Health
Common supplements and medications could cause liver damage, studies show
Scientist shares reversal of liver disease in new trial
Arun Sanyal, M.D., director of the VCU Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, discusses the clinical trial involving 800 participants, in which a weekly dose of semaglutide was effective at treating fatty liver disease.
As cases of drug-induced liver injury (DILI) are on the rise, experts are warning of the hidden dangers associated with some common medications and supplements.
Statistics show that DILI, also known as toxic hepatitis or hepatotoxicity — which is known to be a significant cause of acute liver failure — has been growing in Western countries since the 1960s.
Around one-fifth of the total population who are prescribed medications will experience DILI, according to recent research published in the journal Toxicology Reports.
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Potential triggers of liver injury include herbal products, dietary supplements and medications, the study found.
Those with pre-existing liver conditions and nutritional deficiencies are at a higher risk, as are pregnant women.
As cases of drug-induced liver injury are on the rise, experts are warning of the hidden dangers associated with some common medications and supplements. (iStock)
How drugs can harm the liver
One of the liver’s main functions is to break down substances taken orally, including supplements and medications, according to the American College of Gastroenterology (ACG).
For some people, the process of metabolizing these substances can be slower, increasing the risk of liver damage.
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Even medications that have been tested for safety and approved by the U.S. Food and Drug Administration (FDA) can potentially cause liver injury in rare cases, stated the ACG.
Common symptoms of liver disease include nausea, loss of appetite, abdominal pain, generalized itching, dark urine and jaundice, although some people may notice no signs, per the above source.
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Most common medications that cause DILI
The recent study in Toxicology Reports identified several drugs that are most likely to cause liver injury.
- Paracetamol (acetaminophen), a common over-the-counter pain reliever
- Nonsteroidal anti-inflammatory drugs (NSAIDs), which are often used to treat headaches, fever and chronic inflammatory disorders
- Aspirin, a common over-the-counter medication used as a fever-reducer, pain reliever and blood thinner
- Nimesulide, an NSAID used to relieve pain and reduce fever
- Methotrexate, an antimetabolite medication that is used to treat rheumatoid arthritis, lymphoma, leukemia and other cancers
- Corticosteroids, which are used to treat conditions involving inflammation or overactive immune systems
- Isoniazid, a first-line treatment for tuberculosis
- Tetracyclines, a class of antibiotics that treat multiple types of bacterial infections
- Halothane, which is used as a general anaesthetic during surgical procedures
Turmeric, a common spice added to foods, has been linked to potential liver toxicity. (iStock)
Supplements linked to liver damage
Medications aren’t the only agents that can cause drug-induced liver injuries.
Dr. Marc Siegel, Fox News senior medical analyst, spoke with Fox News Digital about the risks of herbal and dietary supplements (HDS) affecting the liver.
“The biggest problem with herbal supplements is that the amount you are taking of active chemicals isn’t strictly regulated, so you don’t know exactly what you are getting.”
“The biggest problem with herbal supplements is that the amount you are taking of active chemicals isn’t strictly regulated, so you don’t know exactly what you are getting,” he said.
“And since several of the supplements are metabolized through the liver, there is now an increasing incidence of liver toxicity in users.”
Garcinia cambogia, a popular weight-loss supplement, is among commonly used botanical products known for potential liver toxicity. (iStock)
Cases of DILI linked to herbal or dietary supplements have nearly tripled between 2004 and 2014, according to a 2024 study published in JAMA Network Open.
The researchers identified the following most commonly used botanical products known for potential liver toxicity.
- Turmeric, a common spice added to foods
- Green tea
- Ashwagandha, an herb used for stress and anxiety
- Garcinia cambogia, a popular weight-loss supplement
- Red yeast rice, which is said to help lower cholesterol levels
- Black cohosh, a dietary supplement used to relieve menopause symptoms
It is estimated that at least 15.6 million U.S. adults have used at least one of these six botanical products within the past 30 days.
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“The most commonly implicated botanical products in the DILIN (Drug-Induced Liver Injury Network) include turmeric, kratom, green tea extract and Garcinia cambogia, with potentially severe and even fatal liver injury,” the study stated.
Drug-induced liver injury caused by HDS can be severe or even fatal, leading to death or liver transplantation, the researchers noted.
Toxic hepatitis or hepatotoxicity — which is known to be a significant cause of acute liver failure — has been growing in Western countries since the 1960s. (iStock)
Fox News’ Siegel also warned against the potential liver-related risks of some of these named supplements.
“Turmeric is a natural anti-inflammatory and may be useful in small doses, but can be toxic in large doses,” he cautioned.
“Garcinia cambogia is very popular, especially as a weight-loss agent, but there is no real evidence that it actually works, and there is no reason to take it, especially with the new GLP-1 drugs.”
While red yeast rice has cholesterol-lowering statin-type properties, Siegel cautioned that the amount of active chemicals isn’t as strictly regulated as approved medications.
“Turmeric is a natural anti-inflammatory and may be useful in small doses, but can be toxic in large doses.”
“I find it useful in some patients who are reluctant to start statins and are looking for a more natural alternative, but I must strictly monitor the amount taken and the effect on the liver,” he said.
Regarding green tea, Siegel noted that it does have antioxidant properties and can be useful to consume as a beverage (though it has a lot of caffeine) — “but there is no reason whatsoever to take more of it in an extract, where it can be toxic.”
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The FDA states on its website that it does regulate dietary supplement products and dietary ingredients, but under “a different set of regulations than those covering ‘conventional’ foods and drug products.”
Drug-induced liver injury caused by HDS can be severe or even fatal, leading to death or liver transplantation. (iStock)
“Manufacturers and distributors of dietary supplements and dietary ingredients are prohibited from marketing products that are adulterated or misbranded,” the agency says. “That means that these firms are responsible for evaluating the safety and labeling of their products before marketing to ensure that they meet all the requirements of the Federal Food, Drug, and Cosmetic Act as amended by DSHEA and FDA regulations.”
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Fox News Digital reached out to several researchers and the FDA regarding the rise in drug- and HSD-related liver injury.
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Health
Simple daily habit could help people with type 2 diabetes manage blood sugar
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Sitting next to a window may help people with type 2 diabetes control their insulin levels, according to new research.
The study, published in Cell Metabolism, found that exposure to natural light — even indoors next to a window — changes how the body processes glucose and uses energy.
People in Western societies spend 80% to 90% of their time under artificial lights, which are much dimmer and less dynamic than sunlight, the researchers noted. Natural daylight is a powerful cue for the body’s internal clock, also known as the circadian rhythm.
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The body’s internal clock influences many processes, including digestion, hormone release and metabolism, according to research. When it gets out of sync, it can worsen insulin resistance and blood sugar control, which are two of the main issues caused by type 2 diabetes.
Typical lighting in homes and offices is much dimmer and lacks the biological signals provided by natural daylight. (iStock)
To test the effects of daylight on blood sugar, scientists recruited 13 adults with type 2 diabetes. Each person spent two separate 4.5-day periods in a controlled office setting, according to a press release.
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In one period, they worked in front of large windows with natural daylight streaming in. In the other period, participants worked in the same room with the windows covered and were exposed only to typical indoor lighting.
Daylight isn’t a replacement for medication or traditional management strategies like diet and exercise, the researchers noted.
Everyone ate similar meals, followed the same schedule and continued their usual diabetes medications in both conditions.
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While average blood sugar levels didn’t differ drastically between the two conditions, people spent more time in the healthy glucose range when they were exposed to natural daylight — their blood sugar fluctuated less and stayed within a desirable range for a greater portion of the day.
Participants who were exposed to daylight burned more fat and fewer carbohydrates, a metabolic pattern linked to better blood sugar regulation. (iStock)
Exposure to natural light also affected metabolism. In daylight, participants burned more fat and fewer carbohydrates for energy.
Muscle biopsies and laboratory tests further showed that the genes responsible for the body’s cellular clocks were more synchronized under natural light conditions, the study revealed.
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Better alignment of these genes can improve nutrient processing and how cells respond to insulin, the researchers concluded.
Sitting near windows or spending more time outdoors could support diabetes management alongside standard treatments, researchers say. (iStock)
However, daylight isn’t a replacement for medication or traditional management strategies like diet and exercise, according to the team.
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The study did have some limitations, including that the group of patients was small. The researchers cautioned that larger studies are needed to confirm these results and determine how much natural light exposure is optimal.
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“This study also highlights the often unnoticed impact of the built environment on our health, and raises further concerns about the prevalence of office environments with poor (natural) daylight access,” the researchers noted.
Health
Frequent heartburn may be a warning sign of a more dangerous condition, doctor says
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For most people, heartburn is an occasional annoyance and source of temporary discomfort. But for some, chronic heartburn can lead to more dangerous conditions — potentially even pre-cancerous ones.
About 10% of people with chronic gastroesophageal reflux disease (GERD) will develop Barrett’s esophagus, a condition where the lining of the lower esophagus is replaced with abnormal cells that are more prone to cancer, according to medical experts.
Some studies have shown that among those with Barrett’s esophagus, between 3% and 13% will go on to develop cancer, but most will not.
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When acid reflux becomes dangerous
“Your stomach is designed to handle acid. Your esophagus is not,” Dr. Daryl Gioffre, a Florida-based gut health specialist and certified nutritionist, told Fox News Digital.
About 10% of people with chronic acid reflux will develop Barrett’s esophagus, a condition where the lining of the lower esophagus is replaced with abnormal cells that are more prone to cancer. (iStock)
“With reflux, the danger is not the burn in the chest or throat — the real danger is the constant backflow of acid traveling the wrong way.”
In most people, the lower esophageal sphincter — which Gioffre refers to as the “acid gate” — keeps acid in the stomach, which is lined with thick mucus and specialized cells designed to protect it.
“With reflux, the danger is not the burn in the chest or throat — the real danger is the constant backflow of acid traveling the wrong way.”
“But when the gate gets weak, it relaxes or stays slightly open, and acid slips back up the wrong way,” he said. This “gate” can weaken with magnesium deficiency, high stress, alcohol, poor sleep, dehydration and late-night snacking, all of which can disrupt healthy digestion.
When acid hits the esophagus, it irritates tissue that was never designed to withstand it, according to the doctor.
“Every time acid comes back up the wrong way, it injures the lining like a slow chemical burn,” said Gioffre, who is also the author of “Get Off Your Acid” and “Get Off Your Sugar.” Over time, that irritation erodes the lining, drives inflammation and can change the cells.
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“These new cells are no longer normal esophageal cells — they begin to shift into cells that look more like stomach lining, because those cells can tolerate the acid,” the doctor said. “That change is called metaplasia, or Barrett’s esophagus.”
Once the cells start changing, the risk of further mutation goes up. If that process continues, Gioffre warned, it can progress to dysplasia, which is the stage right before esophageal cancer.
Some studies have shown that among those with Barrett’s esophagus, between 3% and 13% will go on to develop cancer. (iStock)
“So the real danger is not the heartburn you feel,” he summarized. “It is the repeated acid exposure forcing the esophagus to adapt in ways it was never designed to. Fixing reflux at the root stops this entire cascade before those cellular changes begin.”
Men at higher risk
Men generally have a higher risk because they burn through magnesium faster, tend to carry more visceral fat pushing upward on the stomach, eat heavier meals and snack late at night, Gioffre cautioned. These activities all weaken the acid gate and shut down healthy digestion.
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“Eating within three hours of lying down almost guarantees the stomach does not empty, and that is one of the biggest drivers of nighttime reflux,” he said. “On top of that, men often ignore symptoms, or mask them with PPIs and antacids instead of fixing the root cause.”
All of these factors contribute to a “perfect storm” for chronic inflammation and long-term damage, according to Gioffre.
Warning signs
There are certain red flags that indicate when acid reflux has gone beyond an occasional annoyance and has progressed to constant and chronic.
“If that burn becomes more frequent or more intense, or starts showing up even when you have not eaten, your body is waving a giant warning flag,” Gioffre said.
Difficulty swallowing, a feeling that food is “stuck,” chronic hoarseness, a constant cough, throat clearing or the feeling of a lump in the throat are all indicators that the acid is moving upward into areas it should never reach. (iStock)
Difficulty swallowing, a feeling that food is “stuck,” chronic hoarseness, a constant cough, throat clearing or the feeling of a lump in the throat are all indicators that the acid is moving upward into areas it should never reach, according to the doctor.
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“Ulcers in your throat, or even in your mouth, are another sign that the acid is doing real damage,” he warned.
“Another major warning sign is when reflux goes from something you notice occasionally to something you feel every day or every night, or when PPIs and antacids stop helping,” Gioffre said. “That usually means the lining is irritated and eroded, and may already be changing on a cellular level.”
Nighttime reflux is the most dangerous because the acid sits on the esophagus for hours, causing deep inflammation and long-term cellular changes, the doctor said. (iStock)
Unexplained weight loss, vomiting blood and black stools are all serious symptoms that demand immediate attention, the doctor added.
“The bottom line: When reflux becomes consistent, chronic and starts impacting swallowing, your voice, or the tissues in your mouth or throat, it is no longer just a nuisance,” Gioffre told Fox News Digital. “That is the point where the esophagus may be moving toward a precancerous state, and men especially cannot afford to wait on it.”
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3 key ways to prevent reflux
Gioffre shared the following essential steps to preventing acid reflux and improving digestive health.
No. 1: Follow the 3-hour rule
“Stop eating three hours before bed,” the doctor recommends. “When you eat late, the stomach does not empty, pressure builds and the acid gate relaxes, guaranteeing that acid travels upward into your esophagus while you sleep.”
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Nighttime reflux is the most dangerous because the acid sits on the esophagus for hours, causing deep inflammation and long-term cellular changes, he warned. “This one rule alone can dramatically lower acid reflux and cancer risk.”
No. 2: Strengthen the acid gate
When stomach acid is low, the lower esophageal sphincter loses its tone, allowing acid to travel upward instead of staying in the stomach, Gioffre said.
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“The fastest way to tighten that gate is to build your mineral reserves, especially magnesium,” he said.
The best way to do this is to load up on magnesium-rich foods like avocado, spinach, pumpkin seeds, chia seeds, quinoa and almonds, and consider adding a clean magnesium supplement.
No. 3: Remove or neutralize daily triggers
The fastest way to protect your esophagus, according to Gioffre, is to eliminate or neutralize the foods and habits that weaken the acid gate and push acid the wrong way.
For people who can’t fully eliminate these triggers, certain habits can help neutralize their impact by reducing acid strength and pressure before it reaches the esophagus.
The doctor recommends cutting back on alcohol and caffeine, both of which relax the acid gate and increase the risk of acid reflux. (iStock)
“Drinking most of your water earlier in the day helps, because pounding water at night stretches the stomach and relaxes the acid gate, making it much easier for acid to flow the wrong way once you lie down,” he said.
He also recommends cutting back on alcohol and caffeine, both of which relax the acid gate instantly.
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Some other major triggers that fuel the reflux cycle include chocolate, spicy foods, garlic, onions, sugar, ultraprocessed foods and heavy nighttime meals, according to the doctor.
“These foods and habits weaken the lower esophageal sphincter, drive up inflammation and push pressure upward,” he said. “That’s exactly how a little heartburn turns into chronic reflux, and slowly causes the kind of damage that puts the esophagus at risk for cancer.”
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