Science
Commentary: She was wrongly snagged by Trump's word police. Now her medical research is down the drain
SAN FRANCISCO — Nisha Acharya, an eye doctor and UC San Francisco professor, was at her campus clinic tending patients when a surprising email arrived.
Her federal research grant had just been terminated, according to a reporter for the Washington Post, who wondered if Acharya had any comment.
She was stunned. Her research, into the workings of the shingles vaccine, didn’t seem remotely controversial. The $3-million grant was the second she’d received, after years of similar work. The National Institutes of Health, which awarded the grant and regularly reviewed Acharya’s performance, had been pleased with all she’d accomplished.
Nevertheless, the NIH tersely informed the university its latest grant was among dozens terminated because the federal government, under President Trump, would no longer support research focused on “why individuals are hesitant to be vaccinated and/or explore ways to improve vaccine interest and commitment.”
Acharya’s research had nothing to do with any of that.
But the mention of “hesitancy” and “uptake” in her grant application — referring to the concern some cornea specialists had about the vaccine for those with shingles in the eye — was apparently all it took to snare Acharya in a dragnet mounted by the Trump administration word police.
Acharya fears the Trump administration’s heedless termination of grants will set back scientific and medical research for years to come.
(Paul Kuroda / For The Times)
Perhaps “hesitancy” and “uptake” generated an AI response, or triggered some on-the-hunt algorithm. Acharya can’t be entirely sure, but there’s no evidence an actual human being, much less any sort of expert on vaccines or shingles, reviewed her grant proposal or assessed her work.
She’s gotten no explanation beyond that one, formulaic March 10 email dispatched to the university. “I lost funding immediately,” Acharya said.
Views of the 47th president, from the ground up
The randomness of the administration’s action, and its apparent error, is maddening enough. But it’s also frightening, Acharya said, to think that political considerations are now guiding science and scientific research, erasing years of effort and thwarting potential cures and the chance at future breakthrough treatments.
“I don’t think government is in a position, or should be, to dictate what’s important in science,” Acharya said over lunch on UCSF’s sparkling Mission Bay campus.
Trump’s heedless, meddlesome policy, she suggested, is going to scare off a whole generation of would-be scientists and medical researchers, undermining the quest for knowledge, hurting the public and negatively affecting people’s health “for years to come.”
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Acharya was in a high school when she reached a fork in the road. Now 50, she pressed her hands into a “V” shape to illustrate the two paths.
Acharya’s grant was worth $3 million spread over five years of research. She was in the second year of the grant when it was abruptly canceled.
(Paul Kuroda / For The Times)
At the time she was a violinist in the Chicago Youth Symphony, touring the world with the orchestra. She also loved science. Her father was a pharmaceutical chemist. Her mother taught high school math and chemistry.
She realized, Acharya said, she wasn’t ready to make the commitment or accept the all-encompassing sacrifice needed to forge a professional career in music. So science became her chosen route.
At Stanford, she majored in biology and received a master’s degree in health services research. From there, it was on to UCSF medical school. “I love scientific knowledge. But I really wanted to be able to directly interact with patients,” said Acharya, a self-described people person.
A favorite professor, who specialized in eye infection and inflammation, steered her into ophthalmology and helped Acharya find her life’s passion. She smiled broadly as she rhapsodized with mile-a-minute enthusiasm about her work, eyes wide and fingers fluttering over the table, as though she was once again summoning Bach or Paganini.
“The body affects everything in the eye,” she explained. “Like, if you have an infection, you can get it in the eye. If you have an autoimmune disease, you can have manifestations in the eye. You have blood pressure problems, you can see it in the eye. The eye is like, really, a window into the body.”
Acharya latest research was focused on how the shingles vaccine works.
Shingles is a rash brought on by the varicella zoster virus, which also causes chickenpox. Once chickenpox subsides, the virus can remain dormant in a person’s body for decades before erupting again.
“In the first grant, we showed that the vaccine is very effective at preventing shingles and shingles in the eye if you’ve never had it,” Acharya said. “But we hadn’t gotten to the question of what if you already have shingles in the eye?”
It was work, Acharya said, that no one else was doing, aimed at preventing a loss of vision or blindness. It was not, she repeatedly emphasized, an attempt to promote vaccination, a once-common practice now tangled in layers of political, social and cultural debate — or, for that matter, to dissuade anyone from getting vaccinated.
“This is the kind of research that you would think the government would want. Safety and effectiveness … the pros and the cons,” Acharya said, giving a small, puzzled shake of her head. “I wanted to just get the information out there so people can use it.”
Now that guidance won’t be available anytime soon.
If ever.
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Acharya has never been politically active. Her whole life and career, she said, have been devoted to the furtherance of science.
While she leans left, she’s never been wedded to any party or ideology; Acharya has found reasons to agree — and disagree — with Democrats and Republicans alike.
She didn’t vote for Trump, but didn’t see her support for Kamala Harris as making any sort of stand for scientific inquiry, or as a means of protecting her grant. “It never crossed my mind,” she said.
Acharya flips through a 1954 book signed by renowned ophthalmologists and researchers in a conference room at UCSF.
(Paul Kuroda / For The Times)
The five-year grant paid 35% of Acharya’s salary — she was nearing the end of Year Two — and, while the loss of income isn’t great, she’ll manage. “I’m a professor and I’m a doctor as well,” she said. “I’m not going to lose my job.”
Acharya has been forced, however, to lay off two data analysts, and a third research position is in jeopardy. Her voice thickened as she discussed those let go. At one point, she seemed to be fighting back tears.
“I’ve cried with my team a lot,” she said over the soft thrum of conversation in the airy cafeteria-style bistro. “I’m just keeping it together because I have to … I still take care of patients. I still teach. I can’t lose it like that. I feel like … I have to find some way to keep on going.”
In its zeal to dismantle the federal government — driven more, it seems, by political calculation and a taste for vengeance than any well-thought-out design — the Trump administration has terminated hundreds of grants, ending research focused on Alzheimer’s disease, cancer, HIV/AIDS, heart disease, COVID-19, mental health services and addiction, among other areas of scientific pursuit.
Hundreds of millions of dollars that already have been spent are now wasted. The fruits of all that research have been blithely and abruptly lopped off the vine.
It’s impossible, Acharya said, to calculate the loss. It’s painful to even try. “All the things that might not be learned,” she mused wistfully. “All the potential gains out there” that may go unrealized.
The termination notice UCSF received from the National Institutes of Health gave Acharya 30 days to appeal if she believed the decision to end her research was made in error. She did so.
A few days later, the university received a pro forma email acknowledging receipt of Acharya’s appeal.
Since then, nothing.
Science
Trump administration declares ‘war on sugar’ in overhaul of food guidelines
The Trump administration announced a major overhaul of American nutrition guidelines Wednesday, replacing the old, carbohydrate-heavy food pyramid with one that prioritizes protein, healthy fats and whole grains.
“Our government declares war on added sugar,” Health and Human Services Secretary Robert F. Kennedy Jr. said in a White House press conference announcing the changes. “We are ending the war on saturated fats.”
“If a foreign adversary sought to destroy the health of our children, to cripple our economy, to weaken our national security, there would be no better strategy than to addict us to ultra-processed foods,” Kennedy said.
Improving U.S. eating habits and the availability of nutritious foods is an issue with broad bipartisan support, and has been a long-standing goal of Kennedy’s Make America Healthy Again movement.
During the press conference, he acknowledged both the American Medical Association and the American Assn. of Pediatrics for partnering on the new guidelines — two organizations that earlier this week condemned the administration’s decision to slash the number of diseases that U.S. children are vaccinated against.
“The American Medical Association applauds the administration’s new Dietary Guidelines for spotlighting the highly processed foods, sugar-sweetened beverages, and excess sodium that fuel heart disease, diabetes, obesity, and other chronic illnesses,” AMA president Bobby Mukkamala said in a statement.
Science
Contributor: With high deductibles, even the insured are functionally uninsured
I recently saw a patient complaining of shortness of breath and a persistent cough. Worried he was developing pneumonia, I ordered a chest X-ray — a standard diagnostic tool. He refused. He hadn’t met his $3,000 deductible yet, and so his insurance would have required him to pay much or all of the cost for that scan. He assured me he would call if he got worse.
For him, the X-ray wasn’t a medical necessity, but it would have been a financial shock he couldn’t absorb. He chose to gamble on a cough, and five days later, he lost — ending up in the ICU with bilateral pneumonia. He survived, but the cost of his “savings” was a nearly fatal hospital stay and a bill that will quite likely bankrupt him. He is lucky he won’t be one of the 55,000 Americans to die from pneumonia each year.
As a physician associate in primary care, I serve as a frontline witness to this failure of the American approach to insurance. Medical professionals are taught that the barrier to health is biology: bacteria, viruses, genetics. But increasingly, the barrier is a policy framework that pressures insured Americans to gamble with their lives. High-deductible health plans seem affordable because their monthly premiums are lower than other plans’, but they create perverse incentives by discouraging patients from seeking and accepting diagnostics and treatments — sometimes turning minor, treatable issues into expensive, life-threatening emergencies. My patient’s gamble with his lungs is a microcosm of the much larger gamble we are taking with the American public.
The economic theory underpinning these high deductibles is known as “skin in the game.” The idea is that if patients are responsible for the first few thousand dollars of their care, they will become savvy consumers, shopping around for the best value and driving down healthcare costs.
But this logic collapses in the exam room. Healthcare is not a consumer good like a television or a used car. My patient was not in a position to “shop around” for a cheaper X-ray, nor was he qualified to determine if his cough was benign or deadly. The “skin in the game” theory assumes a level of medical literacy and market transparency that simply doesn’t exist in a moment of crisis. You can compare the specs of two SUVs; you cannot “shop around” for a life-saving diagnostic while gasping for air.
A 2025 poll from the Kaiser Family Foundation points to this reality, finding that up to 38% of insured American adults say they skipped or postponed necessary healthcare or medications in the past 12 months because of cost. In the same poll, 42% of those who skipped care admitted their health problem worsened as a result.
This self-inflicted public health crisis is set to deteriorate further. The Congressional Budget Office estimates roughly 15 million people will lose health coverage and become uninsured by 2034 because of Medicaid and Affordable Care Act marketplace cuts. That is without mentioning the millions more who will see their monthly premiums more than double if premium tax credits are allowed to expire. If that happens, not only will millions become uninsured but also millions more will downgrade to “bronze” plans with huge deductibles just to keep their premiums affordable. We are about to flood the system with “insured but functionally uninsured” patients.
I see the human cost of this “functional uninsurance” every week. These are patients who technically have coverage but are terrified to use it because their deductibles are so large they may exceed the individuals’ available cash or credit — or even their net worth. This creates a dangerous paradox: Americans are paying hundreds of dollars a month for a card in their wallet they cannot afford to use. They skip the annual physical, ignore the suspicious mole and ration their insulin — all while technically insured. By the time they arrive at my clinic, their disease has often progressed to a catastrophic event, from what could have been a cheap fix.
Federal spending on healthcare should not be considered charity; it is an investment in our collective future. We cannot expect our children to reach their full potential or our workforce to remain productive if basic healthcare needs are treated as a luxury. Inaction by Congress and the current administration to solve this crisis is legislative malpractice.
In medicine, we are trained to treat the underlying disease, not just the symptoms. The skipped visits and ignored prescriptions are merely symptoms; the disease is a policy framework that views healthcare as a commodity rather than a fundamental necessity. If we allow these cuts to proceed, we are ensuring that the American workforce becomes sicker, our hospitals more overwhelmed and our economy less resilient. We are walking willingly into a public health crisis that is entirely preventable.
Joseph Pollino is a primary care physician associate in Nevada.
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Ideas expressed in the piece
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High-deductible health plans create a barrier to necessary medical care, with patients avoiding diagnostics and treatments due to out-of-pocket cost concerns[1]. Research shows that 38% of insured American adults skipped or postponed necessary healthcare or medications in the past 12 months because of cost, with 42% reporting their health worsened as a result[1].
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The economic theory of “skin in the game”—which assumes patients will shop around for better healthcare values if they have financial responsibility—fails in medical practice because patients lack the medical literacy to make informed decisions in moments of crisis and cannot realistically compare pricing for emergency or diagnostic services[1].
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Rising deductibles are pushing enrollees toward bronze plans with deductibles averaging $7,476 in 2026, up from the average silver plan deductible of $5,304[1][4]. In California’s Covered California program, bronze plan enrollment has surged to more than one-third of new enrollees in 2026, compared to typically one in five[1].
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Expiring federal premium tax credits will more than double out-of-pocket premiums for ACA marketplace enrollees in 2026, creating an expected 75% increase in average out-of-pocket premium payments[5]. This will force millions to either drop coverage or downgrade to bronze plans with massive deductibles, creating a population of “insured but functionally uninsured” people[1].
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High-deductible plans pose particular dangers for patients with chronic conditions, with studies showing adults with diabetes involuntarily switched to high-deductible plans face 11% higher risk of hospitalization for heart attacks, 15% higher risk for strokes, and more than double the likelihood of blindness or end-stage kidney disease[4].
Different views on the topic
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Expanding access to health savings accounts paired with bronze and catastrophic plans offers tax advantages that allow higher-income individuals to set aside tax-deductible contributions for qualified medical expenses, potentially offsetting higher out-of-pocket costs through strategic planning[3].
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Employers and insurers emphasize that offering multiple plan options with varying deductibles and premiums enables employees to select plans matching their individual needs and healthcare usage patterns, allowing those who rarely use healthcare to save money through lower premiums[2]. Large employers increasingly offer three or more medical plan choices, with the expectation that employees choosing the right plan can unlock savings[2].
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The expansion of catastrophic plans with streamlined enrollment processes and automatic display on HealthCare.gov is intended to make affordable coverage more accessible for certain income groups, particularly those above 400% of federal poverty level who lose subsidies[3].
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Rising healthcare costs, including specialty drugs and new high-cost cell and gene therapies, are significant drivers requiring premium increases regardless of plan design[5]. Some insurers are managing affordability by discontinuing costly coverage—such as GLP-1 weight-loss medications—to reduce premium rate increases for broader plan members[5].
Science
Trump administration slashes number of diseases U.S. children will be regularly vaccinated against
The U.S. Department of Health and Human Services announced sweeping changes to the pediatric vaccine schedule on Monday, sharply cutting the number of diseases U.S. children will be regularly immunized against.
Under the new guidelines, the U.S. still recommends that all children be vaccinated against measles, mumps, rubella, polio, pertussis, tetanus, diphtheria, Haemophilus influenzae type B (Hib), pneumococcal disease, human papillomavirus (HPV) and varicella, better known as chickenpox.
Vaccines for all other diseases will now fall into one of two categories: recommended only for specific high-risk groups, or available through “shared clinical decision-making” — the administration’s preferred term for “optional.”
These include immunizations for hepatitis A and B, rotavirus, respiratory syncytial virus (RSV), bacterial meningitis, influenza and COVID-19. All these shots were previously recommended for all children.
Insurance companies will still be required to fully cover all childhood vaccines on the CDC schedule, including those now designated as optional, according to the Department of Health and Human Services.
Health Secretary Robert F. Kennedy Jr., a longtime vaccine critic, said in a statement that the new schedule “protects children, respects families, and rebuilds trust in public health.”
But pediatricians and public health officials widely condemned the shift, saying that it would lead to more uncertainty for patients and a resurgence of diseases that had been under control.
“The decision to weaken the childhood immunization schedule is misguided and dangerous,” said Dr. René Bravo, a pediatrician and president of the California Medical Assn. “Today’s decision undermines decades of evidence-based public health policy and sends a deeply confusing message to families at a time when vaccine confidence is already under strain.”
The American Academy of Pediatrics condemned the changes as “dangerous and unnecessary,” and said that it will continue to publish its own schedule of recommended immunizations. In September, California, Oregon, Washington and Hawaii announced that those four states would follow an independent immunization schedule based on recommendations from the AAP and other medical groups.
The federal changes have been anticipated since December, when President Trump signed a presidential memorandum directing the health department to update the pediatric vaccine schedule “to align with such scientific evidence and best practices from peer, developed countries.”
The new U.S. vaccination guidelines are much closer to those of Denmark, which routinely vaccinates its children against only 10 diseases.
As doctors and public health experts have pointed out, Denmark also has a robust system of government-funded universal healthcare, a smaller and more homogenous population, and a different disease burden.
“The vaccines that are recommended in any particular country reflect the diseases that are prevalent in that country,” said Dr. Kelly Gebo, dean of the Milken Institute School of Public Health at George Washington University. “Just because one country has a vaccine schedule that is perfectly reasonable for that country, it may not be at all reasonable” elsewhere.
Almost every pregnant woman in Denmark is screened for hepatitis B, for example. In the U.S., less than 85% of pregnant women are screened for the disease.
Instead, the U.S. has relied on universal vaccination to protect children whose mothers don’t receive adequate care during pregnancy. Hepatitis B has been nearly eliminated in the U.S. since the vaccine was introduced in 1991. Last month, a panel of Kennedy appointees voted to drop the CDC’s decades-old recommendation that all newborns be vaccinated against the disease at birth.
“Viruses and bacteria that were under control are being set free on our most vulnerable,” said Dr. James Alwine, a virologist and member of the nonprofit advocacy group Defend Public Health. “It may take one or two years for the tragic consequences to become clear, but this is like asking farmers in North Dakota to grow pineapples. It won’t work and can’t end well.”
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