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These L.A. musicians investigated a medical mystery. What they discovered launched a new skincare line

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These L.A. musicians investigated a medical mystery. What they discovered launched a new skincare line

The love story of musicians Ann Marie Simpson-Einziger and Mike Einziger was fortified in a lab.

After meeting through a mutual colleague in 2010, the Santa Monica-based couple’s courtship began the following year, as they were collaborating with Oscar-winning composer Hans Zimmer on a series of film scores. Einziger is best known as the founding guitarist of California-based rock band Incubus. His wife is a renowned composer and violinist for artists including Jethro Tull, Ringo Starr, Dave Matthews Band and Stevie Nicks.

The couple had been seeing one another for only about a year when together they stumbled upon a medical mystery. It resulted in a thrilling scientific discovery, the founding of a biotech beauty company called Mother Science — and their own unique happily-ever-after.

“It was an unexpected journey,” said Simpson-Einziger.

“We were simply trying to answer a series of unanswered scientific questions,” her husband added.

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It all began in 2012 when Simpson-Einziger developed a fungal infection while traveling abroad. A classically trained violinist by trade, she was performing with composer A.R. Rahman in India when she noticed lightened patches of skin on her back and under her bra line. They resembled “loosely drawn flower blooms, with rounded edges,” she said.

After consulting her dermatologist, Simpson-Einziger was diagnosed with a temporary fungal infection called Tinea versicolor, which can lighten or darken skin pigmentation as a result of humidity.

“It’s an imbalance of the microbiome,” Simpson-Einziger said. “The condition was harmless, it resolves on its own and [I was told] that the lightened patches of skin would all go back to normal. But I got so curious.”

“We learned pretty quickly that there were no real hypotheses about how this was happening.”

— Mike Einziger, co-founder of Mother Science and Incubus guitarist

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Ann Marie Simpson-Einziger and Mike Einziger both have science backgrounds, which is what inspired their initial curiosity. She majored in biology at UVA and later taught physics and chemistry between music gigs. He studied at Harvard.

(Al Seib / For The Times)

Armed with an undergraduate degree in biology from the University of Virginia, the former physics and chemistry teacher pored through science journals like Pigment International and Chembiochem to find articles that better explained the science behind her skin condition. She then began to wonder if whatever had caused it could also be used as a skincare aid that reduced dark spots.

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She enlisted the help of her then-fiancé, Einziger, who also happened to have a background in science. He had recently completed the two-year Special Student program at Harvard University’s Graduate School of Arts and Sciences, where he studied cosmology and evolutionary biology. He still had access to the university’s considerable research databases, which meant he could help her look up articles on Tinea versicolor. Soon, he joined her obsession.

“There was tons of literature to research, but nothing coming at it from our perspective,” said Einziger. “We learned pretty quickly that there were no real hypotheses about how this was happening.”

Though they still couldn’t prove it, Simpson-Einziger’s theory that her skin condition could be of use in the beauty world kept them both up at night.

“I actually had a nightmare that somebody took her idea,” he said.

It was then, in 2015, that he called Dr. Jonathan Sackier, a family friend and biotech and medical entrepreneur, who co-invented robotic surgery.

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Four silver bottles labeled Mother Science

In 2023 Mother Science launched its first product, the Molecular Hero Serum ($89). The product is meant to reduce hyperpigmentation and brighten skin.

(Al Seib / For The Times)

“I taught his daughter violin lessons when I was a recent college graduate living in Virginia,” Simpson-Einziger said.

“We went to [him] fully prepared that we were going to get laughed out of the room,” Einziger added.

Sackier remembers the couple’s uncertainty during the phone call. “Ann-Marie was in the background, whispering, ‘He’s going to think we’re idiots,’” he said. “[Mike] asked if I could identify what it was about the fungal infection that was causing depigmentation and having identified it, could I synthesize or somehow isolate the chemical so that we could do something to impact pigmentation disorders.”

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A surgeon by specialty, Sackier connected them with his colleague, Timothy Macdonald, a scientist and professor emeritus of chemistry and pharmacology at the University of Virginia.

“I have taken many projects to him over the years,” Sackier said. “I call him ‘Dr. No,’ because he always says, ‘No, that doesn’t make sense. No, that won’t work.’ When I told him this, he went, ‘Holy moly, that’s impressive.’”

Macdonald began advising the couple and helped connect them with a North Carolina-based research organization called PharmaDirections. The drug development company helped design a scientific program to explore various compounds that had caught the Einzigers’ attention while researching.

After countless studies, they discovered that a naturally occurring molecule that had co-evolved with the human microbiome, Malassezin (pronounced mal-uh-say-zin), could be beneficial for sun spots. While the molecule was identified and named in 2001, the Einzigers were the first to recognize that Malassezin could be valuable in the context of skincare.

“Malassezin is made from a yeast,” said New York-based dermatologist Dr. Amy Wechsler. “When someone has the yeast infection on their skin, the skin often bleaches temporarily.”

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The couple filed an application to patent the discovery in 2016. (It was officially granted in 2018.) They then worked with a team of scientists including cosmetic chemist Susan Goldsberry and beauty innovation entrepreneur Tim McCraw to develop Malassezin into a topical serum after previously manufacturing it through a separate process called chemical synthesis.

They began testing to see if it could benefit melanocytes, the skin cells that produce melanin, the dark pigment in question. The couple used their personal savings to fund the initial research.

“I justified it as, ‘How much would I pay for an education where experts in the field teach me how to characterize a molecule and then commercialize it?’” Simpson-Einziger said. “That one-on-one education was worth what we put into investigating this molecule.”

They brought on beauty industry veteran Edna Coryell, McCraw’s daughter, as co-founder and CEO of Mother Science in August 2017 to oversee further research and development, which involved in vitro studies, 3D cell cultures, ex vivo skin testing and genetic analysis. Coryell had never brought a new ingredient to the market until Malassezin.

“It is very rare,” said Coryell. “Truly, as we were going through [the process], it was writing the playbook for this.’”

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The Einzigers also collaborated with Dr. Pearl Grimes, director of the Vitiligo & Pigmentation Institute of Southern California, who specializes in vitiligo and pigmentation disorders.

“This is somebody who’s been looking at Tinea versicolor for decades,” Einziger said. “Her first reaction was, ‘How did you guys figure this out?’”

“I was 100% fascinated,” Grimes said of reviewing their initial in vitro studies. “The science [and] the concept was disruptive.”

Grimes assembled a clinical program, which led to proof-of-concept data that’s since been published in peer-reviewed journals including the American Academy of Dermatology and Journal of Drugs in Dermatology.

She went so far as to take a skin biopsy from her own elbow for lab testing. Using VISIA skin analysis technology, she found that the serum helped fade hyperpigmentation on the sample.

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“That’s when I really knew that it worked,” Grimes said. “I used it in a stubborn area, and I could clearly see via photographic documentation that it was responding.”

“Having holes punched in my face was an ultimate act of belief in what we’ve made.”

— Ann Marie Simpson-Einziger, co-founder of Mother Science and violinist

A couple walking and holding hands

“We had a lot of people who said, ‘You don’t want to do this. This is too hard. It’s going to take years.’” Simpson-Einziger said. “I remember thinking, ‘Years don’t scare me.’”

(Al Seib / For The Times)

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Einziger also biopsied a patch on his arm for Grimes to analyze. “We felt responsible,” he said. “Mine was done before we even did the human clinical study.”

Simpson-Einziger joked that she too “put real skin in the game” after she said she had her face punch-biopsied — a procedure in which an instrument is used to remove a deeper skin sample — three times.

“Having holes punched in my face was an ultimate act of belief in what we’ve made,” Simpson-Einziger said.

Once the Einzigers confirmed that the data supported their initial hypothesis in a human clinical study, they moved forward with a business plan for what eventually became Mother Science. (It joins the couple’s two other co-founded businesses, including Mixhalo, a networking technology company for live events.)

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Mother Science — named as a nod to French physicist and chemist Marie Curie — was born as a result of raising an initial round of approximately $3.2 million in seed funding from a small group of venture capitalists and angel investors, including Hawktail’s Michael Polansky and Drew Houston, the co-founder of Dropbox. After more than six years of research, Malassezin became the DNA of Mother Science, which officially launched in 2023 with its first product, Molecular Hero Serum ($89). The product is meant to reduce hyperpigmentation and brighten skin.

“It’s a powerful antioxidant,” Simpson-Einziger said. “When we started testing, we learned that Malassezin happens to offer superior protection against hydroxyl and peroxyl free radicals, which are [some of] the most damaging. We had this molecule that was going to do something marvelous in protecting the skin.”

A second product, Retinol Synergist ($96), was released earlier this year. And Molecular Genesis Barrier Repair Moisturizer ($68), featuring Malassezin, will be released on Jan. 7.

“Malassezin is really versatile, as it’s able to target hyperpigmentation, improve the skin’s moisture barrier and provide potent antioxidant protection without any irritation,” said Connecticut-based dermatologist Dr. Mona Gohara, who is also an associate clinical professor at Yale University. “The beauty of it is it’s gentle but also highly efficacious.”

In 2016, the same year the Einzigers filed a patent for their scientific discovery, the couple married. They are now parents to four children including a nearly one-year-old son. Because their courtship intersected with their scientific passion project, they consider Mother Science their fifth child.

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“We had a lot of people who said, ‘You don’t want to do this. This is too hard. It’s going to take years.’” Simpson-Einziger said, pausing. “I remember thinking, ‘Years don’t scare me. I have a baby. I’m going to have to take care of a human for 18 years.’ There are no guarantees when you have a child how they’re going to turn out, but you do it out of love, out of passion, and it makes your life richer.”

While the couple continues to grow Mother Science’s product lineup, Simpson-Einziger is most proud of their process of discovery itself.

“We’re excited about contributing to science, and having that legacy as part of our brand,” she said.

She hopes Malassezin will one day be as universally known as Vitamin C and hyaluronic acid.

“I want people talking about Malassezin, not even about our brand, just about Malassezin,” she said.

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In other words, she and her husband hope the ingredients of their products will be front and center — not themselves.

“Nobody is excited about coming to me for their skincare needs,” Einziger, who still regularly sells out stadiums with Incubus, said with a laugh. “I’m just a person who plays music who happens to be curious about the skin microbiome.”

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Lifestyle

Ruby slippers worn in 'The Wizard of Oz' are auctioned for a record $28 million

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Ruby slippers worn in 'The Wizard of Oz' are auctioned for a record  million

Sequin-covered ruby slippers worn by Judy Garland in The Wizard of Oz appear at the offices of Profiles in History in Calabasas, Calif. on Nov. 9, 2001.

Reed Saxon/AP


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Reed Saxon/AP

MINNEAPOLIS — A pair of iconic ruby slippers that were worn by Judy Garland in The Wizard of Oz and stolen from a museum nearly two decades ago sold for a winning bid of $28 million at auction Saturday.

Heritage Auctions had estimated that they would fetch $3 million or more, but the fast-paced bidding far outpaced that amount within seconds and tripled it within minutes. A few bidders making offers by phone volleyed back and forth for 15 minutes as the price climbed to the final, eye-popping sum.

Including the Dallas-based auction house’s fee, the unknown buyer will ultimately pay $32.5 million.

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Online bidding, which opened last month, had stood at $1.55 million before live bidding began late Saturday afternoon.

The sparkly red heels were on display at the Judy Garland Museum in her hometown of Grand Rapids, Minnesota, in 2005 when Terry Jon Martin used a hammer to smash the glass of the museum’s door and display case.

Their whereabouts remained a mystery until the FBI recovered them in 2018. Martin, now 77, who lives near Grand Rapids in northern Minnesota, wasn’t publicly exposed as the thief until he was indicted in May 2023. He pleaded guilty in October 2023. He was in a wheelchair and on supplementary oxygen when he was sentenced last January to time served because of his poor health.

His attorney, Dane DeKrey, explained ahead of sentencing that Martin, who had a long history of burglary and receiving stolen property, was attempting to pull off “one last score” after an old associate with connections to the mob told him the shoes had to be adorned with real jewels to justify their $1 million insured value. But a fence — a person who buys stolen goods — later told him the rubies were just glass, DeKrey said. So Martin got rid of the slippers. The attorney didn’t specify how.

The alleged fence, Jerry Hal Saliterman, 77, of the Minneapolis suburb of Crystal, was indicted in March. He was also in a wheelchair and on oxygen when he made his first court appearance. He’s scheduled to go on trial in January and hasn’t entered a plea, though his attorney has said he’s not guilty.

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The shoes were returned in February to memorabilia collector Michael Shaw, who had loaned them to the museum. They were one of several pairs that Garland wore during the filming, but only four pairs are known to have survived. In the movie, to return from Oz to Kansas, Dorothy had to click her heels three times and repeat, “There’s no place like home.”

As Rhys Thomas, author of The Ruby Slippers of Oz, put it, the sequined shoes from the beloved 1939 musical have seen “more twists and turns than the Yellow Brick Road.”

Over 800 people had been tracking the slippers, and the company’s webpage for the auction had hit nearly 43,000 page views by Thursday, said Robert Wilonsky, a vice president with the auction house.

Among those bidding to bring the slippers home was the Judy Garland Museum, which posted on Facebook shortly after that it did not place the winning bid. The museum had campaigned for donations to supplement money raised by the city of Grand Rapids at its annual Judy Garland festival and the $100,000 set aside this year by Minnesota lawmakers to help the museum purchase the slippers.

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After the slippers sold, the auctioneer told bidders and spectators in the room and watching online that the previous record for a piece of entertainment memorabilia was $5.52 million, for the white dress Marilyn Monroe famously wore atop a windy subway grate.

The auction also included other memorabilia from The Wizard of Oz, such as a hat worn by Margaret Hamilton, who played the original Wicked Witch of the West. That item went for $2.4 million, or a total final cost to the buyer of $2.93 million.

The Wizard of Oz story has gained new attention in recent weeks with the release of the movie Wicked, an adaptation of the megahit Broadway musical, a prequel of sorts that reimagines the character of the Wicked Witch of the West.

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Bill Romanowski Says He's Feeling Great Despite '20 Documented Concussions'

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Bill Romanowski Says He's Feeling Great Despite '20 Documented Concussions'

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Where tradwives and leftists agree : Code Switch

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Where tradwives and leftists agree : Code Switch
Illustration in four panels of woman working, woman cooking, woman cleaning and woman serving husband

The rise of momfluencers and tradwives are filling a void for modern mothers. In this episode, we continue our conversation about the hellscape of modern motherhood, and look into an alternative to the tradwife lifestyle.

We want to hear from our listeners about what you like about Code Switch and how we could do better. Please tell us what you think by taking our short survey, and thank you!

This episode was produced by Jess Kung. It was edited by Courtney Stein. Our engineer was Josephine Nyounai.

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