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Cancer may trigger unexpected defense against Alzheimer’s disease, researchers say

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Cancer may trigger unexpected defense against Alzheimer’s disease, researchers say

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Puzzling cancer and Alzheimer’s link explored in new study: ‘SHORT QUOTE’

A new study may help clarify a long-observed link between cancer history and reduced Alzheimer’s risk.

The research, published in the journal Cell, used mouse models to explore how the biological changes associated with cancer may affect the progression of the most common dementia type.

The findings suggest that certain cancers release a protein called cystatin-C that can travel through the bloodstream and enter the brain, an area that many Alzheimer’s treatments have difficulty reaching.

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Cystatin-C binds to harmful amyloid protein clumps linked to Alzheimer’s and activates a protein called TREM2, which acts like an on-switch for the brain’s immune cells. 

When activated, those cells begin clearing away existing amyloid plaques, a process that was associated with reduced plaque buildup and improved cognitive function, the study found.

New research suggests that cancer-related biological changes may help explain why a history of cancer is linked to lower Alzheimer’s risk. (iStock)

Dr. Bob Arnot, a Vermont-based internal medicine physician, told Fox News Digital that the findings help clarify a pattern doctors have observed for years.

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“Scientists have long observed a puzzling statistical pattern known as ‘inverse comorbidity’ — people with a history of cancer are less likely to develop Alzheimer’s disease, and people with Alzheimer’s are less likely to develop cancer,” said Arnot, who was not involved in the study.

Cystatin-C sticks to harmful amyloid clumps and turns on brain immune cells, helping them clear plaques and improve brain function. (iStock)

The findings suggest that biological signals tied to certain cancers may slow or reverse key features of Alzheimer’s disease.

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Arnot said the research is notable because it identifies a specific biological pathway that could be targeted for future Alzheimer’s treatments.

“This approach targets existing amyloid plaquesnot just early prevention. That distinction could be critical for patients who already have established disease,” he said.

The results suggest that cancer-related biological signals may help slow or even reverse some core aspects of Alzheimer’s disease. (iStock)

Arnot cautioned that the findings do not mean cancer itself is protective.

“This study does not suggest that cancer is protective, desirable or a viable therapy,” he said. “Instead, it reveals that biological programs activated during cancer can inadvertently engage protective immune mechanisms in the brain.”

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The research suggests that future treatments could focus not just on slowing Alzheimer’s, but also on clearing harmful buildup in the brain, Arnot added.

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The results were based on experiments in animal models, and further research is needed to determine whether the same effects occur in humans, the researchers noted.

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‘Call a Boomer’ payphones help cure loneliness, spark friendships across generations

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‘Call a Boomer’ payphones help cure loneliness, spark friendships across generations

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Along a bustling sidewalk in Boston, a bright yellow payphone invites folks to “call a Boomer.”

Almost 3,000 miles away in Reno, Nevada, a nearly identical phone prompts residents of Sierra Manor – an apartment complex for seniors – to “Call a Zoomer.” The goal is simple: to get strangers to talk to each other.

The project, often referred to as simply “Call a Boomer,” is the latest initiative from Matter Neuroscience, a New York-based company dedicated to mapping the “biomarkers of happiness.”

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By connecting “two of the loneliest demographics” (older adults and younger adults), the project aims to prove that on a molecular level, “humans need one another in order to be happy,” according to Calla Kessler, a social strategist at Matter Neuroscience.

Along a bustling sidewalk in Boston, a bright yellow payphone invites folks to “Call a Boomer.” (Matter Neuroscience)

“Younger adults and older adults tend to experience the highest levels of loneliness of any age group,” the company wrote on its website. “So the goal of this project is to inspire generational connection through meaningful conversations, despite differences in age, lifestyle or politics.”

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The hope, according to Kessler, is that the calls will shift the brain’s focus from stress to bonding.

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“Our neuroscience angle is cannabinoids over cortisol,” Kessler told Fox News Digital. “Cannabinoids are the feel-good neurotransmitter in our brain that creates that warm feeling with a friendship — and when you activate cannabinoids, you’re counteracting the negative effects of cortisol, which is our primary stress hormone.”

“Younger adults and older adults tend to experience the highest levels of loneliness of any age group,” the company noted. (Matter Neuroscience)

This isn’t Matter’s first round of payphones. Its initial experiment connected one of the most liberal cities in the U.S. (San Francisco) with one of the most conservative (Abilene, Texas).

“We basically just wanted people to find common ground and encourage people to think beyond labels,” Kessler said.

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She noted that the negative results were “almost negligible,” with most participants enjoying their time speaking to different people.

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Now, the focus has shifted from political labels to generational divides.

The negative results have beem “almost negligible,” with most participants enjoying their time speaking to different people. (Matter Neuroscience)

As the “Call a Boomer” experiment continues, the team is busy collecting audio files of these intergenerational chats to prove that simple connections with other humans can help improve mental health.

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“Our research is essentially trying to find a non-pharmaceutical cure to depression,” Kessler added.

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Looking ahead, she said, “we’ll definitely be doing fun things that we hope get people’s attention and inspire them to learn a little more about themselves.”

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Family pleads for help as teen faces life-threatening bone marrow failure

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Family pleads for help as teen faces life-threatening bone marrow failure

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A New York City father is desperately seeking a donor to save his teenage son’s life.

Max Uribe, now 15 and a high-school freshman, has just weeks until he will need to be hospitalized with a rare blood disorder that could lead to a deadly cancer.

“Max was just 6 when we first noticed there was something wrong with his blood counts,” his father, Juan Uribe, told Fox News Digital. “At the time, we thought it was due to a viral infection, but they never fully recovered back to their normal level.”

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In December 2024, Max’s condition grew worse, and he was diagnosed with clonal cytopenia, a condition involving the blood and bone marrow.

“All three of his blood counts are low — red, white and platelets,” Uribe said. 

Max Uribe, pictured with his parents and sister, is in urgent need of a stem cell transplant to save his life. (Uribe Family)

In August 2025, another bone marrow biopsy revealed that Max is on a path to bone marrow failure, creating an urgent need for a stem cell transplant.

“The disease has continued to progress, as his blood counts continue to drop, and therefore, we have to take him to transplant in May of this year,” Uribe said.

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If left untreated, Max’s condition could lead to MDS (myelodysplastic syndrome), a type of blood cancer, and from there possibly into acute myeloid leukemia (AML).

A bone marrow match must have a specific type of HLA (human leukocyte antigen), which are proteins found on the surface of most cells in the body, according to the National Marrow Donor Program (NMDP).

Max Uribe, pictured with his parents, will be hospitalized for a transplant in May, as his blood count has been steadily decreasing. (Uribe Family)

The closer the donor’s HLA markers are to the patient’s, the more likely the body will accept the new cells without a high risk of complications.

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People from the same ethnic background are more likely to share similar HLA types, meaning a patient is most likely to find a compatible donor among individuals with similar ancestry, per the NMDP.

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Non-Hispanic White patients have a 79% chance of a perfect match. That drops to 49% for Hispanic/Latino patients, 29% for Black patients and even lower for mixed ancestries, the NMDP reports.

Because Max is a “very rare combination” of half-Colombian from his father and a mix of Italian, British and German from his mother, his path to a perfect match is proving much more difficult, Uribe noted.

“For a kid like Max, with complex, mixed heritage, the math is devastating.”

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“For a kid like Max, with complex, mixed heritage, the math is devastating,” he said. “The thinking is, we need large numbers if we’re going to have that perfect match for my son.”

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Max, who participates in competitive tennis and varsity wrestling, just had additional blood work done on Friday, which revealed that his counts continue to plummet.

“We’re at the point where this is beginning to manifest a bit more, which is why the urgency is so critical,” Uribe said.

Because Max is a “very rare combination” of half-Colombian from his father and a mix of Italian, British and German from his mother, his path to a perfect match is proving much more difficult. (Uribe Family)

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If a donor is not secured by Max’s hospitalization in May, the medical team will have to proceed with a partial match, which is not ideal for a number of reasons.

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“The survival rate is meaningfully lower with a partial match, and there’s more risk of graft versus host disease (GVHD), which could lead to complications in the process,” Uribe said. With GVHD, the donor cells begin to attack the body.

Max Uribe, an active athlete, is on a path to bone marrow failure, requiring a stem cell transplant. (Uribe Family)

To help prevent this with a partial match, Max would likely need chemotherapy and immunosuppressants for a longer period of time, which could weaken his immune system.

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Anyone interested in donating can order a free test kit on the Team Max website. The kit includes a quick cheek swab that is sent back to the lab to determine whether someone is a match.

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Eat This Before Bed To Lose Weight Overnight: ‘Second Meal Effect’ Explained

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Eat This Before Bed To Lose Weight Overnight: ‘Second Meal Effect’ Explained


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What To Eat Before Bed To Lose Weight and Burn Fat




















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