build up in the brain and interfere with cognitive function, but researchers have now discovered soft, small clusters that appear first.

When those early clusters were dissolved, it prevented the toxic fibrils from forming, which could effectively block the disease, according to researchers from Tokyo Metropolitan University.

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Led by Professor Rei Kurita, the scientists used precise X-ray and fluorescence methods in a laboratory setting to find the microscopic “precursors,” which measured only tens of nanometers, according to a press release.

Because the tiny precursors were soft, the researchers were able to dissolve them. As a result, no tau fibrils were formed.

Scientists may have found a way to stop Alzheimer’s damage before it starts — by “melting” the tiny protein clumps that are the early triggers of the disease. (iStock)

These results suggest a shift in how scientists might develop Alzheimer’s disease treatments.

Rather than focusing on breaking apart the final fibril formations, new therapies could target the earlier, reversible precursor stage to prevent harmful structures from forming in the first place, according to the release.

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This strategy could eventually be applied to the research of neurodegenerative diseases like Parkinson’s.

The study did have some limitations, primarily that it involved in-vitro biochemical models and no humans or animals. It’s not known whether similar reversible clusters exist in human brain tissue.

Alzheimer’s has long been linked to harmful tau protein fibrils that build up in the brain and interfere with cognitive function. (iStock)

More research is needed to find out if breaking up these protein clusters is safe and could actually help treat the disease.

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Dr. Marc Siegel, Fox News senior medical analyst, was not involved in the study but shared his reactions to the findings.

“There are three essential components structurally involved in the development of Alzheimer’s disease — beta amyloid proteins, tau proteins and neuroinflammation,” he told Fox News Digital.

“In the future, there will likely be triple therapy — anti-inflammation, anti-beta-amyloid and anti-tau.”

“There are already treatments on the market to target beta amyloid buildup, and now here’s a targeted therapy to dissolve and disrupt tau protein buildup before it forms the dreaded neurofibrillatory tangles.”

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Siegel believes this is “bound to be of clinical value” and will likely be better tolerated than other medications currently on the market.

“In the future, there will likely be triple therapy — anti-inflammation, anti-beta-amyloid and anti-tau,” he predicts.

“This is promising basic research that may turn out to deepen our understanding of the mechanisms underlying the disease, but it is preliminary,” an expert said. (iStock)

Courtney Kloske, Ph.D., director of scientific engagement for the Alzheimer’s Association in Chicago, also reacted to the study in an interview with Fox News Digital.

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“This manuscript focuses on altering the structure of tau, one of the hallmark brain proteins involved in Alzheimer’s, and on exploring approaches that could potentially slow or stop disease development,” said Kloske, who was also not involved in the study.

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“This is promising basic research that may turn out to deepen our understanding of the mechanisms underlying the disease, but it is preliminary, and additional studies are needed to determine how these findings can be translated into human studies.”

Fox News Digital reached out to the researchers for comment.

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One walking habit could signal a healthier brain after 80, scientists say

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One walking habit could signal a healthier brain after 80, scientists say

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Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers.

That’s according to a recent study led by Stony Brook Medicine in New York, which evaluated the cognitive function of 4,000 adults 80 and over who participated in multiple aging and longevity studies over several years.

Among this group, 6% to 10% were classified as super movers, which means they walk at a much faster pace than others of the same age and gender — at speeds comparable to people three decades younger.

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The super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed.

The findings were published in the journal Neurology on June 16.

Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers. (iStock)

“The study reinforces that mobility and brain health are closely connected,” lead study author Dr. Joe Verghese, MD, neurologist at Stony Brook Medicine, told Fox News Digital. “This suggests that preserving mobility may be an important marker of healthy brain aging and resilience.”

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The most intriguing finding, according to Verghese, was that super movers maintained cognitive function despite having similar dementia-related brain changes as their peers.

In postmortem brain analysis, there was no difference in dementia-related pathologies between the super movers and the slower walkers, the study stated.

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“This suggests they may possess resilience mechanisms that help preserve brain function even in the presence of age-related changes,” he said. “Understanding these resilience factors could lead to new strategies for promoting healthy brain aging.”

As the study was observational, there were some limitations, and it does not prove that walking faster prevents dementia, the researchers noted.

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Super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed. (iStock)

“Other factors, such as cardiovascular health, physical fitness or genetics, may also contribute to both faster walking and better cognitive outcomes,” Verghese said.

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This study adds to growing evidence that what’s good for the heart and muscles also benefits the brain, he noted, adding that “staying physically active remains one of the most effective, evidence-based ways to support healthy aging.”

“Walking speed is best viewed as a marker of overall health, not a treatment.”

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“The broader message is that physical activity is important at any age,” Verghese said. “Walking is an easy step-up point because you don’t need any special equipment. You can do it inside or outdoors, and you can do it on a regular basis. You can walk with a dog, you can walk with a friend.”

Any activity is beneficial if it’s done regularly and with the right intensity, he added.

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Rather than just trying to walk faster, the neurologist recommends that seniors focus on maintaining mobility through regular physical activity, strength training, balance exercises and good cardiovascular health.

“Walking speed is best viewed as a marker of overall health, not a treatment,” Verghese noted.

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Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking.

Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking. (iStock)

This can be achieved by walking 30 minutes a day, five days a week, or about 20 to 25 minutes most days. Another option is to engage in shorter sessions that add up over the day.

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“You have to do it within your health limitations and medical conditions,” Verghese advised. “So if there are any medical concerns, I would get your physician to clear you before starting exercise.” The good thing about walking, he added, is that you can start at a slow pace and then gradually build up to a brisker pace.

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“And then adding on strength and balance training, whatever age you are, I think is also important.”

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I Tried the Viral Gelatin Weight-Loss Recipe—Here’s My Honest Take

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I Tried the Viral Gelatin Weight-Loss Recipe—Here’s My Honest Take


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I Tried the Viral Gelatin Weight-Loss Recipe: Does It Really Work?




















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Dr Oz warns Medicare scammers are stealing billions — and your personal information could be next

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Dr Oz warns Medicare scammers are stealing billions — and your personal information could be next

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Medicare fraud is a multibillion-dollar problem that government officials say threatens both taxpayer dollars and Americans’ personal identities.

In a July 6 interview with Fox News Digital at the Great American State Fair in Washington, D.C., Dr. Mehmet Oz warned that every dollar stolen through Medicare fraud is a dollar taxpayers lose – a problem that has worsened since the COVID pandemic.

“If I had to just pick one thing to focus on to make healthcare more affordable in America, I’d go to health fraud and all the waste and abuse that accompanies it,” said Oz, who is the administrator of the Centers for Medicare & Medicaid Services. “And just to put this in perspective, we think it’s about $100 billion a year.”

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Medicare fraud can include billing for services that were never provided, overcharging for medical equipment, using stolen patient or doctor information, or performing unnecessary procedures, according to the U.S. Government Accountability Office.

CMS administrator Dr. Mehmet Oz is pictured on stage at the Great American State Fair in Washington, D.C., on July 6, 2026. (Angelica Stabile/Fox News Digital)

As the Trump administration ramped up efforts to combat fraud, CMS reported $41.9 billion in Medicare program integrity savings in 2025, up 59% from $26.3 billion in 2024.

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Medicare fraud not only harms the federal budget and steals from taxpayers, but exposes seniors to identity theft, unnecessary care, higher premiums and reduced access, Oz cautioned.

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Removing corruption from the healthcare system will have the greatest impact among seniors, since “so much of the fraud is perpetrated against them,” the administrator said.

“I’m talking about people tricking seniors to give up their Medicare beneficiary numbers, which is like a credit card basically,” he said. “These scammers can take those numbers and use them for all kinds of illegitimate purposes.”

“If I had to just pick one thing to focus on to make healthcare more affordable in America, I’d go to health fraud and all the waste and abuse that accompanies it,” said Oz. (Fox News Digital)

“People are stealing from you by pretending to send you drugs you don’t want, wheelchairs you don’t need, [and] services you never asked for or don’t benefit from,” Oz added.

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To prevent this, he shared his top advice for seniors: Do not give your Medicare beneficiary number to anybody, do not answer questions on a phone call from an unknown person and do not give away personal information.

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“These scammers are calling seniors, tricking them, and once they have key information, they can steal it,” he said. “And I won’t know it and you won’t know it.”

“We want to protect people who need these programs the most,” Oz went on. “You do that by making sure scoundrels don’t corrupt the systems and steal money out of the till that is designed to help folks in dire straits when they’re vulnerable and in need of services.”

Seniors should never share their Medicare information with unknown people, the administrator advised. (iStock)

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Removing fraud could “double the life expectancy of the trust fund that makes all this possible,” Oz predicted.

“If you’re worried about Medicare being there when you’re ready to retire in a couple decades, depending on how old you are, and you’re concerned that it might not last because of all the fraud that’s hitting it … you’ve got a good [reason to] worry,” he said.

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“If we take the fraud out, we could double the life expectancy, which means you, your kids, your kids’ kids … they could all benefit from this beautiful safety net program.”

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