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Murine Study Uncovers Novel Way CBD Reduces Seizures

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Murine Study Uncovers Novel Way CBD Reduces Seizures

Researchers of a brand new murine research have uncovered a novel mechanism through which cannabidiol (CBD) decreases seizures.

Though earlier knowledge have proven that CBD reduces seizures throughout a number of pediatric epilepsy syndromes, the best way through which the hashish part reduces seizures has remained unclear. The present research, which reveals that CBD blocked indicators carried by the molecule lysophosphatidylinositol (LPI) in neurons, gives new insights into these mechanisms.

Findings revealed lately in Neuron.1

“Our outcomes deepen the sector’s understanding of a central seizure-inducing mechanism, with many implications for the pursuit of latest therapy approaches,” mentioned corresponding writer Richard W. Tsien, PhD, chair of the Division of Physiology and Neuroscience at NYU Langone Well being, in a press launch. “The research additionally clarified, not simply how CBD counters seizures, however extra broadly how circuits are balanced within the mind. Associated imbalances are current in autism and schizophrenia, so the paper might have a broader influence.”2

Utilizing a number of murine fashions, the researchers confirmed earlier analysis on the pro-excitatory influence of LPI, exhibiting that CBD blocks the power of LPI to amplify nerve indicators within the hippocampus by binding to the G-coupled receptor 55 (GPR55) protein, which may promote seizures.

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The findings additionally, for the primary time, present that LPI has an influence on the inhibitory synapses, weakening the indicators that counter seizures. By engineering the mice to be absent of GPR55 or treating them with plant-derived CBD forward of seizure-inducing stimuli, the researchers had been in a position to block LPI’s capacity of excitatory and inhibitory synaptic transmission.

The findings provide a “loop” principle that nerve sign amplification from LPI weakens the indicators that counter seizures, doubtlessly growing the chance of extra seizures, which in flip will increase ranges of LPI and GPR55.

The signaling community that LPI belongs to additionally consists of 2-arachidonoylglycerol (2-AG) and different endocannibinoids that happen naturally in human tissue, which may be regulated by CBD. Nevertheless, defined the researchers, they’ve completely different actions on the synapse.

“Theoretically, the mind may management exercise by toggling between pro-excitatory LPI and the restorative actions of 2-AG,” mentioned first research writer Evan Rosenberg, PhD, a postdoctoral scholar within the Tsien lab, within the press launch. “Drug designers may inhibit the enzymes that underpin LPI manufacturing or promote its conversion to 2-AG, as a further strategy to manage seizures. LPI may additionally function a biomarker of seizures or predictor of scientific responsiveness to CBD, offering an space of future analysis.”

References

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1. Rosenberg E, Chamberland S, Bazelot M, et al. Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity. Neuron. Revealed on-line February 13, 2023. doi:10.1016/j.neuron.2023.01.018

2. Examine reveals how cannabidiol counters epileptic seizures. Information launch. NYU Langone Well being. February 13, 2023. Accessed April 12, 2023. https://nyulangone.org/information/study-reveals-how-cannabidiol-counters-epileptic-seizures

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What makes walking so great for your health and what else you need to do

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What makes walking so great for your health and what else you need to do

Members of the Get Healthy Walking Club walk the paths past the animal enclosures during the morning at the Louisville Zoo in Louisville, Ky.
AP

LOUISVILLE, Ky. — Janet Rapp strode briskly down a paved path through the city zoo, waving at friends and stopping briefly to greet emus she knows by name.

The 71-year-old retiree starts each morning this way with a walking club.

“I’m obsessed,” she said. Not only does it ease her joint pain, “it just gives me energy … And then it calms me, too.”

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Medical experts agree that walking is an easy way to improve physical and mental health, bolster fitness and prevent disease. While it’s not the only sort of exercise people should do, it’s a great first step toward a healthy life.

“You don’t need equipment and you don’t need a gym membership,” said Dr. Sarah Eby, a sports medicine physician with Mass General Brigham. “And the benefits are so vast.”

What can walking do for you?

Walking can help meet the U.S. surgeon general’s recommendation that adults get at least 2½ hours of moderate-intensity physical activity every week. This helps lower the risk of heart disease, high blood pressure, dementia, depression and many types of cancer.

Janet Rapp, a member of the Get Healthy Walking Club stands in front of the zebra enclosure during the early morning at the Louisville Zoo.
AP

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Walking also improves blood sugar levels, is good for bone health and can help you lose weight and sleep better, added Julie Schmied, a nurse practitioner with Norton Healthcare, which runs the free Get Healthy Walking Club.

Another advantage? It’s a low-impact exercise that puts less pressure on joints as it strengthens your heart and lungs.

James Blankenship, 68, said joining the walking club at the Louisville Zoo last year helped him bounce back after a heart attack and triple bypass in 2022.

“My cardiologist says I’m doing great,” he said.

For all its benefits, however, walking “is not enough for overall health and well-being” because it doesn’t provide resistance training that builds muscle strength and endurance, said Anita Gust, who teaches exercise science at the University of Minnesota Crookston.

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That’s especially important for women’s bone health as they age.

Experts recommend adding such activities at least twice weekly – using weights, gym equipment or your own body as resistance — and doing exercises that improve flexibility like yoga or stretching.

Do you really need 10,000 steps a day?

Nearly everyone has heard about this walking goal, which dates back to a 1960s marketing campaign in Japan. But experts stress that it’s just a guideline.

The average American walks about 3,000 to 4,000 steps a day and it’s fine to gradually work up to 10,000, Shmied said.

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Setting a time goal can also be useful. Shmied suggests breaking the recommended 150 minutes per week into 30 minutes a day, or 10 minutes three times a day, for five days. During inclement weather, people can walk in malls or on treadmills.

As they become seasoned walkers, they can speed up the pace or challenge themselves with hills while still keeping the activity level moderate.

“If you can talk but not sing,” Eby said, “that’s what we consider moderate-intensity exercise.”

How do you stay motivated?

Walking with friends – including dogs – is one way.

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Walking clubs have popped up across the nation. In 2022, New York personal trainer Brianna Joye Kohn, 31, started City Girls Who Walk with a TikTok post inviting others to walk with her.

“We had 250 girls show up,” she said.

From left, Lou Ann Parrino, Lisa Weisert, and Janie Reinert, members of the Get Healthy Walking Club pause during their morning walk to say good morning to one of the animals at the Louisville Zoo in Louisville, Ky.
AP

Since then, the group has walked every Sunday for around 40 minutes, with some meeting afterward for brunch or coffee.

The Louisville Zoo launched its walking club in 1987, partnered with Norton in 2004 to expand it, and now boasts more than 15,000 registered members. Every day from March 1 through Oct. 31, people walk around and around the 1.4-mile loop before the zoo officially opens.

Tony Weiter meets two of his siblings every Friday. On a recent morning, they caught up on each other’s lives as they zipped past zebras in a fenced field and a seal sunning itself.

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“I enjoy the serenity of it. It’s cold but the sun is shining. You get to see the animals,” said Weiter, 63. “It’s a great way to start the morning.”

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Bored of Walking? Get Lean With These 5 Strength Exercises Instead

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Bored of Walking? Get Lean With These 5 Strength Exercises Instead

Whether you’re bored of the same old walking routine or want to boost your fitness, strength training is the name of the game. While walking is excellent at torching calories, strength training offers benefits beyond burning calories in the moment. That’s why we spoke with a fitness pro who outlines the best strength exercises to get lean when you’re tired of walking.

“With strength training, you’re not only burning calories during the workout, but you’re also building lean muscle. This added muscle mass increases your metabolism, allowing you to burn more calories even at rest,” explains Stan Kravchenko, celebrity coach and founder of OneFit.com. “Your body will naturally expend more energy to maintain muscle mass, which supports weight loss and overall health over the long term.”

Similar to walking, strength exercises benefit your cardiovascular fitness, but they provide substantial advantages for bone density, muscles, and injury prevention as well. “Building muscle mass promotes longevity and better supports your joints, ligaments, and tendons as you age,” Kravchenko adds. “If your goal is to lose weight and build lean muscle, strength training is an effective path.”

That being said, you don’t have to choose one form of exercise over the other. A well-rounded workout routine should include both! Kravchenko recommends performing strength training on one day and utilizing walking as an active recovery exercise on another.

Below are five excellent strength exercises to get lean that are perfect for your upper body, core, and lower body. “Performing these exercises consistently will help you build strength, improve body composition, and support other health benefits, such as increased muscle size, enhanced bone density, reduced body fat, and more,” says Kravchenko.

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Goblet Squat

trainer doing goblet squat
Stan Kravchenko

The goblet squat is a great choice to target your core and lower body, firing up your hamstrings, quads, glutes, and core muscles. “The goblet squat is suitable for everyone, from beginners to those with more experience, as it helps keep the torso upright, making it a safe and effective option for building lower-body strength,” Kravchenko tells us.

  1. Stand tall, feet hip-width apart, holding a dumbbell with both hands like a goblet at your chest.
  2. Lower into a squat, keeping your chest tall and back straight.
  3. Once your thighs are parallel to the ground, press through your heels to stand up tall.
  4. Complete 3 sets of 8-12 reps.

Here’s How Much You Need To Strength Train Depending on Your Goals

Pulldown

lat pulldownlat pulldown
Stan Kravchenko

“This exercise is ideal for working on your pulling motion and strengthening your back muscles,” explains Kravchenko. “The seated cable pulldown allows you to perform the exercise safely and effectively, with good control over each repetition.”

  1. Sit at a lat pulldown machine with your knees secured under the pad and feet firmly planted on the ground.
  2. Grab the handle and pull it down to your upper chest.
  3. Use control to return to the start position.
  4. Complete 3 sets of 10-12 reps.

How To Combine Incline Walking & Strength Training for Faster Weight Loss

Dumbbell Chest Press

dumbbell chest pressdumbbell chest press
Stan Kravchenko

“The dumbbell chest press is a great exercise for pushing movements, targeting the chest, triceps, and front shoulder muscles,” Kravchenko points out. “Unlike machines or barbells, dumbbells offer more freedom of movement, which is often safer for shoulder joints.”

  1. Lie flat on your back on a workout bench with a dumbbell in each hand and arms extended over your chest.
  2. Lower the dumbbells toward your chest until your elbows reach a 90-degree angle.
  3. Press the weights back up.
  4. Perform 3 sets of 10-12 reps.

The #1 Daily Walking Workout To Slim Down

Single-Leg Press

single-leg presssingle-leg press
Stan Kravchenko

“This exercise allows you to work each side of your body individually, helping to balance any strength differences between your legs,” says Kravchenko. “The single-leg press prevents one side from compensating for the other, making it especially beneficial if you have one leg that is more dominant. Similar to a unilateral dumbbell chest press for the upper body, this exercise targets your glutes and legs effectively.”

  1. Sit at a leg press machine with one foot on the platform.
  2. Press the weight away from your body.
  3. Lower the weight using control.
  4. Switch legs after completing each set.
  5. Perform 3 sets of 8-10 reps for each leg.

10 Ways to Turbocharge Your Weight Loss With Brisk Walking

Pallof Press with Rotation

pallof press with rotationpallof press with rotation
Stan Kravchenko

“This is a fantastic core exercise, chosen specifically because it introduces a rotational movement,” Kravchenko explains. “Unlike the previous exercises, which all operate in the sagittal plane, the Pallof press with rotation works in the transverse plane, challenging your core and obliques in a different way.”

  1. Attach a resistance band or cable at chest level.
  2. Stand tall, perpendicular to the anchor point, holding onto the handle with both hands.
  3. Press the handle away from your body and slowly rotate your torso toward the anchor point, activating your core muscles.
  4. Return to the start position.
  5. Perform 3 sets of 12-15 reps per side.

Alexa Mellardo

Alexa is the Mind + Body Deputy Editor of Eat This, Not That!, overseeing the M+B channel and delivering compelling fitness, wellness, and self-care topics to readers. Read more about Alexa

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Fitness: Is mindfulness the key to a more enjoyable workout?

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Fitness: Is mindfulness the key to a more enjoyable workout?

If exercise pushes you so far outside your comfort zone that physical activity is associated with pain more than pleasure, there’s little motivation to get off the couch.

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There’s no shortage of rumination about why more than half of Canadians don’t meet the recommended 150 minutes of moderate to vigorous physical activity per week. Lack of time is a common excuse, but there are plenty of busy people who exercise regularly. Access is another often-stated barrier, though most Canadians can safely exercise outdoors or in the privacy of their own home should other fitness facilities not be within an easy commute.

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What’s often ignored is the role enjoyment plays in exercise adherence. For those who revel in a tough workout, the idea some people hate to sweat may seem strange. But if exercise pushes you so far outside your comfort zone that physical activity is associated with pain more than pleasure, there’s little motivation to get off the couch.

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Once exercise becomes coupled with discomfort, getting reluctant exercisers to find pleasure and enjoyment in physical activity is an uphill battle. To help improve its appeal, researchers have been looking at the effectiveness of something called “extrinsic strategies” to promote better exercise adherence.  Defined as “environmental manipulations of the exercise experience that fall outside of the FITT principles,” extrinsic strategies are more about the mental, rather than physical aspects of exercise. In short, the focus is less about the frequency, intensity, time and type of exercise, and more about the role feelings play in the adoption of a regular workout routine.

To be clear, we’re not talking about taking the effort out of exercise. Extrinsic strategies work on altering the perception of effort. Even more granular, it’s important to alter how effort is perceived during, not after, a workout. There’s a marked difference in how people feel once they wipe the sweat off their brow compared to when they’re grinding it out just hoping to finish. And while some people use the feeling of accomplishment that comes after a tough workout to motivate their return to the gym, others can’t get past the memory of how uncomfortable it felt in the moment.

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One of the extrinsic strategies to improving the exercise experience is focusing on external stimuli instead of how the body feels. Music is a popular distraction, which is why so many exercisers listen to their favourite playlists. Another option is exercising outdoors where nature works its magic at diverting exercisers from the internal sensations of effort. Exercising with a friend or within a group also helps. But contrary to using external distractions to dampen the effort of exercise, is the novel idea of leaning into how your body feels during a tough workout.

Mindfulness is defined as paying attention to what’s happening in the moment while also being open to how the body responds physically and mentally to the current experience. In other words, instead of trying to disassociate from the feelings of effort, mindfulness aims to accept and acknowledge the exertion it takes to complete a workout.  

The idea that mindfulness is effective at improving exercise adherence is gaining traction, with initial studies suggesting it has merit, but mostly when exercising at lower intensities. Learning to accept and become comfortable with the feelings associated with physical exertion could be a crucial first step in finding pleasure in exercise.

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A recent study published in the Journal of Sports Sciences recently tested the effectiveness of mindfulness in enhancing the exercise experience. The goal of the research team was to see if mindfulness “could prove a useful pleasure enhancing strategy during exercise.”

A test sample of 34 recreationally active men and women were divided into two groups. One group was equipped with a recording taken from Headspace, a popular meditation and mindfulness app, that focused exercisers on tuning into their body and its movement. The control group was without any mindfulness tools.

Both sets of exercisers were asked to follow a 1.5-mile loop through a local park at a self-selected intensity they could sustain for 20-25 minutes. Heart rate was continually monitored, and study subjects were asked to check in with how they felt at two points during the walk (at 0.5 and one mile).

Results indicated listening to a mindfulness recording led to a more pleasurable exercise experience than walking the loop without. That positive response to exercise continued after the workout finished, another sign the mindfulness guided walk produced the kind of enjoyment that could encourage exercisers to walk more often.

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Learning to appreciate the feelings associated with effort is an interesting strategy to introduce, especially to new exercisers who often negatively perceive the physical sensations that occur during a workout. With more practice accepting, instead of tuning out, those feelings, a greater number of novice exercisers could become more tolerant of the effort required to improve overall fitness. It’s also an interesting approach for seasoned exercisers who generally rely on disassociating from the intense feelings of a hard workout.

Acknowledging, accepting and appreciating the effort of being physically active are tools every exerciser can lean into when the going gets tough. More importantly, it could be part an improved strategy to get more Canadians enjoying the 150 minutes a week they spend working up a sweat.

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