Connect with us

Science

A 'calamity waiting to unfold': Altadena residents with standing homes fear long-term health effects

Published

on

A 'calamity waiting to unfold': Altadena residents with standing homes fear long-term health effects

On Jan. 7, two residents on opposite sides of Altadena — Francois Tissot, a Caltech professor who studies the geology of ancient Earth and our solar system, living in the east side of town; and Jane Potelle, an environmental advocate living in the west side — fled the intensifying red glow of the devastating Eaton fire.

The inferno devoured home after home, unleashing what experts estimate to be tons of dangerous metals and compounds, from lead to asbestos to the carcinogen benzene. Carried through the vicious winds, the toxins embedded deep into the soil, seeped into the blood of first responders, and leaked into structures in the area that hadn’t burned down.

Within weeks, Altadena residents whose homes had withstood the fire began to return — yet few were testing for contaminants both Tissot and Potelle knew were almost certainly sitting in their still-standing houses.

Working independently, they both decided to create a comprehensive picture of the contamination lurking within surviving homes, both in the burn area and miles outside it.

They came to similar results: In the houses inside the burn zone, there was lead — a metal capable of dealing irreversible damage to the brain and nervous system — at levels far exceeding 100 times the Environmental Protection Agency’s allowable limits. Tissot’s group also found lead levels exceeding the limit over five miles from the fire’s perimeter.

Advertisement

“Children exposed to lead will have diminished cognitive development,” said Tissot, referencing studies that found exposure to leaded gasoline in though the 1990s was correlated with a drop in children’s IQ (an imperfect but useful metric for reasoning ability) by up to seven points.

“To me, what’s at stake is the future of a generation of zero- to 3-year-olds,” Tissot said. “If nothing is done, then these children will be exposed. But it’s totally avoidable.”

Activists and community leaders, along with residents who were force to evacuate when the Eaton fire swept through the city of Altadena, gather at an apartment complex where several residents are living with little to no utilities.

(Jason Armond/Los Angeles Times)

Advertisement

Potelle, frustrated with the lack of government response to contamination concerns, started a grassroots organization with other Altadena residents with standing homes to collect and publish tests conducted by certified specialists.

The organization, Eaton Fire Residents United, or EFRU, found lead in every single one of the 90 homes for which they’ve collected test results. Of those, 76% were above the EPA limits.

EFRU and Tissot’s team were distressed by these data, particularly seeing debris-removal and remediation contractors work without masks in the burn area and some residents even begin to return home.

In early April, Anita Ghazarian, co-lead of EFRU’s political advocacy team, went back to her standing home within the burn zone to pick up mail. She watched as a grandmother pushed a toddler in a stroller down the street.

“She has no idea … this area is toxic,” Ghazarian recalled thinking. The gravity of the situation sunk in. “To me, it’s just — unfortunately — a calamity waiting to unfold.”

Evidence mounted in the 1950s that even small amounts of lead exposure could harm children’s brains. But by the time the U.S. banned lead in paint in 1978, roughly 96% of the homes in Altadena that burned in the Eaton fire were already built. In the Palisades, that number was 78% — smaller, but still significant.

Advertisement
Jared Franz looks at the state of his kitchen.

Jared Franz looks at the state of his kitchen, which survived the Eaton Fire, but is inhabitable due to smoke damage.

(William Liang/For The Times)

Dust from the fire inside the Franz family's home.

Dust from the fire inside the Franz family’s home.

(William Liang/For The Times)

After the Eaton fire, Tissot did a quick back-of-the-envelope calculation to understand what his Altadena community might be dealing with: roughly 7,000 homes burnt with 100 liters of paint per house and 0.5% of that paint likely made of lead.

Advertisement

“That’s something like several tons of lead that have been released by the fire, and it’s been deposited where the fire plume went,” he said.

As the Eaton fire roared in the foothills of the Angeles National Forest the night of Jan. 7, Tissot fled with his two kids, along with the rest of east Altadena.

Meanwhile, Potelle sat awake in her living room on the west side of town, listening to the howling winds as the rest of her family slept.

When Potelle got the evacuation order on her phone around 3:30 a.m. Jan. 8, her family joined the exodus. As they raced to gather their belongings, Potelle grabbed protective goggles she had bought for her son’s upcoming Nerf-battle birthday party.

Even with them, the soot, smoke and ash made it impossible to see.

Advertisement

The family made it to a friend’s house in Glendale, but as the toxic smoke plume swelled, Potelle had to evacuate yet again, this time to a friend’s garage. Tissot, then in Eagle Rock, left for Santa Barbara the next day as the smoke’s incursion progressed southwest.

As Altadena turned into a ghost town on Jan. 9, some residents — including Potelle’s husband — crept back in to assess the damage. Potelle waited for her husband’s report and watched on social media from the safety of the garage.

“People are just videotaping themselves driving through Altadena, and it’s block after block after block of burnt-down homes. The reality of it started to strike me,” Potelle said. “This is not just carbon. This is like, refrigerators and dishwashers and laundry machines and dryers and cars.”

Fires like these, with smoke made of car batteries, paints, insulation and appliances — and not trees and shrubs — are becoming increasingly common in California. These fuels can contain a litany of toxic substances like lead and arsenic that are not present in vegetation, waiting to be unlocked by flame.

Potelle’s home sustained visible smoke damage. So, she made two trips to a disaster support center set up temporarily at Pasadena City College, hoping to get support from her insurance company and the government for soil and in-home contamination testing.

Advertisement

Officials directed Potelle back and forth between her insurance company, FEMA, the L.A. County Department of Public Health, and the California Department of Insurance. Potelle — who, at this point, had already started to develop a cough and chest pain, which she suspects came from her visits to the burn area — left with without clear answers, feeling dejected.

“I’m driving, going back to my friend’s garage … and I’m just realizing there’s no one looking out for us,” she said.

Potelle set out to find the answers herself.

“Here’s the thing, if you don’t know what’s in your home when you remediate, you could just be pushing those contaminants deeper into your walls, deeper into your personal items,” Potelle said.

Tissot, meanwhile, visited his home a week after the fires to find the windows exploded, melted or warped; the walls cracked; and ash and soot everywhere. He too decided that he ought to do his own testing for contamination.

Advertisement

In his day job, Tissot runs a lab with sophisticated machinery able to discern what metals are present in samples of material, usually comprised of rock and dirt, based on their atomic mass: Only lead has an atomic mass of 0.34 trillion billionths of a gram. He normally uses the machine to study rare elements and isotopes from space and eons ago.

He gathered his lab team together on the Caltech campus to use the equipment to test samples from their own backyard.

The team took 100 samples from windowsills, desks and stairwells in the Caltech geology and planetary science buildings. Some surfaces were untouched since the fire; others had been cleaned by Caltech’s trained custodians.

For the record:

5:56 p.m. April 16, 2025A previous version of this article incorrectly stated that the Caltech team had tested samples from uncleaned surfaces, then cleaned those surfaces and took second samples. The Caltech team tested some samples from surfaces untouched since the fire, and some from surfaces that had been cleaned by Caltech’s trained custodians.

Advertisement

The team found multiple uncleaned surfaces with lead levels above the EPA’s limits. And while the cleaned surfaces had about 90% less lead, some still exceeded the limits.

Tissot quickly set up a webinar to announce the findings. The chat exploded with requests from homeowners in Altadena asking Tissot to test their houses.

Around the same time, Potelle noticed some folks on Facebook sharing the results of in-home contamination testing — which in many cases, they had paid for out of pocket.

Inspired, she advertised a Zoom meeting to discuss a strategy for mapping the test results. Sixty residents showed up; Potelle coordinated the group so that residents could submit results to EFRU’s Data Unification team for analysis.

Meanwhile, Tissot connected with residents who messaged him to set up a testing campaign. The researchers donned full hazmat suits in early February and entered the burn area to test homes and meet with homeowners.

ERFU posted its first dataset of 53 homes on March 24. Tissot’s group announced their results, which included data from 52 homes, just a week later, confirming what many had feared: There was lead everywhere.

Advertisement

“What was surprising to me is how far it went,” said Tissot. “We got very high levels of lead even miles away from the fire, and what’s difficult is that we still can’t really answer a simple question: How far is far enough to be safe?”

The two groups hope their data can help homeowners make better-informed decisions about their remediation and health — and apply pressure on leaders to take more action.

Tissot wants to see the government update its guidebooks and policy on fire recovery to reflect the contamination risks for intense urban fires, and to require testing companies to report their results to a public database.

Nicole Maccalla, a core member of EFRU’s Data Unification team, hopes to see officials enforce a common standard for insurance claims for testing and remediation so every resident doesn’t have to go through the same exact fight.

“You’ve got people stepping up to fill the void,” she said. “There should be an organized, systematic approach to this stuff, but it’s not happening.”

Advertisement

Times data journalist Sandhya Kambhampati contributed to this report.

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Science

New Gene Therapy Enables Children With a Rare Form of Deafness to Hear

Published

on

New Gene Therapy Enables Children With a Rare Form of Deafness to Hear

The Food and Drug Administration on Thursday approved a gene therapy that can cure a rare, inherited form of deafness. The treatment is the first to restore normal hearing in children who were born deaf.

The maker of the therapy, Regeneron, plans to provide it free to any child who needs it. “We wanted to make a statement,” Dr. George Yancopoulos, Regeneron’s chief scientific officer said on Thursday morning.

He explained that the company wants to be sure its treatment “would be able to reach its full potential and help as many people as possible.”

Some gene therapies for other diseases, priced in the millions of dollars, have had dismal sales.

The therapy called Otarmeni, is intended for children with otoferlin deafness, a rare form of hearing loss caused by a mutation in a single gene. The mutation destroys a protein in the inner ear that is needed to transmit sound to the brain.

Advertisement

Although otoferlin deafness accounts for just 2 percent to 8 percent of congenital hearing loss, the new treatment “is groundbreaking,” Dr. Dylan Chan, a pediatric otolaryngologist at the University of California, San Francisco, said.

He added, “This is the first time in history that there has been a medical therapy that has enabled deaf children to hear.”

Dr. Chan has been a paid adviser to Regeneron and to Eli Lilly, which is also developing a gene therapy for otoferlin deafness. He is also a principal investigator for Lilly’s clinical trial of the treatment.

Dr. Daniel Lee, the director of pediatric otology and neurotology at the Massachusetts Eye and Ear Infirmary, said he also viewed the therapy as groundbreaking. “We have now entered the era of biological treatment for inner ear hearing loss,” he said.

Dr. Lee is on the advisory board of a small biotech company, Skylark Bio, that is developing gene therapy for a different form of inherited deafness.

Advertisement

Until now, the only treatment for otoferlin deafness was a cochlear implant, an electronic device placed in the inner ear. The implants can restore sound but not normal hearing. And the sounds come through as robotic or tinny.

People with cochlear implants have difficulty in noisy environments. They do not hear high frequencies. And at night they have to recharge the batteries, leaving them deaf until the morning.

In addition to Regeneron and Lilly, two other companies, in China and in France, are also developing gene therapies for otoferlin deafness.

Dr. Eliot Shearer, a pediatric surgeon who specializes in hearing loss at Boston Children’s Hospital, said the otoferlin gene therapy is only the beginning of treatments for deafness. “There are over 150 known genetic causes of hearing loss, and thousands of mutations in those genes,” Dr. Shearer said. “Now that it is known that it’s possible to correct genetic hearing loss, new possibilities open up.”

Dr. Shearer is a principal investigator of both the Regeneron and Lilly otoferlin clinical trials.

Advertisement

To treat deafness with gene therapy, researchers had to solve a problem: getting the genes to the cochlea, a spiral shaped cavity almost at the center of the skull. The cochlea is filled with fluid and lined with 3,500 inner hair cells, each tuned to a specific pitch.

Sound vibrations ripple through the fluid, bending the microscopic hairs. When a hair cell bends, it fires. An electric signal travels along the auditory nerve to the brain, and the person hears the sound.

Researchers chose to focus on otoferlin deafness because its cause was straightforward. The otoferlin gene is expressed only in the hair cells of the inner ear. The inner ear structures, including the hair cells, are intact. So to allow patients to hear, doctors simply needed to deliver a working copy of the otoferlin gene.

Otolaryngologists had long thought that injecting a medicine into the inner ear would inevitably damage the delicate cells and membranes of the cochlea.

But children with otoferlin deafness are already unable to hear. Even if an attempt at gene therapy damaged their inner ears, they could still receive cochlear implants.

Advertisement

“It was the perfect target,” Dr. Chan said.

Kerri M., whose baby, Miles, had otoferlin deafness, said gene therapy “completely changed our lives.” She spoke on condition of anonymity because she wanted to protect her son’s diagnosis from appearing on the internet.

Dr. Shearer said Miles’s hearing loss was so profound that he could not hear a jet engine if it were next to him.

Miles was given the Regeneron therapy on May 19, 2025, when he was 13 months old. At his last visit, his hearing was normal.

“We are so fortunate,” his mother said. “Our baby was born deaf, and now he can hear.”

Advertisement

Most children who received the gene therapy have had hearing restored, but not all have been as fortunate as Miles. So far, Dr. Chan said, about 80 percent of the patients who have been treated successfully in clinical trials were able to hear well without needing cochlear implants.

Most still needed a hearing aid, but about 30 percent of those who could hear after the treatment were like Miles — their hearing was in the normal range.

The next target for the scientists working on gene therapies to correct deafness is mutations in the GJB2 gene. It causes the most common form of congenital hearing loss in children and accounts for about 20 percent of cases.

Dr. Lee explained that the biology of GJB2 deafness is more complex than that of otoferlin, because cells in the cochlea are damaged. Otoferlin’s gene therapy, in contrast, is like fixing a broken wire — the cells are normal, they just can’t transmit a signal.

Dr. Lee said Skylark Bio hopes to start a gene therapy clinical trial this year for GJB2-related deafness in children 9 months old to 7 years old in the United States.

Advertisement

Dr. John Germiller, a pediatric otology surgeon at Children’s Hospital of Philadelphia and the University of Pennsylvania, predicted that the next frontier will be people with genes that cause progressive hearing loss, not necessarily babies.

Hearing loss and the loss of hair cells in the cochlea tend to occur together, he said. The goal will be to use gene therapy to save the hair cells that are remaining.

Dr. Germiller is a principal investigator for the Lilly otoferlin trial and treated the first patient in the United States two years ago.

Dr. Chan offered an even more ambitious hope for the future — the end of most forms of deafness.

“A lot of people are working on how to reprogram cells of the inner ear to rebuild themselves,” Dr. Chan said. The hope is to recreate the cochlea.

Advertisement

“That,” Dr. Chan added, is “the ultimate holy grail.”

Continue Reading

Science

RFK Jr. Says His Department Advises All Children to Get Measles Vaccine

Published

on

RFK Jr. Says His Department Advises All Children to Get Measles Vaccine

Over four days and nearly 20 hours of testimony, under harsh questioning from Democrats, Health Secretary Robert F. Kennedy Jr. has repeatedly backed away from his longstanding criticism of the measles, mumps and rubella vaccine. On Wednesday, he made his strongest statement yet — albeit on behalf of his department and not himself.

“We promote the M.M.R.,” Mr. Kennedy told the Senate Finance Committee on Wednesday morning, referring to the combined vaccine for measles, mumps and rubella. “We have advised every child to get the M.M.R. That’s what we do.”

The comment stands in stark contrast to Mr. Kennedy’s past advice, and senators wondered aloud why he hasn’t told the public what he said on Capitol Hill this week. Last week, he conceded the measles vaccine is “safe and effective” for most people.

When measles broke out in Texas last year, Mr. Kennedy did not recommend vaccination; he said it should be “a personal choice.” Last year, asked if he would advise parents to vaccinate newborns, he said it was not up to him to provide medical advice. His advice, he said, was: “Do your own research.”

But even as he shifted on measles, Mr. Kennedy stuck by his longstanding assertion that improvements in hygiene and sanitation, and not vaccination, fueled the decline in deaths from infectious diseases during the 20th century.

Advertisement

“If you want to talk about what, why disease mortality has disappeared in the 20th century, it was not vaccines,” he said, testifying before the Senate health committee Wednesday afternoon.

As proof, Mr. Kennedy cited a study published in the journal Pediatrics in 2000. But he failed to note that the study also reported that vaccines introduced in the second half of the 20th century had “virtually eliminated” deaths from diseases including polio and measles. In 1999, the Centers for Disease Control and Prevention listed vaccination as one of “ten great public health achievements” of the 20th century.

After Mr. Kennedy made the assertion, Senator Bill Cassidy, the Republican chairman of the Senate health committee, asked about the author of the study; Mr. Kennedy gave him the author’s name. Later in the hearing, Mr. Cassidy produced the paper and told Mr. Kennedy he had taken it out of context.

Continue Reading

Science

Contributor: Regulate the ‘Enhanced Games’ as a medical experiment and a marketing stunt

Published

on

Contributor: Regulate the ‘Enhanced Games’ as a medical experiment and a marketing stunt

It felt like the Olympics. Crowds cheering. The American flag standing tall above the bleachers. Trainers jumping with anticipation. A swimmer staring in disbelief at the clock after his final stroke. The Jumbotron announced: Kristian Gkolomeev — 20.89 seconds. A new world record in the 50-meter freestyle.

Well, kind of.

I’ve left out some details. There was only one swimmer. The crowd? Just doctors, trainers and filmmakers. This was not in an Olympic city nor an Olympic year, but in Greensboro, N.C., in 2025. And there were no iconic rings on the banners, just “Enhanced Games.”

Yes, Gkolomeev swam faster than César Cielo, the official record holder at the time (20.91 seconds). But he did it “enhanced” — a polite way to say that he used performance-enhancing drugs. At the Enhanced Games, doping isn’t punished. It’s required.

The concept, as described by the organization: “to create the definitive scientific, cultural and sporting movement that safely evolves mankind into a new superhumanity.”

Advertisement

Backed by investors such as Peter Thiel and Donald Trump Jr.’s 1789 Capital, the Enhanced Games embodies a techno-utopian ideal: athletes as canvases for chemical optimization, testing the limits of human health for a lot of money. Gkolomeev earned $1 million for his record.

So far, the competition has happened at one-off pop-up events. But in May, Las Vegas will host the first full-scale Enhanced Games, a four-day meet in swimming, track and field, and weightlifting. The group advertises a “potential prize purse of $7.5 million for just a single day of competition,” plus appearance fees.

Does it need to be said? Apparently yes: The Enhanced Games glorifies the risky use of enhancement drugs.

Steroids can harden arteries, elevate stroke risk, damage the liver and permanently alter hormone systems. They are not electrolyte tablets or a little preworkout creatine. If Lance Armstrong had been rewarded — rather than sanctioned — for doping, what would have happened to competitive cycling?

Fans — and especially kids — mimic their idols. As risky as the drugs are for athletes at the Enhanced Games, with its “medical commission” to give the illusion of safety, the substances are even more dangerous when used by people without medical supervision.

Advertisement

The games also expose the economic neglect that drives athletes toward such competition. As Benjamin Proud, the British silver medalist who recently joined the Enhanced Games, put it: “It would have taken me 13 years of winning a World Championship title in order to win what I could win in one race at these games.”

Indeed, the Enhanced Games might look like an easy way out. Only nine swimmers worldwide received prize money and performance bonuses above $75,000 in 2025, according to World Aquatics.

Investors clearly hope to make money off the games as well. The organization is moving closer to becoming a publicly traded company. The economics are not mysterious.

But the Enhanced Games are not just another sporting event. They are an arena for biomedical experimentation and should be regulated as such. The games should face limits similar to those imposed on other high-risk industries, including age restrictions and strict advertising rules.

We already know how to govern legal, profitable activities that carry serious health risks.

Advertisement

In the United States, that means oversight from the Food and Drug Administration and the Federal Trade Commission — bodies that regulate drug protocols and police misleading commercial claims. A steroid-based competition should not be treated as a sport but as a medical experiment and a marketing stunt.

Regulations on pharmaceutical advertising offer a useful model for the Enhanced Games. Prescription drugs are advertised every night on television, but only under strict rules. They require fair balance (content must present benefits and risks with comparable prominence, readability and duration) and a “major statement” of risks (most serious risks must be spoken aloud and not obscured by visuals or music).

Right now, when you play Gkolomeev’s “world-record” video on YouTube, a medical-risk warning appears for barely five seconds — then vanishes. If a cholesterol drug must audibly warn viewers of stroke risk, why shouldn’t a steroid-based competition do the same?

Enhanced Games content should be accompanied by clear warnings of the risks of performance-enhancing drugs and be clearly labeled, age-gated and distributed as high-risk content more akin to pornography than to a boxing match.

Prohibition is not the answer. Trying to shut down these games only fuels a controversy-driven brand. Just recently, the Enhanced Games sued organizations such as World Aquatics and the World Anti-Doping Agency, alleging antitrust violations and that blocking athletes from participating at the Enhanced Games is illegal. As those organizations fight back, they will be seeking to protect the integrity of mainstream sports, but they will also inadvertently be promoting the Enhanced Games.

Advertisement

If we want kids to admire clean athletes rather than those using banned drugs, the Las Vegas launch must not reach the world as a Super Bowl would. The Enhanced Games should not be televised or allowed to stream online to minors. Otherwise, Las Vegas, in May, risks becoming an unregulated public-health experiment mislabeled as a sporting event.

Fabricio Ramos dos Santos is a lawyer, entrepreneur and sports investor.

Continue Reading
Advertisement

Trending