Renowned visionary English physician William Harvey wrote in 1651 about how our blood contains all the secrets of life.

“And so I conclude that blood lives and is nourished of itself and in no way depends on any other part of the body as being prior to it or more excellent,” he wrote. “So that from this we may perceive the causes not only of life in general … but also of longer or shorter life, of sleeping and waking, of skill, of strength and so forth.”

Dr. Kevin Watt, team leader of the Heart Regeneration and Disease Laboratory at the Murdoch Children’s Research Institute (MCRI) in Melbourne, Australia, understands this concept deeply. 

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He lives it every day, as he and his fellow researchers study and reprogram the potential of the blood to treat disease, specifically heart failure in children. 

Building on the work of Dr. Shinya Yamanaka of Japan, who discovered that specialized cells could be reprogrammed back to immature stem cells, Watt and his collaborators have taken this work several steps further. 

They have used small molecules to turn these new stem cells from the blood into heart cells.

Small heart organoids are developed in the lab — which can then be injected into the failing hearts of children. 

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Relying on the philanthropic support of the Murdoch Institute, the work is progressing rapidly and has been shown to be effective already in mice, pigs and sheep.

“The vision of our research is to develop new therapies that can transform the lives of children with heart failure.”

Clinical trials in humans will be starting soon, and as Dr. Watt told me in an interview from Australia, “Large sheets of heart tissue will be stitched into the failing heart.” 

Congenital heart failure as well as side effects of chemotherapy in children will be targets for this miracle therapy. Millions of children around the world suffer daily from these conditions. 

Researchers at MCRI are studying and reprogramming the potential of the blood to treat disease, specifically heart failure in children.  (MCRI)

Watt said that certain chemotherapy (anthracyclines) have a higher risk of heart failure – up to 15% of the time – and this treatment may be useful to protect the heart.

Watt said, “Heart failure remains an urgent, unmet clinical challenge across the world. While we have made significant advances over several decades in managing the disease, we lack targeted therapies to treat these devastating conditions.”

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He added, “More than 500,000 children around the world live with advanced heart failure that requires transplantation. The vision of our research is to develop new therapies that can transform the lives of children with heart failure.”

“More than 500,000 children around the world live with advanced heart failure that requires transplantation. The vision of our research is to develop new therapies that can transform the lives of children with heart failure.” (iStock)

To achieve this, he said, “we use a technology called induced pluripotent stem cells, where we can convert blood or skin cells of patients with heart failure into stem cells that we then turn into heart cells … or even make engineered heart tissues that can be stitched onto the patient’s heart to help it pump.” 

The cells that are targeted in the blood are known as peripheral blood mononuclear cells (PBMCs). 

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They are “pushed back in time to an earlier time before they became differentiated into heart or kidney cells,” he said. 

Then they can be pushed forward to become healthy heart cells or mutations — or other abnormalities can be corrected.

While the team at the Murdoch Children’s Research Institute is making heart cells from stem cells in the blood for clinical use, it’s also using these stem cells to figure out new drugs to treat heart failure directly.  

The team at MCRI in Melbourne (shown above) is pioneering “methods to turn stem cells into miniature heart tissues.” (MCRI)

Said Watt, “Using stem cells from patients with heart failure caused by chemo, we are actively developing new drugs and cell-based treatments that we believe will transform the lives of patients with these conditions … Our research group has pioneered methods to turn these stem cells into miniature heart tissues that can be used to model disease-in-a-dish, to identify new drug targets for the development of new therapies.”

These treatments are personalized and highly expensive, but they’re also highly effective. 

“Using stem cells from patients with heart failure caused by chemo, we are actively developing new drugs and cell-based treatments that we believe will transform the lives of patients with these conditions.” (MCRI)

Correcting heart failure in young children is only a few years away from becoming a reality. 

It’s a Christmas miracle that relies on the kind of philanthropic support that MCRI is famous for arranging.

“Philanthropic support plays a critical role in accelerating the development of these new, transformative treatments,” said Watt, “and this support will be essential as we work toward bringing stem cell-based precision therapies for heart failure to every child who needs it.” 

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Visit go.fox/MCRI to donate or to learn more about MCRI’s important research.

At the beginning of 2024, the American Cancer Society predicted that 2,001,140 new cancer cases and 611,720 cancer deaths would occur in the United States.

Now, as the year draws to a close, experts are looking back and reflecting on the discoveries and advances that have been made in the field of cancer treatment and prevention.

Fox News Digital spoke with four oncologists from the Sarah Cannon Research Institute in Nashville, Tennessee, about the most notable accomplishments of 2024 and what they see on the horizon for 2025. 

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See the answers and questions below. 

Krish Patel, MD, director of lymphoma research

Q: What do you see as the most important cancer advances in 2024?

A: In the field of lymphomas, we see growing momentum for therapies that use the patient’s own immune system to fight their cancer, such as CAR T-cell therapy and bispecific antibodies. 

These are treatments that are now being studied and are making an impact earlier in the disease course, including one now being studied as the very first treatment a patient might receive for their lymphoma. 

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These treatments are helping us to be less dependent on chemotherapies (which may be effective but have broad side effects) for the treatment of lymphomas.  

Q: What are your predictions for cancer research in 2025?

A: Every year we are improving the curative treatment options we have for specific types of lymphomas, such as diffuse large B-cell lymphoma (DLBCL), which is the most common lymphoma we see. 

We are also gradually becoming better able to offer these treatments closer to – or in – patients’ homes and communities, so they can receive the best care as close to home as possible. 

“Every year, we are improving the curative treatment options we have for specific types of lymphomas.”

I believe that in 2025, we will continue to see more advancement in immunotherapies, development of more targeted therapies (including oral medicines), and hopefully soon the approval of next generations of immunotherapies that may work for patients who have already received today’s immunotherapies but need more treatment options.

Q: How has the state of cancer in your specialty area changed and evolved over the past decade?

A: It has changed and evolved dramatically. A decade ago, care for lymphomas was primarily chemotherapy-based. Now, we are shifting rapidly away from chemotherapies in some types of lymphomas in favor of immunotherapies and targeted oral therapies that lead to excellent long-term outcomes for patients, with fewer side effects than historical treatments.

As 2024 comes to an end, experts are looking back and reflecting on the discoveries and advances that have been made in the field of cancer treatment and prevention. (iStock)

Q: What can people do to reduce their cancer risk?

A: We think of lymphomas as diseases of aging for most patients. Some patients may have select risk factors, such as being on specific immunosuppressants or having exposure to very specific industrial chemicals. 

Those risks may or may not be so modifiable for patients, and they represent the minority of patients who develop lymphoma. 

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While it is not entirely clear what modifiable risks patients may have, there is ongoing work to help better answer that question. However, we know that the better general health someone is in, the more likely they are to have any and all treatment options available to them. 

I would say that for most people, exercising regularly, eating well and sleeping regularly are important.

Q: Anything else people should know?

A: There is great hope and a lot of exciting science happening to help us drive toward more cures, more effective treatments and less toxic treatments for lymphomas. 

We have already made major strides in the last decade, and we continue to build on that momentum through clinical trials that provide early access to cutting-edge therapies. 

Exercising regularly, eating well and getting enough sleep are all recommended activities to help prevent cancer risk, experts agreed. (iStock)

For patients, participating in clinical trials may help to close that time gap between the treatments that are broadly available today and the treatments we expect to be available years from now. 

They also provide a way for patients to contribute positively to the care patients in future generations may receive, which I have been told by many of my patients is something they really want to do and something that is important to them.

Erika Hamilton, MD, director of breast cancer research

Erika Hamilton, M.D., is director of breast cancer research at Sarah Cannon Research Institute in Nashville, Tennessee. (Sarah Cannon Research Institute)

Q: What do you see as the most important cancer advances in 2024?

A: The two most exciting focuses of 2024 were 1) expansion of targeted therapies in the curative setting for hormonally driven breast cancer and 2) antibody drug conjugates. 

First, three different CDK4/6 inhibitors have been approved in the metastatic setting, and they improve survival and outcomes. 

Treatments that are precisely tailored to the genetic makeup of a person’s cancer are becoming more widely available, experts say. (iStock)

In 2024, we saw the approval of a second one in the curative setting, enabling us to identify the highest-risk patients and offer them something additional to endocrine therapy to improve cure rates.

Second, we now have multiple antibody drug conjugates approved across all types of breast cancer. These therapies target a chemotherapy drug directly to the tumor via an antibody-honing mechanism and largely spare normal body cells.

“I anticipate drugs that are better tolerated with decreased side effects for patients, and a continued emphasis on personalized medicine.”

Q: What are your predictions for cancer advances in 2025?

A: I anticipate seeing more targeted agents in 2025 and the approval of antibody drug conjugates in curative early breast cancer — currently, most are only approved in metastatic cancer.

[I also anticipate] drugs that are better tolerated with decreased side effects for patients, and a continued emphasis on personalized medicine. 

Q: How has the state of cancer in your specialty area changed and evolved over the past decade? 

A: In 2024, truly personalized medicine is possible, from mutation testing to direct targeted therapy to what a cancer needs to grow — as well as being able to provide many HR+ breast cancer patients with curative chemotherapy through personalized risk stratification assays.

“I anticipate seeing more targeted agents in 2025 and the approval of antibody drug conjugates in curative early breast cancer,” said Hamilton (not pictured). (iStock)

Q: What can people do to reduce their cancer risk?

A: Continued breast screening with mammograms yearly is really important to find cancers earlier when a cure is more likely.  

People can also reduce their risk through avoiding alcohol and cigarettes and making sure they get regular exercise and maintain a normal body weight.

Vivek Subbiah, MD, chief of early-phase drug development

Vivek Subbiah, M.D., is chief of early-phase drug development at Sarah Cannon Research Institute in Nashville, Tennessee. (Sarah Cannon Research Institute )

Q: What do you see as the most important cancer advances in 2024?

A: In 2024, precision cancer treatment made big strides with many new drug approvals by the FDA, specifically for treatments guided by specific biomarkers, which means treatments can be more precisely tailored to the genetic makeup of a person’s cancer. 

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A key change was moving some therapies from faster, temporary approval processes to full approval, showing strong evidence that these targeted therapy drugs, such as tepotinib and amivantamab for certain types of lung cancer, are effective and safe. 

There were also new drug approvals for rare cancers, including tovorafenib, a BRAF precision medicine for a rare type of brain tumor in children, and afamitresgene autoleucel, a type of immunotherapy for a rare cancer called synovial sarcoma. This highlights important progress in treating these challenging conditions.

“In 2024, precision cancer treatment made big strides with many new drug approvals by the FDA, specifically for treatments guided by specific biomarkers,” Subbiah (not pictured) told Fox News Digital. (iStock)

We have also seen the approval of precision therapies that work on different types of cancer — not just one specific cancer. This is what we call “tissue-agnostic therapies.” 

One such drug is an antibody drug conjugate called trastuzumab deruxtecan, which acts like a smart missile targeting HER2-positive cancers. Another is repotrectinib, which works on any cancer that has the NTRK biomarker, regardless of where it is in the body.

Q: What are your predictions for cancer advances in 2025?

A: By 2025, cancer research is likely to see advancements in precision oncology and the use of artificial intelligence. 

In precision oncology, we can expect more personalized treatment plans based on an individual’s genetic makeup, leading to more effective and targeted therapies with fewer side effects. 

Additionally, AI will likely play a larger role in analyzing vast amounts of data to identify new drug targets, predict patient responses to treatments and enhance early detection methods. 

These advancements have the potential to improve cancer diagnosis, treatment and overall patient outcomes.

Q: How has the state of cancer in your specialty area changed and evolved over the past decade? 

A: In the last 10 years, cancer treatment has changed dramatically. By using genetic information to create personalized treatments that match the specific details of each person’s cancer, therapies are more effective and less harmful. 

“In precision oncology, we can expect more personalized treatment plans based on an individual’s genetic makeup,” Subbiah said. (iStock)

New technologies such as analyzing cancer’s genetic profile, blood tests that detect cancer, and treatments that boost the immune system have greatly improved how we diagnose, track and treat cancer, leading to better results for patients.

Q: What can people do to reduce their cancer risk?

A: To lower the risk of cancer, people can avoid smoking, eat a healthy diet, exercise regularly, limit alcohol, protect their skin from the sun and maintain a healthy weight.

Q: Anything else people should know?

A: Get vaccines for viruses like HPV and hepatitis B, as they can lead to some cancers. Also, go for regular health checks to catch any signs of cancer early. 

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We are in a unique time when treatments can be tailored specifically to each person, and many of these are available through clinical trials. If you or a loved one is diagnosed with cancer, ask your doctor if there are any clinical trials that might be a good fit.

Meredith McKean, MD, MPH, director of melanoma and skin cancer research

Meredith McKean, M.D., MPH, is the director of melanoma and skin cancer research at Sarah Cannon Research Institute in Nashville, Tennessee. (Sarah Cannon Research Institute)

Q: What do you see as the most important cancer advances in 2024?

A: The first cellular therapy, Lifileucel, was approved in melanoma after decades of research in academia and industry. 

“We are in a unique time when treatments can be tailored specifically to each person, and many of these are available through clinical trials.”

This is a significant step forward for both patients with melanoma, but also the field of oncology at large.

Q: What are your predictions for cancer advances in 2025?

A: As we look to bring effective therapies from the metastatic setting into early stages of disease, we are anxiously awaiting updates in the next 18 to 24 months for a number of ongoing trials for combination therapy for patients with high-risk stage 2 or 3 melanoma.

In 2024, the first cellular therapy, Lifileucel, was approved in melanoma after decades of research, according to Meredith McKean, M.D., of the Sarah Cannon Research Institute (not pictured). (iStock)

Q: How has the state of cancer in your specialty area changed and evolved over the past decade? 

A: Outcomes for melanoma have significantly changed over the past 10 years. 

For more Health articles, visit www.foxnews.com/health

The five-year survival for patients with a diagnosis of stage 4 melanoma was less than 5% before 2010, and now clinical trials have shown that more than 50% of patients are still alive 10 years after being treated with FDA-approved immune checkpoint inhibitors.

Q: What can people do to reduce their cancer risk?

A: Lifelong sun protective measures, such as wearing sunscreen, avoiding direct UV exposure during peak hours of 10 a.m. to 2 p.m., and avoiding tanning beds continue to be important starting at an early age.

• A patient was hospitalized with a severe case of bird flu in Louisiana, the CDC said.
• This case is the first confirmed instance of a severe human infection linked to the H5N1 virus.
• The CDC said its assessment of risk to the public remains low.

The U.S. Centers for Disease Control and Prevention said on Wednesday that a patient has been hospitalized with a severe case of H5N1 infection in Louisiana, marking the first known instance of a severe human illness linked to the bird flu virus in the United States.

The case was confirmed by the agency on Friday, it said.

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The CDC said that a sporadic case of severe H5N1 bird flu illness in a person is not unexpected as has previously been experienced in other countries during 2024 and prior years, including in cases that led to death. The agency said its assessment of risk to the public remains low.

The CDC said that partial viral genome data from the infected patient shows that the virus belongs to the D1.1 genotype, recently detected in wild birds and poultry in the United States and in recent human cases in British Columbia, Canada, and Washington state.

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This genotype of the virus is different from the B3.13 genotype detected in dairy cows, human cases than multiple states, and some poultry outbreaks in the country, CDC said.

There have been a total of 61 human cases of H5 bird flu reported in the United States since April, according to the CDC.