Health
Elton John’s vision loss: How an eye infection can cause blindness
Elton John gives final tour performance to sold out crowd
Elton John completed his “Farewell Yellow Brick Road” tour in Stockholm, Sweden on Saturday, after five years and 330 shows. He addressed the crowd and thanked his fans, saying he will miss them and their support has “humbled” him.
World-renowned singer-songwriter Elton John confirmed he has lost sight in his right eye after suffering from a severe infection.
On the opening night of his musical adaptation of “The Devil Wears Prada” in London, John shared, “I haven’t been able to come to many of the previews because, as you know, I have lost my eyesight.”
“So, it’s hard for me to see it, but I love to hear it and, boy, it sounded good tonight,” he said.
ELTON JOHN HAS ‘LOST MY EYESIGHT’ FOLLOWING SEVERE INFECTION
John first posted to his Instagram account in September that he had been dealing with a “severe eye infection” over the summer that has “unfortunately left me with only limited vision in one eye.”
“Since Sir Elton John did not state what type of eye infection he has, it is unclear whether he has complete blindness in his right eye or if there is still some partial vision,” Dr. Thuy Tran, optometrist and founder of Oculist in New York City, told Fox News Digital.
“It is possible that he may still be able to perceive light and motion, but is unable to discern enough details to read letters or musical notes,” added Tran, who did not treat the singer.
“He may also be experiencing other signs and symptoms, such as thick mucous discharge, pain, irritation, excessive tearing and redness.”
Types of eye infections
The most common types of eye infections are viral conjunctivitis and bacterial conjunctivitis, according to Tran.
“Viral conjunctivitis, caused by adenovirus, are like common colds and typically resolve on their own within a few weeks,” he said.
“When caused by herpes simplex virus, varicella zoster virus (same virus that is responsible for chicken pox and shingles), or cytomegalovirus (seen in immunocompromised individuals i.e. those with HIV/AIDS), more serious complications, such as corneal scarring, retinal damage and vision loss, may result.”
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Bacterial eye infections usually resolve within a week with proper antibiotic treatment, usually eyedrops or ointment, the doctor noted.
“A hyperacute bacterial eye infection, however, can be severe and rapidly progressive,” Tran warned. “If not treated immediately, it can lead to corneal ulcers, scarring and blindness.”
“This condition is most commonly caused by Neisseria gonorrhoeae, a type of bacteria that can be transmitted through sexual contact.”
Bacterial eye infections usually resolve within a week with proper antibiotic treatment, usually eyedrops or ointment. (iStock)
Fungal eye infections are often caused by fungi that are naturally present in our environment, according to Tran.
“Common risk factors include trauma to the eye with plant material, extended contact lens wear and diabetes,” he said.
Fungal infections are usually treated with topical or oral antifungal therapies.
“Rarely, they can lead to a medically-urgent condition known as endophthalmitis, which often requires hospitalization for administration of intravenous medications.”
Potential for permanent damage
Dr. Derek Cunningham, eye doctor and director of Dell Laser Consultants in Austin, Texas, also spoke with Fox News Digital about the dangers of both internal and external infections in the eyes.
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An internal infection can be caused by a virus, said Cunningham, who also did not treat Elton John. If it reaches the retina, or the back of the eye, permanent vision loss can occur.
More commonly, eye infections are the result of external triggers and trauma to the front of the eye, like scratches, chemical splashes or the misuse of contact lenses, he noted.
Elton John speaks onstage during the 38th Annual Rock & Roll Hall Of Fame Induction Ceremony at Barclays Center on Nov. 3, 2023, in New York City. (Theo Wargo/Getty Images for The Rock and Roll Hall of Fame)
These incidents then allow bacteria and other foreign organisms to “colonize in the eye,” Cunningham said.
“Because [the eye] is specifically designed to transmit light, the cellular structure of all the tissues is very precise, and it cannot be altered.”
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“So, any amount of immune response or even bacterial or viral infection is going to cause not only a disruption in the cells, but it could potentially cause scarring – and that is going to reduce vision, very often on a permanent level,” he went on.
While the eye is sensitive and may have a harder time warding off infection since it’s a “compartmentalized” system, Cunningham said, the cornea is also the “fastest-healing tissue in the human body.”
Eye infections are more likely to affect the elderly, according to an expert. (iStock)
But as people age, the body heals more slowly – so someone like John, who is 77 years old, will be at a higher risk of elongated infection compared to those who are younger.
“A little kid can scratch their eye and within hours be completely healed,” Cunningham said. “In an elderly person, [injury] can last for days, and that’s where the chance of infection builds up – every minute that the tissue is still compromised.”
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Some eye complications can be spotted and addressed early on during routine eye exams.
Cunningham recommends paying attention to visual function – and if vision is compromised, symptoms should be evaluated by a doctor.
If vision is compromised, symptoms should be evaluated by a doctor, an expert recommended. (iStock)
“If there is … anything really infectious in the eye, the potential for vision loss is extremely high — and it’s permanent. It very often doesn’t ever come back.”
Representatives for John did not return Fox News Digital’s immediate request for comment.
Fox News Digital’s Elizabeth Stanton contributed to this report.
Health
Scientists May Be Able to Make Grapefruits Compatible With Medications They Currently Interfere With
You may be among the millions of people who have seen a surprisingly specific warning like this on the labels of drugs you take:
Avoid eating grapefruit or drinking grapefruit juice while using this medication.
Such warnings are issued for dozens of substances, including docetaxel, a cancer drug; erythromycin, an antibiotic; and some statins, the cholesterol-lowering drugs prescribed to more than a third of American adults over 40.
The problem is a set of molecules, furanocoumarins. High levels of furanocoumarins interfere with human liver enzymes, among other processes. In their presence, medications can build up to unhealthy levels in the body. And grapefruits and some related citrus fruits are full of them.
But there is no such warning for other kinds of citrus, such as mandarins and other oranges. Citrus researchers at the Volcani Center in Israel reported Wednesday in the journal The New Phytologist that, by crossing mandarins and grapefruit, they’ve uncovered genes that produce furanocoumarins in some citrus fruits. It’s a finding that opens the possibility of creating grapefruit that doesn’t require a warning label.
Scientists had worked out the compounds’ structures and pieced together a basic flowchart of how they are made years ago, said Yoram Eyal, a professor at the Volcani Center. But the precise identities of enzymes catalyzing the process — the proteins that snip off a branch here, or add a piece there — remained mysterious. He and his colleagues knew that one way to identify them was to breed citrus high in furanocoumarins with those without. If the offspring of such a cross had varying levels of the substances, it should be possible, by digging into their genetics, to pinpoint the genes for the proteins.
“We were afraid to approach it, because it’s very time-consuming and it takes many years,” he said, noting how involved it can be to grow new trees from seeds and assess their genetics. “But finally, we decided we have to dive in.”
When they examined the offspring of a mandarin and a grapefruit, the researchers saw something remarkable. Fifty percent of the young plants had high levels of furanocourmains, and 50 percent had none. That particular signature meant something very specific, in terms of how the ability to make these substances is inherited.
“We saw there was only one gene that could have controlled it,” said Livnat Goldenberg, a Volcani Center researcher who is the lead author of the new study.
The researchers soon identified the gene controlling the production of furanocoumarins in leaves and fruit, which produces an enzyme called 2-oxoglutarate-dependent dioxygenase, or 2OGD for short. Mandarins, it turns out, have a mutated form of this gene that keeps the enzyme from functioning properly. This version cropped up in all the mandarin and orange varieties the researchers checked, explaining why they do not cause the same problems as grapefruit in people taking prescription medications. In these plants, furanocoumarin production is paused.
With gene editing technology, it should be possible to alter the gene in grapefruit as well, Dr. Eyal suggests. The team at the Volcani Center is now exploring that project.
Looking at how widespread this mutated version is in mandarins and some other citrus, the scientists speculate that some gene nearby on the genome must play an important role in a highly prized trait. A long-ago citrus breeder, selecting for some unknown quality, must have unwittingly spread this furanocoumarin-busting version of the gene to an ancestor of modern varieties of mandarins and oranges.
All these years later, that person’s work is coming to light, under the gaze of geneticists, who may, someday, put grapefruit back on the menu.
Cases of tularemia, also known as “rabbit fever,” are on the rise in the U.S., according to a new report from the Centers for Disease Control and Prevention (CDC).
Caused by the bacteria Francisella tularensis, the disease commonly infects rabbits, hares and rodents. However, it is zoonotic, which means it can spread from animals to humans.
The bacteria is a “tier-1 select agent,” a classification given to agents and toxins that “present the greatest risk of deliberate misuse with significant potential for mass casualties or devastating effects to the economy, critical infrastructure or public confidence, and pose a severe threat to public health and safety,” per the CDC.
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Although tularemia is relatively rare, with only 2,462 diagnoses between 2011 and 2022, cases have risen 56% compared to the prior decade (2001 to 2010), as reported in the CDC’s Morbidity and Mortality Weekly Report.
Cases of tularemia, also known as “rabbit fever,” are on the rise in the U.S., according to a new report from the CDC. (iStock)
“Increased reporting of probable cases might be associated with an actual increase in human infection, improved tularemia detection or both,” the report states.
Millions of new cases of diabetes and heart disease every year are caused by sugary drinks, according to newly published research.
Tufts University in Boston led the study, which found that about 2.2 million new diagnoses of type 2 diabetes and 1.2 million new cases of cardiovascular disease were attributed to sugar-sweetened sodas and juices each year, according to a press release.
The findings were published in the journal Nature Medicine this week.
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The highest rates were found in Colombia, where 48% of new diabetes cases were linked to sugary drinks, and in Mexico, where nearly a third of cases were attributed to them.
Meanwhile, in Latin America, more than 24% of new diabetes cases were linked to sugary beverages, and 21% in sub-Saharan Africa, the study found.
About 2.2 million new cases of type 2 diabetes and 1.2 million new cases of cardiovascular disease occur each year worldwide due to consuming sugar-sweetened soda and juices, according to the findings of a new study. (iStock)
In South Africa, 27.6% of new diabetes cases and 14.6% of cardiovascular disease cases were attributed to sugary drinks.
Sugary drinks are rapidly digested, causing a spike in blood sugar levels with little nutritional value.
Sugary drinks cause blood sugar to spike because they are “rapidly digested,” the research team said.
When consumed on a long-term basis, these types of beverages, in addition to increasing the risk of type 2 diabetes and heart disease, can also lead to weight gain and insulin resistance, the researchers added.
Men are more likely than women to suffer the consequences of sugary drink consumption, as are younger adults compared to their older counterparts, a new study asserts. (iStock)
Professor Dariush Mozaffarian, the study’s senior author, said in a university press release, “Sugar-sweetened beverages are heavily marketed and sold in low- and middle-income nations.”
He added, “Not only are these communities consuming harmful products, but they are also often less well-equipped to deal with the long-term health consequences.”
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Certain groups are more likely to experience negative health effects from sugary drinks, including men and younger adults, the researchers noted, as news agency SWNS also noted.
New Jersey-based registered dietitian Erin Palinski-Wade, who was not involved in the research, said the findings were to be expected, as diets rich in added sugars are more likely to increase the risk of chronic health conditions, including type 2 diabetes.
When consumed on a long-term basis, these types of beverages can also lead to weight gain and insulin resistance, experts say. (iStock)
“Sugar-sweetened beverages are a major cause of added sugar in the diet and easy to overconsume, as they provide little fullness,” she told Fox News Digital.
“The high calorie content and lack of satisfaction due to little protein, fat or fiber in these drinks can lead to excess calorie consumption, which can lead to weight gain — especially gains in visceral fat (belly fat), which has been found to increase the risk of type 2 diabetes,” she went on.
“Sugar-sweetened beverages are easy to overconsume, as they provide little fullness.”
Palinski-Wade pointed out that there were some limitations to the new research.
“This was an observational study, not a causation study, and shows only an association between diets containing sugar-sweetened beverages and diabetes,” she noted.
“It does not prove that those drinks alone trigger an onset of type 2 diabetes.”
What needs to change?
To remedy the issue, the study authors called for a “multi-pronged approach,” including public health campaigns, regulations on advertising and taxes on sugar-sweetened beverages, the release stated.
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“We need urgent, evidence-based interventions to curb consumption of sugar-sweetened beverages globally, before even more lives are shortened by their effects on diabetes and heart disease,” first author Laura Lara-Castor, now at the University of Washington, said in the release.
Approximately 65% of adults in the U.S. consume sugar-sweetened beverages daily. (iStock)
Mexico implemented a sugary drinks tax in 2014, which has shown to be effective in reducing consumption, the researchers stated.
“Much more needs to be done, especially in countries in Latin America and Africa, where consumption is high and the health consequences severe,” wrote Mozaffarian.
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“As a species, we need to address sugar-sweetened beverage consumption.”
Many different factors are involved in insulin resistance and type 2 diabetes, Palinski-Wade noted.
“As a species, we need to address sugar-sweetened beverage consumption.”
“However, reducing your intake of sugar-sweetened beverages can go a long way toward improving overall blood sugar regulation and future health.”
The new research was supported by the Gates Foundation, the American Heart Association and Mexico’s National Council for Science and Technology.
Fox News Digital reached out to the researchers for further comment.
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