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Aspirin may be linked to lower risk of colorectal cancer, new study suggests

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Aspirin may be linked to lower risk of colorectal cancer, new study suggests

Aspirin is widely known for its heart attack prevention benefits, but a new study has also linked the common drug to a reduced risk of colorectal cancer.

The study analyzed data from 107,655 men and women who participated in the Nurses’ Health Study and the Health Professionals Follow-Up Study over a three-decade span. It was published in JAMA Oncology on Thursday.

Researchers from Massachusetts General Hospital, Harvard Medical School and Washington University School of Medicine found that regular aspirin use was linked to a lower risk of colorectal cancer — especially for those with the unhealthiest lifestyles.

DAILY ASPIRIN AFTER A HEART ATTACK CAN REDUCE THE RISK OF FUTURE EVENTS, STUDY FINDS

“It shows an association between regular, low-dose aspirin use and decreased colon cancer use (close to 20%) in patients who are already at higher risk for several reasons, including smoking or poor diet,” said Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, who was not involved in the study.

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Aspirin has been linked to a reduced risk of colorectal cancer, according to a study published in JAMA Oncology. (iStock)

Criteria for determining unhealthy lifestyles included higher body mass index, heavy smoking, higher alcohol intake, lack of physical activity and poor nutrition.

“We observed that participants in our study with the least healthy lifestyle had the greatest absolute benefit from aspirin use,” lead study author Daniel Sikavi, M.D., a board-certified physician at Massachusetts General Hospital, told Fox News Digital.

HEART ATTACK DEATH RISK CAN DOUBLE DURING HEAT WAVES AND HIGH POLLUTION, STUDY FINDS: ‘A PERFECT STORM’

“These participants had multiple risk factors that increased their overall risk of developing colorectal cancer, and our results show that aspirin can proportionally lower this markedly elevated risk.”

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Among patients with a healthier lifestyle, the benefit from aspirin was still evident, but less pronounced.

Aspirin bottle

Based on the findings, the researchers recommend that health care providers might consider recommending aspirin to patients with a less healthy lifestyle. (AP Photo/Emma H. Tobin)

“In the least healthy group, treating 78 patients with aspirin would prevent one case of colorectal cancer over 10 years, while it would take treating 909 patients to prevent one case in the healthiest group,” added Sikavi.

As to why aspirin decreases colon cancer risk, Siegel said it is likely due to the fact that the medication acts as an anti-inflammatory, and many cancers are associated with increased inflammation.

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Based on the findings, the researchers suggest that health care providers consider recommending aspirin to patients with a less healthy lifestyle.

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A doctor with a blue ribbon next to a colon cancer model

The American Cancer Society estimates that about 106,590 new cases of colon cancer and about 46,220 cases of rectal cancer will be diagnosed in 2024. (iStock)

“This work is an example of how we can move beyond one-size-fits-all strategies for cancer prevention by targeting effective preventive agents, such as aspirin, to the populations that are most likely to benefit,” Sikavi said.

Potential limitations

One limitation of the study was that the researchers did not systematically assess potential side effects associated with aspirin use, Sikavi noted.

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“Because this was an observational study, it is possible there may have been additional factors that influenced our findings, although we rigorously accounted for a number of known risk factors for colorectal cancer,” he said.

      

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Siegel reiterated that because this is an observational study, “it is still not proof.”

The American Cancer Society estimates that about 106,590 new cases of colon cancer and about 46,220 cases of rectal cancer will be diagnosed in 2024.

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Is suicide contagious? Mental health experts warn of very real risk

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Is suicide contagious? Mental health experts warn of very real risk

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This story discusses suicide. If you or someone you know is having thoughts of suicide, please contact the Suicide & Crisis Lifeline at 988 or 1-800-273-TALK (8255).

Suicide is a leading cause of death in the U.S., with more than 49,000 people taking their own lives in 2022, according to the Centers for Disease Control and Prevention (CDC).

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Although most suicides stem from mental health disorders, statistics show that the behavior can sometimes be “contagious,” leading to “suicide clusters.”

Suicide clusters are defined as “a group of suicides or suicide attempts that occur closer together in time, space or both than would normally be expected in a community,” the CDC states.

ON WORLD SUICIDE PREVENTION DAY, NEW REPORT IDENTIFIES THREE TOP FACTORS DRIVING SUICIDE RATES

Dr. Caroline Fenkel, a licensed clinical social worker in Pennsylvania, who is an expert in suicide prevention, confirmed that the act can have a contagion effect — particularly among young people.

Although most suicides stem from mental health disorders, statistics show that the behavior can sometimes be “contagious,” leading to “suicide clusters.” (iStock)

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“When individuals hear about a suicide, especially someone close to their age or in their community, it can feel more accessible as an option in moments of distress,” she told Fox News Digital. 

“The more the details are shared, especially in sensational ways, the greater the risk.”

Up to 5% of youth suicides can be attributed to contagion, according to Jennifer Kelman, a licensed clinical care social worker in Florida who works with JustAnswer, an expert help on-demand platform.

AMERICAN VETERANS WHO COMMIT SUICIDE ARE 95% MALE, CRISIS OFTEN DRIVEN BY FAMILY DISPUTES, SAY EXPERTS

“It doesn’t necessarily increase for everyone in that community, but rather for those who are struggling as well — with depression, anxiety and other feelings that may be overwhelming,” she told Fox News Digital. 

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5 possible reasons for suicide contagion

Dr. Deborah Gilman, owner and chief licensed psychologist at Fox Chapel Psychological Services in Pennsylvania, shared the following four factors that could contribute to suicide clusters. 

1. Normalization

When people hear about suicides, it can normalize the idea of using it as a way to deal with problems, according to Gilman.

Support group

Experts encourage people to talk openly and compassionately about mental health to help reduce the stigma. (iStock)

“People often look to others for cues on how to behave,” she told Fox News Digital. 

“If they see that many others are choosing suicide, they may believe that it is the socially acceptable or ‘correct’ thing to do.”

2. Copying or modeling

“Some individuals may feel a sense of connection or empathy with the person who died and may imitate their actions,” Gilman said.

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“In close-knit communities, schools or social groups, the suicide of one member can lead to others in the same environment feeling similar distress or engaging in similar behaviors.”

“The more the details are shared, especially in sensational ways, the greater the risk.”

Some individuals may imitate the behavior of someone who has died by suicide, especially if they are already struggling with their own mental health, she said. 

“This can be due to a sense of hopelessness or a desire to escape their own pain.”

3. Social proof

People may believe that if others are choosing suicide, it must be a valid option for them as well, according to Gilman. 

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“From social learning theory, if the observed behavior — in this case, suicide — is seen as a positive outcome or a solution to problems, it may be reinforced and more likely to be imitated.”

‘SLEEP DISORDER DROVE MY SON TO SUICIDE,’ NEW YORK MOTHER SAYS: ‘BROKE MY HEART’

This risk can escalate when a celebrity or widely admired person dies by suicide, she added, as it can have a disproportionate impact on those who look up to that individual.

4. Vulnerability

“Individuals who are already struggling with mental health issues — especially depression and anxiety — may be more likely to experience suicidal thoughts or behaviors,” Gilman warned. 

Those experiencing difficult life circumstances — such as job loss, divorce or financial struggles — may be more susceptible, she added.

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Sad woman

“Pulling away from friends, family or support groups can indicate that the survivor is struggling more than they can manage on their own,” a mental health expert warned. (iStock)

5. Recency bias

“People tend to overestimate the likelihood of events that are easily recalled,” Gilman said. 

“If a recent suicide has been widely publicized, it may make the idea of suicide more accessible and salient in people’s minds.”

6 warning signs among survivors

For those impacted by suicide, experts agreed that it’s important to watch for signs of deep distress, including the following.

1. Increased suicidal thoughts

“Experiencing recurring or intensifying thoughts of suicide is a critical warning sign that immediate professional help is necessary,” Gilman advised. 

“For instance, the survivor may start having more frequent thoughts about ending their own life or making plans for it.”

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They may also express feelings of being overwhelmed to the point where they believe suicide is the only option, she said.

2. Feelings of being a burden

People saying they feel like a burden is a “major red flag,” according to Thomas Banta, a clinical mental health counselor in Jeffersonville, Indiana.

“Many people who try to end their lives feel they are doing the people around them a favor,” he told Fox News Digital.

“When we hear that type of language, intervention is essential.”

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3. Inability to cope with daily life

“Difficulty managing daily responsibilities or activities can indicate that the emotional burden is too great to handle without professional support,” Gilman said. 

grieving woman supported by man

“It’s crucial to highlight help and hope, encouraging those who are struggling to seek support,” a mental health expert said. (iStock)

The survivor may struggle to maintain a job, manage household duties or care for themselves due to their emotional state.

4. Risky behaviors

Engaging in unsafe or self-harming actions is a serious sign that mental health treatment is needed, experts agree.

“For example, the survivor may start harming themselves physically, such as cutting or burning, as a means of dealing with their emotional pain,” said Gilman.

“Many people who try to end their lives feel they are doing the people around them a favor.”

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“Or they may engage in dangerous activities, like reckless driving, promiscuous sex or substance abuse, which puts their health and safety at risk.”

5. Severe mood or behavior changes 

Significant changes in behavior or mood that affect a survivor’s ability to function in everyday life can be a sign that they need help, according to Gilman.

This might involve the survivor becoming unusually aggressive, withdrawn or apathetic, or displaying behavior that is significantly different from their “normal” demeanor.

Split image of man holding joint and two people drinking liquor

Participating in unsafe or self-harming actions is a serious sign that mental health treatment is needed, experts agree. (iStock)

6. Withdrawal from support systems

“Pulling away from friends, family or support groups can indicate that the survivor is struggling more than they can manage on their own,” Gilman warned. 

The person might avoid social interactions, decline invitations or isolate themselves from people who usually offer support.

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The signs aren’t always obvious, however, Banta noted.

“We also see the opposite end of the spectrum, where somebody will make a plan, and their mood lifts because they feel like they have found an escape,” he said.

Preventing contagion after a suicide

Experts offered the following tips to help reduce the risk of “clusters” following a suicide.

1. Use careful communication

“It’s important to be cautious about how we discuss suicide publicly,” Fenkel said.

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“Reaching out for support is a sign of strength, not weakness.”

The best way to prevent contagion is through responsible communication, she advised.

“This includes limiting the specifics around the method of suicide and focusing on the impact of the loss,” she said. 

2. Offer support

Offering access to crisis resources can help vulnerable individuals feel connected and supported, Fenkel said.

Parent with teen

The best way to prevent contagion is through responsible communication, an expert advised. “This includes limiting the specifics around the method of suicide and focusing on the impact of the loss.” (iStock)

“It’s crucial to highlight help and hope, encouraging those who are struggling to seek support,” she said, noting that many schools and communities provide mental health services to help those who are grieving.

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Banta agreed, noting that intervention and higher levels of care can stabilize people and help them develop a robust support system. 

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“In terms of public health communication, we must let people know that treatment works and that there is effective help out there,” he said. 

3. Stop the stigma

“Stigma can lead to feelings of isolation and loneliness, which can contribute to suicidal ideation,” Gilman warned.

When people feel comfortable discussing their mental health concerns without fear of judgment, they are more likely to seek help from professionals, she noted. 

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Holding hands

“I have worked with many people who felt hopeless and that their lives would never improve, but then they did,” a therapist told Fox News Digital. (iStock)

Fenkel agreed, encouraging people to talk openly and compassionately about mental health.

“Anyone experiencing thoughts of suicide should know that there is help available, and reaching out for support is a sign of strength, not weakness,” she said.

Suicide is a “fleeting state of mind,” Banta pointed out. 

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“I have worked with many people who felt hopeless and that their lives would never improve, but then they did,” he said.

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“So if you are struggling and reading this, there is help. Don’t give up.”

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Superbugs due to antibiotic resistance could kill 39 million people by 2050, large study finds

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Superbugs due to antibiotic resistance could kill 39 million people by 2050, large study finds

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Resistance to antibiotics has led to one million worldwide deaths each year since 1990, for a total of 36 million.

It is expected to cause more than 39 million more fatalities by 2050 — three per minute.

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That’s according to a large study led by the Global Research on Antimicrobial Resistance (GRAM) Project, a partnership between the University of Oxford and the Institute for Health Metrics and Evaluation (IHME) at the University of Washington.

NEW ANTIBIOTIC KILLS DEADLY, DRUG-RESISTANT BACTERIA IN ‘SCIENTIFIC BREAKTHROUGH’

After analyzing 520 million health records, the researchers provided future estimates for 22 pathogens, 84 pathogen-drug combinations and 11 infectious syndromes across 204 countries and territories, according to a GRAM press release. 

Resistance to antibiotics has led to one million worldwide deaths each year since 1990, for a total of 36 million. (iStock)

Findings from the study were published in The Lancet on Monday.

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What is antimicrobial resistance?

Antimicrobial resistance (AMR) occurs when bacteria and other types of germs become stronger than the medications given to treat them, creating so-called “superbugs.” 

This can make infections difficult or impossible to treat, per the U.S. Centers for Disease Control and Prevention (CDC).

WHY ANTIBIOTICS MAY NOT HELP PATIENTS SURVIVE THEIR VIRAL INFECTIONS: NEW RESEARCH

“In modern medicine, the use of antibiotics has allowed us to successfully perform organ transplants, complex surgical procedures and care for extremely preterm infants,” Jasmine Riviere Marcelin, MD, a fellow of the Infectious Diseases Society of America and infectious diseases professor at the University of Nebraska — who was not involved in the study — told Fox News Digital.

“These interventions have been successful because antibiotics have allowed us to prevent and treat infections in these critically ill patients.”

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Taking antibiotics

Antimicrobial resistance occurs when bacteria and other types of germs become stronger than the medications given to treat them, creating so-called “superbugs.”  (iStock)

Now, antibiotic-resistant bacteria pose a “significant health risk,” she warned, because they prevent the ability to treat or prevent infections. 

“Not only will our advancements in medicine be at risk, but we may find ourselves back to where we were in the pre-antibiotic era, when mortality from simple skin/soft tissue infections was significant,” Marcelin added.

“We may find ourselves back to where we were in the pre-antibiotic era.”

Maureen Tierney, MD, associate dean of clinical research and public health at Creighton University School of Medicine in Omaha, Nebraska, was also not involved in the study, but confirmed that it is “the most comprehensive attempt to determine the burden of antimicrobial resistance [in terms of] disability and death.” 

“This was an enormous effort using all different sources of data in countries around the world to estimate the number of deaths caused by microorganisms resistant to several types of antibiotics,” she told Fox News Digital.

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Marking key shifts

Since 1990, the infection that caused the biggest increase was MRSA (methicillin-resistant S. aureus), a type of staph bacteria that has become resistant to some antibiotics. 

Annual MRSA-related deaths increased from 57,200 in 1990 to 130,000 in 2021, the study found.

Despite the overall increase in AMR-related mortality, deaths among kids younger than 5 were cut in half between 1990 and 2021.

Staph bacteria

Since 1990, the infection that caused the biggest increase was MRSA (methicillin-resistant S. aureus), a type of staph bacteria that has become resistant to some antibiotics. (iStock)

The researchers attributed this to childhood vaccination programs and wider access to drinking water, sanitation and hygiene practices.

The sharpest increase was among adults 70 and older, who saw a more than 80% uptick in AMR deaths.

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“Researchers expect these trends to continue in the coming decades, with AMR deaths among children under 5 projected to halve by 2050 globally, as deaths among people 70 years and older more than double,” the press release stated.

Geographically, deaths rose the most in western sub-Saharan Africa, tropical Latin America, high-income North America, Southeast Asia and South Asia.

Combating antimicrobial resistance

Next week, global health leaders plan to meet at the UN General Assembly in New York to discuss new strategies for addressing AMR.

Potential interventions include “infection prevention and control measures, such as new vaccines and antimicrobials, and improved access to water and sanitation — as well as deeper investments across health systems in diagnostics, training and new technologies,” the release stated.

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kid getting vaccinated

“The most important ways to decrease the incidence of antibiotic resistance are vaccination for pneumonia, influenza, COVID, measles and other diseases,” an infectious diseases expert told Fox News Digital. (Jeff Kowalsky/AFP via Getty Images))

“The most important ways to decrease the incidence of antibiotic resistance are vaccination for pneumonia, influenza, COVID, measles and other diseases,” Tierney from Creighton University told Fox News Digital. 

   

Tierney also calls for “antimicrobial stewardship” – which she defines as “the judicious use of antibiotics in humans, animals and farming” – as well as infection prevention practices, especially in health care facilities, and the development of new antibiotics.

“Antibiotics are a shared natural resource that we must all protect.”

While creating new drugs is one way to combat AMR, Marcelin warned that relying only on drug discovery would be “futile,” given the length of time it takes for new medications to be developed, tested and approved.

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“The number of new or repurposed antibiotics in late-stage clinical development is very small, and no single antibiotic candidate claims to have activity against those bacteria resistant to all currently available drugs,” she told Fox News Digital. 

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“If we can’t make new drugs easily, we can combat resistance by controlling the spread of resistant organisms, which is the principle of infection control.”

Cropped picture of young woman holding a glass with water and pills in her hands

To prevent resistance, experts say that antibiotics should be prescribed and used “only when they are indicated, for the optimal duration, and at the right timing and dosing regimen.” (iStock)

To prevent resistance, Marcelin agrees that antibiotics should be prescribed and used “only when they are indicated, for the optimal duration, and at the right timing and dosing regimen.”

She added, “Antibiotics are a shared natural resource that we must all protect, so that we can continue to live in a world where we make medical advances and reduce mortality from bacterial infections.”

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Fox News Digital reached out to GRAM researchers requesting comment.

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