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New obesity treatment may help preserve muscle during weight loss

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New obesity treatment may help preserve muscle during weight loss

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During a recent episode of her podcast, Gwyneth Paltrow spoke with neuroscientist Dr. Andrew Huberman about retatrutide, a new advancement in GLP-1 (glucagon-like peptide-1) therapies.

In recent years, GLP-1 receptor agonists have become a major focus in discussions around biohacking, longevity and wellness – but they’re not without a multitude of side effects.

Huberman noted that while first-generation weight-loss drugs curbed users’ appetites, they frequently plunged them into massive, rapid caloric deficits.

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Without aggressive resistance training, a high percentage of that lost weight came directly from lean muscle. “People would lose a ton of weight, but they would also lose muscle mass,” Huberman told Paltrow.

In clinical trials, retatrutide is administered as a once-weekly subcutaneous injection. (iStock)

That is where retatrutide comes in, he said. Unlike older single- or dual-action medications, retatrutide is a triple agonist.

That means it activates the body’s receptors for glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon – three hormones involved in regulating blood sugar, appetite and metabolism.

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“Retatrutide is a more mild agonist of GLP-1,” said Huberman. “It also increases glucagon and … GIP. So, it hits three different pathways, each a bit more subtly.”

In clinical trials, retatrutide is administered as a once-weekly subcutaneous injection.

Without aggressive resistance training, a high percentage of lost weight can come directly from lean muscle mass, said Andrew Huberman. (iStock)

Because of its balanced, multi-receptor approach, Huberman said the drug has a “lower side effect profile” while still allowing people to lose up to a third of their body weight “across a year or so.”

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Most importantly for fitness and longevity advocates, the doctor pointed out that retatrutide seems to have “some muscle sparing effect.”

Because the drug is still moving through official pipelines, a massive gray market of compounding pharmacies and online peptide suppliers has cropped up to meet the growing demand.

Retatrutide is an investigational molecule that is legally available only to participants in Lilly’s clinical trials, according to Lilly’s website, and the company is currently “evaluating its safety and efficacy” in these clinical studies. (iStock)

Huberman issued a strict warning regarding these unregulated online sources, noting that these options “can say 99% purity, but that 1% means there could be some LPS,” referring to lipopolysaccharides, a type of bacterial toxin.

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“LPS will cause inflammation,” he cautioned. “One injection isn’t gonna do it, but multiple injections over time, I could see where that could become problematic.”

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Paltrow echoed the safety concerns, comparing the current “wild-west” peptide craze to the landscape of supplements in the 90s, “where there’s really no third-party testing and it’s kind of word of mouth.”

“Multiple injections over time, I could see where that could become problematic.”

Both agreed that anyone exploring these therapies should avoid unverified online sources and prioritize working with a medical doctor.

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Retatrutide is an investigational molecule that is legally available only to participants in Lilly’s clinical trials, according to the manufacturer’s website. The company is currently “evaluating its safety and efficacy.”

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The drug has not been reviewed or approved by any regulatory agency, and no one should consider taking anything claiming to be retatrutide outside of a Lilly-sponsored clinical trial, experts advise.

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Why Women Over 50 Are Obsessed With Fiber-Rich Foods for Weight Loss

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Why Women Over 50 Are Obsessed With Fiber-Rich Foods for Weight Loss


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Fiber-Rich Foods for Weight Loss Help Women Over 50 Burn Fat Fast




















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Secret to weight loss may be hiding in your gut, new study suggests

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Secret to weight loss may be hiding in your gut, new study suggests

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A specific gut microbe could help with long-term weight-loss goals.

New research published in the journal Nature Medicine tested whether a pasteurized (not live) gut bacterium, called Akkermansia muciniphila MucT, could help people keep weight off after losing it.

The study enrolled 90 overweight and obese adults from the Netherlands in an eight-week, low-energy diet where they were instructed to lose 8% of their body weight, according to a press release.

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The participants then started a 24-week weight-maintenance phase and were randomly assigned to take either the gut bacterium or a placebo.

People taking Akkermansia regained significantly less weight than those taking the placebo, the study found. (iStock)

People taking Akkermansia regained less weight than those taking the placebo, at an average of 2.6 pounds versus 7.1 pounds — a statistically significant difference, according to the study results.

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The researchers noted that the efficacy of the treatment depends on a person’s existing gut microbiome. There were no serious adverse events reported.

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The study’s short duration and small sample size may not be enough to prove long-term benefits, the team noted. Another limitation is that participants ate whatever they wanted instead of following a standardized diet.

The study enrolled 90 overweight and obese adults from the Netherlands in an eight-week, low-energy diet where they were instructed to lose 8% of their body weight. (iStock)

Dr. Peter Balazs, MD, a hormone and weight loss specialist practicing in New York and New Jersey, called this a “well-designed” trial.

“The finding that a single gut microbe, pasteurized Akkermansia, significantly reduced weight regain is particularly compelling,” the expert, who was not involved in the research, told Fox News Digital. “Most probiotics have demonstrated far less efficacy, making these results especially noteworthy.”

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Balazs pointed out that pasteurized Akkermansia isn’t a live probiotic, but works through “components of the bacteria, particularly a protein called Amuc_1100.”

Akkermansia is “not a miracle pill,” an expert noted, although the study results are promising. (iStock)

“This protein helps strengthen the gut barrier, reduce low-grade inflammation and support healthy metabolic function,” he said. “After weight loss, the body naturally tries to regain fat, but Akkermansia appears to help quiet some of those biological signals, making it easier to maintain results over time.”

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While the study results are promising, the doctor cautioned that Akkermansia is not a miracle pill.

“It helps with maintenance, not initial loss,” he said. “Long-term use is plausible; however, it hasn’t been proven beyond 24 weeks. This does not replace diet, exercise or medical advice.”

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Dirty soda drinks are everywhere, but doctors warn of health risks: ‘Metabolic disaster’

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Dirty soda drinks are everywhere, but doctors warn of health risks: ‘Metabolic disaster’

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The latest beverage trend is far from clean – and it’s raising red flags with doctors.

Known as a “dirty soda,” it’s a soft drink that also includes a combination of added ingredients, such as flavored syrups, creamers, fruit juices and other garnishes. The result is a sweet beverage that’s a combination of a soda, mocktail and dessert.

Dirty sodas can easily deliver 250-400 calories and 55-70 grams of sugar in a single drink – which is often more than double the American Heart Association’s daily added sugar limit, according to Erin Palinski-Wade, a New Jersey-based registered dietitian.

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“It’s more like a dessert beverage than a soft drink, even if people use diet soda as the base,” she told Fox News Digital.

The drinks are most dangerous for those with insulin resistance, prediabetes or diabetes, Palinski-Wade warned.

A dirty soda is a soft drink that also includes a combination of added ingredients, such as flavored syrups, creamers, fruit juices and other garnishes. (iStock)

“The combination of rapidly absorbed sugar plus cream can cause sharp blood sugar spikes and crashes, driving hunger, fatigue and higher insulin demands,” she cautioned.

The trend is said to have originated in Utah years ago at a specialty soda shop, Swig, reportedly due to people in the Mormon faith seeking an alternative to coffee. The drink was then popularized by social media and TV shows, such as “The Secret Lives of Mormon Wives,” according to Eater.com.

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The dirty soda trend is widely credited to Swig, a Utah-based soda shop founded in 2010. The concept reportedly gained popularity in Utah, where many members of The Church of Jesus Christ of Latter-day Saints abstain from coffee and alcohol, helping create demand for customizable, non-alcoholic drinks.

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“There are multiple soda shops in most suburbs here,” one Utah resident wrote on Reddit. “I have many coworkers who stop at one daily on their way to work [because] they don’t drink coffee, but will drink dirty sodas.”

Trend goes mainstream

Dirty sodas have recently grown in popularity, appearing on many restaurant menus and grocery store shelves. Coca-Cola has launched its Coca-Cola Cherry Float, which is designed to mimic the soda-and-cream experience, while PepsiCo offers a Dirty Mountain Dew Cream Soda.

McDonald’s, Taco Bell, Sonic and Dunkin are among the fast-food brands that include dirty soda options in their beverage line-ups.

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Crumbl recently launched a dirty soda that includes multiple sweet ingredients on top of an already sugary soda base. (USA TODAY Network via Reuters Connect)

Perhaps taking the cake is Crumbl, which recently launched a dirty soda that includes multiple sweet ingredients on top of an already sugary soda base.

“Crumbl needs to be stopped,” Dr. Mark Hyman wrote in a recent social media post. “Their new ‘dirty soda’ contains 186 grams of sugar, the equivalent of eating 19 Krispy Kreme donuts. This is a metabolic disaster and should be illegal.”

Experts warn of health risks

Dr. Marc Siegel, Fox News senior medical analyst, echoed the warnings about dirty sodas being “very unhealthy.”

“They are loaded with processed sugar, empty calories and saturated fats,” he told Fox News Digital. “They are also highly addictive, especially because of the high sugar content, and are about 400 calories per serving.”

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Over time, regular consumption of these types of sugary beverages can train the brain to seek repeated dopamine and endorphin releases, Siegel warned. This can increase the risk of obesity, diabetes, heart disease, dementia and other chronic illnesses.

An employee prepares a dirty soda at Floso, a drink shop in Salem, Oregon, in July 2024. (Abigail Dollins/Statesman Journal)

Tanya Freirich, a registered dietitian nutritionist in Charlotte, North Carolina, echoed that daily added sugars increase the risk of obesity, non-alcoholic fatty liver disease, cardiovascular disease and diabetes.

“Additionally, the creamy mix-ins featured in dirty sodas are generally high in saturated fat, another nutrient that should be consumed in limited amounts,” Freirich told Fox News Digital.

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“If you’re looking for a mocktail or fun non-alcoholic beverage, consider using a base of plain seltzer water for a bubbly drink,” she recommended. “Even with the same add-ins, your end result will contain considerably less sugar, but still taste sweet.”

An orange dirty soda is displayed at the Ross County Fair in Ross County, Ohio. (USA TODAY Network via Reuters Connect)

Kenneth J. Perry, M.D., an emergency physician in Charleston, South Carolina, also noted that dirty sodas represent a continuation of the trend toward highly sugary beverages.

“Their effects are short-lived, prompting individuals to consume excessive amounts,” he warned. “This combination of low nutritional value, high sugar content and poor satiety can have significant health implications.”

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Each additional highly sugary beverage consumed daily increases the risk of developing diabetes, high blood pressure or heart disease, Perry cautioned.

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The World Health Organization recommends limiting free sugars – such as those found in beverages with added sugar – to less than 10% of total daily energy consumption, the doctor noted.

“Beverages with added sugar are one of the most easily modifiable risk factors for various downstream health issues,” Perry added.

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For those who do decide to try the dirty soda trend, Palinski-Wade recommends choosing a small size, using a diet soda base and limiting it to a rare treat.

“It really belongs in the same category as a cake or a milkshake – occasionally, and in smaller portions.”

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