Health
Hearing loss could be reversed with popular erectile dysfunction drug
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Researchers may have discovered a way to reverse one type of hearing loss.
A new study found that hearing loss caused by mutations in a certain gene at birth may be reversed by a common supplement along with the erectile dysfunction drug Viagra (sildenafil).
Researchers identified mutations in a gene known as CPD — which produces the enzyme carboxypeptidase D — among three unrelated families from Turkey in which multiple people were born deaf.
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These families all had a form of inherited sensorineural hearing loss, a condition caused by damage to the tiny hair cells in the inner ear that convert sound vibrations into electrical signals sent to the brain, according to the National Institutes of Health.
To better understand the link, the scientists compared the genetic data of affected and unaffected relatives within these families. They then expanded their analysis to other groups.
A new study found that hearing loss caused by mutations in a certain gene at birth may be reversed by a common supplement along with the erectile dysfunction drug Viagra. (iStock)
“We subsequently found that CPD mutations are present in people with hearing loss in a large genome sequencing cohort from England,” study author Dr. Mustafa Tekin, professor of human genetics and chair of Department of Human Genetics at University of Miami Miller School of Medicine, told Fox News Digital.
Lab and animal tests
After turning the CPD gene “off” in human cells in laboratory tests, the researchers noted reduced levels of three substances: arginine (an amino acid), cyclic guanosine monophosphate (cGMP, an important signaling molecule) and nitric oxide, which provides vital signals to the nervous system.
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Although the study began with humans, the reversal experiments were also carried out in mice and fruit flies.
When nitric oxide and cGMP levels were low, the hair cells in the mice’s inner ears — which transmit sound signals to the brain — became overstressed and eventually died.
The authors emphasized that they are not proposing Viagra as a hearing loss treatment. (Alex Segre/UCG/Universal Images Group via Getty Images)
In fruit flies, researchers found that silencing the equivalent of the CPD gene led to defects in the organ that helps them detect sound and stay balanced.
But when the researchers administered arginine to human cells, nitric oxide levels returned to normal, resulting in fewer cells dying.
They also found that Viagra, which acts on the nitric oxide pathway, reversed some of the deficits caused by CPD mutations, Tekin added.
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These findings suggest that nitric oxide deficiency in the cochlea — the part of the inner ear that converts sound vibrations into nerve signals — may be a key driver of hearing loss. The CPD gene appears to regulate this process by maintaining proper arginine and nitric oxide levels in hair cells, which are essential for healthy signal transmission and protection against noise-related damage.
“Nitric oxide is vital for many tissues and must be kept in a fine balance,” Tekin said.
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The authors emphasized, however, that they are not proposing Viagra as a hearing loss treatment.
“We used it to strengthen the argument that nitric oxide deficiency in the ear was the underlying cause of deafness,” Tekin noted.
Experts urge caution
Outside experts also warned of an important adverse side effect of Viagra.
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The medication has been associated with rare but serious cases of sudden hearing loss as well as irreversible tinnitus, underscoring the need for caution, Dr. Nooshin Parhizkar, an ENT physician practicing in the San Francisco Bay Area, told Fox News Digital.
“At this stage, it is not appropriate or safe for the general public to use Viagra for hearing issues,” she added.
Although scientists have identified more than 200 genes linked to hearing loss, commercial genetic screening tests may only focus on the most common mutations. (iStock)
The hearing loss is usually temporary and reversible after stopping the medication, research has shown.
The Food and Drug Administration added a warning label to Viagra and other PDE5 inhibitors about the possible risk of sudden hearing loss after rare reports among those who used the same class of medication.
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It’s unclear whether this side effect is directly caused by the PDE5 inhibitors, as the affected patients may have other medical issues or could be taking other medications that could have led to the hearing loss, according to experts.
Study limitations
The study focused on a very small, genetically defined group of patients, so it is unlikely to apply to most of the population, Parhizkar pointed out.
“At this stage, it is not appropriate or safe for the general public to use Viagra for hearing issues.”
As the research also focused on reversing hearing loss in mice and flies, more studies are needed to evaluate treatment in humans.
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“It is important to get a genetic test done to find the cause of hearing loss,” Tekin advised.
Although scientists have identified more than 200 genes linked to hearing loss, commercial genetic screening tests may only focus on the most common mutations.
Fox News Digital reached out to the maker of Viagra for comment.
Health
Eat This Before Bed To Lose Weight Overnight: ‘Second Meal Effect’ Explained
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Health
The real reasons you’re still exhausted after 8 hours of sleep, according to an expert
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Getting a full eight hours of sleep and still feeling drowsy? Sleep experts say it’s not just about how much shuteye you get.
Dr. Wendy Troxel, a licensed clinical psychologist and senior behavioral scientist at RAND based in Utah, emphasized the “really important distinction” between quantity and quality of sleep.
SLEEP PATTERNS COULD PREDICT RISK FOR DEMENTIA, CANCER AND STROKE, STUDY SUGGESTS
“Many people will say, ‘Man, I’m sleeping enough, I got seven to eight hours of sleep, but I still wake up feeling groggy and not refreshed,’” she told Fox News Digital during an in-studio interview. “About one in three adults has non-restorative sleep quality.”
Sleep quality could be making you feel groggy, despite the number of hours you slept, an expert said. (iStock)
“There are many factors that can contribute to poor sleep quality, regardless of how many hours you slept,” Troxel noted.
These include drinking alcohol — a “major contributor” to poor quality or disrupted sleep — and consuming caffeine late in the day.
Being stressed or feeling worried about something can also contribute to fragmented sleep, as can phone use at bedtime.
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Troxel addressed the belief that women need more sleep than men, noting that research does support it — though only slightly, by about 10 to 15 extra minutes per night.
“What we absolutely know is that women’s sleep quality often suffers more than men’s,” she said. “They may be getting more non-restorative sleep quality, therefore needing slightly more sleep.”
Women are also twice as likely to have insomnia compared to men, and their risk for sleep disturbances “skyrockets” during the menopausal transition.
Women suffer from poorer sleep quality than men, according to the expert. (iStock)
For those who claim they sleep better with fewer hours of sleep — and feel sleepier when they get the recommended seven to nine hours — Troxel said this is not an indicator that they actually require less shuteye. “It’s simply that their body is not used to it,” she said.
Laboratory studies have shown that sleep deprivation causes impairments in judgment, according to the expert. “That means someone who thinks they’re fine with only four hours of sleep per night likely isn’t aware of the impact sleep deprivation has on their cognition and performance.”
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For those getting less than the recommended amount, Troxel recommends taking small steps toward sleeping longer. That might mean adding about 15 minutes each night to see how it impacts the body, eventually getting into a healthier circadian rhythm.
“You will likely see benefits when you increase your sleep in small increments,” she said.
The expert recommends adding a few extra minutes of sleep each night to work up to a longer duration of rest. (iStock)
Tips for better quality sleep
Quality sleep hinges on following a healthy lifestyle and a consistent sleep-wake schedule, according to experts.
INSUFFICIENT SLEEP LINKED TO MAJOR HIDDEN HEALTH RISK, STUDY REVEALS
Eating a nutritious diet free of foods that cause upset stomach or indigestion, especially in the late evening hours, can help improve sleep quality, Troxel shared.
“You don’t want to be starving at bedtime, but you also don’t want to be trying to fall asleep on a full stomach while your body’s still actively digesting,” she said.
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Exercise helps to promote quality sleep, just as sleep also improves exercise quality. However, it’s best to avoid vigorous physical activity too close to bedtime, Troxel advised.
“Exercise is very stimulating, particularly if it’s in a social environment, and that can disrupt sleep,” she said. “Exercising earlier in the day is better.”
“Those who are natural morning people are more likely to benefit from exercising earlier,” Troxel said. (iStock)
That doesn’t have to mean working out first thing in the morning, Troxel noted, as not everyone’s circadian rhythm supports early wake-ups for exercise.
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“Those who are natural morning people are more likely to benefit from exercising earlier,” she said. “If you’re a night owl, don’t expect to love doing a workout first thing in the morning. That might not be consistent with your circadian rhythm.”
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Troxel added that people should not be “sleep-shamed” for adhering to their own internal clocks.
“These cultural trends have these subtle, or not-so-subtle, ways of undermining people’s sleep-wake biology, which is largely out of our control,” she said.
Health
Top 5 states with the highest number of safe hospitals, according to new report
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Hundreds of hospitals across the country are being recognized for keeping patients safe, and a handful of states stand out for having the highest number of top performers.
Healthgrades, a platform for finding doctors, health care providers and hospitals, released its 2026 Patient Safety Excellence Awards this month, naming 438 hospitals in 40 states that rank among the top 10% nationwide for patient safety.
The analysis highlights centers that excel at preventing serious, avoidable complications during hospital stays based on 13 patient safety indicators.
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Among all states, five had the highest number of hospitals earning the distinction: Texas, Florida, California, Ohio and Pennsylvania.
Hundreds of hospitals across the U.S. were recognized for top patient safety performance in a new report. (iStock)
These states led the nation in total award recipients, with counts ranging from 21 to as many as 62 hospitals, according to Healthgrades data cited by MedPage Today. The concentration of high-performing hospitals in these states may be partly driven by size, the outlet noted.
“The prevalence of recipients in a particular state could be related to something as simple as that state having a large number of hospitals,” a Healthgrades spokesperson told MedPage Today.
Nonetheless, the findings point to strong safety performance across several of the nation’s most populated regions, particularly major metro areas such as Los Angeles, Dallas-Fort Worth and New York City.
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Patients treated at these hospitals saw significantly lower risks for some of the most common and serious safety events that account for the majority of in-hospital complications, according to a news release.
The rankings are based on data measuring 13 patient safety indicators, including infections and complications. (iStock)
Compared to other hospitals, patients at award-winning facilities were 52.4% less likely to experience an in-hospital fall resulting in fracture; 57.5% less likely to suffer a collapsed lung related to procedures; 67.8% less likely to develop catheter-related bloodstream infections; and 71.9% less likely to develop pressure sores.
Those four indicators alone make up about 78% of all patient safety events, according to Healthgrades, and if all hospitals performed at the same level as this year’s recipients, more than 100,000 patient safety events could have been avoided between 2022 and 2024.
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“The data behind this year’s Patient Safety Excellence Award highlights how measurable improvements in safety can prevent thousands of complications,” Dr. Alana Biggers, a medical advisor at Healthgrades, said in a statement.
Hospitals were required to report zero cases of serious errors, such as leaving a foreign object behind during a procedure. (iStock)
“Hospitals that prioritize evidence-based safety practices not only achieve better clinical outcomes but also cultivate a culture where patients come first,” Biggers added. “These insights give individuals and families the information they need to make confident and better informed healthcare decisions.”
The award is based on an analysis of Medicare inpatient data, evaluating outcomes such as complications, mortality and preventable safety events. To qualify, hospitals must meet strict clinical thresholds and report zero cases of certain serious errors, such as leaving a foreign object behind during a procedure.
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Overall, 250 hospitals ranked in the top 5% nationwide for safety, including facilities affiliated with major systems such as Mayo Clinic, Cleveland Clinic and HCA Healthcare.
Ten states had no hospitals on the list: Alabama, Alaska, Delaware, Iowa, Maine, North Dakota, Vermont, Washington, West Virginia, Wyoming and the District of Columbia.
Some states had no hospitals on the list, highlighting gaps in access to high-quality care. (iStock)
Experts say factors including rural hospital shortages and “care deserts” may contribute to those gaps because patients in underserved areas often face longer travel times and arrive with more advanced conditions.
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Nearly one-third of this year’s recognized hospitals were new to the list, according to Healthgrades, reflecting continued shifts in hospital performance and safety practices across the country.
The full list of hospitals that received the Patient Safety Excellence Award can be found here.
Fox News Digital has reached out to Healthgrades for additional comment.
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