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Experimental treatment eases knee arthritis pain without surgery or pills

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Experimental treatment eases knee arthritis pain without surgery or pills

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Researchers are testing low-dose radiation to treat the painful symptoms of osteoarthritis in the knee.

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The study, published by researchers in Korea and presented at the American Society for Radiation Oncology (ASTRO) annual meeting in September, suggests that a single course of radiation can be a “safe and effective” treatment option.

Knee osteoarthritis is a degenerative joint disease causing pain, swelling and stiffness in the knees that worsens over time.

MORE PEOPLE TURN TO ACUPUNCTURE FOR BACK PAIN AS STUDY SHOWS RELIEF

The randomized clinical trial enrolled 114 patients with moderate-to-mild knee osteoarthritis who were each assigned a very low dose of radiation, a low dose or a placebo. The only other pain relief used during the study was acetaminophen.

Knee osteoarthritis is a degenerative joint disease causing pain, swelling and stiffness in the knees that worsens over time. (iStock)

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The participants went through six sessions as researchers assessed “meaningful improvement” in at least two of the following markers — pain, physical function and overall assessment of condition.

The patients also completed a questionnaire to report pain, stiffness and function. None of them recorded any treatment-related side effects.

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After four months of treatment, 70% of the low-dose participants met the criteria, compared to 42% in the placebo. Those in the very low-dose group saw a 58.3% improvement.

These findings suggest the low-dose regimen “drove relief beyond placebo effects,” experts noted in a press release.

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A researcher suggested that radiation therapy could delay the need for joint replacement. (iStock)

In the low-dose group, 56.8% recorded meaningful improvements in pain, stiffness and physical function scores, compared to 30.6% in placebo.

The study concluded that low-dose radiation led to significant reductions in pain and improved function after four months, a “small fraction” of what is typically used to treat cancer.

“For people with mild to moderate disease, this approach could delay the need for joint replacement.”

Dr. Byoung Hyuck Kim, principal investigator on the trial and an assistant professor of radiation oncology at Seoul National University College of Medicine, Boramae Medical Center, noted that people with painful knee osteoarthritis “often face a difficult choice” between the risk of side effects from pain medications and the risks of joint replacement surgery.

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“There’s a clinical need for moderate interventions between weak pain medications and aggressive surgery, and we think radiation may be a suitable option for those patients, especially when drugs and injections are poorly tolerated,” he said in a statement.

Other lifestyle factors, such as weight loss, should be factored into the consideration of low-dose radiation as treatment, according to the researchers. (iStock)

Radiation therapy may be a better fit for patients with underlying inflammation and preserved joint structure, Kim added.

“For severe osteoarthritis, where the joint is physically destroyed and cartilage is already gone, radiation will not regenerate tissue,” he said. “But for people with mild to moderate disease, this approach could delay the need for joint replacement.”

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This treatment should also be considered alongside other lifestyle factors, including weight loss, physiotherapy and medications because responses could be “even stronger when radiation is properly combined with other treatments,” Kim said.

“And patient satisfaction may be higher than with current options alone.”

The study did have some limitations, the researchers confirmed, including the relatively short follow-up period.

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The researchers are planning for larger trials to evaluate the outcomes in specific groups of people, comparing low-dose radiation injections with medication regimens.

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Surge in whooping cough cases in southern state prompts health alerts

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Surge in whooping cough cases in southern state prompts health alerts

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Texas health officials are sounding the alarm on a surge of a common childhood illness.

The Texas Department of State Health Services (DHSH) revealed this week that there are nearly four times the number of whooping cough cases in the state compared to this time last year.

According to provisional data, Texas has had over 3,500 cases of whooping cough, also called pertussis, through October 2025. 

EXPERT WARNS OF ‘SILENT EPIDEMIC’ THAT PUTS MEN’S HEALTH AT SERIOUS RISK

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This is the second year in a row the state has reported high increases in cases and the second year in a row a health alert has been issued, according to DHSH.

Children under 12 months are most at risk, although anyone can catch pertussis. (iStock)

Pertussis is a highly contagious respiratory infection caused by the bacterium Bordetella pertussis, according to the National Institute of Allergy and Infectious Diseases.

It begins like a common cold, with a runny nose, sneezing and mild cough, but over time progresses to intense coughing fits that may end in a high-pitched “whoop” as the person gasps for air.

FIVE DEATHS REPORTED AMID BACTERIAL INFECTION OUTBREAK IN MAJOR CITY

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The illness typically goes through three stages: cold-like symptoms, violent coughs and then gradual recovery, according to the Cleveland Clinic.

Experts say testing, treatment and timely vaccination remain the best defenses against whooping cough. (iStock)

While anyone can get whooping cough, complications are most severe in babies 12 months and under. Infants are more likely to be hospitalized and face even greater risk if they are immunocompromised or not vaccinated.

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In babies, the symptoms may not include the classic “whoop” sound. Instead, they may struggle to breathe or pause in breathing, the Cleveland Clinic says.

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Cases this year are quadruple the number seen last year at this time in Texas, officials say. (iStock)

Teenagers and adults can also catch it, often because vaccine protection has faded. They typically experience milder symptoms.

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The CDC recommends pertussis vaccinations for all ages, and Texas health leaders stress that everyone should stay up to date to prevent fading immunity.

Pregnant women are advised to receive a Tdap shot during each pregnancy, ideally between 27 and 36 weeks, to help protect newborns, while adults in close contact with infants should also be vaccinated at least two weeks before exposure, health officials say.

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Clinicians are encouraged to test anyone showing symptoms consistent with pertussis, though treatment can begin based on “strong clinical suspicion” or exposure. PCR tests are preferred because they are quick and widely available.

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Early treatment — regardless of vaccination history — is key to preventing severe illness and stopping spread, officials say. 

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Expert warns of ‘silent epidemic’ that puts men’s health at serious risk

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Expert warns of ‘silent epidemic’ that puts men’s health at serious risk

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While gastroesophageal reflux disease (GERD) affects both men and women, men tend to experience more severe symptoms and complications.

Studies show that men have higher acid exposure and are nearly twice as likely to develop Barrett’s esophagus, a condition that can lead to esophageal cancer if left untreated.

Esophageal cancer is up to nine times more common in men, making them far more likely to progress from chronic reflux to serious outcomes.

HIDDEN CAUSES OF HEART ATTACKS OFTEN OVERLOOKED OR MISDIAGNOSED, STUDY FINDS

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Dr. Daryl Gioffre, gut health specialist, certified nutritionist and author of “Get Off Your Acid” and “Get Off Your Sugar,” spoke with Fox News Digital about how acid reflux is becoming a “silent epidemic” among men — and what they can do about it.

“This isn’t just about heartburn, but about systemic inflammation that starts in the gut and spreads throughout the body,” Gioffre said. 

While gastroesophageal reflux disease (GERD) affects both men and women, men tend to experience more severe symptoms and complications. (iStock)

“Acid reflux is the body’s alarm system, warning that the gut, metabolism and stress response are all out of balance.”

‘The perfect storm’

Men today are living in a “pressure cooker,” Gioffre warned. “Chronic stress, poor sleep, processed foods, alcohol and medication overuse are destroying gut health and digestion,” he said.

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“Combine that with typical diets heavier in meat, alcohol and ultraprocessed foods, and a greater tendency to ignore symptoms, and you’re breeding a perfect storm for chronic inflammation and increased risk of reflux compared to women.”

EVEN LOW-CALORIE PROCESSED FOOD CAUSES WEIGHT GAIN, TESTOSTERONE LOSS IN MEN, STUDY SUGGESTS

Late-night eating, larger portions, less fiber and high caffeine intake also stack the deck against men, he said. In addition to dietary choices, men’s lifestyle behaviors can also impact digestion.

Late-night eating and larger portions are part of what make men more prone to acid reflux and other digestive issues. (iStock)

“Many men skip meals, eat too quickly and rely on convenience foods stripped of minerals and fiber,” Gioffre said.

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Over time, this “ongoing acid assault” erodes the gut lining, drives acid upward and turns normal esophageal cells into precancerous Barrett’s cells, increasing cancer risk dramatically, he warned.

Biggest food culprits

When it comes to ultraprocessed foods, Gioffre called out three specific components that worsen acid reflux: refined salt, sugar and seed oils.

“Together, they inflame the gut and weaken both digestion and the lower esophageal sphincter, the valve that keeps acid in the stomach where it belongs,” he said.

“Men need to slow down, eat foods that support digestion and strengthen the gut, and stop relying on quick fixes.”

Men also tend to drink more coffee than women, often two to three cups a day, usually on an empty stomach, Gioffre pointed out.

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“That constant caffeine hit strips minerals, dehydrates the body and spikes acidity — all of which increase the risk of reflux.”

BREAKFAST TIMING MAY HOLD THE KEY TO LIVING LONGER, NEW RESEARCH REVEALS

Ultimately, he said, “men need to slow down, eat foods that support digestion and strengthen the gut, and stop relying on quick fixes. Otherwise, reflux will only keep getting worse and harder to treat.”

Biological differences

There are some biological differences between the genders that contribute to men’s higher risk of severe gastrointestinal conditions, according to Gioffre.

“Men produce less protective mucus and saliva — the body’s natural defense system that buffers acid when it backflows into the esophagus. So when acid reflux strikes, it hits harder,” he said.

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Some examples of alkaline-rich foods include leafy greens, vegetables, fruits, nuts and seeds, and mineral water or spring water. (iStock)

“That acid burns and erodes tissue that was never designed to handle acid in the first place, setting the stage for inflammation, damage and long-term complications.”

Younger men also tend to carry more visceral (abdominal) fat, Gioffre noted, which increases pressure in the stomach and forces acid up into the esophagus.

SCIENTISTS REVEAL HOW YOUR FAVORITE SODA COULD QUIETLY MESS WITH YOUR MOOD

Hormones also play a role. 

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“Estrogen in women appears to protect the esophagus by improving blood flow and mucosal repair, protection men have much less of,” the doctor said. “Without lower levels than women, their tissue where reflux hits doesn’t recover as quickly from repeated acid exposure.”

7 things to start doing right now

Gioffre recommends that men take the following simple steps to immediately begin lowering their risk.

No. 1: Stop eating three hours before bed

“One of the biggest and most overlooked causes of acid reflux is eating too close to bedtime,” Gioffre said. “When you lie down after a meal, gravity is no longer helping to keep acid in your stomach where it belongs, so it’s much easier for it to travel up the wrong way into your esophagus.”

Reflux symptoms often get worse at night, the doctor noted — “and it’s why so many men wake up coughing, choking or with a burning throat, hoarse voice or sour taste in their mouth.” (iStock)

This is why reflux symptoms often get worse at night, he noted — “and it’s why so many men wake up coughing, choking or with a burning throat, hoarse voice or sour taste in their mouth.”

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Gioffre said it’s best to stop eating three hours before bed, which gives the body time to fully digest, empty the stomach and drop acid levels before lying down.

No. 2: Remove common reflux triggers

Common triggers include garlic, onions, spicy foods, alcohol, chocolate, caffeine, citrus fruits and carbonated water, according to Gioffre.

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“All of these weaken the lower esophageal sphincter, the valve that keeps stomach acid where it belongs,” he said. “Once that muscle relaxes, acid flows upward, causing heartburn by inflaming and irritating the esophageal and throat lining.”

“If you want to heal reflux naturally, you can’t just change what you eat — you have to change how you live.”

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The doctor also recommends adding back alkaline minerals, digestive enzymes and a high-quality probiotic. Some examples of alkaline-rich foods include leafy greens, vegetables, fruits, nuts and seeds, and mineral water or spring water.

No. 3: Stay hydrated

Gioffre recommends starting the morning with warm lemon water with a teaspoon of local honey, or a tea with slippery elm.

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“This helps soothe and calm the upper GI tract and eases reflux,” he said. It’s also important to stay hydrated throughout the day, the doctor added.

No. 4: Stay grounded

Simple grounding practices, like walking barefoot in the grass, doing deep breathing or just stepping outside to reconnect with nature, can help promote gut health.

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Esophageal cancer is up to nine times more common in men, making them far more likely to progress from chronic reflux to serious outcomes. (iStock)

“These activate your parasympathetic ‘rest-and-digest’ system, calm your gut and keep acid levels in check naturally,” Gioffre said. “Get outside and move after meals, and swap your late-night snack for deep breathing or stretching.”

No. 5: Manage stress and sleep

When men don’t sleep well, the body produces more cortisol, which is the main stress hormone.

“High cortisol keeps you locked in a constant state of fight-or-flight, and when you’re in that mode, your body isn’t focused on rest, digest or repair — it’s focused on survival,” Gioffre said.

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In this state, blood flow is pulled away from the gut and sent to the muscles and brain, he noted, which means digestion slows down, stomach acid production drops and food sits in the stomach for too long, which leads to bloating, gas and more reflux.

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“If you want to heal reflux naturally, you can’t just change what you eat — you have to change how you live,” Gioffre said. “Quality sleep and stress management are non-negotiable if you want to restore your gut and calm acid at its root cause.”

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Some cancer patients could avoid surgery with innovative new therapy

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Some cancer patients could avoid surgery with innovative new therapy

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An experimental drug has shown promise in fighting a hard-to-treat form of bladder cancer known as BCG-unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC).

BCG (Bacillus Calmette-Guérin) is an immunotherapy drug that is often the first-line treatment for certain early-stage bladder cancers.

The new drug, TAR-200 — which was evaluated in a trial sponsored and conducted by Janssen Research & Development, LLC, a subsidiary of Johnson & Johnson — may offer a less invasive alternative to bladder removal surgery.

KILLER CONDITION LANDS IN TOP 10 LEADING CAUSES OF DEATH AS GLOBAL CASES SURGE

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TAR-200 is a small, drug-releasing device placed directly into the bladder through a simple outpatient procedure, without general anesthesia, according to the study press release. 

Once inserted, it slowly releases the chemotherapy drug gemcitabine over several weeks.

Researchers say the new bladder-inserted device could spare patients from losing their bladder entirely. (iStock)

“Traditionally, these patients have had very limited treatment options. This new therapy is the most effective one reported to date for the most common form of bladder cancer,” said study lead Sia Daneshmand, M.D., director of urologic oncology with Keck Medicine of USC, in a press release. 

“The findings of the clinical trial are a breakthrough in how certain types of bladder cancer might be treated, leading to improved outcomes and saved lives.”

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Bladder cancer is the fourth most common cancer in men and the 11th most common cancer in women.

According to the Urology Care Foundation, non-muscle-invasive bladder cancer is found in the tissue that lines the inner surface of the bladder. 

“Bladder cancer is one of the 10 most common cancers worldwide, yet treatment options have remained largely unchanged for over 40 years.”

High-risk NMIBC carries a greater chance of coming back after treatment. This study aimed to find an option for patients whose cancer recurred even after standard therapy.

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“The standard treatment plan for these patients was surgery to remove the bladder and surrounding tissue and organs, which has many health risks and may negatively impact patients’ quality of life,” said Daneshmand.

This new therapy could eventually allow some patients to avoid that procedure.

Trial results showed that many patients stayed cancer-free for more than two years. (iStock)

All participants in the study had high-risk NMIBC that did not respond to the standard immunotherapy drug BCG. The study was split into multiple groups who tested different combinations of drugs and treatment methods.

In one group, patients received TAR-200 once every three weeks for about six months, followed by maintenance treatments every 12 weeks for up to two years.

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Among 85 patients in this group, 82.4% showed no detectable signs of cancer after treatment. In that group, 52.9% remained cancer-free at one year, and many stayed cancer-free for more than two years without needing additional therapy.

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In another group of patients with a less aggressive type of early-stage bladder cancer, early disease-free survival rates were 85.3% at six months and 81.1% at nine months. Overall, 94% were able to keep their bladders.

The clinical trial results were published earlier this year in the Journal of Clinical Oncology.

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The TAR-200 device delivers gemcitabine directly to the bladder, keeping the drug where it’s needed most. (iStock)

The researchers emphasized that this is still mid-stage (Phase 2b) data. Longer-term, larger trials and regulatory reviews are still needed before the treatment could become standard care. 

“Because the study didn’t include a traditional comparison (no randomized control arm), we can’t definitively say how TAR-200 stacks up against other treatments in a fair head-to-head way,” the researchers wrote. 

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Patients in this study are a specific subset (BCG-unresponsive and eligible for bladder preservation) and may not represent all bladder-cancer cases.

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“Also, follow-up time remains relatively short and the number of patients modest, meaning we don’t yet know how long the benefits will last or how they apply to larger, more diverse groups of people,” the researchers added.

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