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Column: A cancer survivor's advice: research, persistence and second opinions

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Column: A cancer survivor's advice: research, persistence and second opinions

In the fall of 2022, Robin Clough and Dr. Gene Dorio were going about their lives as they had for many years, serving older adults in the Santa Clarita Valley. Clough was busy with her work as an administrator at the local senior center while Dorio, a house-call geriatrician, crisscrossed the valley visiting his patients.

In November of that year, Clough saw a lump on her neck and had it checked out. The early indication was that she had papillary thyroid cancer.

“I was somewhat worried,” said Clough, but not overly so, because she knew that type of cancer was treatable and highly survivable. “So in the back of my mind it was like, ‘Oh, I’m so lucky. … It’s the easiest type of cancer to take care of.’”

California is about to be hit by an aging population wave, and Steve Lopez is riding it. His column focuses on the blessings and burdens of advancing age — and how some folks are challenging the stigma associated with older adults.

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Then things took a sharp turn for the worse. “I noticed it growing a lot,” Clough, 70, said of the lump. “I was having trouble speaking.”

Surgery was scheduled. Dorio, 72, said it was expected to take about three hours to remove the tumor and half of Clough’s thyroid gland. But the procedure dragged on. When the surgeon updated Dorio nine hours later, the news was grim. The tumor had spread through the thyroid gland, onto the carotid artery and into the tracheal rings.

“He told me it was all over the place,” Dorio said.

Tests revealed that Clough had anaplastic thyroid cancer, a far more aggressive form than papillary.

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We all know our fortunes can turn without much warning, especially as we age and the odds stack against us, raising the threat of our bodies gradually failing and our minds fading. But in just a couple of weeks, Clough and Dorio had gone from cruising through life to confronting death.

Dr. Gene Dorio kisses Robin Clough in the kitchen of their home. Dorio, a house-call geriatrician, has been spending much of his time caring for Clough.

(Genaro Molina / Los Angeles Times)

With her type of cancer, life expectancy is often measured in months rather than years. “It was so hard to process, and I think my mind stopped me from processing it because it’s just too overwhelming,” Clough said.

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They’d fallen for each other about 20 years ago after each had been married and divorced. Dorio has a daughter named Janene. Clough has two daughters, Catie and Amy. The Dorio-Clough courtship and blending of the two families began with him giving her a flu shot at her senior center; then he had her on his local radio show, “The Senior Hour.”

They never married, and still don’t see the need.

“We’re compatible and we love each other … and have the same interests — fighting for people’s rights,” said Dorio, who, along with Clough, pushed for legislation — signed by Gov. Gavin Newsom — giving families more authority to determine medical decisions for loved ones even in the absence of an advance directive. Dorio had also served on the L.A. County Commission for Older Adults.

Robin Clough recalls how difficult the weeks of cancer treatment have been.

(Genaro Molina / Los Angeles Times)

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Facing her grim diagnosis, Clough and Dorio leaned on each other and on Janene, Catie and Amy. There were weekly Zoom meetings to bolster spirits and share information about emerging therapies.

I’d gotten to know Dorio a little bit over the years, having tagged along on his house calls, so I was copied on the periodic updates on Clough’s status that he mailed to friends and family. She beat the three-to-six-month prediction, and in July of 2023 Dorio wrote to say she was better, “but still has a ways to go.”

By then, she’d undergone seven consecutive weeks of chemotherapy and radiation, suffering skin burns on her neck from the latter. A metastatic lesion was surgically removed from her leg. Dorio took Clough to MD Anderson Cancer Center in Houston on a recommendation from Cedars-Sinai.

“To all our friends and family,” Dorio wrote in that July update, “seeking a second opinion and being persistent in researching and asking questions of your doctor team is very important, no matter what the diagnosis might be. It is physically and emotionally a roller coaster. But we have been given wonderful support from our family and many of you in the community. We will provide help and guidance in the future should you need it.”

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In Houston, medical staff queried Clough about her family history. “This cancer is mostly caused by radiation exposure,” Clough said, “and one of the first things they asked me … was where did you grow up?”

Her answer was Arizona, downwind from nuclear weapons testing in nearby Nevada in the 1940s and ’50s that contaminated water, soil and food sources for years.

I asked Clough if she had seen the Oscar-winning movie “Oppenheimer,” about the creation of the first nuclear weapons.

“I won’t watch it,” she said firmly.

It’s impossible to directly link Clough’s cancer to weapons testing, but the federal Centers for Disease Control and Prevention reports that people exposed to radiation fallout, “especially during childhood, may have an increased risk of thyroid disease, including thyroid cancer many years later.”

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Oncologists Alain Mita at Cedars-Sinai and Maria Cabanillas at MD Anderson, who had collaborated previously on patients with anaplastic thyroid cancer, determined that Clough’s form of cancer warranted treatment with Keytruda, a drug that stimulates the immune system.

But after a few months of treatment that had showed some promise, the cancer was growing again. In late December, Clough’s doctors switched to a drug called Retevmo, a targeted therapy that blocks the driver of tumor growth.

Dr. Gene Dorio put off hip surgery to take care of his partner, Robin Clough, and uses a cane for support.

(Genaro Molina / Los Angeles Times)

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A hopeful Dorio recalled that in a 2017 blog post, he had written that “genetic engineering research is on the verge of finding the DNA ‘stop button’ ” for cancer cell growth. He added, “Hopefully one day our great-grandkids will ask … ‘What was cancer?’”

One month into Retevmo medication, Clough had to stop because of adverse side effects to her liver. But a new scan revealed what seemed to her like a miracle.

The cancer was gone.

Two months later, she had another test.

No cancer.

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“Her cancer is, at this moment, undetectable and in remission. For anaplastic cancer that’s very unusual,” Dr. Mita told me.

That doesn’t mean the cancer won’t return, he said. But for the time being, there’s cause for optimism.

Mita said that 10 years ago he could not have predicted this measure of success against such an aggressive cancer, and he’s hopeful medical science will see more advances in the coming years. With some cancers, he said, doctors are now able to skip chemotherapy and radiation in favor of meds like those used to treat Clough.

Cabanillas shared his optimism, saying survival rates at MD Anderson have improved with some forms of anaplastic thyroid cancer by using “immunotherapy in combination with targeted therapy.”

In her kitchen a few days ago, with the girls’ college diplomas and family photos hanging on the walls, Clough said it’s all been overwhelming at times, and Dorio chimed in on his own worries and determination to remain strong for her sake. Clough’s life has been consumed by doctor visits, surgical procedures, continued unpleasant side effects from treatment and the constant anxiety of awaiting the next test results.

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“I never felt like it was too much,” Clough said. “There are times when I think, I’m so tired of this. But it’s never been too much, and I think that’s because of my loved ones.”

Dorio, meanwhile, put his practice on hold to focus on the house-call patient who lives in his own home. He’s been putting off hip replacement surgery, too, and uses a cane.

It’s more than a little helpful, Clough said, when, in the midst of a life-threatening medical crisis, the person you live with is a doctor. She said she never felt that she could beat cancer entirely, “but that I could keep it under control. And I still have that hope.” Each day, she said, is a bonus.

Clough shed a few tears as she told her story, but also flashed a radiant smile.

“I was supposed to be gone, but I’m not. So every day is ‘Wow,’ you know? I get to see my daughters, and in the process of this I had my first grandchild.”

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The baby boy is now 11 months old.

His name is Robin.

steve.lopez@latimes.com

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California’s summer COVID wave shows signs of waning. What are the numbers in your community?

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California’s summer COVID wave shows signs of waning. What are the numbers in your community?

There are some encouraging signs that California’s summer COVID wave might be leveling off.

That’s not to say the seasonal spike is in the rearview mirror just yet, however. Coronavirus levels in California’s wastewater remain “very high,” according to the U.S. Centers for Disease Control and Prevention, as they are in much of the country.

But while some COVID indicators are rising in the Golden State, others are starting to fall — a hint that the summer wave may soon start to decline.

Statewide, the rate at which coronavirus lab tests are coming back positive was 11.72% for the week that ended Sept. 6, the highest so far this season, and up from 10.8% the prior week. Still, viral levels in wastewater are significantly lower than during last summer’s peak.

The latest COVID hospital admission rate was 3.9 hospitalizations for every 100,000 residents. That’s a slight decline from 4.14 the prior week. Overall, COVID hospitalizations remain low statewide, particularly compared with earlier surges.

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The number of newly admitted COVID hospital patients has declined slightly in Los Angeles County and Santa Clara County, but ticked up slightly up in Orange County. In San Francisco, some doctors believe the summer COVID wave is cresting.

“There are a few more people in the hospitals, but I think it’s less than last summer,” said Dr. Peter Chin-Hong, a UC San Francisco infectious diseases expert. “I feel like we are at a plateau.”

Those who are being hospitalized tend to be older people who didn’t get immunized against COVID within the last year, Chin-Hong said, and some have a secondary infection known as superimposed bacterial pneumonia.

Los Angeles County

In L.A. County, there are hints that COVID activity is either peaking or starting to decline. Viral levels in local wastewater are still rising, but the test positivity rate is declining.

For the week that ended Sept. 6, 12.2% of wastewater samples tested for COVID in the county were positive, down from 15.9% the prior week.

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“Many indicators of COVID-19 activity in L.A. County declined in this week’s data,” the L.A. County Department of Public Health told The Times on Friday. “While it’s too early to know if we have passed the summer peak of COVID-19 activity this season, this suggests community transmission is slowing.”

Orange County

In Orange County, “we appear to be in the middle of a wave right now,” said Dr. Christopher Zimmerman, deputy medical director of the county’s Communicable Disease Control Division.

The test positivity rate has plateaued in recent weeks — it was 15.3% for the week that ended Sept. 6, up from 12.9% the prior week, but down from 17.9% the week before that.

COVID is still prompting people to seek urgent medical care, however. Countywide, 2.9% of emergency room visits were for COVID-like illness for the week that ended Sept. 6, the highest level this year, and up from 2.6% for the week that ended Aug. 30.

San Diego County

For the week that ended Sept. 6, 14.1% of coronavirus lab tests in San Diego County were positive for infection. That’s down from 15.5% the prior week, and 16.1% for the week that ended Aug. 23.

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Ventura County

COVID is also still sending people to the emergency room in Ventura County. Countywide, 1.73% of ER patients for the week that ended Sept. 12 were there to seek treatment for COVID, up from 1.46% the prior week.

San Francisco

In San Francisco, the test positivity rate was 7.5% for the week that ended Sept. 7, down from 8.4% for the week that ended Aug. 31.

“COVID-19 activity in San Francisco remains elevated, but not as high as the previous summer’s peaks,” the local Department of Public Health said.

Silicon Valley

In Santa Clara County, the coronavirus remains at a “high” level in the sewershed of San José and Palo Alto.

Roughly 1.3% of ER visits for the week that ended Sunday were attributed to COVID in Santa Clara County, down from the prior week’s figure of 2%.

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Early adopters of ‘zone zero’ fared better in L.A. County fires, insurance-backed investigation finds

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Early adopters of ‘zone zero’ fared better in L.A. County fires, insurance-backed investigation finds

As the Eaton and Palisades fires rapidly jumped between tightly packed houses, the proactive steps some residents took to retrofit their homes with fire-resistant building materials and to clear flammable brush became a significant indicator of a home’s fate.

Early adopters who cleared vegetation and flammable materials within the first five feet of their houses’ walls — in line with draft rules for the state’s hotly debated “zone zero” regulations — fared better than those who didn’t, an on-the-ground investigation from the Insurance Institute for Business and Home Safety published Wednesday found.

Over a week in January, while the fires were still burning, the insurance team inspected more than 250 damaged, destroyed and unscathed homes in Altadena and Pacific Palisades.

On properties where the majority of zone zero land was covered in vegetation and flammable materials, the fires destroyed 27% of homes; On properties with less than a quarter of zone zero covered, only 9% were destroyed.

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The Insurance Institute for Business and Home Safety, an independent research nonprofit funded by the insurance industry, performed similar investigations for Colorado’s 2012 Waldo Canyon fire, Hawaii’s 2023 Lahaina fire and California’s Tubbs, Camp and Woolsey fires of 2017 and 2018.

While a handful of recent studies have found homes with sparse vegetation in zone zero were more likely to survive fires, skeptics say it does not yet amount to a scientific consensus.

Travis Longcore, senior associate director and an adjunct professor at the UCLA Institute of the Environment and Sustainability, cautioned that the insurance nonprofit’s results are only exploratory: The team did not analyze whether other factors, such as the age of the homes, were influencing their zone zero analysis, and how the nonprofit characterizes zone zero for its report, he noted, does not exactly mirror California’s draft regulations.

Meanwhile, Michael Gollner, an associate professor of mechanical engineering at UC Berkeley who studies how wildfires destroy and damage homes, noted that the nonprofit’s sample does not perfectly represent the entire burn areas, since the group focused specifically on damaged properties and were constrained by the active firefight.

Nonetheless, the nonprofit’s findings help tie together growing evidence of zone zero’s effectiveness from tests in the lab — aimed at identifying the pathways fire can use to enter a home — with the real-world analyses of which measures protected homes in wildfires, Gollner said.

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A recent study from Gollner looking at more than 47,000 structures in five major California fires (which did not include the Eaton and Palisades fires) found that of the properties that removed vegetation from zone zero, 37% survived, compared with 20% that did not.

Once a fire spills from the wildlands into an urban area, homes become the primary fuel. When a home catches fire, it increases the chance nearby homes burn, too. That is especially true when homes are tightly packed.

When looking at California Department of Forestry and Fire Protection data for the entirety of the two fires, the insurance team found that “hardened” homes in Altadena and the Palisades that had noncombustable roofs, fire-resistant siding, double-pane windows and closed eaves survived undamaged at least 66% of the time, if they were at least 20 feet away from other structures.

But when the distance was less than 10 feet, only 45% of the hardened homes escaped with no damage.

“The spacing between structures, it’s the most definitive way to differentiate what survives and what doesn’t,” said Roy Wright, president and chief executive of the Insurance Institute for Business and Home Safety. At the same time, said Wright, “it’s not feasible to change that.”

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Looking at steps that residents are more likely to be able to take, the insurance nonprofit found that the best approach is for homeowners to apply however many home hardening and defensible space measures that they can. Each one can shave a few percentage points off the risk of a home burning, and combined, the effect can be significant.

As for zone zero, the insurance team found a number of examples of how vegetation and flammable materials near a home could aid the destruction of a property.

At one home, embers appeared to have ignited some hedges a few feet away from the structure. That heat was enough to shatter a single pane window, creating the perfect opportunity for embers to enter and burn the house from the inside out. It miraculously survived.

At others, embers from the blazes landed on trash and recycling bins close to the houses, sometimes burning holes through the plastic lids and igniting the material inside. In one instance, the fire in the bin spread to a nearby garage door, but the house was spared.

Wooden decks and fences were also common accomplices that helped embers ignite a structure.

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California’s current zone zero draft regulations take some of those risks into account. They prohibit wooden fences within the first five feet of a home; the state’s zone zero committee is also considering whether to prohibit virtually all vegetation in the zone or to just limit it (regardless, well-maintained trees are allowed).

On the other hand, the draft regulations do not prohibit keeping trash bins in the zone, which the committee determined would be difficult to enforce. They also do not mandate homeowners replace wooden decks.

The controversy around the draft regulations center around the proposal to remove virtually all healthy vegetation, including shrubs and grasses, from the zone.

Critics argue that, given the financial burden zone zero would place on homeowners, the state should instead focus on measures with lower costs and a significant proven benefit.

“A focus on vegetation is misguided,” said David Lefkowith, president of the Mandeville Canyon Assn.

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At its most recent zone zero meeting, the Board of Forestry and Fire Protection directed staff to further research the draft regulations’ affordability.

“As the Board and subcommittee consider which set of options best balance safety, urgency, and public feasibility, we are also shifting our focus to implementation and looking to state leaders to identify resources for delivering on this first-in-the-nation regulation,” Tony Andersen, executive officer of the board, said in a statement. “The need is urgent, but we also want to invest the time necessary to get this right.”

Home hardening and defensible space are just two of many strategies used to protect lives and property. The insurance team suspects that many of the close calls they studied in the field — homes that almost burned but didn’t — ultimately survived thanks to firefighters who stepped in. Wildfire experts also recommend programs to prevent ignitions in the first place and to manage wildlands to prevent intense spread of a fire that does ignite.

For Wright, the report is a reminder of the importance of community. The fate of any individual home is tied to that of those nearby — it takes a whole neighborhood hardening their homes and maintaining their lawns to reach herd immunity protection against fire’s contagious spread.

“When there is collective action, it changes the outcomes,” Wright said. “Wildfire is insidious. It doesn’t stop at the fence line.”

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Notorious ‘winter vomiting bug’ rising in California. A new norovirus strain could make it worse

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Notorious ‘winter vomiting bug’ rising in California. A new norovirus strain could make it worse

The dreaded norovirus — the “vomiting bug” that often causes stomach flu symptoms — is climbing again in California, and doctors warn that a new subvariant could make even more people sick this season.

In L.A. County, concentrations of norovirus are already on the rise in wastewater, indicating increased circulation of the disease, the local Department of Public Health told the Los Angeles Times.

Norovirus levels are increasing across California, and the rise is especially notable in the San Francisco Bay Area and L.A., according to the California Department of Public Health.

And the rate at which norovirus tests are confirming infection is rising nationally and in the Western U.S. For the week that ended Nov. 22, the test positivity rate nationally was 11.69%, up from 8.66% two months earlier. In the West, it was even worse: 14.08%, up from 9.59%, according to the U.S. Centers for Disease Control and Prevention.

Norovirus is extraordinarily contagious, and is America’s leading cause of vomiting and diarrhea, according to the CDC. Outbreaks typically happen in the cooler months between November and April.

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Clouding the picture is the recent emergence of a new norovirus strain — GII.17. Such a development can result in 50% more norovirus illness than typical, the CDC says.

“If your immune system isn’t used to something that comes around, a lot of people get infected,” said Dr. Peter Chin-Hong, an infectious diseases expert at UC San Francisco.

During the 2024-25 winter season, GII.17 overthrew the previous dominant norovirus strain, GII.4, that had been responsible for more than half of national norovirus outbreaks over the preceding decade. The ancestor of the GII.17 strain probably came from a subvariant that triggered an outbreak in Romania in 2021, according to CDC scientists.

GII.17 vaulted in prominence during last winter’s norovirus surge and was ultimately responsible for about 75% of outbreaks of the disease nationally.

The strain’s emergence coincided with a particularly bad year for norovirus, one that started unusually early in October 2024, peaked earlier than normal the following January and stretched into the summer, according to CDC scientists writing in the journal Emerging Infectious Diseases.

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During the three prior seasons, when GII.4 was dominant, norovirus activity had been relatively stable, Chin-Hong said.

Norovirus can cause substantial disruptions — as many parents know all too well. An elementary school in Massachusetts was forced to cancel all classes on Thursday and Friday because of the “high volume of stomach illness cases,” which was suspected to be driven by norovirus.

More than 130 students at Roberts Elementary School in Medford, Mass., were absent Wednesday, and administrators said there probably wouldn’t be a “reasonable number of students and staff” to resume classes Friday. A company was hired to perform a deep clean of the school’s classrooms, doorknobs and kitchen equipment.

Some places in California, however, aren’t seeing major norovirus activity so far this season. Statewide, while norovirus levels in wastewater are increasing, they still remain low, the California Department of Public Health said.

There have been 32 lab-confirmed norovirus outbreaks reported to the California Department of Public Health so far this year. Last year, there were 69.

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Officials caution the numbers don’t necessarily reflect how bad norovirus is in a particular year, as many outbreaks are not lab-confirmed, and an outbreak can affect either a small or large number of people.

Between Aug. 1 and Nov. 13, there were 153 norovirus outbreaks publicly reported nationally, according to the CDC. During the same period last year, there were 235.

UCLA hasn’t reported an increase in the number of norovirus tests ordered, nor has it seen a significant increase in test positivity rates. Chin-Hong said he likewise hasn’t seen a big increase at UC San Francisco.

“Things are relatively still stable clinically in California, but I think it’s just some amount of time before it comes here,” Chin-Hong said.

In a typical year, norovirus causes 2.27 million outpatient clinic visits, mostly young children; 465,000 emergency department visits, 109,000 hospitalizations, and 900 deaths, mostly among seniors age 65 and older.

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People with severe ongoing vomiting, profound diarrhea and dehydration may need to seek medical attention to get hydration intravenously.

“Children who are dehydrated may cry with few or no tears and be unusually sleepy or fussy,” the CDC says. Sports drinks can help with mild dehydration, but what may be more helpful are oral rehydration fluids that can be bought over the counter.

Children under the age of 5 and adults 85 and older are most likely to need to visit an emergency room or clinic because of norovirus, and should not hesitate to seek care, experts say.

“Everyone’s at risk, but the people who you worry about, the ones that we see in the hospital, are the very young and very old,” Chin-Hong said.

Those at highest risk are babies, because it doesn’t take much to cause potentially serious problems. Newborns are at risk for necrotizing enterocolitis, a life-threatening inflammation of the intestine that virtually only affects new babies, according to the National Library of Medicine.

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Whereas healthy people generally clear the virus in one to three days, immune-compromised individuals can continue to have diarrhea for a long time “because their body’s immune system can’t neutralize the virus as effectively,” Chin-Hong said.

The main way people get norovirus is by accidentally drinking water or eating food contaminated with fecal matter, or touching a contaminated surface and then placing their fingers in their mouths.

People usually develop symptoms 12 to 48 hours after they’re exposed to the virus.

Hand sanitizer does not work well against norovirus — meaning that proper handwashing is vital, experts say.

People should lather their hands with soap and scrub for at least 20 seconds, including the back of their hands, between their fingers and under their nails, before rinsing and drying, the CDC says.

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One helpful way to keep track of time is to hum the “Happy Birthday” song from beginning to end twice, the CDC says. Chin-Hong says his favorite is the chorus of Kelly Clarkson’s “Since U Been Gone.”

If you’re living with someone with norovirus, “you really have to clean surfaces and stuff if they’re touching it,” Chin-Hong said. Contamination is shockingly easy. Even just breathing out little saliva droplets on food that is later consumed by someone else can spread infection.

Throw out food that might be contaminated with norovirus, the CDC says. Noroviruses are relatively resistant to heat and can survive temperatures as high as 145 degrees.

Norovirus is so contagious that even just 10 viral particles are enough to cause infection. By contrast, it takes ingesting thousands of salmonella particles to get sick from that bacterium.

People are most contagious when they are sick with norovirus — but they can still be infectious even after they feel better, the CDC says.

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The CDC advises staying home for 48 hours after infection. Some studies have even shown that “you can still spread norovirus for two weeks or more after you feel better,” according to the CDC.

The CDC also recommends washing laundry in hot water.

Besides schools, other places where norovirus can spread quickly are cruise ships, day-care centers and prisons, Chin-Hong said.

The most recent norovirus outbreak on a cruise ship reported by the CDC is on the ship AIDAdiva, which set sail on Nov. 10 from Germany. Out of 2,007 passengers on board, 4.8% have reported being ill. The outbreak was first reported on Nov. 30 following stops that month at the Isle of Portland, England; Halifax, Canada; Boston; New York City; Charleston, S.C.; and Miami.

According to CruiseMapper, the ship was set to make stops in Puerto Vallarta on Saturday, San Diego on Tuesday, Los Angeles on Wednesday, Santa Barbara on Thursday and San Francisco between Dec. 19-21.

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