Health
This disease kills more people than all cancers and accidents combined
Heart disease remains the top killer of Americans as risk factors continue to grow.
The latest statistics were revealed in the American Heart Association’s annual report, 2025 Heart Disease and Stroke Statistics.
The report, which was published on Jan. 27 in the AHA’s journal Circulation, revealed that cardiovascular disease kills more people than all types of cancer and accidental deaths combined.
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In 2022 — the most recent year for which mortality data is available — a total of 941,652 people died of heart disease-related conditions, according to the report. This was a little more than 10,000 more deaths than the prior year.
The age-adjusted death rate decreased slightly from last year, however.
In 2022 — the most recent year for which mortality data is available — a total of 941,652 people died of heart disease-related condition (iStock)
“Overall, we are seeing cardiovascular-related deaths leveling out compared to 2022,” said Dr. Bradley Serwer, a Maryland-based cardiologist and chief medical officer at VitalSolution, an Ingenovis Health company that offers cardiovascular and anesthesiology services to hospitals.
“We are making some improvements in regard to improved prevalence of hyperlipidemia (high cholesterol) and lower incidence of smoking, but have lost ground in regard to diabetes, obesity and hypertension,” Serwer, who was not involved in the report, told Fox News Digital.
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Someone dies of heart disease every 34 seconds in the U.S., and a total of 2,500 die per day, according to Keith Churchwell, M.D., the volunteer president of the American Heart Association.
“It’s alarming to note that excess weight now costs us even more lives than smoking.”
“Those are alarming statistics to me – and they should be alarming for all of us,” Churchwell said in a press release.
“Too many people are dying from heart disease and from stroke, which remains the fifth leading cause of death.”
Risk factors
The report also detailed the prevalence of specific risk factors for heart disease.
More than 72% of U.S. adults have “unhealthy weight,” which is defined as a body mass index of at least 25, the report stated.
Nearly 42% of those adults meet the criteria for obesity (a body mass index of 30 or more).
Nearly 42% of those adults meet the criteria for obesity (a body mass index of 30 or more). (iStock)
The report also revealed that more than half of U.S. adults (57%) have type 2 diabetes or prediabetes.
“Although we have made a lot of progress against cardiovascular disease in the past few decades, there is a lot more work that remains to be done,” American Heart Association volunteer Dhruv S. Kazi, M.D., wrote in an editorial that accompanied the report.
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“If recent trends continue, hypertension and obesity will each affect more than 180 million U.S. adults by 2050, whereas the prevalence of diabetes will climb to more than 80 million.”
Experts predict a 300% increase cardiovascular-related healthcare costs, added Kazi, who is also head of health economics and associate director of the Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology at Beth Israel Deaconess Medical Center.
“Too many people are dying from heart disease and from stroke, which remains the fifth leading cause of death.” (iStock)
The report also called out different rates of risk factors among different races and ethnic groups.
Black women were found to have the highest rate of obesity (57.9%) and Asian women had the lowest rate (14.5%).
Black women also had the highest rate of blood pressure (58.4%) and Hispanic women, at 35.3%, had the lowest rate.
“Just because we are seeing improvements in smoking and high cholesterol doesn’t mean we can back off.”
“We are also seeing a rise in obesity in our youth, with as many as 40% having unhealthy weight,” Serwer warned.
“This trend continues into adulthood, when we see nearly 60% of adults having unhealthy weight.”
Excess weight is a contributing factor in as many as 1,300 additional deaths per day in the U.S., or nearly 500,000 per year, according to the report.
“It lowers life expectancy by as much as 2.4 years compared to a healthy weight,” said American Heart Association volunteer Latha P. Palaniappan, M.D., a professor of cardiovascular medicine at Stanford University in Palo Alto, California.
“Any medical or clinical therapies that can treat the risk factors that contribute to cardiovascular disease are essential.” (iStock)
“It’s alarming to note that excess weight now costs us even more lives than smoking – as smoking rates have actually fallen in recent years. Being overweight is the new smoking when it comes to health threats.”
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One positive finding in the report is that rates of high cholesterol have dropped, which is attributed to improved dietary and lifestyle factors, availability of medications and “better clinical control.”
“Recent clinical research has identified a number of new medication therapies to address the growing burden of obesity, as well, and we look forward to learning more about those advances as the body of science builds,” Churchwell noted.
What needs to change?
The researchers called for interventions to help reduce heart disease risk factors.
“Any medical or clinical therapies that can treat the risk factors that contribute to CVD are essential,” Churchwell wrote. “…We need to stop these risk factors in their tracks, keep people healthy throughout their lifespan.”
Serwer agreed that the best way to combat this top killer is to aggressively attack the risk factors.
“Just because we are seeing improvements in smoking and high cholesterol doesn’t mean we can back off,” he said.
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“We need to continue to aggressively attack tobacco use and treat hyperlipidemia while increasing efforts to treat obesity, high blood pressure and diabetes.”
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A new injectable therapy is showing positive results in reducing melanoma throughout a five-year period.
The personalized mRNA cancer therapy, called intismeran autogene, combined with the cancer immunotherapy drug KEYTRUDA (pembrolizumab), is a collaboration between Merck and Moderna.
The results from the phase 2b KEYNOTE-942 study were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago on May 27.
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After about a five-year follow-up, the combo drug was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone.
The researchers analyzed data from 157 patients with high-risk stage 3 and 4 melanoma whose cancer had been removed via surgery. The participants were split into two groups — one received the combo therapy and the other only received pembrolizumab, according to a press release.
The therapy was found to reduce the risk of melanoma recurrence or death by 49% compared to pembrolizumab alone after a five-year follow-up. (iStock)
The findings revealed that the combination group saw benefits that were “sustained and durable over time.”
Intismeran autogene is designed using mutations identified in a patient’s own tumor, with the intention of teaching the immune system what the cancer looks like so that it can recognize and attack it.
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According to the researchers, intismeran is “well-tolerated” with a “manageable” safety profile.
The most commonly cited side effects of the personalized mRNA vaccine plus KEYTRUDA were fatigue, injection-site pain, chills, fever and headache. The researchers reported no new long-term safety concerns and no severe vaccine-related adverse events.
The combination therapy is currently being evaluated in a phase 3 study — the final confirmation stage.
Patients with late-stage melanoma have a “significant risk” of cancer recurrence, according to an expert. (iStock)
In a Merck press release from January, Kyle Holen, MD, Moderna’s senior vice president and head of development, oncology and therapeutics, noted that this data highlights the “potential of a prolonged benefit … in patients with resected high-risk melanoma.”
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“We continue to invest in our platform in oncology because of encouraging outcomes like these, which illustrate mRNA’s potential in cancer care,” he said.
Dr. Marjorie Green, senior vice president and head of oncology, global clinical development at Merck Research Laboratories, also commented that for many patients with stage 3 or 4 melanoma, there is a “significant risk of recurrence following surgery.”
Researchers confirmed that the combination therapy is currently being evaluated in a phase 3 study. (iStock)
“As such, demonstrating the longer-term potential of intismeran autogene and KEYTRUDA to reduce the risk of recurrence for certain patients with melanoma is a meaningful milestone,” she said.
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The company cited encouraging five-year follow-up data and pointed to upcoming late-stage INTerpath trial results with Moderna in several hard-to-treat cancers.
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An accidental lab discovery has opened the door to entirely new ways of preventing the flu.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells, SWNS reported.
By targeting the specific molecules the viruses rely on, scientists found that they could block them from entering new cells and halt their replication altogether.
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Researchers say these “fundamental insights” into seasonal influenza highlight a clear path toward developing better preventive medications.
“The hope is that fundamental, curiosity-based research like this helps to pave the way for novel strategies to treat and prevent influenza infections,” principal investigator Dr. Emily Bruce, from the University of Vermont’s Larner College of Medicine, said in the SWNS report.
While investigating how influenza replicates, researchers discovered that different flu strains use completely different strategies to infiltrate human cells. (iStock)
While several flu strains cause illness, H1N1 and H3N2 influenza A viruses are the most common. However, current flu tests cannot differentiate between them, and clinical treatments are identical for both.
Although vaccines and antivirals are available, Bruce noted a “dire” need for better medications to stop the virus from spreading cell to xxcell.
“You don’t get sick when a virus is in one cell,” he noted. “You get sick because a virus replicates itself and goes into many more cells.”
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The study, which was published in The Journal of Virology, originally aimed to map how viral RNA segments are transported within cells to create new viral particles.
The team used H1N1 and H3N2 viruses isolated from the nasal passages of positive patients in 2022.
Clinical treatments remain identical for both primary strains of the flu virus. (iStock)
During the investigation, the team unexpectedly stumbled upon a cellular pathway that blocked the virus from entering lung cells, SWNS reported.
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The data revealed that when a specific human protein called Rab11B was depleted, H3N2 viruses failed to enter human lung cells. H1N1 viruses were completely unaffected.
Using reverse genetics, the team mapped this defect and uncovered a brand-new, H3N2-specific role for Rab11B during viral entry.
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This discovery challenged the scientific assumption that all flu viruses enter cells the same way.
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“Viruses are like pirates from different countries hijacking someone’s ship,” Bruce said. “Different viruses, like different types of pirates, use different methods to get onboard.”
This discovery challenged the scientific assumption that all flu viruses enter cells the same way. (iStock)
“We had previously thought that all flu viruses used the same way to get into a cell, but we discovered that this is not true,” she went on. “H1N1 and H3N2 need different proteins to get in, and if you get rid of the right protein, a specific virus can’t get in.”
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While these findings identify a critical cellular pathway for viral entry, the study was conducted using isolated cells, the researchers acknowledged.
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Further research is needed to determine whether blocking the protein is safe and effective within a live, complex human respiratory system.
Bruce and the team hope to conduct further research to determine whether this Rab11B-dependency is a fundamental property of H3N2, or if it’s a trait unique to currently circulating flu strains.
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Eating processed meat like ham, sausage and bacon may be linked to a higher risk of certain types of cancer, according to new research.
While health organizations have already confirmed that processed meat can contribute to colon cancer, this study looked closer at cancers in the upper digestive tract, where the link has historically been less clear.
To understand these connections, researchers from the European Prospective Investigation into Cancer and Nutrition (EPIC), one of the world’s largest long-term nutrition and cancer cohorts, tracked the health and diets of 450,112 people across Europe for an average of 14 years.
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The study group included 131,426 men and 318,686 women, according to the study’s press release.
During the follow-up period, 876 people developed stomach cancer and 215 people developed esophageal adenocarcinoma, which is cancer of the tube connecting the mouth to the stomach.
For female participants, eating both processed meat and white meat was linked to an increased risk of developing the disease. (iStock)
Researchers tracked where the stomach cancers grew, separating them into the upper part of the stomach near the throat and the lower part of the stomach.
The researchers also sorted the tumors into two categories based on how the cancer cells appeared under a microscope: intestinal, which forms more organized structures, and diffuse, in which the cells are more scattered throughout the tissue.
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After adjusting for other lifestyle factors, the researchers found that for every extra 30 grams of processed meat a person ate per day, their overall risk of stomach cancer went up by 9%. Eating that same extra 30 grams a day was also linked to a 13% higher risk of esophageal adenocarcinoma.
A standard single slice of regular deli-sliced ham or lunch meat averages around 28 grams, according to USDA data and nutritional tracking databases.
An extra 20 grams of white meat, such as chicken and turkey, was linked to a 12% higher risk of cancer in the main body of the stomach. (iStock)
An extra 20 grams of white meat, such as chicken or turkey, was linked to a 12% higher risk of cancer in the main body of the stomach, the researchers noted.
The study also revealed differences between men and women. For male participants, only processed meat showed a clear, statistically significant link to a higher risk of stomach cancer. For female participants, however, eating both processed meat and white meat was linked to an increased risk.
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These findings align with global health benchmarks, particularly those established by the World Health Organization’s International Agency for Research on Cancer.
The agency has long classified processed meat as a known human carcinogen, primarily due to its strong, well-documented links to colorectal cancer.
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However, health organizations have also consistently pointed to a potential, yet less definitive, relationship between these meats and cancers of the stomach.
Eating 30 grams of processed meat a day, or the equivalent to one slice of ham, was linked to a 13% higher risk of esophageal adenocarcinoma. (iStock)
Further scientific investigation is needed to confirm the findings and to account for other underlying risk factors, such as certain stomach infections, which could interact with dietary habits.
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A key limitation of the study is its reliance on self-reported diets, which can sometimes lead to inaccuracies in how participants recall their meat consumption over time, the researchers noted.
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The findings were published in the International Journal of Cancer.
Fox News Digital reached out to the researchers requesting comment.
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