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Hearing loss could be reversed with popular erectile dysfunction drug

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Hearing loss could be reversed with popular erectile dysfunction drug

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Researchers may have discovered a way to reverse one type of hearing loss.

A new study found that hearing loss caused by mutations in a certain gene at birth may be reversed by a common supplement along with the erectile dysfunction drug Viagra (sildenafil).

Researchers identified mutations in a gene known as CPD — which produces the enzyme carboxypeptidase D — among three unrelated families from Turkey in which multiple people were born deaf. 

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These families all had a form of inherited sensorineural hearing loss, a condition caused by damage to the tiny hair cells in the inner ear that convert sound vibrations into electrical signals sent to the brain, according to the National Institutes of Health.

To better understand the link, the scientists compared the genetic data of affected and unaffected relatives within these families. They then expanded their analysis to other groups.

A new study found that hearing loss caused by mutations in a certain gene at birth may be reversed by a common supplement along with the erectile dysfunction drug Viagra. (iStock)

“We subsequently found that CPD mutations are present in people with hearing loss in a large genome sequencing cohort from England,” study author Dr. Mustafa Tekin, professor of human genetics and chair of Department of Human Genetics at University of Miami Miller School of Medicine, told Fox News Digital.

Lab and animal tests

After turning the CPD gene “off” in human cells in laboratory tests, the researchers noted reduced levels of three substances: arginine (an amino acid), cyclic guanosine monophosphate (cGMP, an important signaling molecule) and nitric oxide, which provides vital signals to the nervous system.

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Although the study began with humans, the reversal experiments were also carried out in mice and fruit flies.

When nitric oxide and cGMP levels were low, the hair cells in the mice’s inner ears — which transmit sound signals to the brain — became overstressed and eventually died.

The authors emphasized that they are not proposing Viagra as a hearing loss treatment. (Alex Segre/UCG/Universal Images Group via Getty Images)

In fruit flies, researchers found that silencing the equivalent of the CPD gene led to defects in the organ that helps them detect sound and stay balanced.

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But when the researchers administered arginine to human cells, nitric oxide levels returned to normal, resulting in fewer cells dying.

They also found that Viagra, which acts on the nitric oxide pathway, reversed some of the deficits caused by CPD mutations, Tekin added.

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These findings suggest that nitric oxide deficiency in the cochlea — the part of the inner ear that converts sound vibrations into nerve signals — may be a key driver of hearing loss. The CPD gene appears to regulate this process by maintaining proper arginine and nitric oxide levels in hair cells, which are essential for healthy signal transmission and protection against noise-related damage.

“Nitric oxide is vital for many tissues and must be kept in a fine balance,” Tekin said.

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The authors emphasized, however, that they are not proposing Viagra as a hearing loss treatment.

“We used it to strengthen the argument that nitric oxide deficiency in the ear was the underlying cause of deafness,” Tekin noted.

Experts urge caution

Outside experts also warned of an important adverse side effect of Viagra.

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The medication has been associated with rare but serious cases of sudden hearing loss as well as irreversible tinnitus, underscoring the need for caution, Dr. Nooshin Parhizkar, an ENT physician practicing in the San Francisco Bay Area, told Fox News Digital.

“At this stage, it is not appropriate or safe for the general public to use Viagra for hearing issues,” she added.

Although scientists have identified more than 200 genes linked to hearing loss, commercial genetic screening tests may only focus on the most common mutations. (iStock)

The hearing loss is usually temporary and reversible after stopping the medication, research has shown.

The Food and Drug Administration added a warning label to Viagra and other PDE5 inhibitors about the possible risk of sudden hearing loss after rare reports among those who used the same class of medication.

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It’s unclear whether this side effect is directly caused by the PDE5 inhibitors, as the affected patients may have other medical issues or could be taking other medications that could have led to the hearing loss, according to experts.

Study limitations

The study focused on a very small, genetically defined group of patients, so it is unlikely to apply to most of the population, Parhizkar pointed out.

“At this stage, it is not appropriate or safe for the general public to use Viagra for hearing issues.”

As the research also focused on reversing hearing loss in mice and flies, more studies are needed to evaluate treatment in humans.

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“It is important to get a genetic test done to find the cause of hearing loss,” Tekin advised.

Although scientists have identified more than 200 genes linked to hearing loss, commercial genetic screening tests may only focus on the most common mutations.

Fox News Digital reached out to the maker of Viagra for comment.

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Family pleads for kidney donor as teen’s health declines: ‘We need help’

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Family pleads for kidney donor as teen’s health declines: ‘We need help’

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A New Jersey family is desperately seeking a living donor to save Thaddeus Giansanti, an eighth-grader who was born with kidney disease. 

Thaddeus has had multiple surgeries throughout his 13 years, including one to remove a kidney as a baby.

Despite his struggles, he has remained positive and optimistic, his parents shared with Fox News Digital.

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“His remaining kidney is now failing,” said his father, Carlo Giansanti. “We are not a match, so now we’re asking for help from the community.”

The family first found out about their son’s kidney disease before he was born, when an ultrasound detected a potential issue.

Christa DeMark and Carlo Giansanti are pictured with their son Thaddeus, who has battled kidney disease his entire life.  (Christa DeMark)

“It was nothing alarming at that point — it looked like he had extra fluid when he was born,” Thaddeus’ mother, Christa DeMark, told Fox News Digital. “Everything seemed normal, but right before we were leaving, they noticed an elevated creatinine number (a measure of kidney function in blood tests) that led to us being in touch with nephrology.”

She added, “There was something wrong with the ureters (tubes that carry urine from the kidneys to the bladder) and the formation of the kidneys.”

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Thaddeus spent an extended period of time in the NICU, where he had multiple procedures. Before he was even 5 months old, he underwent a left nephrectomy to remove his left kidney. 

His remaining kidney was diagnosed with chronic kidney disease, which has required lifelong medications.

“He’s been with nephrology and nephrologists his entire life, and up until last year, everything’s been stable, but that’s been slowly changing,” DeMark said. “He’s getting bigger, and it’s been putting more stress on his remaining kidney.”

Thaddeus, now 13, has had multiple surgeries throughout his life, including one to remove his kidney as a baby. (Christa DeMark)

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Doctors informed the family that their best course of action would be to find a living donor.

“Everything’s been sped up based on his bloodwork lately,” DeMark said. “So it’s looking like we need something quicker than we thought, which is why we’re looking for living donors.”

“It has pushed us to rely on faith in a way that’s very palpable — we are just coming together as a family and taking each day as it comes.”

If Thaddeus does not receive a kidney transplant within a couple of weeks, he will need to be put on dialysis, according to his doctors.

“It’s obviously been challenging for him,” DeMark said. “He’s dealing with it very well, but these are difficult situations we’re navigating.”

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His parents describe Thaddeus as a smart, outgoing boy — a straight-A student who was recently awarded multiple scholarships for next year, when he will become a high-school freshman.

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Thaddeus is very athletic and enjoys playing soccer, golfing and fencing. He also plays piano and often volunteers in his community, including being an altar server and working with the local food pantry.

“He loves his family, and loves doing things with his family,” DeMark said. “He’s just a great kid.”

The boy’s remaining kidney is failing, and his family is asking the community to help find a life-saving donor. (Christa DeMark)

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Thaddeus’ parents said they have not shared much about their son’s medical condition until now. “We wanted Thad to just be the bright, happy person that he is, so we’ve minimized it for years,” DeMark said. 

But in the last couple of weeks, as their son’s condition has become more dire, they have started to speak out about their situation.

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“We never expected to have such an outpouring of people who cared or people trying to help — it’s been incredibly humbling,” DeMark said.

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“It has pushed us to rely on faith in a way that’s very palpable — we are just coming together as a family and taking each day as it comes,” she went on. “We are remaining hopeful because we know there’s a solution to this problem. We just need help.”

“The miracle Thad needs right now is people who have the ability to step up,” his mother said. “He is a great kid, a kind kid.” (Christa DeMark)

To be considered for the donation program, kidney donors must be 45 or younger, have a BMI under 30 and match Thaddeus’ O blood type.

For those who are considering becoming donors, DeMark emphasized that it entails a laparoscopic procedure with a “fairly quick” healing process that is covered by their insurance, not the donor’s.

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“The miracle Thad needs right now is people who have the ability to step up,” she added. “He is a great kid, a kind kid.”

Those interested in being considered as a donor can complete this Kidney Transplant Living Donor Questionnaire.

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Jessie James Decker reveals one wellness habit she never skips to look and feel her best

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Jessie James Decker reveals one wellness habit she never skips to look and feel her best

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Country music star Jessie James Decker is getting real about her health and fitness this year, alongside her family.

In a viral moment posted to Instagram, Decker, who is married to former NFL wide receiver Eric Decker, shared a video of her squatting with a barbell at the gym. The caption reads: “2026 energy! LFG💪”

The video, which has more than 111,000 likes, promotes a focus on “marriage body,” rather than “revenge body.”

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“Forget revenge body. How about marriage body,” the text on the video reads. “How about we get hotter & hotter for the person who chose us forever”

Screenshots from a video posted to Jessie James Decker’s Instagram account on Jan. 19, 2026. (Instagram @jessiejamesdecker)

The post received praise from other celebrities and influencers.

“Biggest fan of this belief,” actress and wellness influencer Daniella Monet commented.

In an interview with Fox News Digital, Decker revealed some of her top wellness habits that help her uphold these standards, while feeling her best mentally and physically.

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The mother of four responded that her No. 1 wellness tip is drinking lots of water.

“Water, water, water,” she said. “I drink water all day. I even have it next to my bed, drinking it all night.”

The celebrity swears by drinking water throughout the day and night for better overall health, although it’s the “boring answer.” (iStock)

“My mom swears by it. My mom walks miles and miles every day, drinks tons of water, and she literally looks like she’s aging backwards,” the singer added. “We’re like Benjamin Button. We’re about to meet in the middle and look the same age here soon. She looks incredible.”

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In addition to focusing on hydration, Decker continues to follow many of her mother’s practices, including eating “really healthy.”

“We cook everything at home. I mean, I barely go out,” she said. “Everything I make is from scratch from home.”I really think when you know what you’re putting in your body, that’s the best bet always.”

Jessie James Decker is seen during a segment of “Good Day New York” on Jan. 29, 2026, in New York City. (Michael Simon/Getty Images)

She summarized, “Water, cook at home and just stay active — it’s really that simple.”

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Decker also instills this mentality into her children — Vivianne, Eric Jr., Forrest and Denver — as sports, outdoor play and pickleball are daily rituals in their household.

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“You know, Vivi’s a gymnast — she’s in the gym five days a week … And little Eric is constantly doing sports,” she told Fox News Digital.

“They’re active … they are busy, busy, busy. They don’t sit around on iPads. They’re out there in the wildlife, barefoot and being free.”

Staying active is something the entire family embraces together, especially when they’re traveling.

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“We’ve done family workouts together, [and] we stay active together,” the singer said. “Maybe when we’re on vacation, we’re doing bike rides together, or whether it’s a football game outside or throwing the ball on the beach.”

One sport in particular has become a family favorite.

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“We love pickleball. That’s probably the thing we all do every day,” Decker said. “We have a pickleball court in the backyard, and if we go on vacation, my husband’s like, ‘Is there a pickleball court at this place?’”

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