Health
Aspirin may be linked to lower risk of colorectal cancer, new study suggests
Aspirin is widely known for its heart attack prevention benefits, but a new study has also linked the common drug to a reduced risk of colorectal cancer.
The study analyzed data from 107,655 men and women who participated in the Nurses’ Health Study and the Health Professionals Follow-Up Study over a three-decade span. It was published in JAMA Oncology on Thursday.
Researchers from Massachusetts General Hospital, Harvard Medical School and Washington University School of Medicine found that regular aspirin use was linked to a lower risk of colorectal cancer — especially for those with the unhealthiest lifestyles.
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“It shows an association between regular, low-dose aspirin use and decreased colon cancer use (close to 20%) in patients who are already at higher risk for several reasons, including smoking or poor diet,” said Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, who was not involved in the study.
Aspirin has been linked to a reduced risk of colorectal cancer, according to a study published in JAMA Oncology. (iStock)
Criteria for determining unhealthy lifestyles included higher body mass index, heavy smoking, higher alcohol intake, lack of physical activity and poor nutrition.
“We observed that participants in our study with the least healthy lifestyle had the greatest absolute benefit from aspirin use,” lead study author Daniel Sikavi, M.D., a board-certified physician at Massachusetts General Hospital, told Fox News Digital.
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“These participants had multiple risk factors that increased their overall risk of developing colorectal cancer, and our results show that aspirin can proportionally lower this markedly elevated risk.”
Among patients with a healthier lifestyle, the benefit from aspirin was still evident, but less pronounced.
Based on the findings, the researchers recommend that health care providers might consider recommending aspirin to patients with a less healthy lifestyle. (AP Photo/Emma H. Tobin)
“In the least healthy group, treating 78 patients with aspirin would prevent one case of colorectal cancer over 10 years, while it would take treating 909 patients to prevent one case in the healthiest group,” added Sikavi.
As to why aspirin decreases colon cancer risk, Siegel said it is likely due to the fact that the medication acts as an anti-inflammatory, and many cancers are associated with increased inflammation.
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Based on the findings, the researchers suggest that health care providers consider recommending aspirin to patients with a less healthy lifestyle.
The American Cancer Society estimates that about 106,590 new cases of colon cancer and about 46,220 cases of rectal cancer will be diagnosed in 2024. (iStock)
“This work is an example of how we can move beyond one-size-fits-all strategies for cancer prevention by targeting effective preventive agents, such as aspirin, to the populations that are most likely to benefit,” Sikavi said.
Potential limitations
One limitation of the study was that the researchers did not systematically assess potential side effects associated with aspirin use, Sikavi noted.
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“Because this was an observational study, it is possible there may have been additional factors that influenced our findings, although we rigorously accounted for a number of known risk factors for colorectal cancer,” he said.
Siegel reiterated that because this is an observational study, “it is still not proof.”
The American Cancer Society estimates that about 106,590 new cases of colon cancer and about 46,220 cases of rectal cancer will be diagnosed in 2024.
Health
The Best Time To Take ‘Nature’s Ozempic’ Berberine for Weight Loss and Blood Sugar Control, According to an MD
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Health
Study reveals why chewing gum might actually help with focus and stress relief
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Humans have been chewing gum for thousands of years, long after the flavor fades and without any clear nutritional benefit.
The habit dates back at least 8,000 years to Scandinavia, where people chewed birchbark pitch to soften it into a glue for tools. Other ancient cultures, including the Greeks, Native Americans and the Maya, also chewed tree resins for pleasure or soothing effects, National Geographic recently reported.
In the late 19th and early 20th centuries, William Wrigley Jr. transformed chewing gum from a novelty into a mass consumer habit through relentless and innovative marketing. His brands, including Juicy Fruit and Spearmint, promoted gum as a way to calm nerves, curb hunger and stay focused.
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“Are you worried? Chew gum,” an article from 1916 said, according to Kerry Segrave’s book, “Chewing Gum in America, 1850-1920: The Rise of an Industry.” “Do you lie awake at night? Chew gum,” it continued. “Are you depressed? Is the world against you? Chew gum.”
Advertisements have long framed chewing gum as a tool for stress relief and mental sharpness. (Keystone View Company/FPG/Archive Photos/Getty Images)
In the 1940s, a study found chewing resulted in lower tension but couldn’t say why.
“The gum-chewer relaxes and gets more work done,” The New York Times wrote at the time about the study’s results.
Gum became an early form of wellness, and companies are trying to revive that idea today as gum sales decline, according to National Geographic.
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But only now are scientists finally beginning to understand the biology behind those long-standing beliefs.
Chewing gum may briefly affect attention and stress-related brain activity, according to studies. (iStock)
A 2025 review by researchers at the University of Szczecin in Poland analyzed more than three decades of brain-imaging studies to examine what happens inside the brain when people chew gum. Using MRI, EEG and near-infrared spectroscopy research, the authors found that chewing alters brain activity in regions tied to movement, attention and stress regulation.
The findings help clarify why the seemingly pointless task can feel calming or focusing, even once the flavor has faded.
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Chewing gum activated not only the brain’s motor and sensory networks involved in chewing, but also higher-order regions linked to attention, alertness and emotional control, the review found. EEG studies found brief shifts in brain-wave patterns linked to heightened alertness and what researchers call “relaxed concentration.”
Humans have chewed gum for pleasure for thousands of years, according to reports. (iStock)
“If you’re doing a fairly boring task for a long time, chewing seems to be able to help with concentration,” Crystal Haskell-Ramsay, a professor of biological psychology at Northumbria University, told National Geographic.
The review also supports earlier findings that gum chewing can ease stress, but only in certain situations. In laboratory experiments, people who chewed gum during mildly stressful tasks such as public speaking or mental math often reported lower anxiety levels than those who didn’t.
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Chewing gum did not, however, consistently reduce anxiety in high-stress medical situations, such as immediately before surgery, and it offered no clear benefit when participants faced unsolvable problems designed to induce frustration.
Some studies suggest chewing gum can reduce stress in mild situations but not extreme ones. (iStock)
Across multiple studies, people who chewed gum did not remember lists of words or stories better than those who didn’t, the researchers also found, and any boost in attention faded soon after chewing stopped.
Gum may simply feed the desire to fidget, experts suspect.
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“Although these effects are often short-lived, the range of outcomes … underscores chewing gum’s capacity to modulate brain function beyond simple oral motor control,” the researchers wrote.
“However, at this time, the neural changes associated with gum chewing cannot be directly linked to the positive behavioral and functional outcomes observed in studies,” they added.
A 2025 review analyzed decades of MRI, EEG and near-infrared spectroscopy studies on gum chewing. (iStock)
Future research should address longer-term impacts, isolate flavor or stress variables and explore potential therapeutic applications, the scientists said.
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The findings also come with caveats beyond brain science. Although sugar-free gum may help reduce cavities, Fox News Digital has previously reported that dentists warn acids, sweeteners and excessive chewing may harm teeth or trigger other side effects.
Fox News Digital has reached out to the study’s authors for comment.
Health
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