Maryland
Why is urine yellow? University of Maryland researchers discovered the answer – WTOP News
A long-standing scientific mystery related to why urine is yellow was solved by researchers at the University of Maryland.
It seems like an answer that the scientific community should have already had, but the exact reason as to why urine is yellow has been elusive until now.
Researchers at the University of Maryland have cracked the code, identifying an enzyme that’s responsible for giving urine its yellow hue.
“We’re elated,” said Brantley Hall, a professor in the department of cell biology and molecular genetics at the University of Maryland in College Park.
Hall is the lead author of the study, which was published Wednesday in the journal Nature Microbiology.
“It’s a really important fundamental discovery, and we’re so happy that people can engage with this because it’s something they’re familiar with,” said Hall.
For decades, researchers had identified the molecule “urobilin” as the thing that makes urine yellow. But Hall’s research went further, finding out where urobilin actually comes from and how the body produces it.
When red blood cells degrade after their six-month life span, a bright orange pigment called “bilirubin” is produced as a byproduct.
Bilirubin is typically secreted into the gut, where it is destined for excretion.
Gut microbes encode the enzyme “bilirubin reductase” that converts bilirubin into a colorless byproduct called urobilinogen.
Urobilinogen then degrades into urobilin.
“We’re building on the shoulders of a lot of people who have studied this phenomenon before,” Hall said. “It’s remarkable that an everyday biological phenomenon went unexplained for so long.”
Aside from solving a scientific mystery, the study could have other health implications.
Hall’s team found that bilirubin reductase is present in almost all healthy adults but is often missing from newborns and people who have inflammatory bowel disease.
Their theory is that the absence of bilirubin reductase may contribute to infant jaundice and the formation of pigmented gallstones.
“Now that we’ve identified this enzyme, we can start investigating how the bacteria in our gut impact circulating bilirubin levels and related health conditions like jaundice,” said study co-author Xiaofang Jiang. “This discovery lays the foundation for understanding the gut-liver axis.”
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Maryland
Central Pa. woman killed in Maryland crash
A 73-year-old Adams County woman died Sunday when a dump truck crossed over and crashed into her vehicle on a Maryland road, police said.
Littlestown resident Sandra Stigler was driving a Dodge Ram pickup truck south on the 3000 block of the Littlestown Pike in Carroll County when the crash happened around 1:30 p.m., according to Maryland State Police.
Police said a northbound dump truck crossed into Stigler’s lane for unknown reasons and crashed into Stigler’s pickup.
Stigler was pronounced dead at the scene, police said. The dump truck’s driver — a 52-year-old man from Manchester, Maryland — was not hurt.
Littlestown Pike was shut down for about four hours after the crash.
The Maryland State Police Crash Team is investigating and will do a post-crash inspection of the dump truck.
Maryland
Payne scores career-high 30 points in Maryland’s 89-63 win over Wagner – WTOP News
Pharrel Payne scored a career-high 30 points and grabbed 10 rebounds, Myles Rice added 16 points, and Maryland cruised past Wagner 89-63 on Tuesday night.
Photo by G Fiume/Getty Images
Photo by G Fiume/Getty Images
COLLEGE PARK, Md. (AP) — Pharrel Payne scored a career-high 30 points and grabbed 10 rebounds, Myles Rice added 16 points, and Maryland cruised past Wagner 89-63 on Tuesday night.
Payne was 8-of-11 from the floor and made 14 of his 20 free-throw attempts in the contest. He also added three blocks, and Rice had five steals.
Maryland (6-3) was in control for the majority of the game, leading for all but 3:39 of the game and last trailing when the score was 24-23 with 2:38 remaining in the first half. The Terrapins held a 33-26 lead at halftime.
Darius Adams had 12 points and six rebounds, but struggled to a 3-for-12 night shooting. Solomon Washington added 10 points and six rebounds of his own for the Terrapins.
Nick Jones had 16 points to lead the Seahawks (1-6), Jaden Baker added 13, and Sam Smith had 10. Wagner was held to 37% (21 of 57) of shooting from the field, and 26% (6 of 23) from deep.
Maryland snapped a two-game losing streak, allowing 100 or more points to No. 11 Gonzaga and No. 12 Alabama.
Up next
Wagner hosts Bryant & Stratton and Maryland visits Iowa on Saturday.
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Maryland
Dead man identified as suspect in 1988 Maryland cold case homicide
A man who died in 2010 was identified as a suspect in a 1988 cold case homicide in Frederick, Maryland, according to the city police department.
The suspect, identified as Calvin Ziegler, was interviewed during the initial investigation. However, due to early DNA testing, he was not determined to be a suspect at the time.
According to police, 23-year-old Delores Marie “Mooda” Thompson was found dead in her apartment in the 100 block of South Market Street on Feb. 1, 1988. There were no signs of forced entry, according to police.
It wasn’t until this year that her family received answers due to a development in the case.
“Thanks to recent advancements in department forensic equipment, our crime scene unit was able to revisit the evidence with fresh eyes,” Frederick Police Chief Jason Lando said.
Police said they examined the initial investigation and found that Thompson’s manner of death was strangulation. They also determined that the case included evidence of sexual assault.
According to police, Ziegler knew Thompson and frequently visited her apartment before her death. But a suspect sample could not be developed from the evidence that was available at the time.
Multiple other suspects were also interviewed during the initial investigation, police said.
This year, detectives went over the evidence again using updated forensic techniques and equipment. They identified a small piece of bedding that had not been previously tested.
By testing the evidence with updated techniques, investigators were able to produce a DNA profile and compare it to national records. It returned a match to Ziegler, who died in 2010, according to police.
Despite criminal charges not being possible, the Frederick County State’s Attorney issued a formal letter confirming that the evidence supports the identification of Ziegler as the person responsible for Thompson’s death and the case was listed as closed.
“To the family of Dolores Thompson, we know this announcement does not take away your pain, but we hope it offers the peace of finally knowing the truth,” Chief Lando said.
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