Science
Wastewater Disease Tracking: A Photographic Journey From the Sewer to the Lab

Monitoring viruses may be tough.
Sewage offers an answer.
(All it’s a must to do is flush.)
Right here’s how a scrappy crew of scientists, public well being consultants and plumbers is embracing wastewater surveillance as the way forward for illness monitoring.
Aug. 17, 2022
The Covid-19 pandemic has turned sewage into gold.
People who find themselves contaminated with the coronavirus shed the pathogen of their stool. By measuring and sequencing the viral materials current in sewage, scientists can decide whether or not circumstances are rising in a selected space and which variants are circulating.
Individuals excrete the virus even when they by no means search testing or remedy. So wastewater surveillance has turn out to be a vital instrument for retaining tabs on the virus, particularly as Covid-19 testing has more and more shifted to the house.
The establishments and localities that invested in wastewater surveillance over the past two years are discovering that it may be used to trace different well being threats, too. The Sewer Coronavirus Alert Community has already begun monitoring the monkeypox virus in wastewater. And final week, New York Metropolis officers introduced that polio had been detected within the metropolis’s sewage.
Six months in the past, NYC Well being + Hospitals, a big, native well being care system, started piloting its personal wastewater surveillance system to trace the coronavirus and the flu. Monkeypox and polio monitoring will begin as quickly as subsequent week. There are a selection of approaches to wastewater surveillance. Right here’s a visible information to how the coronavirus monitoring course of works in a single New York hospital.
Half 1: Within the Hospital Basement
During which the bathrooms are flushed, sewage flows by way of a basement pipe and two intrepid scientists come to gather it.
New York Metropolis was the epicenter of the nation’s first Covid wave, and its hospitals had been hit exhausting by a number of surges within the pandemic. In late 2021, Well being + Hospitals determined to construct a sustainable, long-term pathogen surveillance system to get forward of future outbreaks, mentioned Leopolda Silvera, the worldwide well being deputy at Elmhurst Hospital Heart in Queens, which is a part of the well being care community.
The wastewater surveillance initiative is now working at 10 hospitals, however it started, in February, at Elmhurst.
Coronavirus fragments deposited into hospital bathrooms journey by way of the plumbing system and enter a sewage pipe within the basement.
“That is our child,” John Reilly, the supervisor plumber at Elmhurst, mentioned, banging on the surface of the pipe. Each Monday, a member of the wastewater crew drops a group gadget, which the crew calls the Contraption, into a gap within the pipe.
Over the following 24 hours, the wastewater will rush over, round and thru the gadget.
The subsequent day, two researchers arrive to examine on the Contraption. “I need to warn you that it’s going to be gross,” one mentioned.

Carrying masks and gloves, they fastidiously take away the gadget from the pipe after which use tweezers to extract a tampon – sure, a tampon – from the mesh tube.
The researchers have experimented with completely different designs for the Contraption; at some point this spring they had been utilizing a porous steel cylinder that contained a tampon to soak up the wastewater. Their present design makes use of charcoal water filters as an alternative.
The technicians double-bag the waterlogged tampon to make sure it doesn’t leak on the 15-minute drive throughout Queens.

Then they put the pattern on ice and click on the cooler shut. The soiled work is finished.


Half 2: Within the Queens Faculty Lab
During which the degrees of the virus are measured.
Earlier than the pandemic hit, John Dennehy spent his time finding out bacteriophages, or viruses that infect micro organism, typically isolating them from wastewater. “When the pandemic got here, I felt like I had an obligation as a virologist to contribute my expertise,” Dr. Dennehy mentioned.
In 2020, Dr. Dennehy, with colleagues together with Monica Trujillo, a microbiologist at Queensborough Neighborhood Faculty, started testing samples of town’s wastewater for the coronavirus. After they heard that the hospitals needed to create their very own surveillance system, they had been keen to assist. Dr. Dennehy’s lab at Queens Faculty is the primary cease for the hospital samples.
The pattern is pasteurized in a scorching water bathtub, making it secure for scientists to deal with. Then, the water is filtered to take away solids and particles.
The scientists add two compounds, polyethylene glycol and sodium chloride, to assist the virus kind a strong precipitate.

The pattern incubates within the fridge in a single day after which spins in a centrifuge. When the method is full, the researchers are left with a tiny pellet of virus.
They add a shiny pink chemical known as TRIzol to extract the RNA from the viral pellet. (In actual life, science hardly ever seems the way in which it does within the films – the shockingly pink concoction is an exception, the researchers famous with enthusiasm.)

To find out how a lot virus is current within the pattern, the researchers use P.C.R., the identical technique used to check folks for the virus. They put the RNA they’ve extracted into the tiny wells of a P.C.R. plate after which slide the plate right into a machine generally known as a thermal cycler.
The machine will amplify – make copies of – the viral RNA and measure how a lot is current. The extra RNA there’s, the extra virus presumably is current within the wastewater and, by extension, within the hospital group.
The researchers share the outcomes with hospital officers. This system has already confirmed promising.


Dr. Dennehy, Dr. Trujillo and their colleagues have discovered that the quantity of coronavirus and influenza within the hospital’s wastewater typically started rising 10 to 14 days earlier than the hospital noticed a rise in Covid and flu sufferers.
“When you find yourself testing all the pieces and everyone, the wastewater does not provide you with such a giant lead,” Dr. Trujillo mentioned. However as soon as coronavirus testing within the metropolis dropped off, the wastewater knowledge turned particularly useful. “It is actually one thing that we hope that will probably be integrated as one other instrument for public well being,” she mentioned.

Ms. Silvera, the worldwide well being deputy at Elmhurst, ferries the Queens Faculty samples, and a few further bottles of wastewater, to a business laboratory …

…and deposits them within the fridge…

…to maintain them cool till they’re able to be processed.
Half 3: Within the Pandemic Response Lab
During which variants are recognized.
Opentrons Labworks Inc., a laboratory robotics firm, created the Pandemic Response Lab in 2020 to offer high-volume, high-speed coronavirus testing and, later, coronavirus sequencing of affected person samples. The seek for viral variants in wastewater includes primarily the identical course of.
“It simply so occurs that that pattern shouldn’t be coming from an individual however from wastewater, which, you already know, has some components that got here from folks,” mentioned Jonathan Brennan-Badal, the chief government of Opentrons.
The Queens Faculty laboratory remoted the virus’s RNA. To sequence the genetic materials, the Pandemic Response Lab first converts the RNA into DNA, a course of generally known as reverse transcription.

A pipetting robotic provides the required chemical substances and enzymes to a plate containing small quantities of the viral RNA. The plate is then positioned right into a thermal cycler – each emblazoned with a Snow White-inspired title – and the enzymes convert the RNA into DNA.
The scientists shuffle the pattern backwards and forwards between a small military of laboratory robots.
The robots add chemical substances and enzymes, and the samples are manipulated in a wide range of methods. The viral DNA is amplified after which chopped up into fragments which can be quick sufficient to be learn by the sequencer.
These fragments are then amplified and marked with molecular barcodes, which permit the scientists to later distinguish particular person samples from a pool of them. Lastly, the samples are cleaned after which mixed, typically by hand.
After all of the people and robots have accomplished their respective duties, the pooled samples are loaded into the sequencer, which determines the genetic sequence of every fragment, permitting scientists to find out what mutations and variants are current.

The outcomes are routinely uploaded to a server and processed. The findings are reported to the hospitals weekly.
The sequencing outcomes “replicate what has been seen with scientific knowledge,” Ms. Silvera mentioned. Because the BA.4 and BA.5 variants of the coronavirus unfold, for example, they started to “dominate” the wastewater samples, she added.
The hospital venture is only one of many bobbing up throughout the nation and around the globe. New York Metropolis has its personal city-wide wastewater surveillance system, which includes accumulating sewage samples from municipal wastewater services, together with the Newtown Creek Wastewater Remedy Plant.

And the hospital crew is already trying towards the longer term, contemplating how the identical system could be harnessed to watch a wide range of potential well being threats. “The data is invaluable, truthfully,” Ms. Silvera mentioned.
And all it takes is a flush.

Science
Contributor: The emergency in emergency medicine

If you have been to an ER lately — or if you’ve watched the disturbingly accurate TV show “The Pitt” — you’ve seen scenes that resemble field hospitals more than state-of-the-art medical centers. Waiting rooms have been turned into makeshift care zones. Chairs, cots and cubicles serve as gurneys. Providers eyeball the sick and injured and “shotgun” orders for patients. It feels chaotic and unwelcoming because it is.
This is the new normal for emergency departments in the United States, the result of a dramatic rise in the number of ER beds occupied by patients waiting for a space on a traditional hospital ward. We call them “boarders” and in many emergency departments, they routinely account for half or more of all available care space.
With a fraction of beds in play for new arrivals, waiting room patients — even some arriving by ambulance — are increasingly likely to be seen, examined and treated in the lobby. The consequences are as predictable as they are devastating: worse patient outcomes, fragmented care, longer hospital stays, ballooning costs and rising frustration and anger among staff and patients.
Less visible — but no less harmful — is the toll this takes on young doctors in training.
A recent study led by Dr. Katja Goldflam, a Yale professor, documents the scale of the problem. Nearly three-quarters of the emergency medicine residents she surveyed reported that boarding had highly negative effects on their training. They expressed anxiety and a mounting emotional toll over their diminishing ability to manage patients or handle department surges with confidence, and their growing sense that they could not provide the kind of care they’d expect for their own families.
As emergency medicine educators with a combined six decades of experience, this feels personal to us. We are failing our trainees. We are failing our patients. And we are compromising the future of doctors and patients alike.
The damage is not theoretical. One of us recently experienced it personally, when his father — during the final months of his life — visited two prestigious ERs. Both times, recently trained physicians missed straightforward but life-threatening problems after brief, stopgap-style encounters. Poor clinical judgment is more likely, and more consequential, in a hurried and overwhelmed care environment.
Today, medical education is no longer centered on memorizing facts. With smartphones, decision-support tools and now AI, information is everywhere. What sets a good doctor apart is judgment — the ability to navigate uncertainty, synthesize complex data and make decisive, accurate choices. Building this kind of judgment requires many patient encounters — “reps.”
No amount of classroom learning, reading or podcast listening can replace the formative experience of confronting a clinical puzzle in a patient who has entrusted you with their care. Yet in today’s crowded ERs, physicians in training are losing access to these crucial face-to-face encounters and the skills, competence and confidence they teach.
Shift change “rounds” — once a space for discussion and reflection — now operate more like inventory checks: Here’s a 78-year-old with heart failure, there’s a 35-year-old with appendicitis still awaiting an OR.
Meanwhile, as the waiting room overflows, doctors scatter into the lobby to see new arrivals, hoping to reduce the backlog. “Lobby medicine” — a sanitized term for care delivered in a setting stripped of privacy, dignity and safety — is more than a logistical nightmare. It sends a terrible message to young physicians: that cursory patient assessments, firing off broad-spectrum tests and “moving the meat” is acceptable. It is not.
Why is boarding getting worse?
COVID-19 was the inflection point. While volumes dipped early in the pandemic, they rebounded within a year — and in 2024, according to national hospital metrics, stood at 10% above 2021 levels. In 2023, research showed a 60% increase in boarding and fourfold increase in median boarding times compared with pre-pandemic ERs.
The reasons are complex and systemic: financial pressure to keep hospital beds full (every open space is lost revenue), an aging population with greater needs, dwindling access to primary care and a collapsing system of rehab, skilled nursing or home health options. Hospitals are boxed in, forced to provide basic care while waiting days, sometimes weeks, for aftercare services to become available. It is not uncommon for a third or more of the patients in a hospital to be on hold pending an appropriate discharge destination. The bottleneck trickles down: Wards become holding areas, the ER becomes a de facto ward and the lobby becomes the ER.
So, what’s the fix?
The simple answer — just end boarding — has been the rallying cry of well-intentioned efforts for decades. Nearly all have failed. Why? Because emergency department crowding is not the root problem. It’s the canary in the coal mine of a dysfunctional healthcare delivery system riddled with misaligned incentives and priorities.
Real change will require collective outrage that spills beyond the ERs, into the inboxes and onto the agendas of hospital administrators, insurance executives and elected officials.
Consider air travel. Imagine if Los Angeles International Airport shut down three of its four runways, forcing all takeoffs and landings onto one. Travelers would revolt. The Federal Aviation Administration would intervene. The system would be made to fix itself — because it’s unsafe, ineffective and unsustainable.
But when the same thing happens in healthcare, some patients may bark in anger and frustration at the multi-hour waits, but most simply shrug, grateful, finally, for an exhausted ER doc’s time.
Enough.
If we want better healthcare it means investing more — adding beds, staffing and aftercare capacity. It means creating primary care options other than a default trip to the ER. It means reclaiming the ER not just as a place for healing, but as a place for learning. A place where doctors are taught not in disaster zones, but in environments that allow for connection and understanding of our patients and their diseases. Finally, it means recognizing that designing and investing in better systems and in medical education is crucial to public safety.
Training a great doctor is like training a great athlete. You can’t learn to sink a three-pointer by watching YouTube. You have to step onto the court. In medicine, that means standing in front of a patient and deciding: What now?
That experience — raw, real and imperfect — is irreplaceable. And we’re losing it.
How we care for patients today will define how we all will be cared for tomorrow.
Eric Snoey is an attending emergency medicine physician in Oakland. Mark Morocco is a Los Angeles physician and professor of emergency medicine.
Science
Just 5 minutes a day of these exercises can sharpen your brain as you age

Exercise has long been linked with stronger brains and reduced risk of dementia and other cognitive diseases. But new research suggests that older adults can significantly improve brain health with only a few minutes of daily movement.
Researchers from the University of South Australia and the U.S.-based AdventHealth Research Institute found that as few as five minutes of moderate-to-vigorous exercise a day correlated to significantly better cognitive performance. The study, published in the British journal Age & Ageing in early April, examined data from hundreds of people 65 to 80 years old.
Researchers found that “huff-and-puff” movements, like running or lap swimming, were associated with better brain functions including information processing, focusing and multitasking and short-term memory. They also found that even a few minutes of moderate exercise like walking improves brain functions.
“Our key finding was that moving from doing zero minutes or very little moderate-to-vigorous physical activity to doing just five minutes a day — that’s where the biggest gain in cognitive function was seen,” said the study’s lead author, Maddison Mellow, a research associate at the University of South Australia.
The researchers distinguished between moderate and vigorous exercise by applying a simple test: whether subjects could still manage to speak full sentences after moving around. Vigorous exercise makes that impossible, said Audrey Collins, a postdoctoral research scientist at AdventHealth Research Institute and the paper’s co-lead author.
The study observed 585 people, all in good health. Their physical activity was measured using accelerometers they wore on their wrists; the researchers tested cognitive functions using online and paper-based tests.
Worth noting: This study also found a “strong relationship” between spending little to no time doing moderate to vigorous activity and poorer cognitive performance, Mellow said. One slightly surprising finding, she added, was that the cognitive performance gains from exercise don’t extend to longer-term memory and visual-spatial functions like judging distances or sizes.
The study was novel in that it categorized how people divided their days into three behaviors: sleep, sedentary and active. And though getting enough quality sleep is important to brain health in midlife and beyond, the researchers said that when forced to choose between minutes spent sleeping and minutes spent exercising, reducing sleep time to spend more time moving resulted in better brain function.
“It didn’t really matter, in this sample, where time was coming from, whether from sleep, sedentary behavior or light intensity physical activity,” Mellow said. “So long as time was being increased in moderate vigorous activity, that’s where the benefits were being shown for cognitive outcomes.”
With that in mind, what are some moderate or vigorous bursts of exercise for older adults to do every day? We consulted experts to give you five accessible options.
1. Walking
Two experts I spoke with each said the easiest way to clock those five daily minutes for brain health is by walking.
“Walking is No. 1, because that’s the easiest,” said E. Todd Schroeder, professor of clinical physical therapy and the director of the Clinical Exercise Research Center at USC. Very sedentary older adults may want to start with simple flat-ground walking at their normal pace, Schroeder says.
If you’re already a steady, regular walker, kick up the pace to elevate your heart rate into that all-important moderate category.
“A brisk walk is considered to be moderate activity,” said Rob Musci, an assistant professor of health and human sciences at Loyola Marymount University. On a scale of 1 to 10, moderate exercise is what you would consider being in the 4 to 6 range, Musci said.
To achieve a real huff-and-puff workout, walking or hiking briskly uphill is excellent, Schroeder said, because it also necessarily requires walking back down hill.
“That interval-type training is good,” he said, “where your heart rate goes up for a time then comes back down.”
2. Swimming
Swimming is a terrific way to get a full-body workout and raise your heart rate.
“It’s easy on the joints,” Shroeder said. “Even if you struggle with the technique of swimming, you can put on fins and get some at least moderate exercise.”
3. Cycling
Cycling can be on a stationary bike or an outdoor bike, many of which are now battery-assisted, making pedaling up hills almost too easy. One reason I like old-fashioned outdoor bikes, sans batteries, is that they also train balance and require your brain to keep you safe.
4. Resistance training
Lifting weights is one of the best ways to maintain muscle strength as we age, Musci said. Try these simple exercises you can easily do at home in fewer than three minutes. They include:
- Tossing a weighted ball from one hand to another (try it standing on one leg)
- Squats holding a kettlebell, dumbbell, a bag of oranges or nothing at all
- Weighted chest presses in boat pose
5. Gardening and housework
Gardening can be a great way to engage core muscles, encourage flexibility and practice fine motor skills. Even basic house cleaning, like scrubbing a bathtub or mopping a floor, can qualify as moderate exercise.
“Anything that gets your heart going is what we’re looking for,” Musci said. “You hear about all these high-end interventions, fitness programs and boot camps, but in reality, it’s just movement.”
The most important thing, he said, is “just getting off the couch.”
Von Zielbauer is the creator of Aging With Strength on Substack.
Science
Biden is diagnosed with 'aggressive' form of prostate cancer

WASHINGTON — Former President Biden has been diagnosed with an “aggressive form” of prostate cancer, his office said Sunday, a devastating development after having dropped his bid for reelection last summer over widespread concerns over his age and health.
Biden’s personal office said he was examined last week after the president reported a series of concerning symptoms.
“Last week, President Joe Biden was seen for a new finding of a prostate nodule after experiencing increasing urinary symptoms. On Friday, he was diagnosed with prostate cancer, characterized by a Gleason score of 9 (Grade Group 5) with metastasis to the bone,” the office said in a statement.
“While this represents a more aggressive form of the disease, the cancer appears to be hormone-sensitive, which allows for effective management. The President and his family are reviewing treatment options with his physicians,” the statement added.
The former president, 82, had been making his first public appearances since leaving office in recent weeks, including a public address and a lengthy sit-down on ABC’s “The View,” and also hired a communications strategist to help burnish his legacy amid the publication of a series of books critically examining his time at the White House.
Biden has a tragic personal history with cancer, losing his son, Beau Biden, to glioblastoma in 2015, when he was serving as vice president. At that time, he launched the “cancer moonshot,” a government-wide push for improved cancer treatments that he relaunched during his presidency.
The spread of cancer to the bones will make Biden’s cancer difficult to cure. But its receptiveness to hormone treatments could help his medical team inhibit the cancer’s growth, at least temporarily.
Biden dropped out of the 2024 race in July under immense pressure from leadership in the Democratic Party after a disastrous debate with the Republican presidential nominee, Donald Trump, laid bare concerns over his age and acuity.
Within hours of dropping out of the race, Biden endorsed his vice president, Kamala Harris, to run in his place. She quickly coalesced the party around her nomination and avoided a primary battle, but lost to Trump in November.
In a post on X, Harris said she and her husband, Doug Emhoff, were saddened to learn of Biden’s diagnosis. “We are keeping him, Dr. Biden, and their entire family in our hearts and prayers during this time,” she wrote. “Joe is a fighter — and I know he will face this challenge with the same strength, resilience, and optimism that have always defined his life and leadership. We are hopeful for a full and speedy recovery.”
Last week on “The View,” Biden said he took responsibility for Trump’s return to power, because he was in office at the time. “I do, because, look, I was in charge and he won. So, you know, I take responsibility,” he said.
But he continued to reject criticisms that he and his team worked to conceal the effects of his age on his performance as president, saying he was not surprised by Harris’ loss and suggesting he still believes he could have beaten Trump had he stayed in the race.
“It wasn’t a slam dunk,” he said, referring to President Trump’s victory. “Let me put it this way. He’s had the worst 100 days any president’s ever had. And I would not say honesty has been his strong point.”
Trump expressed concern about Biden’s condition in a Truth Social post Sunday. “Melania and I are saddened to hear about Joe Biden’s recent medical diagnosis. We extend our warmest and best wishes to Jill and the family, and we wish Joe a fast and successful recovery,” he wrote.
California Gov. Gavin Newsom was among the many politicians from both parties who posted their warm wishes and prayers for the former president. “Our hearts are with President Biden and his entire family right now. A man of dignity, strength, and compassion like his deserves to live a long and beautiful life. Sending strength, healing and prayers his way,” Newsom wrote on X.
House Speaker Mike Johnson (R-La.) wrote on X: “This is certainly sad news, and the Johnson family will be joining the countless others who are praying for the former President in the wake of his diagnosis.”
Biden was spending the weekend in Delaware with family, an aide said.
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