Fitness
Cardiovascular risk almost halved by a few minutes of intense exercise
- Past studies show that getting enough physical activity can help lower a person’s risk for major adverse cardiovascular events (MACE).
- Researchers from the University of Sydney have found that just 1.5 to 4 minute small bursts of high intensity exercise throughout the day may lower a person’s MACE risk.
- This correlation was observed more significantly in female participants compared to male participants.
“Physical inactivity is a major public health issue contributing to
“There is a pressing need to identify feasible ways and support people to be physically active. Structured exercise such as gyms, running, classes, etc is fantastic towards these goals but only 20% of the middle aged and older population do it regularly,” he pointed out.
Stamatakis is the lead and corresponding author of a new study recently published in the British Journal of Sports Medicine that has found that just 1.5 to 4 minute small bursts of high intensity exercise throughout the day — scientifically known as vigorous intermittent lifestyle physical activity (VILPA) — such taking the stairs instead of an elevator or carrying groceries a short distance may help lower a person’s risk of MACE, especially in women.
For this study, researchers analyzed UK Biobank data from more than 103,000 middle-aged men and women with an average age of 61. All participants had worn an activity tracker 24 hours a day for a full week between 2013 and 2015.
About 22,000 participants said they did not follow any structured exercise program or only took one recreational walk a week, while the remaining participants said they regularly exercised.
Researchers used the activity trackers to determine which participants had bouts of VILPA during the day and for how long.
“Incidental physical activity, things we do as part of our daily routines, offers many untapped opportunities, but we do not understand what is the best way to promote, and how to support people — VILPA offers such an option,” Stamatakis explained.
“These are short bursts of vigorous incidental activity, typically lasting [between] 10 seconds [and] 1 minute, that are part of people’s daily living. This kind of activity may be more feasible than structured exercise for many people as it does not require preparations, time commitment, or traveling to a facility to be active,” he detailed.
“Using advanced wearable measurement methods that allow us to scrutinize the effects of daily movement at a very high resolution — 10-second time windows — we wanted to understand what are the effects of VILPA on major cardiovascular disease events,” added Stamatakis. “No such study has been published before.”
Study participants’ cardiovascular health was tracked until November 2022.
Upon analysis, researchers found that female participants with no formal exercise regimen who recorded an average of 3.4 minutes of VILPA a day were 51% less likely to have a heart attack, 67% decreased risk for heart failure, and 45% less likely to develop any type of MACE compared to female participants who did not clock any VILPA during their day.
Additionally, scientists discovered for women that even VILPA amounts of 1.2 to 1.6 minutes a day were associated with a 40% decreased risk of heart failure, 33% lowered risk of heart attack, and 30% lower risk of all MACE.
“This finding is significant for at least two reasons,” Stamatakis said. “First, it represents a much lower amount of physical activity [than] any current exercise related recommendation, and this activity is incidental — which implies that it may be easier for many people to incorporate it into their daily routine.
“The second noteworthy aspect of these findings is that we should not be fooled into thinking that small amounts of VILPA are a quick fix of a complex problem, like physical inactivity,” he continued.
“The beneficial associations we observed were in women who committed to short bursts of VILPA almost daily, several times each day — nine to 10 bursts on average. Turning such behavior into habit is not necessarily easy. Our results show that even a little bit of higher intensity activity can help and might be just the thing to help people develop a regular physical activity, or even exercise, habit in the long term. In most occasions people who are unaccustomed to vigorous exertion will need support to develop such a habit.”
– Emmanuel Stamatakis, PhD
When looking at male participants, those who averaged 5.6 minutes of VILPA each day with no formal exercise had a 16% reduced risk of having any type of MACE than those who did not clock any VILPA. However, scientists did not find any correlation between VILPA and separate types of MACE.
“It is hard to speculate why we observed this, our study was not specifically designed to understand mechanisms,” Stamatakis said.
“However, there is a good possibility that because men’s relative VILPA intensity was only 70% versus 83% for women — around 20% higher — [meaning that] women exerted themselves more during VILPA bouts, and as a result we could see a markedly lower cardiovascular disease risk in women, in the long term.”
“We are now examining the associations of incidental physical activities of any intensity, light, moderate, as well as vigorous, and heart disease risk,” he added. “We are particularly interested in understanding what is the ‘heart health value’ of each minute of moderate and light intensity activities against each minute of vigorous (activity).”
After reviewing this study, Cheng-Han Chen, MD, a board-certified interventional cardiologist and medical director of the Structural Heart Program at MemorialCare Saddleback Medical Center in Laguna Hills, CA, told MNT that it is very promising to see such dramatic improvements in cardiovascular disease-related mortality with seemingly small amounts of vigorous exercise — something that could conceivably be accomplished by most people.
“Cardiovascular disease still remains the major cause of morbidity mortality in the world, so any intervention we can do to help lower that disease profile will have a great impact on the country’s health,” Chen continued.
“So we specifically promote lifestyle interventions that people can do on their own to improve people’s heart disease risk as preventive medicine, rather than waiting for the disease to progress and for us to have to intervene, either through medicines or through procedures,” he told us.
MNT also spoke with Rigved Tadwalkar, MD, a board-certified consultative cardiologist and medical director of the Cardiac Rehabilitation Center at Providence Saint John’s Health Center in Santa Monica, CA, about this study.
“My initial reaction to this study is one of optimism,” Tadwalkar commented. “The findings suggest that even minimal amounts of VILPA can significantly reduce the risk of MACE in women who typically do not engage in structured exercise. This is especially encouraging for patients who find it challenging to adhere to traditional exercise regimens due to time constraints, physical limitations, or other barriers.”
“The study highlights the potential of incorporating brief, intense physical activities into daily routines as an alternative to more conventional exercise programs, offering a practical and accessible strategy for improving cardiovascular health,” he continued. “The gender-specific results also underscore the importance of tailoring exercise recommendations to individual needs, which could lead to more personalized and effective prevention and treatment plans.”
For those looking to increase their daily VILPA, Chen said there are different types of activities people can incorporate throughout their day for brief periods of time.
“The easiest would be to use your environment to your advantage,” he detailed. “For instance, if there are stairs in your home or in your workplace, then we’re talking about just taking 1 to 2 minute brisk walks up and down the stairs just a few times a day would accomplish what the study has shown. This study also mentioned that just vigorous day-to-day, lifestyle activities such as carrying heavy groceries could also provide the same heart health benefit.”
Tadwalkar advised setting reminders to move every hour can prompt these brief but intense activities,
“Many smartwatches and wearable devices already provide this capability,” he continued. “For those working from home or in an office setting, consider using a standing desk and/or periodically performing quick exercises — some effective options include jumping jacks and squats.”
“The key is to find opportunities to increase the heart rate in short intervals throughout the day, making physical activity both manageable and effective,” Tadwalkar added. “These strategies not only help to reduce cardiovascular risk but can also improve overall energy and general well-being.”
Fitness
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Fitness
Exercise Boosts Brain ‘Ripples’ Tied to Learning and Memory
While exercise is known to improve memory, scientists have mostly studied this effect by using behavioral tests or brain imaging methods like MRIs, says Michelle Voss, PhD, one of the study’s authors, a professor, and the director of the Health, Brain, and Cognitive Lab at the University of Iowa in Iowa City.
But she says these approaches can’t precisely identify where “ripples” originate, particularly in the deep brain structures like the hippocampus, a part of the brain strongly connected to memory and learning, she says.
The current study, published in Brain Communications, recorded electrical activity directly, using surgically implanted (intracranial) electrodes. “This allowed us to observe how exercise changes the brain’s memory circuits in real time,” Dr. Voss says.
20-Minute Bursts of Exercise Increase Brain Ripples
The participants performed a 5-minute warm-up and then rode a stationary bike for 20 minutes at a pace they could maintain. Researchers recorded their brain activity before and after the biking session.
The electrodes showed an increased rate of so-called sharp-wave ripples from the hippocampus and connections with cortical regions of the brain, which are involved in learning and memory.
“Sharp-wave ripples have long been known from animal studies to play a central role in memory,” Voss says, adding that recent studies using intracranial recordings in humans also support the importance of ripples for human memory.
“Our findings are the first to show that exercise can modulate these ripple signals in the human brain,” she says.
Researchers also observed that larger increases in heart rate during exercise were associated with larger changes in ripple activity in cortical networks, Voss adds.
What’s Already Known About Exercise, Memory, and Learning
Exercise helps build connections between neurons, which deepens and strengthens brain networks, Franssen says.
Physical activity also improves metabolism, which improves insulin sensitivity, helping blood sugar regulation and giving the brain a “more stable and reliable supply of fuel,” Dr. Perlmutter says.
“This is critically important because the brain is an energy-intensive organ, consuming roughly 20 percent of the body’s energy despite representing only a small fraction of body weight,” he adds.
The Research Has Limitations
Voss says researchers were careful to “exclude signals that contained epileptic activity. However, of course, we can’t statistically control for the accumulated effects of having epilepsy on the brain.”
The exercise-brain ripple patterns observed in the current study also closely match those observed in healthy adults using noninvasive brain imaging, such as MRI, she added.
“That convergence across very different methods is one of the strongest indicators that the effects are not specific to epilepsy, but reflect a more general human brain response to exercise,” Voss said.
Researchers also didn’t directly test memory performance, Voss notes. “While hippocampal ripples are strongly linked to memory processing in decades of neuroscience research, the next step will be to measure how exercise-related changes in ripples relate to memory performance in the same individuals.”
Future studies should also compare exercise with other everyday activities, such as sitting quietly or light movement, to determine how specific these effects are to aerobic exercise at the intensity that was studied, she says.
Satisfy Your Brain’s Exercise Craving
It’s never too early or too late to start exercising for brain health, Franssen says.
People of any age, from grade-school children to people in their nineties, can benefit from increased physical activity, Perlmutter says. “My recommendation is to consider taking advantage of the connection between physical activity and brain health across the entire range of human aging.”
Any type of exercise is great, Franssen says, but especially “repetitive behaviors,” like swimming, jogging, and walking.
“Sometimes we let the hugeness of putting in a huge fitness routine get in our way,” she says. “Having a little exercise snack every so often is also very important to improving cognition.”
Fitness
Higher Fitness Levels Amplify Brain Benefits After Exercise, Study Finds
Increasing our level of physical fitness leads to a bigger release of brain-boosting proteins following one session of exercise, a new study led by a UCL researcher has found.
The study, published in Brain Research, took a group of inactive unfit participants through a 12-week training programme of cycling three times per week and made them fitter. Researchers found as their fitness increased, so did the amount of brain-derived neurotrophic factor (BDNF) released following exercise, resulting in improved brain function.
Just 15 minutes of moderate to vigorous aerobic exercise releases BDNF, a brain protein which is known to support the formation of new neurons and new synapses (connections between brain cells), and maintains the health of existing neurons. This is the first study to show that for unfit people, just 12 weeks of consistent training can boost the brain’s response to a single 15-minute workout.
The study, led by Dr Flaminia Ronca (UCL Surgery & Interventional Science, and the Institute of Sport, Exercise and Health), involved 30 participants – 23 male and seven female – taking part in the 12-week programme. To assess fitness levels throughout the programme, participants completed VO2max tests every six weeks, which measures the maximum rate of oxygen your body can consume and use during intense exercise.
BDNF levels were measured pre- and post-VO2max testing, alongside a series of cognitive and memory tests, while also measuring changes in brain activity in the prefrontal cortex – where executive functions such as decision-making, emotion regulation, attention and impulsivity are controlled.
By the final week of the trial, results showed that baseline levels of BDNF did not change, but participants did show a larger spike of BDNF following intense exercise, compared to how their brains responded to intense exercise before the 12-week programme. This was linked to improvements in VO2max (aerobic fitness).
Higher overall BDNF levels and stronger exercise-induced increases were also associated with changes in activity across key areas of the prefrontal cortex during attention and inhibition tasks, though not during memory tasks.
Overall, the results showed that increasing physical fitness can enhance the brain’s ability to produce BDNF in response to acute bouts of exercise, which can have a strong positive influence on neural activity.
Lead author Dr Flaminia Ronca said: “We’ve known for a while that exercise is good for our brain, but the mechanisms through which this occurs are still being disentangled. The most exciting finding from our study is that if we become fitter, our brains benefit even more from a single session of exercise, and this can change in only six weeks.”
Notes to editors:
For more information or to speak to the researchers involved, please contact: Tom Cramp, UCL Media Relations , T: +447586 711698, E: [email protected]
The research paper: ‘BDNF relates to prefrontal cortex activity in the context of physical exercise’, Flaminia Ronca, Cian Xu, Ellen Kong, Dennis Chan, Antonia Hamilton, Giampietro Schiavo, Ilias Tachtsidis, Paola Pinti, Benjamin Tari, Tom Gurney, Paul W. Burgess, is published in Brain Research, March 2026,
About UCL (University College London)
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Since 1826, we have championed independent thought by attracting and nurturing the world’s best minds. Our community of more than 50,000 students from 150 countries and over 16,000 staff pursues academic excellence, breaks boundaries and makes a positive impact on real world problems.
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Journal
Brain Research
DOI
10.1016/j.brainres.2026.150253
Method of Research
Experimental study
Subject of Research
People
Article Title
BDNF relates to prefrontal cortex activity in the context of physical exercise
Article Publication Date
4-Mar-2026
Media Contact
Tom Cramp
University College London
[email protected]
Journal
Brain Research
DOI
10.1016/j.brainres.2026.150253
Journal
Brain Research
DOI
10.1016/j.brainres.2026.150253
Method of Research
Experimental study
Subject of Research
People
Article Title
BDNF relates to prefrontal cortex activity in the context of physical exercise
Article Publication Date
4-Mar-2026
Tags
/Health and medicine/Human health/Physical exercise
bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer yoksa bilgisi ilgili kısmı yazma.:
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Keywords
Tags: 12-week cycling training program benefitsbrain plasticity and physical fitnessbrain-derived neurotrophic factor after exerciseeffects of aerobic exercise on BDNFexercise and neuron healthexercise-induced neurogenesisfitness level impact on brain proteinsfitness training for cognitive improvementimproving brain function through fitnessmoderate to vigorous aerobic exercise effectsphysical fitness and brain healthVO2max and brain function correlation
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