Connect with us

Fitness

Murine Study Uncovers Novel Way CBD Reduces Seizures

Published

on

Murine Study Uncovers Novel Way CBD Reduces Seizures

Researchers of a brand new murine research have uncovered a novel mechanism through which cannabidiol (CBD) decreases seizures.

Though earlier knowledge have proven that CBD reduces seizures throughout a number of pediatric epilepsy syndromes, the best way through which the hashish part reduces seizures has remained unclear. The present research, which reveals that CBD blocked indicators carried by the molecule lysophosphatidylinositol (LPI) in neurons, gives new insights into these mechanisms.

Findings revealed lately in Neuron.1

“Our outcomes deepen the sector’s understanding of a central seizure-inducing mechanism, with many implications for the pursuit of latest therapy approaches,” mentioned corresponding writer Richard W. Tsien, PhD, chair of the Division of Physiology and Neuroscience at NYU Langone Well being, in a press launch. “The research additionally clarified, not simply how CBD counters seizures, however extra broadly how circuits are balanced within the mind. Associated imbalances are current in autism and schizophrenia, so the paper might have a broader influence.”2

Utilizing a number of murine fashions, the researchers confirmed earlier analysis on the pro-excitatory influence of LPI, exhibiting that CBD blocks the power of LPI to amplify nerve indicators within the hippocampus by binding to the G-coupled receptor 55 (GPR55) protein, which may promote seizures.

Advertisement

The findings additionally, for the primary time, present that LPI has an influence on the inhibitory synapses, weakening the indicators that counter seizures. By engineering the mice to be absent of GPR55 or treating them with plant-derived CBD forward of seizure-inducing stimuli, the researchers had been in a position to block LPI’s capacity of excitatory and inhibitory synaptic transmission.

The findings provide a “loop” principle that nerve sign amplification from LPI weakens the indicators that counter seizures, doubtlessly growing the chance of extra seizures, which in flip will increase ranges of LPI and GPR55.

The signaling community that LPI belongs to additionally consists of 2-arachidonoylglycerol (2-AG) and different endocannibinoids that happen naturally in human tissue, which may be regulated by CBD. Nevertheless, defined the researchers, they’ve completely different actions on the synapse.

“Theoretically, the mind may management exercise by toggling between pro-excitatory LPI and the restorative actions of 2-AG,” mentioned first research writer Evan Rosenberg, PhD, a postdoctoral scholar within the Tsien lab, within the press launch. “Drug designers may inhibit the enzymes that underpin LPI manufacturing or promote its conversion to 2-AG, as a further strategy to manage seizures. LPI may additionally function a biomarker of seizures or predictor of scientific responsiveness to CBD, offering an space of future analysis.”

References

Advertisement

1. Rosenberg E, Chamberland S, Bazelot M, et al. Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity. Neuron. Revealed on-line February 13, 2023. doi:10.1016/j.neuron.2023.01.018

2. Examine reveals how cannabidiol counters epileptic seizures. Information launch. NYU Langone Well being. February 13, 2023. Accessed April 12, 2023. https://nyulangone.org/information/study-reveals-how-cannabidiol-counters-epileptic-seizures

Continue Reading
Advertisement
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Fitness

No time to exercise? Try this five-minute exercise snack while waiting for the air fryer to ping

Published

on

No time to exercise? Try this five-minute exercise snack while waiting for the air fryer to ping

When you’re busy, exercise is often one of the first things to fall by the wayside. When this happens to you, don’t beat yourself up about it—it happens to us all. Maintaining a positive mindset towards exercise is one of the things that will ensure it’s enjoyable and keep you motivated.

It’s also worth remembering that a little bit of exercise is better than none at all.

Continue Reading

Fitness

Should I get a weighted vest to boost my fitness? And how heavy should it be?

Published

on

Should I get a weighted vest to boost my fitness? And how heavy should it be?

Exercise training while wearing a weighted vest is undergoing somewhat of a renaissance. Social media posts and trainers are promoting them as a potential strategy for improving fitness and health.

Exercising with additional weight attached to the body is nothing new. This idea has been used with soldiers for many centuries if not millennia – think long hikes with a heavy pack.

The modern weighted vest comes in a range of designs that are more comfortable and can be adjusted in terms of the weight added. But could one be helpful for you?

What the research says

One of the earliest research studies, reported in 1993, followed 36 older people wearing weighted vests during a weekly exercise class and at home over a 20-week period. Wear was associated with improvements in bone health, pain and physical function.

Since then, dozens of papers have evaluated the exercise effects of wearing a weighted vest, reporting a range of benefits.

Advertisement

Not surprisingly, exercise with a weighted vest increases physiological stress – or how hard the body has to work – as shown by increased oxygen uptake, heart rate, carbohydrate utilisation and energy expenditure.

Adding weight equal to 10% of body weight is effective. But it doesn’t appear the body works significantly harder when wearing 5% extra weight compared to body weight alone.

Does more load mean greater injury risk?

A small 2021 study suggested additional weights don’t alter the biomechanics of walking or running. These are important considerations for lower-limb injury risk.

The safety considerations of exercising with weighted vests have also been reported in a biomechanical study of treadmill running with added weight of 1% to 10% of body weight.

While physiological demand (indicated by heart rate) was higher with additional weight and the muscular forces greater, running motion was not negatively affected.

Advertisement

To date no research studies have reported increased injuries due to wearing weighted vests for recreational exercise. However a 2018 clinical study on weight loss in people with obesity found back pain in 25% of those wearing such vests. Whether this can be translated to recreational use in people who don’t have obesity is difficult to say. As always, if pain or discomfort is experienced then you should reduce the weight or stop vest training.

Better for weight loss or bone health?

While wearing a weighted vest increases the energy expenditure of aerobic and resistance exercise, research to show it leads to greater fat loss or retaining muscle mass is somewhat inconclusive.

One older study investigated treadmill walking for 30 minutes, three times a week in postmenopausal women with osteoporosis. The researchers found greater fat loss and muscle gain in the participants who wore a weighted vest (at 4–8% body weight). But subsequent research in obese older adults could not show greater fat loss in participants who wore weighted vests for an average of 6.7 hours per day.

There has been considerable interest in the use of weighted vests to improve bone health in older people. One 2003 study reported significant improvements in bone density in a group of older women over 32 weeks of weighted vest walking and strength training compared to a sedentary control group.

But a 2012 study found no difference in bone metabolism between groups of postmenopausal women with osteoporosis walking on a treadmill with or without a weighted vest.

Advertisement

Making progress

As with any exercise, there is a risk of injury if it is not done correctly. But the risk of weighted vest training appears low and can be managed with appropriate exercise progression and technique.

If you are new to training, then the priority should be to simply start exercising and not complicate it with wearing a weighted vest. The use of body weight alone will be sufficient to get you on the path to considerable gains in fitness.

Once you have a good foundation of strength, aerobic fitness and resilience for muscles, joints and bones, using a weighted vest could provide greater loading intensity as well as variation.

It is important to start with a lighter weight (such as 5% bodyweight) and build to no more than 10% body weight for ground impact exercises such as running, jogging or walking.

For resistance training such as squats, push-ups or chin-ups, progression can be achieved by increasing loads and adjusting the number of repetitions for each set to around 10 to 15. So, heavier loads but fewer repetitions, then building up to increase the load over time.

Advertisement

While weighted vests can be used for resistance training, it is probably easier and more convenient to use barbells, dumbbells, kettle bells or weighted bags.

The benefits of added weight can also be achieved by adding repetition or duration.
Geert Pieters/Unsplash

The bottom line

Weighted vest training is just one tool in an absolute plethora of equipment, techniques and systems. Yes, walking or jogging with around 10% extra body weight increases energy expenditure and intensity. But training for a little bit longer or at a higher intensity can achieve similar results.

There may be benefits for bone health in wearing a weighted vest during ground-based exercise such as walking or jogging. But similar or greater stimulus to bone growth can be achieved by resistance training or even the introduction of impact training such as hopping, skipping or bounding.

Exercising with a weighted vest likely won’t increase your injury risk. But it must be approached intelligently considering fitness level, existing and previous injuries, and appropriate progression for intensity and repetition.

Advertisement

Continue Reading

Fitness

Kareena Kapoor is jumping and punching her way into 2025 with an inspiring fitness game at 44. Watch

Published

on

Kareena Kapoor is jumping and punching her way into 2025 with an inspiring fitness game at 44. Watch

Celebrity fitness instructor Mahesh Ghanekar, who trains celebrities like Kareena Kapoor Khan, Soha Ali Khan, and Suriya, often shares their progress on Instagram. On the weekend, Mahesh posted a clip of Kareena’s intense workout routine that shows the actor bringing her workout A-game. Even at 44, the actor slayed the routine and inspired us to be active.

Kareena Kapoor’s new fitness video will inspire you.

Also Read | Man who dropped from 95 kg to 68 kg shares 3 fat-loss meals that helped him lose 27 kg in 4 months

Kareena Kapoor’s intense workout routine

The celebrity trainer posted Kareena’s clip with the caption, “Jumping and punching onto the New Year’s Fitness Game #2025 #newyear #newpost #newwork #newgoals #celebrity,” The video shows the actor doing two different full-body exercises. In the first exercise, she can be seen jumping continuously on one leg with the other balanced on the wall. She kept her spine neutral, her arms near her torso, and repeated the routine while keeping her breath in check.

In the second exercise, Kareena sat down on her yoga mat with her torso and legs lifted up from the ground. Maintaining this position and holding dumbbell weights in both hands, Kareena punched her arms forward. She kept her back in a neutral position during the routine.

Advertisement

How did the internet react?

Fans loved Kareena’s dedication towards her fitness routine and felt inspired by her intense workout. One wrote, “Queen.” Another commented, “Even after two kids! Insane.” A comment read, “OMG! Wow.” Another said, “She looks amazing in her body. She’s in her 40s, she has had two kids, and still, she appears healthy and happy.”

Taimur’s sweet gesture for his Maa

Apart from an inspiring fitness routine, Kareena’s 2025 began with a sweet gesture from her and Saif Ali Khan’s oldest son, Taimur Ali Khan. The actor shared pictures of her son carrying her heels with the caption, “MAA ki seva iss saal and forever. Happy New Year, friends ❤️ More Pictures coming soon. Stay tuned.”

Kareena and Saif welcomed Taimur on December 20, 2016. They are also parents to Jehangir Ali Khan. Jeh was born on February 21, 2021.

Catch every big hit,…

Advertisement

See more

Catch every big hit, every wicket with Crick-it, a one stop destination for Live Scores, Match Stats, Quizzes, Polls & much more. Explore now!.

Catch your daily dose of Fashion, Taylor Swift, Health, Festivals, Travel, Relationship, Recipe and all the other Latest Lifestyle News on Hindustan Times Website and APPs.

Advertisement
Continue Reading

Trending