TORONTO — Will Ferrell is building up a head of steam.

Seated in the nondescript hotel conference room that’s been seized for our interview — a setting that lends our conversation the air of “Between Two Ferns” — the actor has taken up the subject of transphobia in Hollywood films like “Ace Ventura” and is running with it.

“The entertainment culture has taught us to have a flippant attitude that trans people aren’t real people,” Ferrell says. “It’s silly. It’s make-believe. Obviously, we’re getting closer to educating everyone—”

“Are we?” his friend, former “Saturday Night Live” colleague and now road-movie co-star Harper Steele interrupts, stopping him hilariously short. Her deadpan is laced with the ring of truth.

This is the animating question of their new documentary, “Will & Harper,” which follows the pair on a cross-country road trip as they unpack Steele’s 2022 coming out as a trans woman. Along the way, Ferrell and Steele meet Indiana Gov. Eric Holcomb, a supporter of anti-trans legislation; connect with the trans community in Peoria, Ill.; suffer hateful trolling in Texas; and experience the unexpectedly warm embrace of dive bar patrons in Oklahoma. Within the structure of an absurdist buddy comedy from the goofballs who brought you “SNL” sketches like “Oops! I Crapped My Pants” and “More Cowbell,” the film, launching Friday on Netflix, offers one of American pop culture’s most successful portraits to date of the contemporary trans experience — unafraid to answer “all the questions you’re not supposed to ask trans people.”

“You confront someone fast like Dave Chappelle and you’re going to get eviscerated,” says Steele. “It’s like going on Fox News with [former host] Tucker Carlson. Why would I subject myself to that when I’m just going to get eaten up in ways I won’t enjoy?”

(Raul Romo / For The Times)

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You might even call “Will & Harper” the trans “Will & Grace.”

“The impact that a sitcom like ‘Will & Grace’ had for the queer community, gay community, is massive,” says the film’s director, Josh Greenbaum. “It’s certainly not what we would call high art, but it speaks a little bit to something we were striving for with our film. I love the expression that laughter is the shortest distance between two people. I’m a big believer in it. We talked about making sure that our film was funny and accessible and an easy on-ramp.”

As with NBC’s landmark sitcom, though — praised by then-Vice President Joe Biden for doing “more to educate the American public than almost anything anybody’s ever done,” but panned by some LGBTQ+ observers for oversimplifying queer identity for straight viewers — this spoonful-of-sugar approach cuts both ways. For Steele, who admits that she loves an “aggressive approach” when it comes to discussing trans rights, “ ‘normalizing’ is a reductive word that puts queer people in a place. It makes me feel like the goal is gay marriage, not generalized liberation.”

“Will & Harper’s” ability to walk a fine line between being edifying and didactic, entertaining and superficial, is woven into its very structure, with its stars’ connection deepening by degrees until they reach the Mojave Desert town of Trona, where Steele, in a shattering moment, reveals the depths of her past self-hatred. At every juncture, it threatens to leave important stones unturned, vital context unaddressed — and at every juncture, instead, it confronts the viewer’s skepticism head-on.

A scene from the documentary “Will & Harper.”

(Sundance Institute)

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Not that they planned it that way. Jettisoning an early idea to build the film around comedy bits, Ferrell, Steele and Greenbaum found themselves subject to the vagaries of nonfiction storytelling, and thereby stumbled into the journey’s most bracing scenes. They did not expect, for instance, that a gag involving Ferrell trying to eat a 72-ounce steak in under an hour at a Texas steakhouse would expose him and Steele to uncomfortable leering from the other patrons and a subsequent flurry of social media abuse. Nor did they know that Holcomb would be at a Pacers game they attended in Indianapolis, where the governor and Ferrell were introduced courtside — leading to an on-camera reckoning for the actor about the rudiments of effective allyship.

“If we were in a moment like that again, I wouldn’t hesitate to [ask], ‘By the way, what are your views?’ ” says Ferrell. “Just because I’m OK with poking the bear a little bit more. Especially if I had some knowledge going in. Literally last night at dinner, the waiter misgendered [Steele]. He said, ‘Hello, gentlemen.’ And I said, ‘Nope.’ … That’s now how I react because it feels natural.”

Our conversation, ahead of the film’s Toronto International Film Festival screening, takes place the morning after the presidential debate between Vice President Kamala Harris and former president Donald Trump, in which Trump raised the specter of “transgender operations on illegal aliens in prison.” (“That feels like a line written in an ‘SNL’ sketch,” Ferrell quips.) But politicians’ and pundits’ use of transgender people as a scapegoat would not be possible without their historical mistreatment, or outright erasure, in popular culture. As for the roughly 60% of Americans who do not know a trans person, according to Pew, “Will & Harper” hopes to be an introduction: “Now you know Harper,” Greenbaum says.

Steele and Ferrell with “Will & Harper” director Josh Greenbaum.

(Raul Romo / For The Times)

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Such positive messages will compete for attention against transphobic rhetoric from high-profile figures such as Dave Chappelle and Ricky Gervais, even on the same platform. (Netflix, which is releasing “Will & Harper,” is also home to numerous projects by the firebrand comedians in which trans people are treated as the butt of the joke.) But Steele refuses to take their comments seriously — or bend her own creative process simply to combat them.

“When egos get hurt, people troll,” she says. “And I’m looking at a lot of these people and they’re enjoying the trolling.” She hopes Algerian boxer Imane Khelif, Olympic gold medalist in women’s welterweight, “sues the s— out of J.K. Rowling” over tweets in which the “Harry Potter” author falsely described Khelif as a man. “These people, they need help.”

“I want our voice and my example to be louder, in the end,” Steele adds. “I just hope it drowns out the voice that is weaker, and that’s my method. I don’t like confronting. For one, you confront someone fast like Dave Chappelle and you’re going to get eviscerated. It’s like going on Fox News with [former host] Tucker Carlson. Why would I subject myself to that when I’m just going to get eaten up in ways I won’t enjoy?”

“Will & Harper” actively seeks to neutralize the cries of “cancel culture” from cable news anchors and stand-up comics by taking no topic of conversation off the table. With Ferrell as her curious everyman interlocutor, Steele explains her choice of a new name, discusses her physical appearance and sexuality, acknowledges her bouts of suicidal ideation; she introduces her children, visits her sister, shares her letters, diaries and most painful memories. As a result of this vulnerability, she offers a remarkable invitation to viewers who might otherwise pass judgment, or avoid the conversation entirely, out of fear that they will say the wrong thing, or cause offense, or discover that their experience is not in fact universal.

“One of the many things that I loved about her transition is her constant wanting to talk about it,” says Steele’s friend and former “SNL” collaborator Kristen Wiig, who co-wrote and performed an original song for the film. “[It fostered] this open dialogue to keep those connections, make them stronger and to really explain what she had been going through for years that a lot of us weren’t privy to.”

“Will & Harper” has helped Ferrell learn to be a more vocal ally: “I’m OK with poking the bear a little bit more,” he says.

(Raul Romo / For The Times)

The film has already succeeded in sparking that dialogue among viewers, according to Greenbaum. At one screening at the Sundance Film Festival, where the film had its world premiere earlier this year, he recalls meeting a woman and her son, a trans man, who had been estranged since his transition but reconnected when she bought them tickets to “Will & Harper” as a sort of cinematic olive branch. Steele, for her part, admits to having more nerves over “Will & Harper” resonating with trans audiences than persuading cis ones — perhaps because she understands firsthand the harm produced by Hollywood’s powerful mirror.

“Klinger probably destroyed my life,” she says of the cross-dressing “M.A.S.H.” character played for laughs by Jamie Farr. “He was literally looking to be discharged for being crazy for that. That was his whole character.” By contrast, the 1974 James Caan/Alan Arkin buddy cop movie “Freebie and the Bean” became one of her favorite movies, thanks to its thieving female impersonator. “To see a man look that beautiful was confusing,” she says.

In such confusion lay the other animating question of “Will & Harper,” and indeed of LGBTQ+ popular culture more broadly: What story would we, should we, tell about ourselves if we could tell any story we wanted? Some will argue that self-expression is the goal, others moral suasion; some will prefer soft power to storming the barricades and some the reverse. Advocates for populism will confront those for high art while the diplomats among us try to squeeze them together into our society’s narrowing middle ground. And anyone who tells you that theirs is the one true path is either uninformed or lying.

“I guess shame on me, but that was just a funny show with talented actors,” Ferrell says, of “Will & Grace,” gently pushing back on Greenbaum’s earlier assessment. “Big, landmark, statement show, in a way — yes, of course, I recognize that at the same time. But also, that’s just great ensemble comedy. Fun writing. Great premises.”

Notably, Steele doesn’t weigh in on this one. She doesn’t need to. “Will & Harper” — as “Will & Grace” was for gay men of a certain generation — is just one of countless possible varieties of trans representation. There’s no shortage of stories to tell, or unanswerable questions to ask.