World
GLP-1 Meds Linked to 265 Reports to FDA of Suicidal Ideation: Reuters

The FDA says it is looking into reports related to semaglutide and liraglutide, branded for weight loss and diabetes.
Since 2010, the US Food and Drug Administration has received 265 reports of suicidal ideation in patients taking a glucagon-like peptide 1 (GLP-1) receptor agonist marketed for diabetes or weight loss, a Reuters analysis has found.
Moreover, Novo Nordisk, the manufacturer of semaglutide (Wegovy/Ozempic) and liraglutide (Saxenda/Victoza), was responsible for filing 180 of the reports to American regulators. Tirzepatide (Mounjaro), the GLP-1 receptor agonist sold by Eli Lily, also was named in the adverse event reports.
Demand for GLP-1 receptor agonists is soaring, particularly for weight loss, with cardiologists excited about the implications for cardiovascular health. Top-line results from the SELECT trial were released last month showing that semaglutide 2.4 mg reduces the risk of major adverse cardiovascular events in adults with overweight or obesity; full findings are due out at the upcoming American Heart Association 2023 Scientific Sessions in Philadelphia, PA.
According to Reuters journalists Robin Respaut and Chad Terhune, 36 of the documents filed with the FDA involved deaths due to suicide or suspected suicide. “In a statement to Reuters, the FDA said it is evaluating such reports and will decide on what action, if any, to take after a thorough review,” their news story notes.
As reported by TCTMD, the European Medicines Agency’s Pharmacovigilance Risk Assessment Committee (PRAC) announced in July that it was investigating reports of suicidal thoughts or thoughts of self-harm after three patients taking liraglutide or semaglutide in Iceland reported thinking about suicide or self-injury. Regulators in Canada and the UK are also reviewing the drugs for suicidal ideation, the Reuters article notes.
For their story, Respaut and Terhune filed public records requests to obtain 113 more-detailed descriptions for individual incidents within the 265 database reports. These indicate that suicidal thoughts typically surfaced around the time patients started on the agents, or increased their dosage, as noted in more than half of the “narrative summaries.” One-fifth of these 113 more-detailed summaries—91 of which were filed by Novo Nordisk—mentioned that the suicidal thinking disappeared when patients stopped taking the agent or lowered their dose.
The Reuters story notes that the possibility of suicidal thinking is specifically mentioned in the labelling for the weight-loss drugs Wegovy and Saxenda, but not on the label for Ozempic, which is the brand name of the formulation indicated for diabetes.
Statements from both Novo Nordisk and Eli Lilly cited in the article emphasize that the companies take all reports of adverse events very seriously.

World
World oil demand to keep growing this decade despite 2027 China peak, IEA says

World
Israel's US ambassador says beeper operation will 'seem simple' compared to what is planned for Iran

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Israel’s Ambassador to the U.S. Yechiel Leiter said there will be some surprises amid the Jewish State’s conflict with Iran that will make Israel’s explosions of pagers and walkie-talkies used by members of Hezbollah in Lebanon and Syria last year look “simple.”
“We’ve pulled off a number of surprises,” Leiter said during a Tuesday appearance on the TV network Merit Street.
“When the dust settles, you’re going to see some surprises on Thursday night and Friday that will make the beeper operation almost seem simple,” he continued.
Leiter was referring to near-simultaneous detonations of pagers used by members of the Iran-backed Hezbollah terror group that killed at least 12 people, including two children, and wounded nearly 3,000 on Sept. 17 in Lebanon and Syria. The following day, at least 25 people were killed and more than 600 were wounded when walkie-talkies were detonated in the region.
TRUMP, RUBIO CUTTING G7 TRIP SHORT, RETURNING TO DC AS CHATTER INDICATES IRANIANS FLEEING TEHRAN
Israel’s Ambassador to the U.S. Yechiel Leiter said there will be some surprises that will make Israel’s beeper operation look “simple.” (Getty Images)
Israel was subsequently found to be behind the attacks, in which small amounts of explosives hidden in the devices were detonated. A U.S. official told The Associated Press at the time that Israel briefed the U.S. government after the attacks.
But then-Secretary of State Antony Blinken said the U.S. “did not know about, nor was it involved in, these incidents.”
Leiter on Tuesday also posted a video message on X that was recorded outside the Situation Room in the Israeli Embassy in Washington, D.C., where he explained that Israel was “not in the business of regime change.”
MIKE JOHNSON CALLS OFF ISRAEL TRIP AMID IRAN CONFLICT

Israel’s Ambassador to the U.S. Yechiel Leiter said Israel was “not in the business of regime change.” (Getty Images)
“Today we continue to peel back the surface-to-surface missile systems that are spread throughout Iran. We’ve reached the point where between a third and a half have been demolished,” he said. “We hit today the broadcast center in the middle of Tehran after we informed the people living in the vicinity to leave. Hundreds of thousands of Tehranis have escaped Tehran to be out of the line of danger. And we took out the broadcast system. This is very important because this serves the mullahs and their information campaign, the propaganda campaign throughout.”
“Iran, to incite the public and to warn the public against any kind of demonstrations against the government,” the ambassador continued. “A lot of questions have been asked today about regime change. In many of the interviews that I gave, that was the key question. We’re not in the business of regime change. We’re interested in neutralizing the threat to our existence through a nuclear weaponization program in Iran and a ballistic missile program.”
Iran has maintained that its nuclear program is peaceful, and U.S. intelligence agencies and the International Atomic Energy Agency have said Iran was not pursuing a nuclear weapon.

Israel’s Ambassador to the U.S. Yechiel Leiter said the Jewish State has “pulled off a number of surprises.” (Getty Images)
“If the Iranian people rise up and change their regime, that’s their choice,” Leiter said. “And if we play a role in facilitating that eventuality, then history will judge us favorably, I believe. It’s important also to emphasize that our economy remains strong and resilient despite the war, and the stock market in Israel once again, for the second day in a row, continued to rise.”
“We are working very hard to assist those stranded both in Israel wanting to leave and those wanting to get back to Israel, to their families, to their positions in society and the army,” he added. “And we’re hoping to find solutions through our neighbors in the next couple of days. We continue to press on. We continue to press forward. And we thank you for your support and prayers.”
Fox News’ Greg Norman and Jennifer Griffin contributed to this report.
World
Coal-hooked Poland constructs first ever offshore wind farm

Published on
Once reliant on coal for the majority of its electricity, the country of 36 million that currently holds the EU rotating presidency is trying to reduce its dependence on the fossil fuel.
With many mines becoming unprofitable and old infrastructure in decline, the Polish government of Prime Minister Donald Tusk has planned a gradual closure of coal facilities in the south of the country. As the coal regions of the country come to terms with this shift, northern Poland adjacent to the Baltic Sea is booming.
Ignacy Niemczycki, the deputy minister in the Chancellery, briefed a handful of Brussels-based journalists on board the Jantar passenger ship, telling Euronews that the wind farm should have a lifecycle of up to 30 years and be a major part of the energy transition.
“It’s in the interest of the Polish economy to invest in renewables, nuclear, and gas to stabilise the grid,” the minister told Euronews.
Baltic Power – a joint venture between ORLEN and Northland Power
Situated 23 kilometres off the northern coast near Choczewo and Łeba, the wind farm is among the most advanced renewable energy projects in the Polish Economic Zone. The final installed capacity of the project is expected to reach 1140 MW, enough to supply electricity to approximately 1.5 million Polish households.
Poland also to invest in nuclear
Renewables will only be one part of the Polish energy mix. Plans for the first ever nuclear plant, which will also be located on Poland’s northern Baltic Sea coast, were put in place under the former Law and Justice (PiS) government and have been continued by Prime Minister Donald Tusk’s current ruling coalition.
Niemczycki told Euronews that a second nuclear project is being considered and Poland is keeping a close eye on Canada as it experiments with the first ever mini nuclear plant, known as a Small Modular Reactor (SMR). SMRs could can potentially power up to 300 MW(e) per unit.
“We will see a major change in Poland’s energy mix over the next 15 years,” said Niemczycki. “Nuclear will become the new baseline, with renewables and gas providing flexibility and stability.”
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