A medical ambulance plane transporting a young girl who had just received life-saving treatment crashed on a street Friday night near the Roosevelt Mall in Philadelphia, Pennsylvania.

Jet Rescue Air Ambulance, the global ambulance flight company operating the plane, said its Learjet 55 crashed while departing from Northeast Philadelphia Airport at about 6:30 p.m.

The company said there were four crew members and two passengers on the plane at the time – a pilot, copilot, physician, paramedic, pediatric patient and her mother. They were all Mexican nationals.

The Federal Aviation Administration confirmed the number of crew members and passengers.

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Air Ambulance spokesperson Shai Gold told Fox News Digital the patient was a Mexican national who was in the U.S. for life-saving medical treatment. At the end of treatment, she was released to go home.

The plane was scheduled to fly from Philadelphia to Tijuana International Airport, with one technical stop in Springfield, Missouri for fuel, according to Gold. 

The FAA confirmed the plane was on its way to Missouri at the time of the crash.

The company could not confirm the identities or ages of anyone onboard until family is notified, but said it is unlikely there are survivors.

“The plane was loaded with jet fuel that’s highly flammable,” Gold said. “There is no indication that anybody survived, and by the debris field, I would be pleasantly surprised to learn otherwise.”

Air Ambulance is a Mexican-registered company that is licensed in Mexico and Florida, according to Gold. The aircraft was licensed, insured and accredited, he said.

“[There was] a very seasoned pilot [and a] very seasoned co-pilot,” Gold said. “They know the job, and they do it many times. We fly 600 to 700 missions a year. We are very busy, very active, and we keep top-notch staff.”

The same service helped transport Boston Red Sox star and MLB Hall of Famer David Ortiz in 2019 after he was shot at a bar in the Dominican Republic. Ortiz, who was severely wounded, survived emergency surgery.

The aircraft that went down was based out of the company’s headquarters in Mexico and Toluca International Airport, Gold confirmed.

Chilling audio from an air traffic control tower at Northeast Philadelphia Airport revealed the final moments before the crash. 

The audio, obtained by Fox News Digital, reveals operators were desperately trying to make contact with the Learjet 55 before it crashed, but received no response.

“What’s going on down there?” one air traffic controller can be heard saying. 

“We have a lost aircraft. We’re not exactly sure what happened. So, we’re trying to figure it out,” replies another air traffic controller. “The field is going to be closed so no inbounds-outbounds.” 

Shriners Hospitals for Children confirmed in a statement to Fox News the girl received care at its Philadelphia location, which is 12 miles away from the airport.

“Because of patient privacy concerns, we cannot say any more about the patient and her family at this time,” the hospital wrote in the statement. “Our hearts and prayers go out to the families of the medical crew and pilots who were also lost in this tragic event – as well as all of the people who were affected on the ground – and we’re thankful to the first responders for their quick action.”

Nearby Temple University Hospital Jeanes Campus confirmed six patients were taken to the hospital. 

Of the six, three were treated and released, the other three remain in “fair condition,” according to a hospital spokesperson. 

It is unclear if the patients were plane occupants, or people on the ground at the time of the crash.

A senior Philadelphia fire official tells Fox News the fires that were sparked by the crash are “now under control.”

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The official said when the plane went down, it sprayed jet fuel, soaking nearby row homes. The homes then went up in flames. The fire official tells Fox News six houses and six cars caught on fire.

President Donald Trump took to Truth Social to react to the tragedy.

“So sad to see the plane go down in Philadelphia, Pennsylvania. More innocent souls lost. Our people are totally engaged,” Trump wrote. “First Responders are already being given credit for doing a great job. More to follow. God Bless you all.”

Vice President JD Vance later took to X, calling the situation “very sad.”

“May God bless the victims and their families,” Vance wrote.

U.S. Department of Transportation Secretary Sean Duffy posted on X that he briefed Trump and other officials on the disaster.

“Just briefed the President and @GovernorShapiro from FAA HQ. I offered the full support of the @USDOT to the Governor and local officials,” Duffy wrote. “Investigators are on site.”

Philadelphia Mayor Cherelle Parker at a press conference Friday night said she was unable to confirm the number of fatalities and asked for prayers.

“We know there will be loss in this region,” Parker said.

Earlier, she advised locals not to touch anything and call 911 if they come across debris.

A medical oxygen tank donning the name of the transport company was seen on the ground outside a McDonald’s near the scene of the crash. A police commander told FOX 29’s Steve Keeley that there were “pieces everywhere.” 

The City of Philadelphia posted on X, calling the incident “major.”

“Major incident near Cottman and Bustleton Avenues in Northeast Philadelphia across from Roosevelt Mall,” according to the post. “Roads closed in area including parts of Roosevelt Boulevard. Avoid area.”

City officials confirmed 45 state troopers are on the ground assisting.

A video shows the plane loudly crashing in the distance, with a burst of light covering the area.

Gov. Josh Shapiro posted on X, noting he was in communication with the mayor, police and fire departments.

“We are offering all Commonwealth resources as they respond to the small private plane crash in Northeast Philly,” Shapiro wrote. “We’ll continue to provide updates as more information is available.”

The National Transportation Safety Board (NTSB) is leading the investigation and the FAA will assist.

An NTSB investigator arrived on scene Friday night and additional team members will arrive Saturday, the agency wrote in a post on X.

The Bureau of Alcohol, Tobacco, Firearms and Explosives Philadelphia said it was also on site investigating.

The Philadelphia Eagles, who will face the Kansas City Chiefs in Super Bowl LIX on Feb. 9, posted to X late Friday extending their condolences.

“The Eagles organization was heartbroken to learn of the tragic loss of life earlier this evening as a result of the plane crash in Northeast Philadelphia,” the organization wrote in the post. “We extend our condolences to the victims and loved ones they leave behind. We are grateful to the first responders for their heroic actions at the scene.”

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The crash comes just days after an American Airlines passenger plane collided midair with an Army Black Hawk Helicopter near Reagan National Airport, killing 67 people.

This is a developing story. Please check back for updates.

Fox News Digital’s Jackson Thompson and Bradford Betz contributed to this story.