Health
Alzheimer’s risk could rise with common condition affecting millions, study finds
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The first study to evaluate the link between Alzheimer’s disease and body weight found a significant association.
Researchers at Washington University Medicine in St. Louis, Missouri, discovered that Alzheimer’s blood biomarkers increased 95% faster in people with obesity than in non-obese individuals.
The study, which was presented Tuesday at the annual meeting of the Radiological Society of North America (RSNA) in Chicago, investigated five years of data from 407 participants from the Alzheimer’s Disease Neuroimaging Initiative, including PET scans (medical imaging) and blood samples.
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The researchers assessed the association between Alzheimer’s biomarkers and body mass index (BMI), according to a press release.
When the participants were first measured, a higher BMI was associated with lower Alzheimer’s blood biomarkers due to blood dilution, since people with higher body weight often have larger blood volume.
Alzheimer’s blood biomarkers increased 95% faster in people with obesity, the study found. (iStock)
But when the researchers followed the same participants over a longer period, they found that those with obesity developed a greater Alzheimer’s disease burden than those without obesity.
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In analyzing how the Alzheimer’s biomarkers matched up with PET scan results, they noted a buildup of amyloid plaques in the brain — a central hallmark of the most common type of dementia.
PET scans reveal a buildup of amyloid plaques in the brain – a “central hallmark” of Alzheimer’s. (iStock)
In an interview with Fox News Digital, the study authors discussed the impact of these findings.
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“Our study shows that over a five-year period, obesity is associated with a steady increase in Alzheimer’s-related pathology,” said lead author Dr. Soheil Mohammadi, a post-doctoral research associate at the Mallinckrodt Institute of Radiology, part of WashU Medicine.
“What surprised me was how sensitive the blood biomarkers were in detecting this relationship. They captured subtle changes even better than brain imaging.”
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Senior study author Dr. Cyrus Raji, associate professor of radiology and neurology at Washington University, noted that the progression of Alzheimer’s is “influenced by pathologies happening overall in the body, such as obesity.”
“It is critical to preserve brain health by optimizing body health as well,” he said.
“It is critical to preserve brain health by optimizing body health as well,” the lead researcher said. (iStock)
Recent clinical trials (EVOKE and EVOKE+) have explored whether GLP-1 drugs such as semaglutide (Ozempic) could slow cognitive decline in people already diagnosed with early Alzheimer’s disease.
“While the recent Evoke trials failed to show an effect of Ozempic for the treatment of Alzheimer’s dementia, our work should motivate future trials to determine if this class of drugs can help prevent Alzheimer’s by treating obesity earlier in life,” Raji said. “Caretakers and clinicians are key partners in making such trials happen.”
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One limitation of this research, according to Mohammadi, is the fact that not all body fat carries the risk of Alzheimer’s disease.
“Our prior work shows that belly fat, rather than fat under the skin, drives much of obesity’s impact on the brain,” he said. “Future studies should distinguish between these fat types instead of treating obesity as a single category.”
“Our prior work shows that belly fat, rather than fat under the skin, drives much of obesity’s impact on the brain.”
Fox News senior medical analyst Dr. Marc Siegel, who was not involved in the research, said he considers this a “very important study.”
“I think this finding makes complete sense, because obesity leads directly to inflammation and insulin resistance, which provoke neuro inflammation — one of the pillars of Alzheimer’s development,” he told Fox News Digital.
Other risk factors that often coincide with obesity — such as diabetes, hypertension and inflammation — may also contribute to Alzheimer’s biomarker changes. (iStock)
The study did have some limitations, the researchers noted.
The study sample was relatively small and specific, and may not represent the general population. Also, the BMI measurement can’t distinguish between fat and muscle mass or reflect differences in fat distribution that may influence Alzheimer’s risk.
The study also relies on observational data, which can reveal associations but can’t prove that obesity directly causes faster Alzheimer’s pathology, the researchers noted.
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Other risk factors that often coincide with obesity — such as diabetes, hypertension and inflammation — may also contribute to Alzheimer’s biomarker changes.
This initial research sparks the need for larger studies in more diverse populations with longer follow-ups.
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A former Ironman triathlete was stunned to learn that his vision problems were actually the first sign of stage 4 lung cancer.
Dave Nitsche, 57, was initially given just 12 to 24 months to live – but a newly approved drug has helped him surpass that timeframe by several years.
“In 2019, I noticed that I was having trouble seeing with my left eye,” the Canadian man shared during an interview with Fox News Digital. “I went to the optometrist, and they said it was probably a detached retina.”
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After scans revealed fluid buildup and rising pressure, doctors determined that Nitsche had lost vision in the eye — and ultimately removed it. A biopsy of the fluid revealed that it was cancerous.
Next, Nitsche saw more specialists, who extracted fluid from his lungs for more testing. “The next day, the oncologist told me that I had stage 4 lung cancer,” he said.
Dave Nitsche, pictured in Calgary, Alberta in 2025, was stunned to learn that his vision problems were actually the first sign of stage 4 lung cancer. (Dave Nitsche)
Nitsche said his doctors were “very shocked” to find that his initial eye issues had stemmed from lung cancer – particularly because he had never been a smoker.
Azam J. Farooqui, M.D., a hematology and oncology physician at Ironwood Cancer & Research Centers in Chandler, Arizona, agreed that Nitsche’s case was “very surprising.”
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“Cancer can find its way to some very odd locations, but the eye is a very, very rare one,” Farooqui, who did not treat Nitsche, told Fox News Digital. “Usually cancer will get there via a nerve channel or blood vessel, but it’s very uncommon.”
Nitsche, an ex-triathlete who has done multiple Ironman races, hadn’t experienced any other symptoms other than the eye issues. “I was running quite a bit at the time,” he shared. “I had a little bit of back pain here and there, but lung cancer definitely wasn’t on my radar.”
Nitsche, an ex-triathlete who has done multiple Ironman races, hadn’t experienced any other symptoms other than the eye issues. “I had a little bit of back pain here and there, but lung cancer definitely wasn’t on my radar.” (Dave Nitsche)
His first treatment was a targeted therapy called afatinib, which lasted about three months. When doctors found that the cancer had spread to Nitsche’s brain, he began taking another medication called Tagrisso (osimertinib), which crosses the blood-brain barrier.
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After six years, when those drugs stopped working, Nitsche started taking Rybrevant (amivantamab), a chemo-free drug that he receives via IV infusion every three weeks in a supervised medical setting. After a year on the drug, which is developed by Johnson & Johnson, his scans are looking “very, very good,” he said.
“There are days that you feel strong and there are days that you’re a little weaker, but you just adjust accordingly.”
“Science is catching up to me perfectly with all these drugs that I’m on,” Nitsche said. “Now, we’ll just wait for the next thing to come along, and we’ll jump onto that. But for now, the Rybrevant is working perfectly.”
Nitsche has experienced a few side effects, but said for the most part, the drug he is taking is “very tolerable.” (Dave Nitsche)
Nitsche has experienced a few side effects, primarily skin irritation and fingernail infections, but said for the most part, the drug is “very tolerable.”
Compared to the full-dose chemo and other lung cancer treatments, Farooqui agreed that Rybrevant is “very manageable.”
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Other common side effects can include infusion reactions, muscle and joint pain, mouth sores, swelling, fatigue, nausea, bowel changes, vomiting, cough, shortness of breath and low appetite, according to FDA prescribing information.
In rare cases, serious effects can include lung inflammation, blood clots, severe skin reactions and eye problems. Pregnant women should not take the drug due to fetal risks.
Embracing his role as an advocate, Nitsche now speaks openly about his experience and what others should know. (Dave Nitsche)
“If somebody is having too many side effects, or if it is feeling too aggressive, we can do dose reductions,” Farooqui noted. “In my experience, we’ve had patients do really well on it, and we’ve been able to manage their side effects without any major concerns.”
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Rybrevant has now been approved to treat certain types of non-small cell lung cancer in the U.S. and Canada, and Nitsche said a few of his friends are also taking the drug.
“Doctors gave me a year to two years – they told me to get my affairs in order. And it’s been seven years now,” he said. “I’ll take it.”
“For almost any type of cancer, a diagnosis is not a death sentence.”
Nitsche is now preparing for a 600-mile biking expedition in June to raise awareness for lung cancer. He credits his endurance training and high fitness level with helping to extend his survival.
“There are days that you feel strong and there are days that you’re a little weaker, but you just adjust accordingly,” he said.
Rybrevant has now been approved to treat certain types of non-small cell lung cancer in the U.S. and Canada. (iStock)
Embracing his role as an advocate, Nitsche now speaks openly about his experience and what others should know.
“If you have lungs, you can get lung cancer – but at this point, for almost any type of cancer, a diagnosis is not a death sentence,” he said. “They’re doing so much research on it, especially with lung cancer… I’ve known people who have lasted 12 to 18 years, so for me, seven years is great. So I’ll just keep going.”
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Farooqui echoed the importance of patients “advocating for themselves and getting the most up-to-date therapy there is.”
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At 75, Jane Seymour isn’t fighting the years under her belt — she’s leaning into them. The former Bond girl in “Live and Let Die” and star of “Dr. Quinn, Medicine Woman” has a simple outlook on aging: She’s just grateful for the opportunity.
Her perspective shifted radically in her 40s after a near-death experience involving anaphylactic shock, according to an interview the actress did with Women’s Health.
“I remember looking at my body from above and thinking, ‘That’s your vehicle. I am responsible for taking care of this car,’” Seymour recalled.
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The actress shared the following four key habits she uses to navigate her 70s with vitality.
1. Embrace a positive attitude
Seymour’s perspective shifted in her 40s after a near-death experience involving anaphylactic shock, she told Women’s Health. (Michael Loccisano/Getty Images for Elton John AIDS Foundation)
For Seymour, the mental game of aging is just as important as the physical. She said she approaches every day with a sense of optimism, which she describes as “getting up and not giving up.”
In a recent interview with Future of Personal Health, Seymour said that being depressed over lost youth is “redundant.” Instead of mourning the past, she embraces the present.
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“You were 20, and you had whatever that experience was,” she said. “Now, maybe you’re 70, and it’s a whole new world.”
2. Know your body
Seymour’s fitness routine is built on consistency rather than intensity, she shared. The actress aims to work out at least three times a week, but refuses to push herself to the point of injury.
“You were 20, and you had whatever that experience was,” she said. “Now, maybe you’re 70, and it’s a whole new world.” (Jane Seymour/Instagram)
“I listen to my body,” she told Women’s Health. “I’m not going to overdo it.”
Seymour’s workouts focus on strengthening her core, arms and legs. While her preference is the reformer (a Pilates machine), she is highly adaptable.
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When traveling without workout equipment, Seymour said she performs bodyweight exercises, even doing incline press-ups against a kitchen counter.
“I’m not going to pretend I’m 20 when I’m 70,” she said. “I’m going to be the best I can be at the age I am.”
3. Nourish your body
Rather than fighting the natural signs of a life well-lived, Seymour said she views her appearance as a professional asset.
Seymour focuses on a rigorous skincare and nutritional routine to maintain the “vehicle” she was given, she said. (Emma Mcintyre/Getty Images)
“I’m not chasing wrinkles,” she added. “My laugh lines and even my frown lines are useful in my work – they’re part of my toolkit.”
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The actress said she focuses on a rigorous skincare and nutritional routine to maintain the “vehicle” she was given.
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This includes a daily regimen of exfoliation and hydration, alongside a diet rich in fruits and vegetables.
“I’m going to be the best I can be at the age I am.”
When her filming schedule makes fresh meals difficult, Seymour supplements with antioxidant blends to ensure there are “no nutritional gaps,” aiming for a holistic balance that allows her to “think sharper and move stronger.”
4. Nourish your mind
Perhaps the most profound tool in Seymour’s toolkit, she said, is her commitment to purpose. Inspired by her mother, a survivor of WWII concentration camps, Seymour believes that longevity is tied to how much one gives back to the world.
Seymour, inspired by her mother, a survivor of WWII concentration camps, created Open Hearts Foundation to give back to the community. (Jane Seymour/Instagram)
“My mother always said there’s someone worse off than you, and you can find purpose by helping others – listening and making them feel heard,” she shared.
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This philosophy led Seymour to found the Open Hearts Foundation, a nonprofit that empowers others through grant-making and volunteerism.
“That’s the best way to end the day — knowing it wasn’t wasted.”
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