Health
Study challenges negative cannabis stereotypes, claiming link to brain benefits
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While cannabis has recently come under fire for potential negative health risks, a recent study suggests that its use could increase brain volume and cognitive fitness.
Researchers at the University of Colorado Anschutz Medical Campus analyzed cannabis usage, brain scans and cognitive test results for more than 26,000 adults between the ages of 40 and 77, using data from the UK biobank.
The study found that cannabis users — particularly those who reported moderate lifetime usage — showed larger volumes in several brain regions.
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“Compared to individuals with no history of cannabis use, those who reported using cannabis showed larger volumes in several brain regions characterized by a high density of cannabinoid (CB1) receptors — regions involved in processes such as memory, information processing and emotion regulation,” lead study author Anika Guha, Ph.D., a researcher at the University of Colorado Anschutz Medical Campus, told Fox News Digital.
A recent study suggests that cannabis use could increase brain volume and cognitive fitness. (iStock)
The cannabis users also scored better on cognitive tests that measured learning, processing speed and executive function.
This outcome differs from many previous studies, which have focused on short-term cognitive impairment during or shortly after cannabis use, the researcher pointed out.
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“These findings suggest that the relationship between cannabis and the brain may differ across the lifespan, and that moderate use in mid-to-later adulthood may be associated with positive brain health outcomes,” Guha said.
Not all areas of the brain showed positive effects among cannabis users. The posterior cingulate, which is involved in self-reflection and memory, had lower volume with higher marijuana use.
“The takeaway is not that people should start using more cannabis based on these findings alone.”
As cannabis has been rising in popularity among all ages, this type of study is important for understanding its long-term effects and the pros and cons of use, according to Matt Glowiak, Ph.D., chief addiction specialist with Recovered, an organization that provides information and resources for mental health and addiction treatment.
The drug’s effects likely depend on factors such as age, dose, frequency, product composition and individual vulnerability. (AP Photo/Martin Meissner, File)
“Given the connection between cannabis use and larger brain volume, it is believed that it may help [older] individuals retain cognitive function that might otherwise naturally decline,” Chicago-based Glowiak, who was not involved in the study, told Fox News Digital.
“This is a huge benefit, but one we need to explore a bit further, ahead of encouraging those who would otherwise not consider integrating cannabis into their healthcare regimen.”
Limitations and caveats
As the study was observational in nature, it could not prove that cannabis use improves brain health — instead, it only showed an association, according to Dr. Marc Siegel, Fox News senior medical analyst, who was not involved in the study.
“The preponderance of previous evidence does not line up with improved cognitive function from chronic cannabis use,” Siegel told Fox News Digital. “This study is an outlier, and though it cannot be ignored, it is not justification for use.”
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The study also relied on the UK Biobank, which offers a “large and rich dataset,” Guha said — but it is limited to the questions that were originally posed to the participants.
“In particular, we have only a broad measure of how many times someone has used cannabis over their lifetime,” she said. “We do not have access to details about how they used cannabis, such as whether they smoked or used edibles, the type or potency of cannabis, or when in their life they used most heavily.”
Cannabis users scored better in learning, processing speed and executive function. (iStock)
“Those details likely matter a great deal for understanding how cannabis affects the aging brain.”
Given these limitations, Guha suggests that the findings should be seen as an early indicator that cannabis use may be related to brain aging, “and as a starting point for more targeted research that can tease apart these relationships.”
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“The takeaway is not that people should start using more cannabis based on these findings alone,” she emphasized. “While cannabis may have potential benefits in some contexts, a substantial body of research also documents important risks, underscoring that cannabis is neither completely beneficial nor completely harmful.”
The drug’s effects likely depend on factors such as age, dose, frequency, product composition and individual vulnerability, according to Guha.
“Given the widespread use and legalization of cannabis, it would be great to know that it is net-positive for brain health — however, this feels too good to be true, and too early to claim,” one expert said. (AP)
“As with any substance, individuals should consult with a healthcare provider before initiating use, particularly if they have a history of mental health concerns, as THC (the primary psychoactive component of cannabis) can exacerbate symptoms such as psychosis in vulnerable individuals,” she added.
Dr. Alex Dimitriu, who is double board-certified in psychiatry and sleep medicine and the founder of Menlo Park Psychiatry & Sleep Medicine, reiterated that this study is an “outlier,” as most previous research has shown “detrimental effects” from cannabis use.
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“Given the widespread use and legalization of cannabis, it would be great to know that it is net-positive for brain health — however, this feels too good to be true, and too early to claim,” he said. “I would advise proceeding with caution and moderation.”
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Dimitriu agreed that more large-scale studies and review papers are needed to get a “clearer picture.”
“What this cannabis study shows is that there may be conflicting information, which warrants more investigation.”
Health
New blood test detects 90% of aggressive prostate cancer cases, beating current screenings
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A new test could make it easier to detect high-risk prostate cancer cases earlier.
The blood test, called Stockholm3, is showing promise in clinical trials, beating out the traditional, standard prostate-specific antigen (PSA) test.
In a new study published in the Annals of Internal Medicine, researchers from the Karolinska Institutet in Sweden studied the test’s efficacy in more than 12,000 men — mostly Swedish or European — aged 50 to 74.
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All participants were tested with PSA and Stockholm3 and were followed for two years. During the follow-up period, 443 men were diagnosed with aggressive prostate cancer.
Stockholm3 detected 90% of aggressive prostate cancer cases compared to 74% for PSA tests.
Stockholm3 detected 90% of aggressive prostate cancer cases compared to 74% for PSA tests. (iStock)
Stockholm3 missed “significantly fewer” serious cancer cases than PSA. The number of men incorrectly classified as high-risk was similar across both tests, according to a press release.
Thorgerdur Palsdottir, a researcher at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, wrote in a statement that one of the major challenges in prostate cancer is being able to identify the cases that are “truly dangerous.”
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“Our results show that Stockholm3 identifies significantly more aggressive cancer cases than PSA without increasing the number of unnecessary follow-ups,” she said.
“These results point toward a potential change in how prostate cancer screening can be conducted,” the researcher added. “A more precise blood test could enable earlier detection of aggressive disease while reducing the number of unnecessary follow-up examinations and procedures.”
“A more precise blood test could enable earlier detection of aggressive disease while reducing the number of unnecessary follow-up examinations and procedures,” a researcher commented. (iStock)
Study co-author Hari Vigneswaran, chief medical officer of Stockholm3-maker A3P Biomedical, commented on these “promising” findings in an interview with Fox News Digital.
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He confirmed that the PSA has been the standard for prostate cancer screening since the 1990s despite its “well-documented limitations.”
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“It leads to invasive and costly follow-up testing, contributes to over-diagnosis of non-aggressive cancers and, most importantly, it misses a substantial share of aggressive disease,” Vigneswaran said.
When aggressive prostate cancer is found while still confined in the prostate, the five-year survival is close to 100%. (iStock)
When aggressive prostate cancer is found while still confined in the prostate, the five-year survival rate is close to 100%, which highlights the importance of early detection, according to the doctor.
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Data from the National Cancer Institute’s SEER database show that metastatic prostate cancer has risen over the past decade, suggesting that “we have not improved early detection of the aggressive, curable disease that screening is meant to catch,” Vigneswaran said.
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“The goal of screening is to find the cancers that need treatment while they are still curable, without raising the number of men who screen positive but don’t have aggressive disease,” he said.
Stockholm3 could reduce the need for unnecessary MRIs and biopsies, according to the researcher. (Getty Images)
Stockholm3 could reduce the need for unnecessary MRIs and biopsies, according to the researcher.
The findings did have some limitations. Stockholm3 is an investigational device and is not available for sale in the U.S., Vigneswaran noted.
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The test estimates a man’s risk of aggressive prostate cancer, but a biopsy remains the gold standard for confirming the disease.
The company plans to seek FDA approval to use the test for routine screening and will “generate the evidence needed to support that pathway, including U.S. data,” Vigneswaran said.
Health
This Protein Smoothie Trick Helps Women Over 40 Lose Twice as Much Fat
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Health
These leafy greens could help protect your lungs, study suggests
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Scientists have linked eating leafy green vegetables such as spinach, kale and broccoli to better lung health.
There are two primary forms of vitamin K found in foods. The primary kind is vitamin K1, found mainly in vegetables, which plays a major role in the body’s blood-clotting process.
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Vitamin K2 is found in fermented foods, certain dairy products, eggs and meats and helps regulate calcium in the body and supports bone health.
Researchers at Australia’s Edith Cowan University examined whether dietary intake of vitamins K1 and K2 was associated with chronic obstructive pulmonary disease (COPD), asthma and lung function.
Leafy green vegetables are high in vitamin K1, a nutrient that researchers have observed conributes to improved lung health. (iStock)
“Chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are among the most prevalent noncommunicable diseases worldwide and were the third leading cause of death in 2019, accounting for 4 million deaths and affecting 454.6 million individuals globally,” the scientists reported in the introduction to their study, published in The American Journal of Clinical Nutrition.
“Although asthma and COPD can be managed with available treatments, neither condition is curable, underscoring the need for effective prevention strategies,” they added.
The leading cause of COPD is smoking, the Mayo Clinic reported. Exposure to other irritants, such as dust, chemicals and pollution, can also cause it.
The researchers analyzed data from 179,062 participants over a 10-and-a-half-year period and concluded that, “Higher dietary vitamin K1 intake was associated with better lung function and a lower rate of COPD.”
Researchers found that people who increased their vitamin K1 intake were less likely to develop COPD. (iStock)
Participants who consumed the most vitamin K1 had a 16% lower likelihood of COPD, the researchers observed. The effects were more pronounced in smokers and participants with high-risk occupations.
Consumption of vitamin K2 did not result in lower COPD rates.
“No association was observed for vitamin K1 or vitamin K2 intakes and asthma,” the researchers also wrote.
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Associate Professor Marc Sim, who was involved in the study, said that it’s likely Vitamin K activates a protein that may help keep lung tissue flexible and prevent damage.
Because the study was observational, it cannot prove that vitamin K1 directly reduces COPD risk, only that higher intake was associated with better lung health.
Researchers have associated higher consumption of leafy green vegetables with better lung function. (iStock)
Just one extra serving of leafy greens “is an achievable way to boost your vitamin K1 intake,” said Chengfeng Li, one of the study’s researchers.
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Other foods rich in vitamin K1 include collard greens, Swiss chard, Brussels sprouts and turnip greens.
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