Connect with us

Seattle, WA

Synbio Hub Founded in Seattle by UW, CZI, and Allen Institute

Published

on

Synbio Hub Founded in Seattle by UW, CZI, and Allen Institute


In a first-of-its-kind initiative, synthetic biology is at the center of a new research institute which aims to develop technologies that will reveal how changes in cells and genes over time influence human health and disease.

The institute, named the Seattle Hub for Synthetic Biology, is being launched by The Allen Institute, the Chan Zuckerberg Initiative (CZI), and the University of Washington (UW). By developing new technologies, the researchers hope to advance the understanding of not just end point measurements of cells and genes in health and disease, but the dynamics of their trajectories over time. It will bring together large-scale science and philanthropy with academic research to develop, refine, and share single-cell technology.

The Seattle Hub for Synthetic is led by Jay Shendure, MD, PhD, Marion Pepper, PhD, Cole Trapnell, PhD, and Jesse Gray, PhD—all UW Medicine researchers.

“Imagine being able to put a smart watch into each of your cells to record the genome itself and everything that cell is experiencing,” says Shendure, executive director of the Seattle Hub for Synthetic Biology and a professor of genome sciences at UW School of Medicine. “Currently, when biologists take measurements, we’re limited to either observing how a few things change over time with a microscope, or to measuring everything but only at the moment in time that we break open the cell. With the kind of genomic smart watch that we’re aiming to build, one could recover the full autobiography of each cell, rather than only the last page.”

Advertisement

The Seattle Hub will build on technology pioneered at the Allen Discovery Center for Cell Lineage Tracing and UW Medicine’s Brotman Baty Institute for Precision Medicine to reimagine living cells and genomes as devices for recording complex biological information over time.

“Every cell in our body has its own unique history. By developing new technologies to measure and understand the history of our cells over time, including how they are impacted by the environment around them, genetic mutations, and other factors, we can expand scientists’ understanding of what happens at the cellular level when we go from healthy to sick and help pinpoint the earliest causes of disease,” says Priscilla Chan, MD, co-founder and co-CEO of the Chan Zuckerberg Initiative.

This new paradigm has the potential to advance how scientists study the role of cells and genes in human health by providing clarity into how biological events unfold over time. For example, the causal chain of molecular and cellular events that begins with a genetic mutation and culminates in a developmental disease seen in the clinic. The technology will be proven out in the form of a research tool to study changes in cells in the context of development and immunology, with the vision to potentially extend the project into diverse research, diagnostic, and clinical applications.

The Allen Institute and the Chan Zuckerberg Initiative share a joint commitment to open science, and as such, findings from the new institute will be shared with the scientific community to fuel progress in labs and around the world.

“We are incredibly excited to enter this new era of collaboration to tackle big moonshot projects in partnership with others,” says Rui Costa, DVM, PhD, president and chief executive officer of the Allen Institute. “We’re bringing together experts in genomic engineering and synthetic biology to advance a new age of experimentation that will allow us to record the history of biological events in our cells, and eventually to design new, smart interventions for disease.”

Advertisement





Source link

Continue Reading
Advertisement
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Seattle, WA

New York hosts Seattle following Loyd’s 24-point game – WTOP News

Published

on

New York hosts Seattle following Loyd’s 24-point game – WTOP News


Seattle Storm (1-2, 0-2 Western Conference) at New York Liberty (3-0, 3-0 Eastern Conference) New York; Monday, 7 p.m. EDT…

Seattle Storm (1-2, 0-2 Western Conference) at New York Liberty (3-0, 3-0 Eastern Conference)

New York; Monday, 7 p.m. EDT

BOTTOM LINE: Seattle Storm takes on the New York Liberty after Jewell Loyd scored 24 points in the Storm’s 84-75 victory against the Washington Mystics.

Advertisement

New York finished 15-5 at home a season ago while going 32-8 overall. The Liberty averaged 6.7 steals, 4.5 blocks and 13.5 turnovers per game last season.

Seattle went 11-29 overall last season while going 7-13 on the road. The Storm averaged 78.8 points per game last season, 14.6 from the free-throw line and 25.5 from beyond the arc.

INJURIES: Liberty: None listed.

Storm: MacKenzie Holmes: out for season (knee).

___

Advertisement

The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.

Copyright
© 2024 The Associated Press. All rights reserved. This material may not be published, broadcast, written or redistributed.



Source link

Advertisement
Continue Reading

Seattle, WA

Banda scores twice as Pride prevail at Seattle to stay atop NWSL

Published

on

Banda scores twice as Pride prevail at Seattle to stay atop NWSL


Barbra Banda scored two goals on Sunday as the Orlando Pride defeated the Seattle Reign 3-2 at Lumen Field, putting them at the top of the NWSL to close out the weekend.

The Pride (7-0-3) remain undefeated and have won seven straight games, tying a league record set by the Reign in 2014. The Pride and the Kansas City Current are the lone two undefeated teams this season.

“I think most importantly, there’s the win — and a win away from home as well,” Pride coach Seb Hines said. “It’s something we talked about last year, picking up more points away from home.”

Emily Sams opened the scoring for the Pride in the 9th minute, scoring her first professional goal from the top of the box.

Advertisement

Banda headed in Adriana’s cross 10 minutes later, doubling Orlando’s lead.

Angharad James-Turner’s shot was deflected into the upper right corner just before the halftime whistle, putting Seattle on the board.

Just a few minutes into the second half, Bethany Balcer equalized for the Reign (2-7-1). Jess Fishlock sent a pass over the top, which Balcer ran onto and finished into the left corner for her fourth goal of the year.

A Pride corner kick in the 58th minute bounced once in the box before Banda volleyed in her second goal of the match.

“I thought the first 43 minutes of the game we were really good,” Hines said. “I thought we played some terrific football, played some good lines, caused Seattle a lot of problems. And to concede so late on in the first half is something that we need to reflect and review moving forward. The second half, it was a grind. It was great determination, getting through that adversity, as well, [after] conceding so early in the second half to come back and get that third goal was really important for us.”

Advertisement

Banda has six goals and two assists in just five NWSL starts.

Balcer received a second yellow card in the 83rd minute and will miss the Reign’s next game.

If you go …

Pride vs. Thorns

When: Friday at Inter&Co Stadium, 7

TV: Bally Sports Florida

Advertisement



Source link

Continue Reading

Seattle, WA

Seattle Mariners fall to Baltimore Orioles 6-3 in series rubber match

Published

on

Seattle Mariners fall to Baltimore Orioles 6-3 in series rubber match


BALTIMORE (AP) — Gunnar Henderson hit his major league-leading 15th home run, Ryan O’Hearn also went deep and Corbin Burnes notched 11 strikeouts to help the Baltimore Orioles beat the Seattle Mariners 6-3 Sunday.

Baltimore Orioles 6, Seattle Mariners 3: Box score

Henderson’s fifth leadoff homer of the season was the first of nine hits against George Kirby (4-4) in the deciding matchup of the three-game series. Henderson homered in each game while going 5 for 12 with two walks and five RBIs.

Burnes (4-2) allowed one run and seven hits in six innings to earn his first win in five starts since April 20. The 11 strikeouts matched his season high, set on opening day against the Angels.

Advertisement

Craig Kimbrel, who lost his job as Baltimore’s closer after a series of ineffective appearances, returned to the role and got three straight outs for his ninth save of the season and 426th of his career.

Luis Urías drove in two runs and Luke Raley had three hits for the Mariners, who fell behind 5-1 in the third inning and could not make up the deficit. Seattle had won eight of nine series dating back to April 15.

Kirby gave up five runs over six innings. He entered with a string of eight successive scoreless innings, a streak that abruptly ended when Henderson ripped a 1-2 pitch over the center-field wall.

It was 3-1 before O’Hearn led off the third with a drive to right, and Cedric Mullins added an RBI single later in the inning.

Advertisement

After the Mariners closed to 5-3, Mullins singled in a run off Cody Bolton in the eighth for a three-run cushion.

TRAINER’S ROOM

Mariners: INF Jorge Polanco (hamstring) missed a fifth straight game, and the team will decide whether to put him on the IL after arriving at Yankee Stadium on Monday for a four-game series. “We will probably make a decision when we get to New York,” manager Scott Servais said. “He is feeling better. That is why we are holding off as long as we can.” … SS J.P. Crawford (oblique) has been working out in Seattle after getting hit in the hand with a pitch during his rehab assignment. Servais said Crawford could join the team in New York.

Orioles: RF Anthony Santander sat out the game with a bruised left knee.

UP NEXT

Advertisement

Mariners: Logan Gilbert (3-2, 3.07 ERA) starts Monday night against the Yankees in a battle of division leaders.

Orioles: Dean Kremer (3-3, 3.72) helps Baltimore launch a three-game series in St. Louis on Monday night.

More on the Seattle Mariners

• Mariners Injury Updates: The latest on Polanco and Crawford
• Is Mariners’ Scott Servais a good manager? MLB insider explains
• Ranked: 5 Mariners who need to step up
• Rost on M’s: What we’ve learned a quarter through the season
• Seattle Mariners the ‘team to beat’ in AL West? Why that’s now the case





Source link

Advertisement
Continue Reading

Trending