Health
Weight-loss medications may also benefit common medical problem, study finds

Weight-loss medications known as glucagon-like peptide-1 (GLP-1) agonists, which have gained popularity for treating type 2 diabetes and obesity, have been shown to have the surprising secondary benefit of reducing alcohol intake.
A team of international researchers from Ireland and Saudi Arabia followed 262 adult patients with obesity who started taking two GLP-1 medications: liraglutide or semaglutide.
Among the regular drinkers, weekly alcohol intake decreased by 68%, from approximately 23 units of alcohol to around 8 units.
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The findings were recently published in the journal Diabetes, Obesity and Metabolism and were also presented last week at the European Congress on Obesity in Spain.
GLP-1 agonists mimic a hormone called GLP-1, which is released from the gastrointestinal system after eating, according to study co-author Carel Le Roux, a professor at University College Dublin.
Weight-loss medications known as glucagon-like peptide-1 (GLP-1) agonists have been shown to have the surprising secondary benefit of reducing alcohol intake. (iStock)
These medications activate GLP-1 receptors in the brain, decreasing the sense of “reward” people feel after eating or drinking, eventually leading to reduced cravings for both food and alcohol, he told Fox News Digital.
“It is this commonality of function that suggests the GLP-1 receptors in the brain may be a therapeutic target for not just the disease of obesity, but also for alcohol use disorder,” the professor said.
Study findings
Before the participants started the weight-loss drugs, they self-reported their weekly alcohol intake, then were categorized as non-drinkers, rare drinkers or regular drinkers.
Approximately 72% had at least two follow-up visits and 68% reported regular alcohol consumption.
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After starting the weight-loss medications, the participants’ weekly average alcohol intake decreased by almost two-thirds overall — from approximately 11 units of alcohol to four units after four months of treatment with the GLP-1 agonists.
The reduction in alcohol use was comparable to the decrease that can be achieved by nalmefene, a drug that decreases the “buzz” feeling in people with alcohol use disorder in Europe, according to the researchers.

Among the regular drinkers, weekly alcohol intake decreased by 68%, from approximately 23 units of alcohol to around 8 units. (iStock)
For the 188 patients who were followed over an average of four months, none had increased their alcohol intake after starting the weight-loss medications.
Patients reported that after an evening meal, they were too full to have their usual drink — and when they did drink, they reported becoming full extremely quickly and drinking at a slower pace, Le Roux noted.
“The findings in this study suggest that we may have just found a therapeutic target for alcohol use disorder.”
This suggests that the experience was less enjoyable, partly due to the reduced rate of alcohol absorption.
Some patients also reported that they didn’t enjoy the flavor of the alcoholic beverages as much, and also that hangovers were much worse.
All of these experiences showed that the weight-loss medications create “guard rails” that prevent most patients from drinking excessively, giving them a degree of control over their alcohol intake, according to Le Roux.

After starting the weight-loss medications, the participants’ weekly average alcohol intake decreased by almost two-thirds overall. (iStock)
“The findings in this study suggest that we may have just found a therapeutic target for alcohol use disorder — the GLP-1 receptor,” the professor told Fox News Digital.
“This finding potentially opens the possibility of an entirely new pharmacological treatment paradigm, which could be used in conjunction with conventional methods, such as behavior therapy and group support.”
Potential limitations
The study was limited by its relatively small number of patients, the researchers acknowledged.
Also, the researchers were not able to verify the participants’ self-reported alcohol intake, and roughly one-third of them were not available for follow-up.
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There was also no control group, which means the researchers couldn’t prove that taking weight-loss medication reduces alcohol intake.

The main advantage of GLP-1 agonists is that they only need to be taken once a week and continue to work for the entire week. (iStock)
“Randomized, controlled trials with diverse patient populations — including patients diagnosed with alcohol use disorder — are needed to provide the quality and quantity of data that could be used to support an application for licensing the medication for the treatment of alcohol use disorder,” Le Roux said.
(One such trial is currently underway in Denmark.)
Study implications
With the current medications available to treat alcohol use disorder, the “major problem” is compliance, Le Roux said — “because the cravings for alcohol tend to come in waves.”
“This means a patient might be fully committed to treatment at one point in the week, but then stop taking the medication later in the week when a craving comes,” the professor added.

“This research suggests a promising ancillary benefit of GLP-1 analogs, potentially influencing cravings for alcohol and offering a new avenue for managing alcohol use disorder,” a physician said. (iStock)
There are currently three FDA-approved medications to treat alcohol use disorder: naltrexone (which helps decrease cravings by reducing the “buzz” feeling that comes with drinking alcohol); disulfiram (which helps some people avoid alcohol by making them feel sick when they drink), and acamprosate (which restores the balance of hormones in the brain to reduce cravings), according to the National Institute on Alcohol Abuse and Alcoholism.
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But less than 10% of people with alcohol use disorder get the proper treatment, with many resuming use within the first year of treatment, past research shows.
The main advantage of the GLP-1 agonists is that they only need to be taken once a week and continue to work for the entire week.

For the 188 patients who were followed over an average of four months, none had increased their alcohol intake after starting the weight-loss medications. (iStock)
Outside experts say the study’s findings highlight the potential of weight-loss medications to help treat alcohol use disorder.
“This research suggests a promising ancillary benefit of GLP-1 analogs, potentially influencing cravings for alcohol and offering a new avenue for managing alcohol use disorder,” Dr. Fatima Cody Stanford, obesity medicine physician at Massachusetts General Hospital and Harvard Medical School, who was not part of the study, told Fox News Digital.
For more Health articles, visit www.foxnews.com/health
“While the exact mechanisms are still being explored, the findings contribute to our understanding of the broader benefits of GLP-1 analogs beyond obesity treatment,” Stanford added.

Health
Eating more fruits and vegetables linked to surprising effect on sleep

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Your daily meal selections could influence the quality of your sleep, new research says.
A study from the University of Chicago Medicine and Columbia University found that increasing your intake of fruits and vegetables could help promote more restful sleep.
Previous research has shown that people who lack quality sleep may be more likely to indulge in unhealthy foods that are high in fat and sugar — and now this new finding sheds more light on how consumed foods impact sleep.
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In the small study — which was published in “Sleep Health: The Journal of the National Sleep Foundation” — 34 healthy young adults reported their daily food consumption and wore a tracker to measure how often they woke up or changed sleep patterns during the night, according to a press release.
Those who reported eating more fruits and vegetables during the day were found to have “deeper, more uninterrupted sleep.”
A study from the University of Chicago Medicine and Columbia University found that increasing your intake of fruits and vegetables could help promote more restful sleep. (iStock)
Greater amounts of healthy carbohydrates, like whole grains, were found to have that same benefit, the study found.
“Dietary modifications could be a new, natural and cost-effective approach to achieve better sleep,” said co-senior author Esra Tasali, MD, director of the UChicago Sleep Center, in the release.
HOW TO CHOOSE THE BEST SLEEPING POSITION FOR YOU, ACCORDING TO THE EXPERTS
“The temporal associations and objectively-measured outcomes in this study represent crucial steps toward filling a gap in important public health knowledge.”
Based on the study findings, the researchers concluded that people who eat at least five cups of fruits and veggies per day could have a 16% increase in quality of sleep compared to those who eat none of those foods.
“Small changes can impact sleep. That is empowering — better rest is within your control.”
“16 percent is a highly significant difference,” Tasali said in the release. “It’s remarkable that such a meaningful change could be observed within less than 24 hours.”
“Based on current data, the experts confidently advise that regularly eating a diet rich in complex carbohydrates, fruits and vegetables is best for long-term sleep health,” the release stated.

Those who reported eating more fruits and vegetables during the day were found to have “deeper, more uninterrupted sleep.” (iStock)
The American Heart Association provides the following examples of fruit and veggie servings that equate to 1 cup of produce.
- 8 large strawberries
- 1 large bell pepper
- 1 medium potato
- 22 grapes
- 2 medium carrots or 12 baby carrots
- 1 medium apple, orange, pear, peach, grapefruit or nectarine
Dr. Chelsie Rohrscheib, head sleep expert at Wesper in Michigan, said that most sleep professionals recognize that a healthy diet supports overall well-being, including sleep quality — “so the findings of this study are not entirely unexpected.”
“However, it’s important to note that this was a relatively small study composed primarily of young adult male participants, which limits generalizability,” Rohrscheib, who was not involved in the study, told Fox News Digital.
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“While the results were statistically significant, the overall reduction in sleep fragmentation was modest, about 16%.”
The study was also observational in nature, she noted, which means it lacked the control of a randomized trial.

“Based on current data, the experts confidently advise that regularly eating a diet rich in complex carbohydrates, fruits and vegetables is best for long-term sleep health,” the researchers wrote. (iStock)
“Ideally, future research would compare a group consuming a fruit- and vegetable-rich diet to a control group with limited intake to better establish causality,” the doctor added.
The researchers plan to conduct more studies to confirm that eating produce causes better sleep and to determine the “underlying mechanisms of digestion, neurology and metabolism” driving this impact, the release stated.
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“People are always asking me if there are things they can eat that will help them sleep better,” said co-senior author Marie-Pierre St-Onge, PhD, director of the Center of Excellence for Sleep & Circadian Research at Columbia, in the release.
“Small changes can impact sleep. That is empowering — better rest is within your control.”
Health
Bill Gates reveals 'next phase of Alzheimer's fight' as he shares dad's personal battle

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Bill Gates is speaking out about his personal experience with Alzheimer’s — and his hope for progress in fighting the disease.
In an essay published this week on his blog at GatesNotes.com, the Microsoft co-founder and tech billionaire, 69, reflected on the difficulty of spending another Father’s Day without his dad, Bill Gates Sr.
The elder Gates passed away in 2020 at the age of 94 after battling Alzheimer’s.
RATES OF DEMENTIA ARE LOWER IN PEOPLE WHO EAT THIS SPECIFIC DIET, RESEARCH SHOWS
“It was a brutal experience, watching my brilliant, loving father go downhill and disappear,” Gates wrote in the blog post.
Today, motivated by his own experience with the common dementia, Gates — who serves as chair of the Gates Foundation — is committed to working toward a cure for the common dementia, which currently affects more than seven million Americans, or one in nine people over 65.
Bill Gates and Bill Gates Sr. pose in a meeting room at the Seattle headquarters of the Bill & Melinda Gates Foundation in 2008. (Gates Ventures)
In his blog, Gates expressed optimism about the “massive progress” being made in the fight against Alzheimer’s and other dementias.
Last year, Gates said he visited Indiana University’s School of Medicine in Indianapolis to tour the labs where teams have been researching Alzheimer’s biomarkers.
BILL GATES LIKELY HAD AUTISM AS A CHILD, HE REVEALS: ‘WASN’T WIDELY UNDERSTOOD’
“I also got the opportunity to look under the hood of new automated machines that will soon be running diagnostics around the world,” he wrote. “It’s an exciting time in a challenging space.”
One of the biggest breakthroughs in Alzheimer’s research, according to Gates, is blood-based diagnostic tests, which detect the ratio of amyloid plaques in the brain. (Amyloid plaques, clumps of protein that accumulate in the brain, are one of the hallmarks of Alzheimer’s.)

Bill Gates Jr. (right) poses with his father at his graduation ceremony in 1973. (Gates family)
“I’m optimistic that these tests will be a game-changer,” Gates wrote.
Last month, the U.S. Food and Drug Administration (FDA) approved the first blood-based test for patients 55 years and older, as Fox News Digital reported at the time.
“A simple, accurate and easy-to-run blood test might one day make routine screening possible.”
Traditionally, Gates noted, the primary path to Alzheimer’s diagnosis was either a PET scan (medical imaging) or spinal tap (lumbar puncture), which were usually only performed when symptoms emerged.
The hope is that blood-based tests could do a better job of catching the disease early, decline begins.

The Gates family poses for a photo in 1965. The elder Gates passed away in 2020 at the age of 94 after battling Alzheimer’s. (Gates family)
“We now know that the disease begins 15 to 20 years before you start to see any signs,” Gates wrote.
“A simple, accurate and easy-to-run blood test might one day make routine screening possible, identifying patients long before they experience cognitive decline,” he stated.
Gates said he is often asked, “What is the point of getting diagnosed if I can’t do anything about it?”
To that end, he expressed his optimism for the future of Alzheimer’s treatments, noting that two drugs — Lecanemab (Leqembi) and Donanemab (Kisunla) — have gained FDA approval.
“Both have proven to modestly slow down the progression of the disease, but what I’m really excited about is their potential when paired with an early diagnostic,” Gates noted.

Alzheimer’s disease currently affects more than seven million Americans, or one in nine people over 65. (iStock)
He said he is also hopeful that the blood tests will help speed up the process of enrolling patients in clinical trials for new Alzheimer’s drugs.
To accomplish this, Gates is calling for increased funding for research, which often comes from federal grants.
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“This is the moment to spend more money on research, not less,” he wrote, also stating that “the quest to stop Alzheimer’s has never had more momentum.”
“There is still a huge amount of work to be done — like deepening our understanding of the disease’s pathology and developing even better diagnostics,” Gates went on.
“I am blown away by how much we have learned about Alzheimer’s over the last couple of years.”
Gates pointed out that when his father had Alzheimer’s, it was considered a “death sentence,” but that is starting to change.
“I am blown away by how much we have learned about Alzheimer’s over the last couple of years,” he wrote.
For more Health articles, visit www.foxnews.com/health
“I cannot help but be filled with a sense of hope when I think of all the progress being made on Alzheimer’s, even with so many challenges happening around the world. We are closer than ever before to a world where no one has to watch someone they love suffer from this awful disease.”
Health
This Tropical Fruit May Improve Your Skin, Heart Health and More

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