Health
Misunderstood illness leaves millions exhausted, with most cases undiagnosed
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Fatigue can stem from a variety of illnesses and life stressors, but when that exhaustion lasts for months — often following an infection — it may indicate a condition called chronic fatigue syndrome.
Approximately 3.3 million people in the United States currently have the syndrome, with about one in four people confined to their bed at some point during the illness, according to the Centers for Disease Control and Prevention.
Despite its prevalence, experts say it’s a poorly understood condition that physicians frequently miss, with past research suggesting that only about 15% of those affected are diagnosed correctly.
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What is chronic fatigue syndrome?
Formally known as myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS) is a chronic disease that causes fatigue so severe that it impairs the ability to perform daily activities.
Approximately 3.3 million people in the United States currently have the chronic fatigue syndrome, with about one in four people confined to their bed at some point during the illness. (iStock)
The National Academy of Medicine defines the syndrome as having the following three symptoms that last at least six months.
- Severe fatigue that is 1) new and 2) decreases the ability to perform activities that you did normally prior to illness
- “Malaise” that worsens after physical or mental effort that previously was well-tolerated
- Unrestful sleep
People may also experience trouble with thinking and memory (often called “brain fog”) or lightheadedness when standing up.
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There are no tests to confirm chronic fatigue, so doctors diagnose it by talking to their patients, examining them and excluding other disorders, like hypothyroidism and depression, that often share the same symptoms.
Chronic fatigue is frequently missed by physicians, with past research suggesting that only about 15% of those affected are diagnosed correctly. (iStock)
“CFS, fibromyalgia and long COVID are all related conditions with different names,” Dr. Jacob Teitelbaum, author of “From Fatigued to Fantastic” — whose research focuses on chronic fatigue syndrome — told Fox News Digital. “What these illnesses have in common is that they are immune disorders, and immune disorders predominantly affect women.”
Many genes related to immune disorders are on the X chromosome, suggesting a genetic component, the doctor added.
Causes of chronic fatigue
Chronic fatigue syndrome may be triggered by infection or other physiologic stressors, but its causes and symptoms can vary widely from person to person, according to Dr. Julia Oh, a professor in dermatology, molecular genetics and microbiology, and integrative immunobiology at the Duke University School of Medicine in North Carolina.
Teitelbaum compared the condition to a “severe energy crisis” in the body. When energy drops low enough, the “control center” in the brain — the hypothalamus, which regulates sleep, hormones, blood pressure and pulse — may not work as well.
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Although hypothalamic dysfunction can trigger dozens of other symptoms, the hallmark signs are insomnia (despite exhaustion), brain fog and widespread pain, the doctor said.
Anything that causes severe energy depletion can trigger the syndrome, including chronic life stressors, nutritional deficiencies, thyroid and stress hormone imbalances, and sleep problems.
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These triggers are usually associated with a gradual onset of CFS, but sudden onset can be caused by certain infections, with two classic ones being COVID and mononucleosis, past research has shown.
Head and neck trauma and sudden hormonal shifts after pregnancy can also trigger chronic fatigue, Teitelbaum warned.
Anything that causes severe energy depletion can trigger the syndrome, including chronic life stressors, nutritional deficiencies, thyroid and stress hormone imbalances, and sleep problems, according to one doctor. (iStock)
There aren’t currently any blood tests to uniformly diagnose the syndrome, but Dr. Oh said she is hopeful that will change in the future.
Her research team developed an experimental artificial intelligence-based tool, BioMapAI, that has been shown to identify the condition with high accuracy by analyzing stool, blood and other common lab tests, according to early research published in July in the journal Nature Medicine.
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“Instead of finding one smoking gun for the disease, our AI model uncovered a distinct biological fingerprint that was dysregulated in the patients, which spanned changes in gut bacteria, hyperactive immune cells and disrupted metabolism,” Oh told Fox News Digital.
Treatments and therapies
Given how differently chronic fatigue syndrome can affect people, there is no universally effective therapy, according to Oh.
The CDC recommends that patients with CFS work with their doctors to create a management plan based on the symptoms that most affect quality of life.
There are no tests to confirm chronic fatigue, so doctors diagnose it by evaluating symptoms and excluding other disorders.
Treatments generally include a combination of lifestyle changes, therapies and medications. Patients and their physicians should weigh the potential benefits and risks of any approach.
There are some alternative therapies that have shown to be effective for some. Teitelbaum developed a protocol called SHINE, which focuses on sleep, hormones and hypotension, infections, nutrition and exercise. Some research has shown that this approach can help to improve the quality of life for people with CFS and fibromyalgia.
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Others may find alternative treatments, like physiotherapy (physical therapy) to be helpful.
Those who experience persistent fatigue that hinders their ability to participate in regular activities or impacts their quality of life should speak with a doctor.
Health
Early peanut exposure in babies tied to sharp drop in food allergy diagnoses
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Historically, parents were advised to avoid feeding peanuts to babies for the first few years of life, but emerging research has confirmed that introducing them sooner — as early as infancy — could help stave off food allergies.
A 2025 study led by the Children’s Hospital of Philadelphia analyzed medical records from dozens of pediatric practices across the U.S., finding that early introduction of peanuts resulted in a 27% decrease in peanut allergy diagnoses among children and a 38% decrease in overall food allergies.
The latest research also found that eggs had surpassed peanuts as the most common food allergen in the children studied. Beyond peanuts, other common food allergens include milk, egg and wheat.
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The new research — published in Pediatrics, the journal of the American Academy of Pediatrics, in October 2025 — focused on a two-year period after new guidance was issued by the National Institute of Allergy and Infectious Diseases, which first advised parents to introduce peanuts earlier.
Emerging research has confirmed that introducing peanuts as early as infancy could help stave off food allergies. (iStock)
That updated guidance was based on a landmark 2015 study — the Learning Early About Peanut Allergy (LEAP) trial — which found that for infants who had severe eczema or an egg allergy, exposing them to peanuts when they were between 4 and 11 months old could reduce peanut allergy risk by 81%.
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The guidelines were updated again in 2021, encouraging the introduction of peanut, egg and other major food allergens as early as 4 to 6 months for all children — including those without a history of prior reaction, according to health experts.
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“Everyone has been wondering whether these landmark public health interventions have had an impact on reducing rates of IgE-mediated food allergies in the United States,” said first author Stanislaw Gabryszewski, M.D., Ph.D., an attending physician in the Division of Allergy and Immunology at the Children’s Hospital of Philadelphia, in a statement.
A 2025 study led by the Children’s Hospital of Philadelphia found that early introduction of peanuts resulted in a 27% decrease in peanut allergy diagnoses among children and a 38% decrease in overall food allergies. (iStock)
“We now have data that suggest the effect of this landmark public health intervention is occurring.”
The latest findings “are supportive of efforts to increase education and advocacy related to early food introduction practices,” the study authors wrote.
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“If confirmed, these findings would represent a meaningful public health advance — affirming that clinical research, when coupled with clear guidelines and committed dissemination, can indeed shift the trajectory of childhood food allergy.”
Study limitations
The study only included data through early 2019 and did not consider the guidance released in 2021, which recommended early introduction of multiple allergens regardless of risk, the researchers acknowledged.
It also relied on allergy diagnoses from electronic health records, which may miss some cases. Also, the researchers did not capture individual feeding patterns.
Parents are encouraged to discuss any concerns with their pediatrician before introducing potential food allergens. (iStock)
Because the study was observational, it cannot prove cause and effect, but only association, the researchers noted. Other factors may influence the outcome.
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In some children, peanut allergy can trigger severe, life-threatening reactions, including difficulty breathing, swelling of the throat and a dangerous drop in blood pressure, according to Mayo Clinic. These reactions require immediate treatment with epinephrine, a life-saving allergy medication.
Not all parents may be comfortable with these revised guidelines, health experts say.
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“Not everyone has followed those guidelines, but this is further evidence that this early introduction is effective at preventing food allergies,” Dr. Susan Schuval, chief of the Division of Pediatric Allergy and Immunology at Stony Brook Children’s Hospital in New York, previously told Fox News Digital.
Parents are encouraged to discuss any concerns with their pediatrician before introducing potential food allergens.
Amy McGorry contributed reporting.
Health
Homeless encampment at center of health alert over rat-borne disease
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encampment in Berkeley, California.
Leptospirosis, which is caused by Leptospira bacteria, is a zoonotic infection that can be passed from animals to people.
The disease has been confirmed in multiple rats and dogs at the homeless encampments along Harrison Street near Eighth Street in West Berkeley, according to an alert from City of Berkeley Public Health.
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Rats and their urine are the primary vectors of the disease, officials warned. It can also be transmitted through contaminated soil or water exposed to infected animal urine.
“People or animals who touch or drink contaminated water or mud are potentially exposed to the bacteria,” the alert stated. “The disease is transmitted to humans and animals when the contaminated water touches mucous membranes, such as eyes, nose, mouth or skin cuts. This disease is not spread in the air or by coughing or sneezing.”
Health officials are warning of a dangerous bacterial infection that has been detected at a homeless encampment in Berkeley, Calif. (iStock)
There is a higher risk after heavy rainfall, flooding or hurricanes, as this increases contact with infected water or soil.
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Leptospirosis typically causes flu-like symptoms, including fever, chills, headache, body aches, vomiting or nausea, according to the CDC. Infected people may also experience yellowed eyes or skin, rash, stomach pain or diarrhea.
Rats and their urine are the primary vectors of the disease, officials warned. It can also be transmitted through contaminated soil or water exposed to infected animal urine. (iStock)
Without antibiotic treatment, the disease can lead to serious illness, including kidney damage, liver failure, meningitis and difficulty breathing. In rare cases, it can be fatal to humans and animals, health officials say.
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Illness usually begins between two and 30 days of exposure to the bacteria, according to the CDC. People generally start feeling better within a few days or weeks, but recovery without treatment could take several months.
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“The presence of rats that are transmitting leptospirosis has made the area unsafe for human encampment conditions in the vicinity of Harrison Street encampments in the area generally bounded by San Pablo Avenue, Gilman Street, Codornices Creek and the railroad tracks,” the alert stated.
The disease has been confirmed in multiple rats and dogs at the homeless encampments along Harrison Street near Eighth Street in West Berkeley, according to an alert from City of Berkeley Public Health. (iStock)
The city has designated public health risk zones, with the Red Zone marking the highest risk area inside the encampment. Surrounding areas have been defined as the Yellow Zone, with an elevated but lower risk.
“The City’s Health Officer strongly recommends that encampment residents move out of the defined encampment ‘RED ZONE’ area as soon as possible and at least ⅓ of a mile away due to the public health risk caused by the rat infestation transmitting leptospirosis in the area,” officials advised.
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Residents in the area are encouraged to avoid contact with standing water and mud, use protective clothing and monitor themselves and their pets for signs of illness.
Anyone who has been exposed or is experiencing symptoms should seek immediate medical attention.
Health
Forcing an early wake-up time could harm your health, sleep doctors warn
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With a new year underway, it might seem like a good idea to embrace a stricter morning routine of waking up early and getting a jump-start on the day — but a 6 a.m. alarm isn’t for everyone, experts say.
“Morning birds” fall asleep and reach deep sleep earlier, often waking up more alert, while “night owls” naturally sleep later and rely more on late-night and early-morning REM. Waking too early can leave night owls groggy and less mentally restored.
“We need to move beyond the ‘early bird gets the worm’ sayings and consider the biological cost of fighting one’s internal clock,” Dr. Aaron Pinkhasov, chair of the Department of Psychiatry at NYU Grossman Long Island School of Medicine, told Fox News Digital.
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The science of sleep
People sleep in repeated 90- to 110-minute cycles that alternate between deep NREM sleep and REM sleep, according to Pinkhasov.
Early in the night, deep sleep dominates, supporting physical repair, immunity and memory. Later cycles include more REM sleep, which supports learning, emotional regulation and brain function. Brief awakenings between cycles are normal.
Woman stopping an alarm clock (iStock)
Whether someone naturally rises early or late depends on the body’s “chronotype,” that is, whether they’re a morning bird or a night owl, he said.
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The chronotype is a “genetic blueprint” that determines when the body is naturally more alert or ready to rest, according to Pinkhasov.
“About 40% to 50% of our sleep-wake preference is inherited, meaning our internal clock is hardwired,” he noted.
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Waking earlier than one’s body’s clock often means sacrificing REM sleep. Forcing this discrepancy between the internal clock and the alarm clock can lead to “wired but tired” fatigue, mood instability and long-term metabolic risks, Pinkhasov warned.
“About 40% to 50% of our sleep-wake preference is inherited, meaning our internal clock is hardwired,” one expert said. (iStock)
“Unfortunately, because a lot of people have early work, family or social commitments, night owls have a higher prevalence of anxiety, depression, eating disorders, obesity, obstructive sleep apnea and [type 2 diabetes],” Dr. Nissa Keyashian, a California board-certified psychiatrist and author of “Practicing Stillness,” told Fox News Digital.
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Ultimately, health and productivity are highest when prioritizing consistency and sleep quality over an early-morning goal, experts say.
“The main benefit of switching to an earlier schedule is social alignment. It makes it easier to navigate a world built around a 9-to-5 lifestyle. However, the drawbacks can be significant if the shift is forced,” Pinkhasov said.
While waking at set times may improve social alignments, it can harm those who don’t naturally fit the mold. (iStock)
Smart shifts
There are some ways to “rewire” internal clocks or at least lessen the negative effects. Experts agree that having a regular bedtime and wake-up time — even on the weekends — can help.
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Pinkhasov recommends a wind-down nighttime routine that includes minimizing electronics, meditating, using essential oils, taking a warm shower or bath or drinking warm, herbal tea.
Pushing up your wake-up time by just 15 minutes a day is the most helpful, according to Keyashian.
Briefly waking up between REM cycles is normal, and adjusting to those cycles may help people wake up easier. (iStock)
The expert also recommends exposure to bright light in the morning, which can be helpful for mood, energy and concentration. People who experience dips in mood during the winter months can also benefit from using a therapeutic light box.
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“If you believe this might be you, I recommend speaking with a psychiatrist,” she advised. “I also recommend minimizing caffeine. Some people also notice difficulty falling asleep with exercise late in the day, so be mindful of this as well.”
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