Health
Ozempic, other weight-loss drugs may strengthen New Year's resolutions, experts say: Health goal 'boost'
New year, new motivation?
For 2024, some of the most common New Year’s resolutions include adopting fitness and diet regimens, plus losing weight, according to a Forbes survey.
As weight-loss medications like Ozempic and Wegovy peak in popularity, experts believe these meds could make it more likely that people stick with their resolutions.
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Galit Shokrian, a Los Angeles-based CEO and co-founder of the online weight loss program Trimly, agreed that the widespread use of GLP-1s will impact the way people approach New Year’s goals.
GLP-1 agonists, which include semaglutides, are medications that help to reduce blood sugar and aid in weight loss.
“Semaglutides are a total game-changer in New Year’s resolutions this year,” she told Fox News Digital.
As weight-loss medications like Ozempic and Wegovy peak in popularity moving into the New Year, semaglutide experts believe these meds could make it more likely that people will stick with their resolutions. (iStock; SEBASTIEN BOZON/AFP via Getty Images)
Millions of Americans make resolutions to lose weight each year — but 40% to 50% give up by the end of January, according to Shokrian.
“The introduction of semaglutide and tirzepatide treatments are finally allowing overweight women and men to not only lose the weight, but successfully keep it off,” she said.
(Tirzepatide, another GLP-1 medication, is sold under the brand name Mounjaro.)
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“They kickstart a new lifestyle for someone who needs a boost in getting to their health goals.”
Losing weight via medication “staves off future health complications, increases confidence, increases sex drive and allows patients to become more active,” Shokrian noted.
Galit Shokrian, co-founder and CEO of Trimly, said semaglutide and tyrzepatide treatments are “finally allowing overweight women and men to not only lose the weight, but successfully keep it off.” (Myles Pettengill III)
Colin Banas, M.D., M.H.A., Virginia-based chief medical officer at the medication data platform DrFirst, said in a statement to Fox News Digital that he’s “never seen a therapy adopted so quickly.”
He said, “Our research shows that 80% of Americans believe more people will take these drugs for weight loss in the future, most stating it will become the norm.”
Semaglutide medications have “transformed” lives, effecting “dramatic results” for people who previously had complications with weight loss, Banas added.
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Avantika Waring, 9amHealth’s chief medical officer and a trained physician and endocrinologist in San Francisco, noted that these previous complications have led to many failed resolutions.
“So many people make weight-loss resolutions for the New Year but find the months ahead to be challenging and frustrating because weight-loss and lifestyle changes are not easy to maintain,” she told Fox News Digital.
Wegovy is an injectable prescription weight-loss medicine that has helped people with obesity. (Michael Siluk/UCG/Universal Images Group via Getty Images)
With the aid of semaglutide and related drugs, Waring said people are seeing quicker success with their weight-loss efforts.
“I predict this will get them even more motivated to make resolutions and stick with them, because they’re more likely to see a real impact,” she said.
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Insurance plans, said the physician, often require a “demonstrated commitment to lifestyle change” in order for people to access these drugs.
“So it will be even more important to start with a firm commitment to a healthy lifestyle to ‘supercharge’ those New Year’s resolutions,” she said.
Colin Banas, Virginia-based chief medical officer at the medication data platform DrFirst, said he’s “never seen a therapy adopted so quickly.” (DrFirst)
Although semaglutide treatments are “quickly changing the paradigm” for how people approach weight loss, Banas said it’s important to remember that it is “not a magic wand.”
He added, “For sustained weight loss, people will still need to exercise and follow a healthy diet.”
“Semaglutide and tyrzepatide treatments are finally allowing overweight women and men to not only lose the weight, but successfully keep it off.”
A recent study by Morgan Stanley found that weekly exercise doubled — rising from 35% to 71% — after participants began taking weight-loss medication.
Teddy Savage, national lead trainer at Planet Fitness in Maryland, told Fox News Digital that he doesn’t foresee fitness motivation decreasing in 2024.
A Planet Fitness gym in New York is pictured on Nov. 2, 2023. Teddy Savage, national lead trainer at Planet Fitness, told Fox News Digital that he doesn’t foresee fitness motivation decreasing in the New Year. (Michael Nagle/Bloomberg via Getty Images)
“The COVID-19 pandemic opened people’s eyes to the importance of getting and staying healthy, so I’d say more people are making their health a priority,” he said.
“We always see more people committing to their fitness goals in the New Year, which is great,” he added. “We encourage everyone to start slow, set achievable goals and enjoy the journey.”
He also said, “It’s a marathon, not a sprint.”
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Despite the growing popularity and availability of weight-loss drugs, Savage said staying active should remain a priority.
“Physical activity is always a key ingredient to overall health and well-being, and we believe it’s important to prioritize fitness no matter the time of year,” he said.
A recent study by Morgan Stanley found that weekly exercise rose from 35% to 71% after participants began taking weight-loss medication. (iStock)
Savage also noted that mental health is just as important as physical health. “It’s not just how you look, it’s how you feel.”
Said Savage, “Regular exercise benefits your heart, muscles and body, but exercise also has immense mental health benefits. It can help you sleep better, feel less stressed, and ready to tackle all that 2024 brings.”
For optimal wellness, Savage said it’s important to have a “full-body workout consisting of both cardio and strength training while eating a balanced, nutritious diet.”
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Surviving cancer as a child or young adult may have a lasting impact on aging, new research suggests.
Researchers at the University of Rochester Medical Center looked at whether life-saving treatments, like chemotherapy and radiation, could speed up biological aging.
They also aimed to determine whether this age acceleration was linked to cognitive issues related to memory, focus and learning.
The team analyzed blood samples from a group of 1,400 long-term survivors treated at St. Jude Children’s Research Hospital, using epigenetic clocks — tools that estimate biological age by examining chemical tags on DNA.
Biological age is determined based on damage the cells accumulate over time, versus chronological age, which is measured by how long someone has been alive, according to scientists.
Biological age is determined based on the damage cells accumulate over time, according to scientists. (iStock)
“These well-established aging-related biomarkers have previously been associated with neurocognitive impairment and decline in older non-cancer populations, particularly in cognitive domains related to aging and dementia, such as memory, attention and executive function,” the study stated.
Most of the group consisted of acute lymphoblastic leukemia survivors, or Hodgkin lymphoma survivors. Participants were at least five years past their treatment, though some had survived for several decades.
They underwent neurocognitive testing to measure their attention span, memory and information processing speed.
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Chemotherapy was found to have the greatest impact on aging acceleration. The study suggests the treatment can alter DNA structure and cause cellular damage.
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“It’s no surprise to find out that young people with cancer who have chemo early in life are affected in terms of long-term aging,” Dr. Marc Siegel, senior medical analyst for Fox News, told Fox News Digital.
Participants underwent neurocognitive testing to measure their attention span, memory and speed of information processing. (iStock)
Researchers also found that cellular aging was closely linked to cognitive performance, as survivors of a higher biological age had more difficulty with memory and attention.
“Chemo poisons and damages cellular function — hopefully the cancer cells more than normal cells, but there is a significant impact on normal cells as well,” said Siegel, who was not involved in the study.
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“There is also something called ‘chemo brain,’ which causes at least temporary difficulty with memory, concentration, word finding and brain fog,” the doctor added.
The research team hopes to use these findings to focus on intervention efforts, specifically by determining when accelerated aging begins.
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“Young cancer survivors have many more decades of life to live,” lead study author AnnaLynn Williams, PhD, said in a press release. “If these accelerated aging changes are occurring early on and setting them on a different trajectory, the goal is to intervene to not only increase their lifespan, but improve their quality of life.”
The team hopes this research will help in the development of early intervention tools that aim to prevent cognitive decline. (iStock)
There were some limitations to the study. The researchers could not adjust for chronic health conditions or education because they are directly impacted by treatment.
Additionally, the study only looked at the survivors at a single point of time, so it could not directly prove causation.
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The study was published in the journal Nature Communications.
Fox News Digital reached out to the researchers for comment.
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A popular class of weight-loss drugs may prevent life-threatening cardiac complications by opening microscopic blood vessels that often remain blocked after a heart attack, according to a study published this week in Nature Communications.
The research, led by the University of Bristol and University College London, identified a biological brain-gut-heart signaling pathway.
This discovery appears to explain how GLP-1 drugs — which mimic glucagon-like peptide-1, a hormone that helps regulate blood sugar and appetite — protect heart tissue from a condition known as “no-reflow.”
“In nearly half of all heart attack patients, tiny blood vessels within the heart muscle remain narrowed, even after the main artery is cleared during emergency medical treatment,” Dr. Svetlana Mastitskaya, the study’s lead author and a senior lecturer at Bristol Medical School, said in a press release.
“This results in a complication known as ‘no-reflow,’ where blood is unable to reach certain parts of the heart tissue.”
In nearly half of all heart attack patients, tiny capillaries (blood vessels) remain narrowed even after the main blocked artery is cleared. (iStock)
This lack of blood flow increases the risk of heart failure and death within a year. GLP-1 medications could prevent this, according to the researchers.
How it works
When the GLP-1 hormone is released in the gut or administered as a drug, it sends a signal to the brain, which then sends a signal to the heart that switches on special potassium channels in tiny cells called pericytes.
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When these channels open, the pericytes relax, which allows the small blood vessels (capillaries) to widen and improve blood flow to the heart muscle, the researchers noted.
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The new study used animal models and cellular imaging to track how GLP-1 interacts with heart tissue. When the researchers removed the potassium channels, the drugs no longer protected the heart — confirming they play a key role.
The findings suggest that existing GLP-1 medications, already used for type 2 diabetes and obesity, could be repurposed as emergency treatments. (iStock)
The findings suggest that existing GLP-1 medications, already used for type 2 diabetes and obesity, could be repurposed as emergency treatments during or immediately after a heart attack to reduce tissue damage.
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The researchers noted several limitations, including that the study relied on animal models.
Clinical trials are necessary to determine whether the brain-gut-heart pathway operates with the same timing and efficacy in humans.
While the study highlights the drug’s immediate benefits during a heart attack, it des not establish whether long-term use of these drugs provides a pre-existing level of protection. (iStock)
Additionally, while the study highlights the drug’s immediate benefits during a heart attack, it does not establish whether long-term use of the medication provides a pre-existing level of protection.
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The research was primarily funded by the British Heart Foundation.
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