Health
Fish oil supplements linked to greater first-time heart attack risk in study: ‘Not universally good or bad'
Taking fish oil supplements could raise the risk of heart attack and stroke, a new study suggests.
Among healthy people, regular use of fish oil was found to make them more susceptible to developing heart disease and stroke for the first time, the study found.
Among those who had existing heart disease, however, fish oil consumption was shown to slow the progression of cardiovascular disease and reduce the risk of mortality.
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Researchers analyzed nearly 12 years of data for more than 415,000 participants from the UK Biobank study; the participants ranged in age from 40 to 69.
“Regular use of fish oil supplements might be a risk factor for atrial fibrillation and stroke among the general population, but could be beneficial for progression of cardiovascular disease from atrial fibrillation to major adverse cardiovascular events, and from atrial fibrillation to death,” the researchers wrote in the study, which was published in The BMJ (British Medical Journal).
Taking fish oil supplements could raise the risk of heart attack and stroke among certain people, a new study suggests. (iStock)
“Further studies are needed to determine the precise mechanisms for the development and prognosis of cardiovascular disease events with regular use of fish oil supplements.”
Study highlights ‘uncertainty,’ cardiologist says
Dr. Jim Liu, a cardiologist at The Ohio State University Wexner Medical Center, who was not involved in the study, pointed out that there has been conflicting data about whether or not fish oil or omega 3 fatty acids can help reduce the risk of cardiovascular disease.
“This is yet another study that reminds us there is still a lot that needs to be investigated when it comes to fish oil and heart disease.”
“This study appears to echo the same sentiment that there is still some uncertainty about their relation to heart health,” he told Fox News Digital.
“Similar to previous studies, I think this study indicates that fish oil is not necessarily universally good or bad for all.”
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Whether or not fish oil is beneficial or harmful depends on an individual’s specific underlying health conditions, he said — such as a history of heart attack or atrial fibrillation, and on other factors such as dosing and different formulations of the substance.
“Further studies are needed to determine the precise mechanisms for the development and prognosis of cardiovascular disease events with regular use of fish oil supplements,” the authors of a new study wrote. (iStock)
“Previous studies have shown that certain formulations of fish oil can help reduce cardiovascular events in people with elevated triglycerides and previous cardiovascular events,” Liu noted.
“Overall, this is yet another study that reminds us that there is still a lot that needs to be investigated when it comes to fish oil and heart disease.”
Dietitians weigh risks and benefits
Tanya Freirich, a registered dietitian nutritionist in Charlotte, North Carolina, who practices as The Lupus Dietitian, also was not involved in the study but offered insights.
“In this study, there was a slightly increased association between healthy people who took fish oil and developing atrial fibrillation and stroke, whereas for those people who took the fish oil after being diagnosed with cardiovascular disease, there was a slightly decreased association and risk of atrial fibrillation and stroke,” she told Fox News Digital.
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“Overall, I would say to take these results with a grain of salt, as it was a prospective study.”
A prospective study monitors what people self-report and their eventual health outcomes over time, she noted — versus a control study, where similar people are placed in two groups and one group takes the fish oil while the other does not.
“We don’t know about the population of healthy participants and why they decided to take fish oil,” Freirich said.
A registered dietitian recommended that most people get their omega 3s from food sources such as salmon, sardines, tuna, ground flaxseed, chia seeds, walnuts and almonds. (iStock)
“Perhaps they have a family history of heart disease, or other lifestyle features that are contributing to their risk of developing atrial fibrillation and stroke outside of the fish oil supplement.”
As a registered dietitian, Freirich said she recommends most people get their omega 3s from food sources such as salmon, sardines, tuna, ground flaxseed, chia seeds, walnuts and almonds.
“Making small changes to your diet over time can have big benefits in reducing your overall cardiovascular risk.”
“Many people do not get enough omega 3 fatty acids in their diet, and this can be a great way to consume healthy fats while also benefiting from protein and sources of fiber,” she said.
When preparing meals, replacing a serving of red meat with fatty fish can promote heart health by decreasing the intake of saturated fats and increasing the intake of omega 3s, according to Freirich.
“Always discuss your supplement use with your medical care providers, as some may be unnecessary or even increase your risk for poor health outcomes,” said one expert. (iStock)
“Making small changes to your diet over time can have big benefits in reducing your overall cardiovascular risk,” she advised.
“Always discuss your supplement use with your medical care providers, as some may be unnecessary or even increase your risk for poor health outcomes.”
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Michelle Routhenstein, a New York-based preventive cardiology dietitian at EntirelyNourished.com, agreed that prior research has indicated that taking high doses of fish oil supplements could potentially elevate the risk of atrial fibrillation — while regularly consuming fatty fish four to five times a week may lower that risk.
To determine the potential benefits of fish oil and the appropriate dosage, experts recommended consulting with a registered dietitian specializing in heart disease. (iStock)
“We need to recognize that when it comes to fish oil — and many other foods and supplements — more or a concentrated dose isn’t necessarily better,” Routhenstein, who was not involved in the study, told Fox News Digital.
“It is also important to note that not all fish oil supplements are created equal. Factors like dosage, quality and additional ingredients can influence cardiovascular health outcomes.”
To determine the potential benefits of fish oil and the appropriate dosage, Routhenstein recommended consulting with a registered dietitian specializing in heart disease.
Fox News Digital reached out to the study researchers for more detail, as well as several manufacturers of fish oil supplements requesting comment on the findings.
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Research conducted partly aboard the International Space Station (ISS) suggests that “microgravity” could help scientists fight drug-resistant superbugs, according to a report from SWNS.
Microgravity is the condition in which people or objects appear to be weightless, NASA states.
Experiments by researchers at the University of Wisconsin-Madison show that viruses and bacteria behave differently in near-weightless conditions. In space, they develop genetic changes not typically seen on Earth.
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Lead study author Dr. Phil Huss, a researcher at the University of Wisconsin–Madison, noted that interactions between viruses that infect bacteria — known as phages — and their hosts play an “integral” role in how microbial ecosystems function, per the SWSN report.
Viruses that infect bacteria were still able to infect E. coli in space. However, the way those infections unfolded was different from what is typically observed on Earth.
E. coli is a group of bacteria that can live in the gut and are harmless most of the time, according to Cleveland Clinic. (iStock)
Bacteria and phages are often described as being locked in an evolutionary arms race, Huss said, with each side constantly adapting to outmaneuver the other.
“Microgravity is not just a slower or noisier version of Earth — it is a distinct physical and evolutionary environment,” researcher Srivatsan Raman, Ph.D., professor of biochemistry at the university, told Fox News Digital.
“Even in a very simple phage-bacteria system, microgravity altered infection dynamics and pushed both organisms down different evolutionary paths,” he added.
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While these interactions between bacteria and phages have been well-studied on Earth, few studies have examined them in space, where they can lead to different outcomes.
For the study, Huss and his colleagues compared two sets of E. coli samples infected with a phage known as T7. One set was incubated on Earth, while the other was grown aboard the ISS.
The ISS is a microgravity environment — where people and objects appear weightless. (NASA / SWNS)
The team found that after an initial slowdown, the T7 phage successfully infected E. coli in space. Genetic analysis later revealed clear differences in how both the bacteria and the virus mutated in space compared with how they behaved on Earth, per the report.
Huss said the phages grown aboard the space station developed mutations that could improve their ability to infect bacteria or attach to bacterial cells. At the same time, the E. coli grown in space developed mutations that could help them resist infection and survive better in near-weightless conditions.
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Raman said some of the findings were unexpected. In particular, he noted, microgravity led to mutations in parts of the phage genome that are not well-understood and are rarely seen in Earth-based experiments.
The E. coli grown in space developed mutations that could help them resist infection and survive better in near-weightless conditions. (iStock)
Researchers then used a technique called deep mutational scanning — a method that tracks how genetic changes affect function — to examine changes in the T7 receptor-binding protein, which plays a key role in infection.
Additional experiments on Earth linked those changes to increased effectiveness against E. coli strains that are normally resistant to T7.
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“Equally surprising was that phages shaped by microgravity could be more effective against terrestrial bacterial pathogens when brought back to Earth,” Raman told Fox News Digital.
“That result suggests microgravity can reveal combinations of mutations that are difficult to access through standard laboratory evolution, but [are] still highly relevant for real-world applications.”
“Microgravity is not just a slower or noisier version of Earth — it is a distinct physical and evolutionary environment.”
Huss said the findings could help address antibiotic-resistant infections, including urinary tract infections, which have been increasing in recent years.
“By studying those space-driven adaptations, we identified new biological insights that allowed us to engineer phages with far superior activity against drug-resistant pathogens back on Earth,” Huss told SWNS.
Study limitations
“Experiments on the ISS are constrained by small sample sizes, fixed hardware and scheduling constraints,” Raman noted. “Samples also experience freezing and long storage times, which can complicate interpretation.”
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He added that the research has broader implications.
“Studying microbes in space isn’t just about space biology,” Raman said. “These experiments can uncover new aspects of viral infection and microbial evolution that feed directly back into terrestrial problems, including antimicrobial resistance and phage therapy.”
Space should be treated as a discovery environment rather than a routine testing platform, one researcher said. (iStock)
He added that space should be treated as a discovery environment rather than a routine testing platform. The most effective approach, according to Raman, is to identify useful patterns and mutations in space and then study them carefully in Earth-based systems.
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Scientists also noted that the findings highlight how microbial ecosystems, like those associated with humans, could change during long space missions.
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“Understanding and anticipating those changes will be essential as space travel becomes longer, more routine and more biologically complex,” Raman said.
The findings were published in the journal PLOS Biology.
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A simple blood test may detect Crohn’s disease years before symptoms appear, according to a new study reported by SWNS.
Canadian researchers say the discovery could enable earlier diagnosis and potential prevention of the chronic inflammatory bowel disease (IBD).
The test measures the immune system’s response to flagellin, a protein found in gut bacteria. Researchers found that this response is elevated in some people years before Crohn’s develops.
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The findings, published in Clinical Gastroenterology and Hepatology, highlight the “interplay” between gut bacteria and immune system responses as a key step in the disease’s development, per the SWNS report.
Crohn’s disease is a chronic inflammatory condition of the gastrointestinal tract that causes persistent digestive symptoms, pain and fatigue, significantly affecting quality of life. Its incidence among children has doubled since 1995, according to official figures.
Crohn’s disease is a type of inflammatory bowel disease (IBD) that causes swelling and irritation of the tissues, called inflammation, in the digestive tract. (iStock)
The presence of flagellin antibodies long before symptoms appear suggests that the immune reaction may help trigger the disease, according to research leader Dr. Ken Croitoru, clinician-scientist and professor of medicine and immunology at the University of Toronto.
A better understanding of this early process could lead to improved prediction, prevention and treatment, the expert said.
“We haven’t cured anybody yet, and we need to do better.”
“With all the advanced biologic therapy we have today, patients’ responses are partial at best,” Croitoru told SWNS. “We haven’t cured anybody yet, and we need to do better.”
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“We wanted to know: Do people who are at risk, who are healthy now, have these antibodies against flagellin?” he said. “We looked, we measured, and yes indeed, at least some of them did.”
This new research is part of the Genetic, Environmental and Microbial (GEM) Project, which has followed more than 5,000 healthy first-degree relatives of people with Crohn’s disease worldwide since 2008. The project collects genetic, biological and environmental data to better understand how the disease develops.
The presence of flagellin antibodies long before symptoms appear suggests that the immune reaction may help trigger the disease, according to the lead researcher. (iStock)
The study followed 381 first-degree relatives of Crohn’s patients, 77 of whom later developed the disease. Of those, more than 30% had elevated antibody responses.
The responses were strongest in siblings, underscoring the role of shared environmental exposure, researchers said.
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So far, 130 of the study participants have developed Crohn’s, giving researchers a rare opportunity to study its earliest stages. The average time from blood sample collection to diagnosis was nearly 2-½ years.
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Previous GEM research showed that an inflammatory immune response targeting gut bacteria can appear long before the disease develops.
The study followed 381 first-degree relatives of Crohn’s patients, 77 of whom later developed the disease. (iStock)
In healthy people, gut bacteria coexist peacefully and play an essential role in digestive health — but in Crohn’s patients, the immune system appears to mount an abnormal response against the microbes, experts say.
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The Canadian team also confirmed that this pre-disease immune response was associated with intestinal inflammation and gut barrier dysfunction, both hallmarks of Crohn’s disease.
The study did have some limitations, including that it did not include experiments to show exactly how the immune response might lead to Crohn’s disease. (iStock)
Research team member Dr. Sun-Ho Lee, a gastroenterologist, commented that this new study supports the idea of designing a flagellin-directed vaccine for certain high-risk individuals to prevent the disease, according to SWNS.
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The study did have some limitations, including that it did not include experiments to show exactly how the immune response might lead to Crohn’s disease.
As a result, the researchers could not determine the biological steps linking the immune reaction to the onset of the illness. “Further validation and mechanistic studies are underway,” they noted.
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This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255).
A new study suggests that exercise can treat depression just as effectively as therapy and antidepressants.
A Cochrane review looked at 73 randomized controlled trials involving nearly 5,000 adults with a depression diagnosis. The studies compared exercise with either other active treatments — such as therapy or medication — or with “inactive interventions,” like being placed on a wait list or in a control group.
The London-based team discovered that exercise may be “moderately effective” compared to no therapy in reducing depression symptoms, according to a press release.
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“There is probably little to no difference in depressive symptoms between people undertaking exercise and those receiving psychological therapy,” the authors noted in a study discussion on Cochrane’s website, and “there may be little to no difference in depressive symptoms between people doing exercise and those taking antidepressants.”
The analysis discovered that exercise may be “moderately effective” compared to no therapy in reducing depression symptoms. (iStock)
The review found that light- to moderate-intensity exercise was more beneficial for easing depression symptoms than vigorous exercise.
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No single type of physical activity stood out as the best, but mixed programs that included resistance training appeared to be “more effective” than just aerobic exercise.
Some forms of exercise, like yoga and stretching, were not included in the analysis, but are areas to be further researched, the review noted.
Mixed exercise programs and resistance training appeared to be “more effective” in easing depression symptoms than just aerobic exercise. (iStock)
Professor Andrew Clegg, lead author of the review, wrote in a statement that exercise “appears to be a safe and accessible option for helping to manage symptoms of depression.”
“This suggests that exercise works well for some people, but not for everyone, and finding approaches that individuals are willing and able to maintain is important,” he said.
Study limitations and risks
The researchers noted that there was a high risk of bias in some of the studies included in the review, and noted that the long-term effects of exercise on depression symptoms remain uncertain.
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Clegg noted that “larger, high-quality studies” are needed to determine which types of exercise work best and whether the benefits last over time.
The comparison between exercise and other treatments and how they benefit people’s quality of life were also “inconsistent and uncertain.”
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“Adverse events from exercise were not common,” the researchers mentioned. “The small number of participants who experienced them usually reported muscle and joint problems or worsening of depression.”
About 21 million U.S. adults had at least one major depressive episode in a recent year — equivalent to roughly 8.3% of all U.S. adults, according to the National Institutes of Health. (iStock)
“Future research should focus on improving the quality of the studies, working out which characteristics of exercise are effective for different people, and ensuring different types of people are included in the studies so that health equity issues can be considered,” they went on.
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About 21 million U.S. adults had at least one major depressive episode in a recent year — equivalent to roughly 8.3% of all U.S. adults, according to the National Institute of Mental Health.
Depression symptoms include feelings of sadness, hopelessness, anxiety, guilt or irritability, as well as loss of interest or pleasure in hobbies and activities. Fatigue, poor concentration, sleep disturbances, appetite changes and social withdrawal are also red flags, in addition to thoughts about dying or suicidal ideations.
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The condition is most often treated by antidepressant medications and psychological therapies, such as talk therapy. Anyone who needs help should consult their doctor.
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