Health
Traveling Without Sight: How Blind and Visually Impaired Explorers Navigate the World
Luke walked beside me, one hand curled around my arm, the other tapping a gentle rhythm with his white cane. We were crossing the Taj Mahal’s grounds just after sunrise, the air already balmy and faintly perfumed. From the scattered murmur of tourists, Luke said he could sense a grand, open space around us. I described the Persian-style gardens — reflecting pools, clipped shrubs, stone walkways in perfect symmetry. Then I read aloud a sign: “Don’t make direct eye contact with monkeys.”
Near the mausoleum’s entrance, the ground changed — rough sandstone yielding to cool marble, smooth beneath our feet. I guided Luke’s hands to the white facade …
As his fingers roamed, Luke recalled the photographs he’d seen as a child, before retinitis pigmentosa, a hereditary eye disease, gradually narrowed his vision and then, at 18, took it away.
“I get the impression of something opulent and magnificent,” he told me.
Inside, we joined the flow of tourists circling the tombs of Shah Jahan and his beloved, Mumtaz Mahal. Their voices echoed beneath the dome, drawn out into long, soft reverberations. In the past, this space carried recitations of the Quran — with acoustics meant to evoke the sound of paradise.
Luke tilted his head toward the ceiling. “It’s almost like you’re inside a speaker,” he said.
I closed my eyes and listened.
What does it mean to travel somewhere new and not be able to see it? That question led me on a 10-day journey through northern India’s Golden Triangle with Traveleyes, a British tour company that pairs visually impaired and sighted travelers.
So much of the language we use around travel — sightseeing, scenic vistas, must-see lists — assumes that the world is best, or only, understood through the eyes. But as the writer Pico Iyer wrote to me in an email before the trip: “Travel is not about seeing the sights so much as opening oneself up to the unfamiliar — a matter of perception and vision in a deeper sense.”
For years, whenever I returned from a trip abroad, a friend of mine would ask: What did it smell like? I always fumbled for a meaningful answer. What layers of experience — what deeper kind of vision — had I been missing?
Amar Latif, a British entrepreneur, founded Traveleyes in 2004 to address the lack of accessible travel options for blind and visually impaired people. After losing most of his sight by age 18 because of retinitis pigmentosa, Mr. Latif struggled to travel independently. Mainstream tour companies often rejected him, insisting he bring a caregiver and excluding him from more adventurous activities like hiking and skiing. Those exclusions pushed him to create something of his own: a company that would allow blind travelers to explore the world without relying on friends or family. “Friends and family switch off,” he told me. “They’re not as eager to describe things.”
Traveleyes runs on a simple but radical model: It pairs blind and sighted travelers as equal companions. Sighted participants assist with navigation and describe visual details — in exchange for a discounted trip — while blind travelers bring a fresh perspective that often deepens the experience for both. The company promises “a truly multisensory travel experience,” with itineraries designed to engage all five senses.
Destinations include Cuba, Eswatini and Britain’s Lake District, among many others, and trips often include immersive, tactile experiences: paragliding in the Canary Islands, kneading pizza dough in a Tuscan farmhouse, handling museum artifacts typically kept behind glass. On Lake Titicaca in Peru, locals built a miniature reed island for Traveleyes visitors to explore by touch. In Xi’an, China, they were granted rare permission to feel the terra-cotta warriors. To me, India — with its sensory onslaught of honking horns, potent smells, vivid colors, spices and heat — seemed like the perfect place to experience travel in its fullest, most immersive form.
After I booked my trip, Traveleyes sent me a “Sighted Guide Pack” — a short primer. “Don’t be nervous!” it began. “Guiding may seem daunting, but once you get into the swing of it, nothing could be easier.”
No prior experience was required — just a friendly attitude and a willingness to describe what you saw. Each day, I’d be paired with a different visually impaired traveler — referred to as a “V.I.” — and together we’d find our rhythm.
I met the group at a hotel in New Delhi. Among the travelers were two women — one visually impaired — who had met on a previous Traveleyes trip; this was now their sixth journey together.
On our first day I was paired with Daniel, a 38-year-old software consultant from Oxford. It was his 12th Traveleyes trip; he’d previously visited Romania, Bhutan and Jordan. Daniel had several eye conditions, including nystagmus, which causes involuntary eye movement and makes it difficult to focus or judge depth. He often held his phone just inches from his eyes.
On a visit to Old Delhi, I guided Daniel barefoot through a Jain temple, fragrant with wafting incense and filled with soft instrumental music, and into the adjoining bird hospital, a rather crowded and grimy convalescent home for the winged and wounded. He gripped my arm lightly, reading shifts in elevation through subtle cues in the movement of my body. I told him when steps were coming, how many and in which direction. For tight entryways, I walked ahead, with my guiding arm behind me. I felt like I was getting into the swing of it.
Strolling in pairs through the tight, noisy streets of Old Delhi, our group of 18 made for a curious sight. It struck me how rare it is to see so many visually impaired travelers moving together — especially in a place that feels overwhelming even for the sighted. We navigated uneven pavement, wove around men carting guavas and sacks of cement.
As our tour bus crawled through Delhi’s snarling traffic, Daniel reflected on how blind and visually impaired people make sense of the world. “Everyone builds the world in their own way,” he said. Some rely on the spatial qualities of sound, others on scent, or even the feel of air moving around them. “Even sighted people use some combination of these elements,” he pointed out. “But when you’re deprived of one, you compensate with the others — and everyone does that differently.”
The next day, on our drive to Agra, I was paired with Candie, a blind woman from Seattle who works in taxpayer advocacy at the Internal Revenue Service. Born with glaucoma, she could once detect light and the presence of large objects, but her vision gradually deteriorated. A decade ago, at 40, she had one eye removed and now has an ocular prosthesis.
“The whole sights thing doesn’t thrill me,” she said. What excited her were immersive, hands-on experiences — zip lining, rappelling down waterfalls, white-water rafting. On a previous Traveleyes trip to Peru, she rode a rickety train and leaned out the window, arms in the wind as if she were on a roller coaster. In Costa Rica, she tried surfing.
Candie said she wanted to hear about “the reality of India.” She preferred descriptions of people — their behavior and appearances — over scenery. “Tell me what they’re doing,” she said. “Even if it’s just someone lying on a bench or sleeping on the sidewalk — that’s more interesting to me than, ‘There’s a tree over here with yellow leaves.’” I peered out the bus window. Along the roadside were barbers who’d hung mirrors on fences, shaving customers perched on low stools, and flower vendors threading marigold garlands. I told Candie how cars here drive on the left, and how clearly marked lane lines were almost universally ignored. Vendors had strung multicolored snack packets across the fronts of their stands like strands of vibrant beads.
“Oh, that’s interesting,” she said.
We passed six-story apartment blocks with laundry fluttering from open windows.
“Hmm,” she said. “In a lot of places in the States, you can’t do that.”
At a truck stop cafeteria where we had lunch, I described the triangular structure of a samosa and the ingredients in dal, then used clock-face references to guide Candie to each item on her tray. She paid for the meal, carefully handling the rupee notes — colorful, textured bills adorned with traditional Indian motifs and Gandhi’s portrait at the center. I described those to her, too.
I was beginning to notice how speaking these details aloud sharpened my perception. Things I might have otherwise overlooked or skimmed past — the kind of prosaic elements that quietly define a place, like the black-and-white stripes on New Delhi’s curbs or the mandala murals painted on highway overpasses — became more visible to me when I put them into words. In naming them, I was also etching them into memory.
In Agra, we joined the early-morning crowds jockeying for photographs of the Taj Mahal at dawn, its pale, glowing silhouette mirrored in the long reflecting pool. “They took a bunch of blind people to watch the sunrise — kind of funny,” Ann, a visually impaired traveler from England, said wryly. We toured the site in pairs; one sighted guide told me she described the domed mausoleum to her partner as a giant Hershey’s Kiss.
One visually impaired traveler recalled his time inside the mausoleum as being deeply moving. “I heard this low, generic hum — almost like an ‘om’ — filling the space from people quietly talking,” he told me. “I realized that everyday conversation had created this peaceful resonance, like a background chant. Sighted people probably wouldn’t even hear it; they’re too busy snapping photos.”
We eventually arrived in Ranthambore, a town in Rajasthan near a national park that was once the private hunting grounds of the Jaipur royal family. Today, it’s considered one of the best places in India to spot wild Bengal tigers. Before our safari, in the hotel gift shop, I placed a tiger figurine in Candie’s hands. She ran her fingers along its long torso and stout legs, tracing the raised stripes.
“Oh wow,” she said. “It’s much longer than I’d thought!”
We toured the park in an open-topped bus, its diesel engine rattling as we bounced along rutted dirt tracks that wound through dry forest, open meadows and rocky outcroppings. Every so often, our driver stopped at the sight of antelope, sambar deer or a quick-moving mongoose. Channeling David Attenborough, I narrated for Candie as a peacock fanned his feathers in a slow, deliberate courtship display.
The next day, I experienced my own version of that thrill aboard an auto rickshaw in Bundi, a hillside town known for its blue-painted houses and ancient step wells. I was paired with Chris, an accessibility specialist for the British government. Highly expressive with his eyes, Chris explained that he had optic nerve hypoplasia, a congenital condition that left him with a “pinhole-camera-type view of the world.”
I closed my eyes as we climbed toward Bundi’s palace, perched above the town. The sudden jolting turns, the rush of wind, the blare of horns and the shifting smells — spices, incense, street food, exhaust, cow dung — turned the ride into a visceral blur of motion, sound and scent. I felt every brake, every bump and sway.
Chris described it much the same way. “I feel all the micromovements — it’s like a 1970s fairground ride,” he said as we twisted up the road. “A bit edgy. A bit bumpy. It jolts and pivots. It’s got that amusement park atmosphere.”
As our group strolled in pairs through the center of Bundi, weaving between loitering cows and whizzing traffic, our local guide, Munish, paused at a street stall where a smiling man was stirring a drink made from a vivid green paste. He was, Munish explained, a government-authorized vendor of bhang, a traditional, cannabis-infused beverage.
Inexperienced but curious, a few of the V.I.s decided to try it. Later, Chris described how the high distorted his sense of time and space. Lying in his hotel room, the hum of the air-conditioner seemed to harmonize with the sound of the shower. Together, they sang.
Over the course of the trip, I’d heard a few visually impaired travelers grumble that some of the sighted participants were being too heavy-handed in their approach to guiding — “overwarning and overcautioning,” as one put it. As we boarded the bus to Udaipur the next day, Suzie announced that some V.I.s felt as if they were being “passed around like furniture,” with items taken from their hands as if they were children. The issue was clear: Sighted guides sometimes forget that their V.I. companions are independent adults. “I’m another human being,” Susan, a V.I. from San Francisco, told me. “I’ll say what I need. When someone sees themselves as a helper, the whole relationship gets skewed.”
Traveleyes promotes guiding as companionship, not caregiving — someone to explore with, to share a drink at the hotel bar with, not someone to manage. But the lines can blur when you’re also escorting someone to a bathroom stall.
“It’s a little like a complex dance routine,” Chris told me. “You have to learn each other’s moves and try not to tread on each other’s toes, but you also have to give each other room to learn and grow.”
On our long drives across the Rajasthani desert, past sand-colored cliffs and craggy outcroppings, Munish offered insights into Indian society — the caste system, arranged marriage, the law of karma. “If I can’t buy a Ferrari in this life, that’s fine,” he quipped, introducing the concept of reincarnation. “I’ll wait. I’ve got plenty more chances.”
One afternoon, he shared a well-known Hindu parable about six blind men who encounter an elephant for the first time. Each tries to describe it while touching a different body part. One, feeling a leg, insists the elephant is like a massive cow. “No, it’s a giant snake,” says another, gripping the trunk. A third, stroking a floppy ear, imagines a flying carpet.
They argue, each convinced his perception is correct.
The moral, Munish explained, is that everyone experiences the world differently, and that no single viewpoint captures the whole picture. Understanding others’ perspectives, the parable teaches, is part of seeing the fuller truth.
I thought about this later, on our train ride to Jaipur, when I asked Candie to share some of her most memorable moments from the trip. One had taken place in Delhi, just after she stepped off the bus at Humayun’s Tomb, a 16th-century Mughal mausoleum. She felt a small hand tap gently against her arm. Instinctively, she reached out and gave it a squeeze. The hand squeezed back.
What struck her was the texture — rougher than any child’s hand she’d ever touched. She realized it must have belonged to a young beggar.
For Candie, that brief moment of contact was transporting — a brush with the unfamiliar. “I just wanted to hang out with them and find out as much as I could about their lives,” she told me. What had shaped those hands? What had they endured? What did survival look like, day to day?
It reminded me of something Mr. Latif told me about the difference between how blind and sighted people experience travel: For blind travelers, it’s like reading a book; for sighted ones, it’s more like watching a film.
Sighted people tend to rely on immediate visual cues — architecture, color, landscape — forming quick, vivid impressions, like a movie that lays everything out on the screen. For blind travelers, Mr. Latif explained, the world reveals itself more slowly, through layers of sound, touch, scent and spatial awareness. It’s a more immersive, interpretive process — like reading a novel, where the story unfolds through detail and imagination.
“And the book,” he said, “is often better than the film version.”
On the last day of our tour, in Jaipur, we visited a jewelry workshop and the Amber Palace, a hilltop fort of mirrored halls and ancient ramparts. Later, we stopped at a community-run elephant park, the kind of modest place where you can feed bananas to the animals.
Suzie guided Candie up to one of the elephants.
Candie reached out, wrapped her arms around the elephant’s thick leg and slowly traced her hands along its limber trunk. I asked what it felt like.
She paused. “Honestly,” she said, “like a tall, obese man with a big, hairy leg.”
Health
Finding the sleep ‘sweet spot’ could help you live longer, study suggests
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How long you sleep could be linked to how long you’ll live.
A new study, published in the journal Nature, found that people who slept too little or too long showed signs of “older biology.”
Researchers from Columbia University in New York used global biobank data from about 500,000 people who disclosed self-reported sleep duration in a 24-hour period, including naps.
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Reported sleep times were compared with 23 biological aging clocks, estimating whether various parts of the body looked biologically older or younger than the individual’s actual age.
Short and long sleep were both linked with signals of a higher biological age. They were also associated with a higher risk of future diseases and all-cause mortality, the researchers found.
According to study results, short sleep and long sleep were both linked with signals of higher biological age. (iStock)
In nine of the aging clocks, the researchers found “statistically significant” links between sleep and aging, including in the brain, heart, immune system and skin.
Those with the “lowest biological age gap” were women who slept for 6.5 to 7.8 hours and men who slept for 6.4 to 7.7 hours, according to the study.
Longer sleep had a stronger link to psychiatric-related outcomes, while short sleep had more physical impacts on cardiovascular, metabolic, musculoskeletal, psychiatric, neurological, pulmonary and gastrointestinal conditions.
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The U-shaped results also showed that shorter sleep led to a 50% higher relative risk for all-cause mortality, while longer sleep had about a 40% higher risk.
The researchers noted that self-reported sleep poses a limitation to the study. As it was observational in design, it does not prove that sleeping exactly six to eight hours will slow aging.
Both women and men who slept roughly six to eight hours showed the lowest signals for biological aging. (iStock)
Saema Tahir, MD, a New York-based board-certified sleep medicine physician, reflected on these findings in an interview with Fox News Digital.
“Sleep is really when the body does its most critical repair work, including cellular restoration, immune regulation, hormonal balance, and even clearing out metabolic waste from the brain through what we call the glymphatic system,” said Tahir, who was not involved in the study.
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“When sleep is consistently too short or too long, those processes get disrupted. Over time, that disruption accumulates at the cellular level.”
This effect is proven in increased inflammatory markers and cellular changes, which are “hallmarks of accelerated aging,” Tahir noted.
“So, the relationship isn’t just correlational; there are real physiological mechanisms connecting poor sleep to the body aging faster than it should.”
“Sleep is really when the body does its most critical repair work,” the doctor noted. (iStock)
Tahir cautions her patients not to treat the six- to eight-hour recommendation as a “rigid prescription,” as sleep is individualized.
For example, a healthy 25-year-old and a 70-year-old with cardiovascular disease have “very different sleep architecture and needs,” according to the expert.
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“What I tell my patients is to use that range as a starting framework, but pay attention to how you feel,” she advised. “Are you waking up refreshed? Can you stay alert throughout the day without caffeine propping you up? Those functional cues matter just as much as the number on the clock.”
For certain people, like pregnant women, athletes and people recovering from illness, these sleep needs can shift “considerably.”
As sleep is individualized, a rigid six- to eight-hour framework may not work for everyone. (iStock)
“Sleep duration is important, but … getting adequate sleep and REM sleep that allows our bodies to heal, clear, process and repair is much more important,” Tahir said.
Regardless of sleep time, those who don’t achieve quality sleep often struggle, she shared.
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“I’ve seen patients who log seven hours but spend most of that time in light sleep, barely touching the deep slow-wave or REM stages that are most restorative,” Tahir said. “They age just as poorly, sometimes worse, than someone getting six hours of genuinely consolidated, high-quality sleep.”
Deep sleep is the phase when growth hormone is released and tissue repair peaks, and REM sleep is “critical” for cognitive health and emotional regulation, according to the expert.
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“So, chasing hours without addressing sleep fragmentation, sleep apnea or poor sleep architecture is missing the bigger picture,” she said.
The takeaway from this study, according to Tahir, is that sleep is not a “lifestyle luxury,” but a “biological necessity with measurable consequences for how we age and how healthy we are.”
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There’s still a cultural tendency to see sleep deprivation as a “badge of productivity,” which she pushes back against. “But I also want people to avoid the other extreme — health anxiety about their sleep can actually make sleep worse.”
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The sleep expert concluded that “consistent, good-quality sleep is one of the most accessible tools we have for healthy aging.”
“It doesn’t require a prescription or expensive intervention — it requires prioritization.”
Health
‘Wild West’ peptide craze surges beyond GLP-1s as FDA faces pressure to ease access
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As GLP-1 weight-loss medications gain traction, the peptide market is experiencing a surge in interest.
A variety of peptides — commonly marketed for weight loss, muscle building, injury recovery and other uses — have emerged as largely unregulated drugs sold through both licensed compounding pharmacies and unverified vendors.
The U.S. Food and Drug Administration is set to evaluate whether to loosen regulations on several peptides during a meeting this summer.
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Peptides are short chains of amino acids — the building blocks of proteins — that play key roles in biological functions, according to the National Institutes of Health. Peptide drugs are lab-made versions of natural molecules in the body that are designed to mimic or influence biological signals to treat disease, experts say.
GLP-1s are “incredibly effective at what they do when it comes to changing body composition, benefiting metabolic health, cardiovascular health [and] neurologic health,” the expert said. (iStock)
Though the peptide market has been described as the “Wild West,” demand remains strong, potentially challenging pharmaceutical giants that dominate the GLP-1 market.
Dr. Alex Tatem, an Indiana-based board-certified urologist with expertise in men’s health and peptides, discussed how “life-changing” GLP-1s kicked off the rise of peptides.
“These were all medications that were designed to help people live well and live as healthy as possible.”
“They are incredibly effective at what they do when it comes to changing body composition, benefiting metabolic health, cardiovascular health [and] neurologic health,” he said. “These are truly miracle compounds, and as a result we’ve seen an explosion of interest – not just on the pharmaceutical side or the doctor’s side, but from the general public.”
According to Tatem, the challenge is that nearly all commercial GLP-1 products are administered in a single-dose weekly pen, which works for the “overwhelmingly majority” of patients, but not for everyone.
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“There are patients I can prescribe tirzepatide to and they can do OK with a once-a-week [dose], but they end up developing nausea with that initial injection – and then by the end of the week, they’re hungry again.”
Because some patients respond better to smaller, more frequent doses — an option not offered by commercial drugs — compounding, or the customization of medications, has grown in popularity, Tatem said.
Several GLP-1 weight loss medications have been approved by the FDA with positive results from consumers. (iStock)
“We’ve had compounding pharmacies that have now developed compounded versions of semaglutide and tirzepatide that allow that sort of dosing flexibility,” he said.
“The reason compounders had to do this was because there was so much demand for GLP-1s that there was actually a national shortage.”
Current legislation allows compounders to step in during widespread national shortages, according to Tatem, prompting the industry to invest millions of dollars into developing and manufacturing these drugs.
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Once commercial pharmaceutical companies could catch back up, compounders continued making these medications in smaller batches for custom doses, allowing for more patient accessibility.
“That creates a huge clash between commercial pharmaceutical companies and compounders, because commercial pharmaceutical companies view that as an infringement of their property,” Tatem noted.
The expert noted a “huge clash” between pharmaceutical companies and compounding pharmacies in peptide production. (iStock)
Tatem raised concerns about the FDA’s regulation of compounding pharmacies, warning that it could limit patients’ access to customized medications.
“That is a real concern for clinicians like me who really care more about patient access, making sure we can get the right medication to the right patients at the right time,” he said.
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Some peptides have been widely administered for more than a decade without major health complications like toxicity or cancer, according to Tatem.
“These are compounds that haven’t gone through the full FDA approval process that you would normally see for a commercial drug, [yet] we didn’t see anything adverse,” he said.
The FDA plans to consider loosening restrictions on several peptides during a summer 2026 meeting. (Issam Ahmed/AFP)
In September 2023, the FDA “quietly” tightened regulation of 19 peptides, making them illegal to manufacture and cutting off patient access.
“They seemed to be working and seemed to be efficacious for patients, and all of a sudden they were banned, which inadvertently ended up contributing to this surge in interest,” Tatem said. “We kind of saw the same thing happen with peptides that we saw with prohibition.”
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While the rising popularity of GLP-1 drugs has fueled growing public and regulatory interest in peptides, most of the so-called “trendy” peptides still are not available by prescription, according to Tatem.
They may help with injury recovery, skin rejuvenation, sleep improvements and boosting of natural growth hormones, he said.
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“These were all medications that were designed to help people live well and live as healthy as possible,” the doctor told Fox News Digital. “And in reality, that was also their downfall in the American healthcare system, because if you are going to get a drug approved and to market, it has to treat a disease state.”
“These were all medications that were designed to help people live well and live as healthy as possible,” Tatem told Fox News Digital. (iStock)
Tatem confirmed that he’s seen a shift in patients confronting more than just baseline ailments, seeking advice on how to feel their best through new modes like testosterone therapy.
“The desire to function at our highest level is something that we all feel,” he said.
While nothing replaces the fundamentals — getting eight hours of sleep, eating a high-protein diet and maintaining a fitness routine that blends resistance training and cardio — Tatem said individualized treatments such as peptides may help support those healthy habits.
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“If you end up pulling a tendon or pulling a hamstring, and you’re just now starting to get some momentum in the gym, that’s really where peptides start to step in,” he added.
Experts advise consumers to avoid gray-market products, to work only with qualified physicians and reputable pharmacies, and to treat peptides as part of a broader health plan — not a shortcut or risk-free supplement.
Semaglutide (GLP-1) weight-loss drug Wegovy, made by pharmaceutical company Novo Nordisk, is designed to treat type 2 diabetes, but is widely known for its effect on weight loss. Picture date: Wednesday, October 16, 2024. (James Manning/PA Images via Getty Images)
In a statement shared with Fox News Digital, a Novo Nordisk spokesperson said the drugmaker is committed to working with regulators, law enforcement and “other key stakeholders” to ensure “affordable access to safe, effective and FDA-approved GLP-1 obesity medication like Wegovy and to protect patients from unapproved and untested knockoff drugs.”
“The desire to function at our highest level is something that we all feel.”
“Novo Nordisk supports FDA’s recent thorough scientific analysis and conclusion that there is no medical basis or clinical need for the continued mass compounding of unapproved semaglutide and liraglutide drugs,” they went on.
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“The agency’s decision reaffirms that compounding is meant to be a rare and limited exception to FDA’s gold-standard drug approval framework that ensures that medicines in the U.S. are safe and effective.”
Fox News Digital reached out to the FDA and Eli Lilly for comment.
Health
New obesity treatment may help preserve muscle during weight loss
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During a recent episode of her podcast, Gwyneth Paltrow spoke with neuroscientist Dr. Andrew Huberman about retatrutide, a new advancement in GLP-1 (glucagon-like peptide-1) therapies.
In recent years, GLP-1 receptor agonists have become a major focus in discussions around biohacking, longevity and wellness – but they’re not without a multitude of side effects.
Huberman noted that while first-generation weight-loss drugs curbed users’ appetites, they frequently plunged them into massive, rapid caloric deficits.
‘NEXT OZEMPIC’ AIMS TO DELIVER 30% WEIGHT LOSS WITH FEWER SIDE EFFECTS
Without aggressive resistance training, a high percentage of that lost weight came directly from lean muscle. “People would lose a ton of weight, but they would also lose muscle mass,” Huberman told Paltrow.
In clinical trials, retatrutide is administered as a once-weekly subcutaneous injection. (iStock)
That is where retatrutide comes in, he said. Unlike older single- or dual-action medications, retatrutide is a triple agonist.
That means it activates the body’s receptors for glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon – three hormones involved in regulating blood sugar, appetite and metabolism.
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“Retatrutide is a more mild agonist of GLP-1,” said Huberman. “It also increases glucagon and … GIP. So, it hits three different pathways, each a bit more subtly.”
In clinical trials, retatrutide is administered as a once-weekly subcutaneous injection.
Without aggressive resistance training, a high percentage of lost weight can come directly from lean muscle mass, said Andrew Huberman. (iStock)
Because of its balanced, multi-receptor approach, Huberman said the drug has a “lower side effect profile” while still allowing people to lose up to a third of their body weight “across a year or so.”
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Most importantly for fitness and longevity advocates, the doctor pointed out that retatrutide seems to have “some muscle sparing effect.”
Because the drug is still moving through official pipelines, a massive gray market of compounding pharmacies and online peptide suppliers has cropped up to meet the growing demand.
Retatrutide is an investigational molecule that is legally available only to participants in Lilly’s clinical trials, according to Lilly’s website, and the company is currently “evaluating its safety and efficacy” in these clinical studies. (iStock)
Huberman issued a strict warning regarding these unregulated online sources, noting that these options “can say 99% purity, but that 1% means there could be some LPS,” referring to lipopolysaccharides, a type of bacterial toxin.
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“LPS will cause inflammation,” he cautioned. “One injection isn’t gonna do it, but multiple injections over time, I could see where that could become problematic.”
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Paltrow echoed the safety concerns, comparing the current “wild-west” peptide craze to the landscape of supplements in the 90s, “where there’s really no third-party testing and it’s kind of word of mouth.”
“Multiple injections over time, I could see where that could become problematic.”
Both agreed that anyone exploring these therapies should avoid unverified online sources and prioritize working with a medical doctor.
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Retatrutide is an investigational molecule that is legally available only to participants in Lilly’s clinical trials, according to the manufacturer’s website. The company is currently “evaluating its safety and efficacy.”
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The drug has not been reviewed or approved by any regulatory agency, and no one should consider taking anything claiming to be retatrutide outside of a Lilly-sponsored clinical trial, experts advise.
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