Health
In Alzheimer’s study, sleeping pills are shown to reduce signs of disease in the brain
Sleep difficulties are a typical grievance amongst these residing with Alzheimer’s illness — and consultants say these challenges usually begin nicely earlier than the prognosis.
In a latest research printed in Annals of Neurology, researchers at Washington College College of Drugs in St. Louis, Missouri, evaluated how taking sleep treatment may impression the brains of individuals with Alzheimer’s.
Contributors who took a sleeping capsule known as suvorexant earlier than going to mattress confirmed a discount within the ranges of Alzheimer’s proteins of their spinal fluid. Suvorexant is an FDA-approved treatment offered beneath the model identify Belsomra to deal with insomnia.
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Folks with Alzheimer’s illness are identified to expertise sleep disturbances, medical doctors say — however it’s not so clear which one causes the opposite.
“Poor sleep can enhance the chance of Alzheimer’s, and it may also be a symptom of early Alzheimer’s,” stated Dr. Raymond J. Tesi, CEO and CMO of INmune Bio, a clinical-stage biotechnology firm in Boston, Massachusetts, which develops immune-based remedies to battle Alzheimer’s illness.
Dr. Tesi was not concerned within the Washington College research.
“Sufferers with the illness usually have poor sleep patterns, so it’s possible to say that sleep is said to Alzheimer’s, although it’s unclear which comes first,” he continued.
“The query is whether or not Alzheimer’s causes poor sleep or whether or not poor sleep causes Alzheimer’s.”
Proteins enhance with development of illness
Alzheimer’s illness is the commonest type of dementia. It begins when substances known as “plaques” and “tangles” start to type within the mind.
Plaques are “deposits of a protein fragment known as beta-amyloid that construct up within the areas between nerve cells,” in keeping with the Alzheimer’s Affiliation web site.
“Folks experiencing poor sleep ought to communicate to their well being care supplier earlier than taking any drugs.”
Years after the amyloids begin forming, one other kind of protein known as tau begins to build up, creating tangles that block vitamins and different important provides from transferring although mind cells. The formation of tangles often happens across the time that cognitive signs start.
Each varieties of proteins enhance because the illness progresses — and former research have proven that they’re at larger ranges in individuals who have poor sleep.
Early outcomes are promising
Washington College’s two-night sleep research included 38 contributors between ages 45 and 65 who had no identified cognitive impairments and no proof of Alzheimer’s-related adjustments within the mind.
The contributors had been divided into three teams. One group took a decrease dose of suvorexant, one took a better dose and one took a placebo earlier than going to sleep.
Throughout a 36-hour interval, researchers analyzed spinal fluid each two hours to measure the degrees of Alzheimer’s proteins.
Those that had taken the upper dose of sleeping treatment had wherever from 10% to twenty% much less protein in comparison with those that acquired the placebo.
Those that took the decrease dose didn’t present a big distinction in protein ranges.
“Poor sleep can enhance the chance of Alzheimer’s, and may also be a symptom of early Alzheimer’s.”
The protein ranges decreased once more when a second dose was administered the next evening.
“This means that taking suvorexant over lengthy intervals of time may scale back these proteins and forestall or delay the onset of Alzheimer’s illness signs,” lead researcher Dr. Brendan Lucey, an affiliate professor of neurology and director of Washington College’s Sleep Drugs Heart in Saint Louis, informed Fox Information Digital in an e-mail.
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“Nevertheless, extra research are wanted the place contributors obtain medicine like suvorexant for longer intervals of time — months, as an example — and we monitor if amyloid-beta and phosphorylated tau are decreased,” he added.
The findings are in keeping with earlier work that has proven poor sleep is linked to larger ranges of amyloid and tau within the mind, famous Dr. Percy Griffin, the Chicago, Illinois-based director of scientific engagement on the Alzheimer’s Affiliation.
“What’s thrilling right here is {that a} quick intervention of solely two nights can impression these markers,” he informed Fox Information Digital.
“Alzheimer’s and sleep have a bidirectional relationship the place poor sleep could result in Alzheimer’s-related adjustments and these adjustments in flip disrupt sleep additional,” he continued. “
This work demonstrates that it’s attainable to intervene on this relationship and immediately impression the mind adjustments that result in Alzheimer’s illness.”
Additional questions stay
Past marking a lower in Alzheimer’s proteins, there stays the query of whether or not that can lead to improved cognition, stated Dr. Tesi.
“The gold normal for Alzheimer’s remedy is stopping cognitive decline,” he informed Fox Information Digital. “Even when we don’t perceive the precise mechanism of how sleeping drugs have an effect on Alzheimer’s, if using sleeping drugs safely decreases the speed of cognitive decline, it’s a massive deal. Sadly, this research doesn’t reply this query.”
“The gold normal for Alzheimer’s remedy is stopping cognitive decline.”
Moreover, the day by day use of sleeping drugs can include unwanted effects, the physician famous.
“The ‘hangover’ results of sleeping drugs are actual and magnified within the age group that has Alzheimer’s,” he stated.
Bigger research to observe
This preliminary research checked out solely a small group of wholesome, middle-aged contributors over a really quick time period.
Dr. Lucey, the lead researcher, is planning longer-term research to research whether or not sleep treatment can scale back indicators of early Alzheimer’s in older adults.
“Future research want to provide medicine like suvorexant for longer intervals of time, embody a bigger variety of contributors and embody contributors with biomarker proof of adjustments within the mind from Alzheimer’s illness, corresponding to amyloid deposition,” Dr. Lucey informed Fox Information Digital.
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If the bigger research affirm the preliminary findings, Dr. Lucey stated he hopes to “transfer ahead quickly with part III trials testing if this class of drug can forestall or delay Alzheimer’s illness — particularly since suvorexant (and different twin orexin receptor antagonists) is already FDA-approved for the remedy of insomnia.”
High quality sleep is vital for Alzheimer’s sufferers
Though he sees the preliminary outcomes as “very encouraging,” Dr. Lucey doesn’t but suggest taking nightly sleep treatment as an Alzheimer’s prevention measure.
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“This research doesn’t assist taking suvorexant to forestall or delay Alzheimer’s illness,” he informed Fox Information Digital.
“I like to recommend that people who’ve unrefreshing or nonrestorative sleep ought to see their physician and be evaluated for sleep issues corresponding to sleep apnea and insomnia.”
“Remedy of sleep issues can enhance high quality of life (because of decreased daytime sleepiness) and enhance well being,” he added.
Dr. Griffin from the Alzheimer’s Affiliation agrees: “Folks experiencing poor sleep ought to communicate to their well being care supplier earlier than taking any drugs.”
Health
Spinal cord treatment restores function for paralyzed patients in study: ‘New hope’
Ninety percent of paralyzed patients regained strength or function in their upper limbs after receiving an experimental therapy, a new study found.
After receiving spinal cord simulation from ONWARD Medical’s ARC-EX system, the participants saw “significant improvement” in their hand and arm function, according to a press release.
The study, published on Monday in Nature Medicine, included 65 participants at 14 leading spinal cord injury centers in the U.S., Europe and Canada.
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The participants received non-invasive electrical stimulation of the spinal cord using ARC-EX, and then researchers gauged the safety and effectiveness of the system.
Improvement was seen even in people whose injuries occurred up to 34 years ago, the release stated.
“When a person suffers a spinal cord injury, after two to three months of rehabilitation, they are sent home and told there is nothing further that can be done,” Dave Marver, CEO of ONWARD Medical, told Fox News Digital.
The company is global; its main headquarters is in The Netherlands.
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“This week’s publication in Nature Medicine heralds a new era in spinal cord injury care. The Up-LIFT trial demonstrated that ONWARD ARC therapy can restore strength and function of the hands and arms up to 34 years after a spinal cord injury.”
“This is a game-changer for the spinal cord injury community and their loved ones.”
The trial results far exceeded the researchers’ expected 50% response rate — giving “new hope” to people with SCI, noted lead study author Chet Moritz, Ph.D., professor of electrical and computer engineering and rehabilitation medicine at the University of Washington, in the release.
After two months, more than half the paralyzed participants regained enough “grasp force” to lift up a filled cup, pick up an item with a fork or insert a key, according to Moritz.
“This is a game-changer for the spinal cord injury community and their loved ones.”
“This indicates not only improved strength and function, but also the potential for greater independence with ARC-EX Therapy,” he said.
Additional benefits included reduced muscle spasms, improved sleep and a greater sense of touch in the upper body, the release said.
Eighty-seven percent of the participants reported having an improved quality of life after receiving the therapy.
“Improvement in arm and hand function is among the highest priorities for people with tetraplegia (paralysis in the upper and lower body) who have endured far too long without effective therapies for functional recovery,” Marver, the company CEO, said in the release.
“The findings published in Nature Medicine provide critical and compelling evidence that ARC-EX has the potential to restore independence in daily activities and improve [the patients’] quality of life.”
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Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was not involved in the trial but commented on the results.
“This has been tried for many years with reports that it helps, but it has not yet gone mainstream in patients with upper and lower spinal cord paralysis,” he told Fox News Digital.
“Improvement in arm and hand function is among the highest priorities for people with tetraplegia.”
“This small study in a very prominent journal is very encouraging in terms of some return of upper extremity function,” Siegel continued.
“It warrants further study and more universal use in these patients.”
It’s possible that this type of spinal cord stimulation could be combined with the increasing use of other brain and spine interfaces to restore function, the doctor added.
John Hinson, M.D., an orthopedic surgeon in Florida, was also not involved in the study but shared his insights on the findings.
“Patients with incomplete quadriplegia can be left with weakness and muscle spasm, as well as sensory changes that can cause significant loss of function,” he told Fox News Digital.
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Traditional treatments for these injuries have included physical therapy, he noted, but results can be limited.
“Review of the trial results shows that by two months of use, over half of the patients showed significant functional improvement in activities such as grasping and pinching required for basic daily tasks,” Hinson said.
“If these results can be predictably achieved, it would greatly improve the lives of patients with spinal cord injuries that resulted in incomplete quadriplegia.”
This could potentially be a “big factor” in the treatment of these patients, according to Hinson.
ONWARD has submitted an application to the U.S. Food and Drug Administration (FDA) to gain approval for the ARC-EX system, with clearance expected later this year.
“We are laser-focused on our commitment to bringing this first-of-its-kind technology to the SCI community as soon as possible,” Marver said.
The ARC-EX System will require a prescription from a qualified health care professional once it is cleared for use, according to the company.
For more Health articles, visit www.foxnews.com/health.
Health
Three women — ages 41, 55 and 64 — share their secrets to better health and longevity
For an increasing number of women over 40, age really is just a number.
It may not be possible to stop the passage of time — but certain healthy habits can help slow down biological age, experts say.
“As we age, our abilities to perform certain physical and cognitive tasks decline, while our risks for disease and ultimately death increase,” Chris Mirabile, CEO and founder of NOVOS, a longevity supplements company in New York, told Fox News Digital.
“Although these changes are correlated with chronological age, biological age is a more accurate predictor, because it looks at individuals and how well – or poorly – they are aging.”
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If a 40-year-old woman has a biological age of 35, it implies that she is biologically in the same place as an average 35-year-old, Mirabile said – which means a significant reduction in risk for disease and death, plus an increased capacity for activities associated with a high quality of life.
For Women’s Health Month, three mothers at three different stages of life shared how they are defying age through simple lifestyle practices and interventions.
The women all participated in a six-month-long trial of NOVOS Core and Boost, supplements that are designed to slow down the aging process. Over the course of the study, they took three epigenetic tests, which analyzed DNA via a small blood sample to measure their “pace of aging.”
Lil Eskey, 41 years old, still has young kids
Lil Eskey, 41, is a stay-at-home mom and former fitness instructor in Phoenix, Arizona.
Growing up, she frequently had allergies and a constant sore throat.
“The way that my mom handled it was to put me on antibiotics so many times when I was a kid,” she told Fox News Digital.
“I also had gut issues most of my life, so my path into health and wellness stemmed from trying to figure out what was going on with my body.”
Prioritizing her sleep is the biggest thing Eskey does for her health, she told Fox News Digital.
“Good sleep is so underrated,” she said.
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“Having a consistent bedtime and wake-up time is so important for overall wellness. Everything works so much better when you’re well-rested, including any stressors in your life or anything going on with the mind.”
Eskey also tries to incorporate movement into her life wherever possible.
“When my son goes to preschool, I pull him on a bike trailer. The same goes for anything that’s a few miles away, like grocery shopping.”
“I want to be completely present for my kids and maintain a level of energy and vitality in life.”
After dinner, the family often goes out on bike rides or jumps on the trampoline.
“We do anything to make it fun,” she said.
When it comes to mental health, Eskey has made the decision not to use social media.
“I hear about anything that’s super important, and I’ll check the news occasionally to see what information I need, but to me, social media just seems like an additional stressor on the body,” she said.
Eskey and her family often experiment with different health practices, she said.
“I listen to different podcasts on health and fitness to hear about new science or new ideas, and then we’ll test it out to see what works,” she said.
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“For example, I realized I feel way better when I have a couple of hours between having my last meal and going to bed.”
She’s also experimented with using a continuous glucose monitor to track her blood sugar.
“We’re always just doing different experimental things to see what makes the biggest change,” Eskey said.
She has also been using anti-aging supplements from NOVOS. During the course of the study, Eskey’s biological pace of aging was reduced from .99 to .77.
“The time we’re here on this earth doesn’t always have to reflect the cumulative stress on our bodies. Rather, it’s stress that causes aging,” she said.
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“It’s more important now than ever, with all the toxins and stressors we’re facing.”
Maintaining a more youthful energy level is important to Eskey, as she is still raising young children, she said.
“The biggest thing is being able to keep up with my kids and be totally active,” she said.
“When my kids want to play at the park, it’s important to me that I’m not just sitting on the bench watching them. I want to be completely present for my kids and maintain a level of energy and vitality in life.”
Julie Gibson Clark, 55 years old, focuses on movement
A recruiter who lives in Phoenix, Arizona, Julie Gibson Clark said she focuses on seven key areas to help slow down biological aging.
The first is movement, both strength and cardio. “I focus on full-body strength training twice per week and a mix of zone 2 and Vo2Max training the rest of the week,” she told Fox News Digital.
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In her diet, Clark focuses heavily on veggies.
“I mix cooked greens and veggies, about 1 pound total every day,” she said. “I started small (about 4 ounces) and added about 1 ounce per week.”
Clark also prioritizes 90 to 100 grams of healthy protein each day: a mix of vegan protein, collagen and healthy, pasture-raised meats and eggs.
Sleep is also a big priority for Clark. “It’s hard to perform well at anything without proper sleep,” she told Fox News Digital.
Saunas and cold showers are another part of Clark’s regular routine. “This is my natural antidepressant and helps with focus during the day,” she said. “For anyone struggling with low mood or stressful times, I highly recommend trying this.”
Clark also began meditating in 2019, which she described as “a game-changer for stress and sleep.”
“I like to think of longevity practices like a braid with three strands — exercise, eating right and prioritizing sleep.”
“Twenty minutes every afternoon improves my sleep and allows me to recalibrate stress levels during the day,” she said.
Clark also takes NOVOS supplements, which she credits with increasing her energy levels and slowing her pace of aging by 8%, according to the study results.
“I like to think of longevity practices like a braid with three strands — exercise, eating right and prioritizing sleep,” she told Fox News Digital. “And there’s an extra colorful strand in there: supplements. Each of these works together to help the others.”
She added, “When you start moving, you’ll likely be more motivated to eat well, and your sleep will be better. When you sleep, it’s easier to stay on track with your diet and fitness plans. They all work together.”
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Clark said she adheres to the motto, “It’s not the years in your life, but the life in your years.”
“I want all the years I have to be full of mobility, vibrance and vitality.”
Amy Hardison, 64 years old, makes exercising fun
A writer and grandmother of 11 in Mesa, Arizona, Amy Hardison has always had consistent health and exercise habits.
“I have exercised aerobically an hour a day, six days a week for 50 years and have rarely missed a day,” she told Fox News Digital.
“I always listen to an audiobook while exercising, making it even more fun.”
Hardison’s favorite exercises include swimming and working out on the elliptical.
“I love working out at home — other people love going to a gym and having a trainer. Do whatever works for you and then do it consistently,” she advised.
Regarding nutrition and exercise, Hardison’s philosophy is to find something you love that you can stick with long-term.
“Aging will take you places you have never been.”
“Some people totally cut out sugar from their diet, often because they tend to eat too much once they start,” she said. “Others, like me, eat small amounts each day.”
Hardison had never been into vitamins and supplements until she got involved in the NOVOS study.
“I really liked that the study included bloodwork at the beginning, middle and end of the year-long trial,” she said.
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“My bloodwork revealed that at the beginning of the study, I was aging at .86 biological years for every chronological year. At the end of the study, I was aging at .74. That is compelling empirical data.”
Although Hardison does what she can to stay physically healthy and mentally sharp, she acknowledges that there is a limit to what she can control.
“There is even a limit to how much I am willing to invest in longevity,” she said. “Life is to be lived and enjoyed.”
“Aging will take you places you have never been,” Hardison continued.
“There is so much to learn and experience. Embrace the normal and natural decline with humor and perspective. Thank your body for taking you on the journey.”
A biohacker’s 5 quick tips for healthy aging
Melanie Avalon, health influencer, entrepreneur and host of The Intermittent Fasting Podcast and “The Melanie Avalon Biohacking Podcast,” agreed that women can take proactive steps to slow their pace of aging.
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“The ever-growing online bloodwork and genetic platforms allow women access to personal data, providing a deeper view of their aging on a cellular level, including monitoring their biological age, which may differ from their chronological age,” she told Fox News Digital.
“Women can then make dietary and lifestyle choices to optimize these markers.”
1. Optimize sleep
One of the biggest issues aging women experience is restless sleep, often characterized by tossing, turning and hot flashes, according to Avalon.
“Women can implement a ‘sleep sanctuary’ to best support a restorative night, including sticking to a consistent wind-down routine and sleep schedule, in a cool, dark environment,” she advised.
Using a cooling mattress, avoiding late-night blue light exposure, and finding the optimal sleep position are some ways women can achieve better sleep quality, Avalon advised.
2. Seek hormonal support as needed
“Women often dread the perimenopausal years for their seemingly inevitable rollercoaster of hormonal issues,” Avalon said.
“Women can support healthy hormonal levels and natural transitions into the menopausal years by nourishing their bodies with micronutrient-rich whole foods, getting ample sleep, addressing stress levels, and reducing their exposure to toxins.”
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For some women, hormone replacement therapy may be an option.
“Many women may find that the benefits outweigh the risks,” Avalon noted.
3. Optimize muscle mass
Maintaining muscle mass is crucial for healthy aging, according to Avalon.
“Declines in muscle mass and strength are intrinsically tied to mortality, playing a causative role in falls and metabolic issues,” she said.
“Aging typically leads to reduced muscle protein synthesis,” Avalon noted.
“Women should pay careful attention to getting ample protein as they age, with a particular focus on the amino acid leucine, which stimulates muscle protein synthesis.”
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Aging women should aim for a gram of protein per pound of body weight, Avalon recommended.
“Women can also engage in strength training to further support muscle growth and maintenance,” she added.
4. Monitor essential markers
“Aging women should embrace the agency to take their health into their own hands,” Avalon said.
She recommends working with conventional doctors to regularly check key health metrics, such as blood pressure, blood sugar levels, cholesterol and bone density, along with other markers of disease.
5. Achieve proper glycemic control
Poor glycemic control is linked to a myriad of degenerative diseases, from prediabetes and diabetes to cardiovascular disease and cognitive decline, according to Avalon.
“Aging women can implement an unprocessed, whole-food-based diet, low to moderate in carbs, depending on their tolerance,” she said.
Women can also opt to wear a continuous glucose monitor (CGM) to monitor their blood sugar levels.
For more Health articles, visit www.foxnews.com/health.
Health
Heart attacks more likely during presidential elections and other stressful times, study shows
Your genes could put you at a higher risk of heart attack during very stressful times.
Research from Massachusetts General Hospital found that people who have specific genetic traits, paired with anxiety or depression, are at a “significantly higher heart attack risk” during periods of social or political stress, such as presidential elections, winter holidays or even the Super Bowl.
The study, presented at the American College of Cardiology’s annual scientific session in April, was the first to examine stress sensitivity based on genetics as a driver of acute coronary syndromes (ACS).
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These syndromes include heart attacks and other “serious conditions where the heart is suddenly deprived of blood supply,” a press release noted.
Of 18,428 Mass General Brigham Biobank participants, 1,890 developed ACS between 2000 and 2020.
The researchers measured the participants’ stress sensitivity by measuring their neuroticism polygenic risk score (nPRS).
Stressful periods — including five days after presidential elections and 10 days surrounding Christmas Day — made up 3.2% of the observed timeline.
A total of 71 ACS cases took place during stressful periods, compared to 1,819 during control periods.
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People with high genetic stress sensitivity had a 36% higher risk of ACS, the researchers found.
Those with high genetic stress who also developed anxiety or depression had three times the risk.
“High nPRS, indicating elevated genetic susceptibility to stress, mediates ACS risk during periods of socio-political stress,” the study authors wrote as a conclusion. “A multifaceted approach to [cardiovascular disease] prevention may benefit.”
In an interview with Fox News Digital, lead study author Shady Abohashem, M.D., instructor of cardiovascular imaging at Massachusetts General Hospital and Harvard Medical School, said that while the numbers are “striking,” the results overall are not surprising, since anxiety and depression alone have been associated with a substantial risk for heart attack regardless of genetics.
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“So, if you have both conditions, you would expect to have a substantial increase in your risk,” he said.
Through scientific analysis, Abohashem and his fellow researchers found that about 25% of ACS cases were due to anxiety and depression.
The impact of genetic susceptibility on heart attack risk could be an important factor for cardiologists and general care physicians to consider, Abohashem said.
He suggested implementing these screenings into cardiovascular risk assessments to help identify those people at most risk.
“The mind-heart connection is strong, and this study highlights that not only our bodies, but also our minds, need rest and care.”
“Based on that identification, we could develop targeted intervention, or maybe preventive strategies, that could help us protect those people from developing heart attacks in the future,” he added.
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The researchers are currently working on a study to discover how lifestyle modifications can benefit people with a high genetic risk for stress.
As 2024 is an election year, Abohashem advised Americans to manage stress through effective outlets like exercise or yoga.
Dr. Laxmi Mehta, an American Heart Association medical expert and cardiology director at The Ohio State University, commented on the study in a statement sent to Fox News Digital.
“This is an interesting study that further supports the data of the mind-heart connection,” said Mehta, who was not involved in the research. “It highlights the importance of mental health and its impact on overall health, including the heart.”
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Mehta did note that the “retrospective nature” of the study “limits the ability to show a direct causal relationship between mental health conditions” such as depression and anxiety.
The study “reinforces whole-person preventative care,” the cardiologist emphasized.
“The mind-heart connection is strong, and this study highlights that not only our bodies, but also our minds, need rest and care,” she said.
“The public needs to be aware of the impact social and political stress has on us, that it is OK to take a break from these stressors, and also that it is good to learn more about interventions like yoga, exercise and mindfulness.”
The expert encouraged doctors to advise their patients on the American Heart Association’s “Life’s Essential 8,” which are key measures to maintaining cardiovascular health.
These eight steps include eating better, being more active, quitting nicotine products, getting healthy sleep, managing weight, controlling cholesterol, managing blood sugar and maintaining healthy blood pressure.
For more Health articles, visit foxnews.com/health.
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