SAN DIEGO – Precision micro-printing provider Boston Micro Fabrication (BMF) has launched San Diego-based BMF Biotechnology Inc., a spinout dedicated to making specialized chips through cultivated large-scale tissues in vitro, helping accelerate new drug and cosmetic development.

“BMF Biotechnology’s BioChips allow scientists to grow human-like tissues in a lab setting and because these chips mimic how substances would be processed inside the body, scientists can use them to test drugs and cosmetic products,” BMF Biotechnology Chief Scientific Officer Jennifer Sun told the Business Journal.

“These microfluidic chips are an organ-on-a-chip platform, which can replicate the physiological conditions found in the human body by controlling the flow of small amounts of fluid through micro-size channels.”

Founded in 2016, BMF says it supports more than 2,000 customers globally with offices in Boston, China, Japan and now in San Diego.

“BMF has raised over $80M in investment funding, including $24M in 2023,” added Sun. “We have over 250 employees worldwide with global revenue growth exceeding 30% in 2023.”

Wanting to be housed in San Diego’s vibrant biotech ecosystem, the company’s San Diego Research Institute was born in 2022. The newly launched biotech division will operate out of Carroll Canyon with ten or so employees to start.

Preliminary feedback has yielded promising results, says BMF.

“Specifically, significant progress has been made in terms of developing functional prototypes of the BMF Biotechnology’s BioChip, validating their efficacy in replicating human tissue models accurately,” shared Sun. “Furthermore, preliminary tests have shown encouraging outcomes of disease modeling and validating human drug responses.”

BMF is entering an arena of competitors like MIMETAS and InSphero – working to commercialize organ-on-a-chip technology. Sun says its product stands apart.

“Our BioChip platform offers distinctive features, including a micro-channel network designed to mimic blood vessels with micron level three dimensional features. This network ensures efficient nutrient delivery and waste removal throughout the chip, enabling the comprehensive replication of human tissues on a large scale.”

Hybrid Printing Solution

In recent years, micro molding and 3D printing innovations have swept the micro-manufacturing world, advancing how production companies do business.

New England-based BMF’s core tech enables highly precise, micro-scale 3D printing across industries like healthcare, life sciences, electronics and machining.

“3D printing has often been known for its ability to rapidly iterate on product design, but this same benefit can also be applied to developing custom, high-precision solutions that advance research in other ways – such as through pharmaceutical development,” said Sun. Now the industry is trending toward miniaturization. “As products and technology get smaller, the connective parts become micro and more intricate. There is an urgent need for highly precise and accurate manufacturing methods that allow engineers and product designers to consistently create small-scale parts with the precision, resolution and accuracy needed to move industries forward.”

This month, BMF announced what it calls the industry’s first line of hybrid printing solutions for micro-scale and ultra high-resolution applications that allow the user to print two resolutions within a single layer or in different layers.

“Our driving motivation for innovation has been to offer new platforms that can help realize high-value applications for 3D printing,” said BMF CEO-Global John Kawola. “Increasingly, we have been pushed by our customers to bring our technology to applications where higher precision and tighter tolerances would result in an overall increase in quality and performance, regardless of part size.”

It comes after another big win for the company. Last year it launched what it deems the world’s thinnest cosmetic dental veneer, UltraThineer™. This April, BMF secured FDA 510(k) clearance on the material.

“As we think about the future for BMF Biotechnology, we anticipate expanding our product portfolio to address a wider range of therapeutic areas and applications, revolutionizing the way drugs are developed and tested,” Sun added. “Our goal is to be a globally recognized leader in organ-on-a-chip technology, driving transformative advancements in drug discovery, cosmetic development, toxicity testing, and personalized medicine to improve human health and safety.”

Boston Micro Fabrication
FOUNDED: 2016 in Boston, San Diego Research Institute in 2022
CEO: John Kawola
LOCAL DIVISION HQ: San Diego
EMPLOYEES: 10 in San Diego; 200+ globally
BUSINESS: biotech
CAPITAL RAISED: $80 million
WEBSITE: bmf3d.com
CONTACT: info@bmf3d.com
NOTABLE: BMF was named one of the Boston Business Journal’s “Fast 50” companies, an annual honor recognizing the 50 fastest-growing private companies in Massachusetts.

By Cailin Acosta

SAN DIEGO – When I learned that the RUTH: Remember Us The Holocaust exhibit at the Rancho San Diego Library would be having its closing ceremony this weekend, I felt a little sad. It is a very thorough exhibit and I spent time reading the many stories of survivors. I am going on Thursday (tomorrow) with the Jewish Women’s Circle of Chabad East County one more time.

I will think of my dear late friend Rose Schindler who told me personally her father told her to “stay alive, so that you can tell the world what they are doing to us.” With the exhibit having its closing ceremony (it will remain open until June) I thought of Schindler’s words and wondered, now what? Who is going to continue to tell the story? Our survivors are sadly aging and passing so it relies on us to tell the stories and to not forget.

I will never forget the amazing survivors I met and the connections I had with them. At the closing ceremony, they will be showing a video presentation looking back at the then and now of the exhibit. Special guest speakers feature Matt Dunford from Love on the Spectrum, San Diego County Assessor Jordan Marks, Mayor Ron Morrison of National City, Mayor Bill Wells of El Cajon, and Roosevelt Williams the III “The Man Behind the Rose.” This event is free and starts at 3 pm.

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Chabad of Downtown is hosting a Shabbat Dinner on May 17, services start at 7 pm, and then a festive dinner to follow. If you have never been to a community Shabbat dinner, then you really should experience it. Click here to send in your reservation.

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The JCC has an action-packed event on May 19 to celebrate Israel now and forever. This free event will feature musical performances, food, and community. Click here to register.

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I love finding free family activities online to celebrate Jewish holidays together. The IAC Keshet and OFEK put together this family booklet you can print and celebrate Yom Ha’atzmaut creating some fun activities together. Click here for the free booklet.

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Hadassah is hosting a FUNdraiser for fun people on June 23 at Tifereth Israel Synagogue! Marsha Starr is the featured Hypno Diva along with the San Diego Miriam Group. If you love a show with a laugh-a-minute explosion of hilarity, then this is the show you need to attend, and you MIGHT be able to jump on stage and be a part of the show! Proceeds will be contributed to a state-of-the-art rehabilitation hospital in Israel that serves everyone regardless of religion, ethnicity, or political persuasion. Click here to attend and laugh knowing you are donating to an amazing cause.

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GOVERNMENT AND POLITICS

Congresswoman Sara Jacobs (CA-51) and Rep. Maria Salazar (FL-27) introduced the bipartisan Global Internet Freedom Act to reinforce that internet freedom is fundamental to human rights. Jacobs said: “In the 21st century, internet freedom is a human right. It’s essential to get news and information about current events, connect with loved ones, ensure transparency and accountability of elected officials, and so much more. Unfortunately, dozens of countries use censorship and suppression online or issue draconian punishments for online activity, stifling people’s freedom of expression and ability to connect and engage with others. AI also poses new and heightened risks to internet freedom, empowering governments to wage online disinformation campaigns and surveil and censor online speech, websites, and social media platforms.”

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San Diego City Councilwoman Dr. Jen Campbell has endorsed Heather Ferbert for San Diego City Attorney.  Advertisements in which she was listed as having endorsed Ferbert’s opponent, Assemblyman Brian Maienschein, were lies, according to Dan Rottenstreich, Ferbert’s campaign consultant.  Maienschein’s campaign did not return a request for comment. Ferbert is San Diego’s chief deputy city attorney.   The incumbent city attorney, Mara Elliott, is termed out.

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Cailin Acosta is the assistant editor of San Diego Jewish World.

San Diego has long been a craft beer town. But based on the recent proliferation of wine bars, events, clubs, and retail shops, we seem poised to embrace grapes as our regional beverage of choice. 

Wine bar and shop Merenda will be the newest addition to San Diego’s burgeoning wine scene when it opens at The Flats in Oceanside this July-ish. “Very heavy on the ish,” jokes Aaron Crossland, who co-owns Merenda with his wife, Lauren Crossland-Marr. “We’re moving really quickly so far, but there are always things that come up.”

Merenda is Italian for “snack,” or, more specifically, a snack shared with others. The duo spent time in Italy while Crossland-Marr studied food anthropology and culture, which led to a love of food, drink, and especially wine, explains Crossland. Neither planned to get into the wine business for themselves until two things happened.

“We got this idea for Merenda during Covid, and thought it would probably happen when we were a little older,” he says. “But as it happens, when you hit 40, I realized I really kind of hated what I did for a living and wanted to pursue my passions.”

The two moved back to Oceanside, Crossland’s hometown, to be closer to family and participate in the city’s revitalization. “[We] saw how wonderful Oceanside has been doing economically, with all the new restaurants and stuff coming into town, and wanted to be a part of it,” he explains.

It took about a year to find the right space, but they jumped on it when they saw the opportunity to take over The Flat’s retail suite. “I love the idea of having people actually living in the same space where we’re doing this,” he says, adding there are 18 residential units on-site. Merenda will occupy around 2,000 square feet of space on the ground floor, plus a small patio, with approximately 300 square feet reserved for the retail area. Crossland says they’ll start with a small collection but hope to grow to offer a few hundred SKUs of different wines, heavily emphasizing Old World wines. 

The food program will feature local produce and ingredients as well as Eastern Mediterranean and Middle Eastern influences, with a lot of the direction still being worked out. But Crossland says their charcuterie program will set them apart, with items like housemade salumi, coppa, bresaola, and mortadella. Overall, it’ll be the experience that he says people will come back for.

“We’re really going for an Old World European feel,” he explains. “Lots of wood, very approachable decor.” Bells + Whistles (Jeune et Jolie) handles the design, which Crossland describes as his living room, but better. Details like hand-painted tiles from Portugal, artwork from their collection, and a mural over the pass-through window between the kitchen and dining area will give the space a balance between “comfort and quality,” he says. There will also be a small particular event space for private events.

Once open, Crossland says they plan to launch a wine club and host many events, collaborations, and other tastings to cater to locals who may already know about wine and those just getting started. “A space for people like myself, who obviously love wine, but without all that pretentious B.S.. that goes along with it.”

San Diego Restaurant News & Food Events

Sea & Sky Now Open Atop Hotel La Jolla

Former Juniper & Ivy chef Anthony Wells is now the executive chef at Sea & Sky, the new sea-to-table restaurant at Hotel La Jolla, Curio Collection by Hilton in La Jolla Shores. Open seven days a week for breakfast, lunch, and dinner, Sea & Sky uses seafood and other local ingredients for dishes like yellowtail crudo, whole snapper, bone marrow with tuna sashimi, and more. The recently renovated hotel has more in store for guests, with a second renovation on track for late 2024. Reservations for Sea & Sky are available here. 

Beth’s Bites

Rancho Valencia Resort & Spa is upping the dining game, announcing its 2024 culinary series lineup with superstars like Javier Plascencia (July 14), David Castro Hussong, Alfredo Villanueva, and Maribel Aldaco (June 27), and adding Emiliano Safa as the property’s new executive chef. Lots of news to chew on (literally)!

Calling all plant lovers—on Saturday, May 18 from 10 a.m. to 1:30 p.m., come enjoy, buy, and chat plants at TapRoom Beer Company with House Plant House Call. Plants and beer? The definition of my perfect Saturday. 

Say it ain’t so, Sicilian Thing. The stalwart North Park pizzeria has apparently and unceremoniously shuttered after 17 years on 30th street. I know we still have Tribute and Blind Lady nearby, but it still feels like the end of an era.

The Michelin Guide finally made it to Mexico. Congrats to all the fantastic teams and people the Guide recognized for the first time, including Drew and Paulina Deckman (Conchas de Piedra, Deckman’s en el Mogor), Javier and Lauren Plascencia (Animalón), and more. Check out the complete list here.