Health
The year in cancer: Advances made in 2024, predictions for 2025
At the beginning of 2024, the American Cancer Society predicted that 2,001,140 new cancer cases and 611,720 cancer deaths would occur in the United States.
Now, as the year draws to a close, experts are looking back and reflecting on the discoveries and advances that have been made in the field of cancer treatment and prevention.
Fox News Digital spoke with four oncologists from the Sarah Cannon Research Institute in Nashville, Tennessee, about the most notable accomplishments of 2024 and what they see on the horizon for 2025.
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See the answers and questions below.
Krish Patel, MD, director of lymphoma research
Krish Patel, M.D., is director of lymphoma research at Sarah Cannon Research Institute in Nashville, Tennessee. (Sarah Cannon Research Institute )
Q: What do you see as the most important cancer advances in 2024?
A: In the field of lymphomas, we see growing momentum for therapies that use the patient’s own immune system to fight their cancer, such as CAR T-cell therapy and bispecific antibodies.
These are treatments that are now being studied and are making an impact earlier in the disease course, including one now being studied as the very first treatment a patient might receive for their lymphoma.
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These treatments are helping us to be less dependent on chemotherapies (which may be effective but have broad side effects) for the treatment of lymphomas.
Q: What are your predictions for cancer research in 2025?
A: Every year we are improving the curative treatment options we have for specific types of lymphomas, such as diffuse large B-cell lymphoma (DLBCL), which is the most common lymphoma we see.
We are also gradually becoming better able to offer these treatments closer to – or in – patients’ homes and communities, so they can receive the best care as close to home as possible.
“Every year, we are improving the curative treatment options we have for specific types of lymphomas.”
I believe that in 2025, we will continue to see more advancement in immunotherapies, development of more targeted therapies (including oral medicines), and hopefully soon the approval of next generations of immunotherapies that may work for patients who have already received today’s immunotherapies but need more treatment options.
Q: How has the state of cancer in your specialty area changed and evolved over the past decade?
A: It has changed and evolved dramatically. A decade ago, care for lymphomas was primarily chemotherapy-based. Now, we are shifting rapidly away from chemotherapies in some types of lymphomas in favor of immunotherapies and targeted oral therapies that lead to excellent long-term outcomes for patients, with fewer side effects than historical treatments.
As 2024 comes to an end, experts are looking back and reflecting on the discoveries and advances that have been made in the field of cancer treatment and prevention. (iStock)
Q: What can people do to reduce their cancer risk?
A: We think of lymphomas as diseases of aging for most patients. Some patients may have select risk factors, such as being on specific immunosuppressants or having exposure to very specific industrial chemicals.
Those risks may or may not be so modifiable for patients, and they represent the minority of patients who develop lymphoma.
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While it is not entirely clear what modifiable risks patients may have, there is ongoing work to help better answer that question. However, we know that the better general health someone is in, the more likely they are to have any and all treatment options available to them.
I would say that for most people, exercising regularly, eating well and sleeping regularly are important.
Q: Anything else people should know?
A: There is great hope and a lot of exciting science happening to help us drive toward more cures, more effective treatments and less toxic treatments for lymphomas.
We have already made major strides in the last decade, and we continue to build on that momentum through clinical trials that provide early access to cutting-edge therapies.
Exercising regularly, eating well and getting enough sleep are all recommended activities to help prevent cancer risk, experts agreed. (iStock)
For patients, participating in clinical trials may help to close that time gap between the treatments that are broadly available today and the treatments we expect to be available years from now.
They also provide a way for patients to contribute positively to the care patients in future generations may receive, which I have been told by many of my patients is something they really want to do and something that is important to them.
Erika Hamilton, MD, director of breast cancer research
Erika Hamilton, M.D., is director of breast cancer research at Sarah Cannon Research Institute in Nashville, Tennessee. (Sarah Cannon Research Institute)
Q: What do you see as the most important cancer advances in 2024?
A: The two most exciting focuses of 2024 were 1) expansion of targeted therapies in the curative setting for hormonally driven breast cancer and 2) antibody drug conjugates.
First, three different CDK4/6 inhibitors have been approved in the metastatic setting, and they improve survival and outcomes.
Treatments that are precisely tailored to the genetic makeup of a person’s cancer are becoming more widely available, experts say. (iStock)
In 2024, we saw the approval of a second one in the curative setting, enabling us to identify the highest-risk patients and offer them something additional to endocrine therapy to improve cure rates.
Second, we now have multiple antibody drug conjugates approved across all types of breast cancer. These therapies target a chemotherapy drug directly to the tumor via an antibody-honing mechanism and largely spare normal body cells.
“I anticipate drugs that are better tolerated with decreased side effects for patients, and a continued emphasis on personalized medicine.”
Q: What are your predictions for cancer advances in 2025?
A: I anticipate seeing more targeted agents in 2025 and the approval of antibody drug conjugates in curative early breast cancer — currently, most are only approved in metastatic cancer.
[I also anticipate] drugs that are better tolerated with decreased side effects for patients, and a continued emphasis on personalized medicine.
Q: How has the state of cancer in your specialty area changed and evolved over the past decade?
A: In 2024, truly personalized medicine is possible, from mutation testing to direct targeted therapy to what a cancer needs to grow — as well as being able to provide many HR+ breast cancer patients with curative chemotherapy through personalized risk stratification assays.
“I anticipate seeing more targeted agents in 2025 and the approval of antibody drug conjugates in curative early breast cancer,” said Hamilton (not pictured). (iStock)
Q: What can people do to reduce their cancer risk?
A: Continued breast screening with mammograms yearly is really important to find cancers earlier when a cure is more likely.
People can also reduce their risk through avoiding alcohol and cigarettes and making sure they get regular exercise and maintain a normal body weight.
Vivek Subbiah, MD, chief of early-phase drug development
Vivek Subbiah, M.D., is chief of early-phase drug development at Sarah Cannon Research Institute in Nashville, Tennessee. (Sarah Cannon Research Institute )
Q: What do you see as the most important cancer advances in 2024?
A: In 2024, precision cancer treatment made big strides with many new drug approvals by the FDA, specifically for treatments guided by specific biomarkers, which means treatments can be more precisely tailored to the genetic makeup of a person’s cancer.
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A key change was moving some therapies from faster, temporary approval processes to full approval, showing strong evidence that these targeted therapy drugs, such as tepotinib and amivantamab for certain types of lung cancer, are effective and safe.
There were also new drug approvals for rare cancers, including tovorafenib, a BRAF precision medicine for a rare type of brain tumor in children, and afamitresgene autoleucel, a type of immunotherapy for a rare cancer called synovial sarcoma. This highlights important progress in treating these challenging conditions.
“In 2024, precision cancer treatment made big strides with many new drug approvals by the FDA, specifically for treatments guided by specific biomarkers,” Subbiah (not pictured) told Fox News Digital. (iStock)
We have also seen the approval of precision therapies that work on different types of cancer — not just one specific cancer. This is what we call “tissue-agnostic therapies.”
One such drug is an antibody drug conjugate called trastuzumab deruxtecan, which acts like a smart missile targeting HER2-positive cancers. Another is repotrectinib, which works on any cancer that has the NTRK biomarker, regardless of where it is in the body.
Q: What are your predictions for cancer advances in 2025?
A: By 2025, cancer research is likely to see advancements in precision oncology and the use of artificial intelligence.
In precision oncology, we can expect more personalized treatment plans based on an individual’s genetic makeup, leading to more effective and targeted therapies with fewer side effects.
Additionally, AI will likely play a larger role in analyzing vast amounts of data to identify new drug targets, predict patient responses to treatments and enhance early detection methods.
These advancements have the potential to improve cancer diagnosis, treatment and overall patient outcomes.
Q: How has the state of cancer in your specialty area changed and evolved over the past decade?
A: In the last 10 years, cancer treatment has changed dramatically. By using genetic information to create personalized treatments that match the specific details of each person’s cancer, therapies are more effective and less harmful.
“In precision oncology, we can expect more personalized treatment plans based on an individual’s genetic makeup,” Subbiah said. (iStock)
New technologies such as analyzing cancer’s genetic profile, blood tests that detect cancer, and treatments that boost the immune system have greatly improved how we diagnose, track and treat cancer, leading to better results for patients.
Q: What can people do to reduce their cancer risk?
A: To lower the risk of cancer, people can avoid smoking, eat a healthy diet, exercise regularly, limit alcohol, protect their skin from the sun and maintain a healthy weight.
Q: Anything else people should know?
A: Get vaccines for viruses like HPV and hepatitis B, as they can lead to some cancers. Also, go for regular health checks to catch any signs of cancer early.
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We are in a unique time when treatments can be tailored specifically to each person, and many of these are available through clinical trials. If you or a loved one is diagnosed with cancer, ask your doctor if there are any clinical trials that might be a good fit.
Meredith McKean, MD, MPH, director of melanoma and skin cancer research
Meredith McKean, M.D., MPH, is the director of melanoma and skin cancer research at Sarah Cannon Research Institute in Nashville, Tennessee. (Sarah Cannon Research Institute)
Q: What do you see as the most important cancer advances in 2024?
A: The first cellular therapy, Lifileucel, was approved in melanoma after decades of research in academia and industry.
“We are in a unique time when treatments can be tailored specifically to each person, and many of these are available through clinical trials.”
This is a significant step forward for both patients with melanoma, but also the field of oncology at large.
Q: What are your predictions for cancer advances in 2025?
A: As we look to bring effective therapies from the metastatic setting into early stages of disease, we are anxiously awaiting updates in the next 18 to 24 months for a number of ongoing trials for combination therapy for patients with high-risk stage 2 or 3 melanoma.
In 2024, the first cellular therapy, Lifileucel, was approved in melanoma after decades of research, according to Meredith McKean, M.D., of the Sarah Cannon Research Institute (not pictured). (iStock)
Q: How has the state of cancer in your specialty area changed and evolved over the past decade?
A: Outcomes for melanoma have significantly changed over the past 10 years.
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The five-year survival for patients with a diagnosis of stage 4 melanoma was less than 5% before 2010, and now clinical trials have shown that more than 50% of patients are still alive 10 years after being treated with FDA-approved immune checkpoint inhibitors.
Q: What can people do to reduce their cancer risk?
A: Lifelong sun protective measures, such as wearing sunscreen, avoiding direct UV exposure during peak hours of 10 a.m. to 2 p.m., and avoiding tanning beds continue to be important starting at an early age.
Dr. Megan Jack, a neurosurgeon in Cleveland, often works 60 or 70 hours a week. And she’s completely unavailable when she’s in the operating room. That makes it tough to be a caregiver for her 76-year-old mother, who lives in a separate unit on Dr. Jack’s property, 30 minutes away from the hospital.
To help care for her mother, who has Alzheimer’s disease, Dr. Jack uses an array of high-tech tools, some of which didn’t exist just a few years ago. She manages her mother’s medications with a smart pill box. She changes her television channels with an app, sends appointment reminders through a digital message board — and, with her mother’s blessing, uses cameras for communication and monitoring.
“It’s been invaluable that I can both make sure she’s safe and make sure everything is going well,” Dr. Jack said, “but also give her the independence and the freedom that she still deserves.”
America is aging rapidly. Roughly 11,000 people are turning 65 each day in the United States. And many of them — 75 percent of people over 50, according to AARP’s most recent survey, from 2024 — hope to spend their remaining years in the comfort of their homes, rather than in assisted-living or other care facilities.
One thing that could help fulfill those wishes is the budding field of “age tech,” which encompasses tools that support older adults. Industry experts say that age tech is making homes safer for older adults and is easing the minds of their caregivers, especially those who live far away or work outside the home.
Dr. Jack said that age tech had “really allowed me to integrate caregiving into my life, as opposed to caregiving taking over my life.”
The age tech boom
If older adults don’t have loved ones who are both close by and able to help, they might believe they don’t have a ton of options. They can live independently, or, if they can afford it and qualify medically, they can move to an assisted-living facility or a nursing home, without a lot of choices in between. In-home help can be expensive without Medicaid and can also be difficult to find, given the serious shortage of home care workers.
Age tech can help bridge some important gaps, said Emily Nabors, the associate director of innovation at the National Council on Aging, a nonprofit advocacy group. Already, AARP reports that 25 percent of caregivers are remotely monitoring their loved ones with apps, videos or wearables, nearly double the percentage from five years ago.
“We used to say homes are the health care settings of the future, but they really are health care settings now,” Ms. Nabors said. “Aging in place is very realistic.”
More than 700 companies are in AARP’s AgeTech Collaborative, a group that connects businesses, nonprofits and funders to help get new technologies off the ground. Altogether, the collaborative’s start-ups have raised nearly $1 billion in the past four years.
The products include smart walkers, glasses with lenses that provide real-time captions of conversations for those with hearing issues, and a concierge service that connects older people to drivers and deliveries, even if they don’t have a smartphone.
Ms. Nabors does foresee some affordability and access barriers to age tech, including the lack of high-speed internet in rural areas, but she said one vital resource would be local aging agencies, which can offer advice and, sometimes, free support.
Janet Marasa leaned on the agency near her home in Rockland County, N.Y., to get a free robotic pet for her mother, Carol DeMaio, 80, who has dementia. The pets, manufactured by a company called Joy for All, aim to offer emotional support without the upkeep.
Ms. DeMaio named the robotic dog Sabrina, after a golden retriever who died. The new Sabrina stays at the foot of her bed at night. As soon as Ms. DeMaio stirs awake, the dog reacts. “She said it gives her a reason to get up in the morning,” Ms. Marasa said.
The dog has been a boon to her, too. “It provides comfort and interaction that I can’t provide every second,” said Ms. Marasa, who lives with her mother but works full time for the county government. “It gives her something that she can feel like is totally her own.”
In Broward County, Fla., where the population of residents over 85 is expected to nearly triple over the next few decades, the local agency on aging has used state and federal money and private grants to provide technologies to nearly 4,000 of the county’s seniors at no cost.
Its offerings include a company that uses radar to sense falls and a program that allows seniors to make video calls through their televisions.
“The possibilities are endless,” Charlotte Mather-Taylor, the agency’s chief executive, said. “It’s pretty great to see all the new technology coming out so quickly, and I think that can only benefit our older population and also our caregivers.”
Here comes A.I.
Even technologies not specifically marketed as age tech can help older adults maintain their independence, said Laurie Orlov, founder of the blog Aging and Health Technology Watch. She pointed to video-calling and telehealth platforms; remotely controlled thermostats and lights; and smart speakers, doorbells and watches.
“All technology can be customized to help older adults stay longer in their homes and help their family members feel good about it, or at least tolerate it,” Ms. Orlov said.
That will only become more true with the continued proliferation of artificial intelligence, Ms. Orlov added. Some older adults are already using conversational A.I. to get answers about things like the weather or their medications. (Relying too heavily on A.I. can, however, have negative consequences because chatbots often give flawed medical advice and can lead patients astray.) A.I. can also assist in pattern detection: alerting caregivers to signals that might indicate declines in someone’s cognition or mental health, such as changing their speech pattern or leaving the house less frequently.
One A.I.-powered age tech tool is ElliQ, a tabletop companion robot that looks like a sleek silver desk lamp with a screen. About a year and a half ago, Camille Wolsonovich got one for free, thanks to a local nonprofit, for her 90-year-old father, Bill Castellano. He lives alone in a senior community.
Ms. Wolsonovich, who runs a consulting business, relies on ElliQ to lead her father in exercises and remind him to take his pills and drink water. The robot also asks her father about his sleep and mood via automated check-ins.
“Everything’s just another layer that gives us more confidence, from a caregiving standpoint, that he’s good,” Ms. Wolsonovich said. “I don’t have to necessarily track everything all the time and be overbearing.”
As for Mr. Castellano? He plays trivia digitally and converses daily with ElliQ. The robot, which has a friendly female voice, asks questions, cracks jokes and remembers his likes, dislikes and friends. “She’s great company,” he said. “Everybody around me wants one.”
What about ethical concerns?
Clara Berridge studies the ethics of age tech at the University of Washington.
She has many privacy concerns, namely that most direct-to-consumer products aren’t subject to medical privacy laws, despite being privy to sensitive health information. Though she hopes the federal government will eventually step in to regulate these products, as it has in other countries, the onus remains on the consumer for now.
And even if an age tech product isn’t selling mom’s personal data to the lowest bidder, Dr. Berridge said there’s still the question of whether certain tools are ethical.
“It’s really important for caregivers to recognize that using these new technologies that give them more information about someone can represent greater intrusion into someone’s life,” she said.
What may be well-intentioned monitoring could reveal information that an older adult would rather keep private, such as issues with incontinence, or the comings and goings of a romantic partner.
“It can lead to somebody feeling infantilized,” Dr. Berridge said. “Like there’s not a place to hide within your own home.”
Her research shows that adult children often underestimate how much their parents can understand about technology and how much they want to be involved in tech-related decisions.
She encouraged caregivers to have transparent conversations about privacy implications and to avoid ultimatums or the idea that any decision must be permanent. She said caregivers should put themselves in their parents’ shoes: Is this something they’d want their own children monitoring?
Dr. Berridge is working on an advanced directive for technology, which outlines older people’s wishes for how technology is used in their care. Ultimately, she hopes that questions about age tech will become a standard part of planning for the future.
“If you’re at the start of what, for many people, ends up being a long road of supporting someone potentially through the end of their life,” she said, “seeking to understand each other’s concerns and priorities better is time very well spent.”
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A distraught mother who thought she was having a heart attack was instead hospitalized with broken heart syndrome — otherwise known as takotsubo syndrome (TTS) — less than a year after her veteran son tragically took his own life.
Dawn Turner, 57, of the U.K., lost her son in August of last year.
Just last month, the mom of three awoke with “unbearable” chest pains, she said — and called an ambulance, worried she was going into cardiac arrest. But when she arrived at the hospital, doctors told her she was suffering from the effects of grief caused by a broken heart, as news agency SWNS reported.
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TTS is a temporary, reversible heart condition often triggered by extreme emotional or physical stress, such as grief, fear or severe illness, according to experts.
Symptoms usually mimic a heart attack, with sudden and severe chest pain and shortness of breath the most common — and it primarily affects women over the age of 50.
A mom whose soldier son took his own life feared she was suffering cardiac arrest — only to be told by hospital doctors that she was feeling the effects of grief caused by a broken heart. Dawn Turner, mother of deceased soldier Rob Homans, is pictured above, April 2026. (SWNS)
Turner, of Eckington in Worcester, said, “I was [sitting] downstairs earlier that night and thought I had a bit of indigestion. I went to bed and just couldn’t get comfortable — I was breaking out in a sweat and had heart palpitations.
“Then, around midnight, I had pain down my arm and in my jaw. I was still putting it down to indigestion… My partner Paul asked me if I was all right, and I said, ‘I think I’m having a heart attack.’”
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She said she couldn’t catch her breath — “and my heart felt as though it was missing a beat and then [started] thudding again. For those moments, I truly believed I was having a heart attack.”
“Your heart is all over the place — there’s an extra beat,” Turner was told.
She said her partner called emergency services, and an ambulance arrived within five minutes.
“They came in and linked me up to an ECG. They said, ‘Your heart is all over the place — there’s an extra beat, and it’s all over the place,’” she said, as SWNS reported.
Turner was rushed to the hospital by ambulance.
Turner is shown with her son in full dress uniform. He worked as an artilleryman and spent 10 years in the U.K.’s Royal Horse Artillery after joining in 2006. He was battling mental health challenges after his military service, and ultimately took his own life. (SWNS)
In emergency care, Turner was also given blood tests.
She added, “They came back and said I didn’t have the enzymes produced from a heart attack in my blood. But they said there [was] something going on.”
After undergoing more tests and seeing a cardiologist, Turner was told she had takotsubo syndrome.
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“I told [the doctor] that my heart feels broken. I told her about [my son] Rob, and she said it’s exactly that. She said it’s a real thing, and that I’d been under so much stress. The body can only take so much, and the grief and the stress can be quite physical.”
Turner’s son committed suicide in August 2025 after struggling to get help with his mental health.
He spent 10 years in the Royal Horse Artillery after joining in 2006, when he worked as an artilleryman.
Turner’s son did two tours of duty in Afghanistan, she said. After he returned to civilian life, he began suffering from a number of health conditions. She’s shown above with a flower-draped memorial to her son. (SWNS)
He did two tours of duty in Afghanistan, she said, and returned to civilian life in 2016 before suffering several worsening health conditions.
Turner, who is also the CEO of a veterans charity called Stepway, “When he left the army, he got married, and they settled down in London. He walked straight into a job as a delivery driver. But then his health took a downward spiral, and he started having digestive troubles.”
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He was eventually told he had PTSD — but those symptoms may be similar to those of mild traumatic brain injury, Turner said.
“He was deaf in one ear from using the guns,” she said. “He realized he was putting so much pressure on his marriage, so he moved back up with me. He started to build himself up — then COVID hit.”
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Turner said there were unfortunate delays as her son tried to get access to various services and facilities.
“When people lose loved ones, you’re obviously distraught, but you eventually find closure,” she said, per SWNS. “I found peace when I lost my sister in 2015. But with Rob, I can’t find closure because there’s no justice there.”
“I had never really understood that a person could become so overwhelmed by stress and grief that it physically affects the heart,” said the grieving mom. “Broken heart syndrome can look and feel like a heart attack.” (iStock)
Turner is now on the mend and hopes to be fully recovered in a couple of weeks, SWNS reported.
“Until that moment, I had never really understood that a person could become so overwhelmed by stress and grief that it physically affects the heart,” she shared. “Broken heart syndrome can look and feel like a heart attack. It was a warning sign for me, and for anyone. It can change the shape of one of your heart chambers … it can cause some serious damage.”
She added, “The cardiologist told me that thankfully, my heart itself is healthy and there was no damage, but that it will take around two weeks to a month for my heart to reboot itself.”
“Maybe the extra [heart]beat is for Rob. You are carrying on living for him,” her partner told her.
Turner was told she needed to rest, seek counseling and make lifestyle changes to reduce stress.
“Things have settled down, and I’m taking things easy — I’m pacing myself now, and I feel a lot better. Paul said, ‘Maybe the extra beat is for Rob. You are carrying on living for him.’”
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Turner said, “That broke me and healed me a little bit all at once.”
Fox News Digital previously reported that broken heart syndrome, which causes the heart to temporarily weaken, has been linked to the brain’s reaction to stress, as studies have found.
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In an article published in the European Heart Journal in March 2019, Swiss researchers said they found that the syndrome is linked to the way the brain communicates with the heart.
Broken heart syndrome, which causes the heart to temporarily weaken, has been linked to the brain’s reaction to stress, studies have found. (iStock)
Caused by intense emotional events, TTS is a rare, temporary condition that weakens the left ventricle and disrupts its normal pumping function.
The syndrome causes the heart’s main pumping chamber to change shape and get larger. The heart muscle becomes weaker, and its pumping action loses strength.
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Symptoms include sudden, intense chest pain, pressure or heaviness in the chest, along with shortness of breath.
It is treated with beta blockers and blood-thinning medicine to reduce risks of clots and other flareups.
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