Health
Sperm donor with hidden cancer gene fathers nearly 200 kids, families blindsided
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A sperm donor whose samples helped conceive nearly 200 children across Europe unknowingly carried a cancer-causing genetic mutation — a hidden risk now tied to multiple childhood illnesses and early deaths.
An investigation led by the BBC and many other public service broadcasters revealed that the donations were made to Denmark’s European Sperm Bank (ESB). Those donations were then used by 67 fertility clinics in 14 countries over a 17-year span.
The donor, who was not identified, was paid to donate as a student beginning in 2005, according to the report.
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Although the donor passed the initial health screenings, he had hidden genetic mutations that damaged the TP53 gene, which helps to prevent cancer by repairing DNA damage or trigger the death of cancer cells.
When TP53 is mutated, those protective functions are lost, which can lead to uncontrolled cell division, accumulation of mutations and tumor growth, research has shown.
A sperm donor whose samples helped conceive nearly 200 children across Europe (not pictured) unknowingly carried a cancer-causing genetic mutation — a hidden risk now tied to multiple childhood illnesses and early deaths. (Getty Images)
Up to 20% of the man’s sperm would contain that mutated gene, and any children conceived from that affected sperm would have the mutation in every cell of their body, the BBC report stated.
As a result, these children would have a 90% risk of developing some type of cancer in their lifetime, including breast cancer, bone cancers, brain tumors and leukemia. This heightened risk is known as Li Fraumeni syndrome.
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Doctors raised these concerns at the annual congress of the European Society of Human Genetics (ESHG), which was held in Milan in May 2025.
At that conference, Edwige Kasper — a specialist in cancer genetics at Rouen University Hospital in France — presented the case of the sperm donor whose genetic material carried the harmful variant.
“This is the abnormal dissemination of genetic disease. Not every man has 75 children across Europe.”
It was reported that 23 children had been confirmed to have the variant at that time, 10 of which had already been diagnosed with cancer.
The actual number is likely much higher, the report surmised, as at least 197 children were born from the donated sperm — but not all data has been collected.
Kasper called for a limit on the number of births or families for a single donor in Europe.
“We can’t do whole-genome sequencing for all sperm donors — I’m not arguing for that,” she said. “But this is the abnormal dissemination of genetic disease. Not every man has 75 children across Europe.”
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She also recommended that children born from this donor’s sperm undergo genetic counseling.
“We have some children that have already developed two different cancers, and some of them have already died at a very early age,” Kasper recently told the investigators.
Up to 20% of the man’s sperm would contain that mutated gene, and any children conceived from that affected sperm would have the mutation in every cell of their body, the BBC report stated. (iStock)
There is no worldwide law that limits how many times a donor’s sperm can be used or how many children may be born from a single donor, according to the European Society of Human Reproduction and Embryology (ESHRE).
However, individual countries may have their own rules or guidelines surrounding sperm donor usage. The ESHRE recently proposed a cap of 50 families per donor as an international limit.
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Dr. Marc Siegel, Fox News senior medical analyst, commented on these developments to Fox News Digital.
“This awful story emphasizes the growing need for up-to-date genetic screening for all donors,” he said. “It also provides context for the idea that knowing the donor provides an advantage.”
“This awful story emphasizes the growing need for up-to-date genetic screening for all donors,” Dr. Marc Siegel said. (iStock)
“Genetic screening, including for oncogenes (genes that have the potential to cause cancer) is improving dramatically, and all use of sperm donations must include it,” Siegel went on.
He also called for AI to be used to improve and speed up the process.
“When a propensity for disease is suspected, the sperm must be discarded,” the doctor added.
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In a statement sent to Fox News Digital, the European Sperm Bank expressed “deepest sympathy” for the families involved.
“We are deeply affected by the case and the impact that the rare TP53 mutation has on a number of families, children and the donor. They have our deepest sympathy,” the ESP said.
The American Society of Reproductive Medicine provided its guidance on embryo and gamete donation, which stated in part that all prospective donors should undergo “appropriate genetic evaluation.” (iStock)
“ESB tests and performs an individual medical assessment of all donors in full compliance with recognized and scientific practice and legislation.”
In the case of this particular sperm donor with the TP53 mutation, the ESB noted that it occurs only in a small part of the donor’s sperm cells and not in the rest of the body.
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“In such cases, the donor himself and his family members are not ill, and a mutation of this type is not detected preventively by genetic screening,” the agency said.
When the ESB later confirmed the mutation in 2023, the donor was “immediately blocked” and authorities and clinics were notified.
“Donors should be healthy and have no history to suggest hereditary disease.”
“The clinics are responsible for informing the patients, partly because we as a sperm bank do not necessarily know the patients, and because the patients’ own treating physicians are best equipped to advise them in the specific situation,” the agency stated.
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When contacted by Fox News Digital, the American Society of Reproductive Medicine (ASRM) provided its guidance on embryo and gamete donation, which stated in part that all prospective donors should undergo “appropriate genetic evaluation.”
“Donors should be healthy and have no history to suggest hereditary disease,” the ASRM continued.
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Parents with concerns are encouraged to contact both their treating clinic and the relevant fertility authority in that country.
U.S. health officials are monitoring 16 additional people across the country for symptoms of hantavirus whom the Centers for Disease Control and Prevention has not previously mentioned, the agency said on Thursday.
The new people the C.D.C. reported were not on the cruise ship but were passengers on an April 25 flight to Johannesburg and exposed to someone known to have been infected, said Dr. David Fitter, who is leading the C.D.C.’s response to the outbreak.
The new total of those being monitored in the United States is 41, a significant increase over the 18 passengers from the Dutch cruise ship who were brought back to the United States on Monday. They are quarantining at special facilities in Omaha and Atlanta.
Seven other passengers from the cruise ship had disembarked on April 24 in St. Helena, an island in the Atlantic Ocean, returned to the United States on commercial flights and are being monitored by state health departments.
As of Thursday, there were no confirmed cases in the United States, Dr. Fitter said.
The infected passenger was a 69-year-old Dutch woman whose husband was the first person to die in the outbreak, on April 11. She was among those who disembarked from the ship on April 24. The next day, she flew from St. Helena to Johannesburg. She collapsed shortly after arrival and died on April 26. She was confirmed on May 4 to have had hantavirus.
C.D.C. officials would not give any other information about the 16 passengers, including where they had gone once they reached the United States.
It was not clear whether all Americans exposed to the virus are now back in the country, or whether there are additional people being monitored abroad.
“Our job is to ensure that we are monitoring and in contact with anybody that might have been on the flight this person had taken,” Dr. Fitter told reporters. The agency is “monitoring all Americans that potentially would have been exposed, whether in the U.S. or abroad, and we have been in contact with them,” he said.
In an interview on Sunday with CNN, Dr. Jay Bhattacharya, the C.D.C.’s acting director, said none of the seven passengers who returned to the United States earlier had symptoms at the time of their travel, so officials had not seen a need to alert the public or trace contacts.
For the moment, quarantine is essentially voluntary. Officials are encouraging those who were exposed to the virus to “stay at home and avoid being around people during their 42-day monitoring period,” Dr. Fitter said.
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Concerns about rising hantavirus cases has Americans reflecting on the coronavirus pandemic.
Although COVID-19 began with a foreign strain and spread rapidly around the world, experts say it’s not likely that hantavirus will behave the same way.
The rare Andes virus, which was linked to the MV Hondius cruise ship outbreak, is the only known hantavirus strain that has the capability to spread from person to person, usually through prolonged close contact.
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Fox News senior medical analyst Dr. Marc Siegel spoke with Fox News Digital about the similarities and differences between hantavirus and coronavirus, noting that there is “no comparison.”
“You could say the comparison ends at that they’re both single-stranded RNA viruses,” he said. “That’s a comparison, but [hantavirus] has been unchanged basically for decades.”
Dr. Marc Siegel says there’s “no comparison between these two viruses, other than that the single-stranded RNA viruses are both carried by animals.” (iStock)
Coronavirus was different because it began to mutate, which started to cause “all kinds of problems,” Siegel noted.
“We don’t know why it started to mutate, but this one doesn’t appear to have done that,” he said. “And every day that goes by seems to show that theory is correct – the genetics of it is the same.”
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“So, there’s no comparison between these two viruses, other than that the single-stranded RNA viruses are both carried by animals.”
Siegel added that COVID is an airborne virus, while hantavirus is mainly a secretion-borne virus, although it can be transmitted through dust and droppings in the air.
The rare Andes virus, which was linked to the MV Hondius cruise ship outbreak, is the only known hantavirus strain that has the capability to spread from person to person, usually through prolonged close contact. (Andres Gutierrez/Anadolu)
“It’s not airborne … in terms of respiratory droplets hanging in the air,” he said. “It’s very difficult to transmit.”
While coronavirus “moved in the direction of humans in a significant way,” hantavirus has not, except for “very rare” human-to-human transmission, according to the doctor.
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There have been hantavirus cases in the U.S. for decades, although they are “very rare,” Siegel noted.
Certain factors of this disease spread are changing, including warming temperatures that are causing rodents to migrate north toward Buenos Aires, according to the doctor.
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The current outbreak stemming from the cruise ship did not help the cause, Siegel went on — but this spread doesn’t suggest that the virus has changed. Rather, it shows how close quarters on a ship are “very conducive” to spread, he said.
Passengers disembark from the hantavirus-stricken cruise ship MV Hondius at the port of Granadilla in Tenerife, Canary Islands, Spain, on May 10, 2026. (AP Photo)
“Every day that goes by shows that … we’re not seeing a second generation of spread,” he reiterated.
The better comparison to make is between hantavirus and bird flu, which is a predominantly animal-based virus that “occasionally infects humans,” Siegel said.
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“There are billions of birds, and every year we talk about how it’s going to cause a pandemic, but it would have to mutate significantly,” he pointed out. “I feel that [hantavirus] would have to mutate significantly before it could go human to human in any significant way, because this is basically an animal virus … it’s very comfortable inside a rodent host.”
Siegel went on, “If you get this virus, you’re in trouble, but getting this virus is very difficult.”
A person visits a COVID testing site on a Manhattan street in New York City on Jan. 21, 2022. “Coronaviruses are airborne … this is not,” Dr. Siegel said. “And coronaviruses mutate a lot, and this does not.” (Spencer Platt/Getty Images)
Regarding fears that another global pandemic may be looming, Siegel said that just because one virus becomes widespread does not mean all viruses will.
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“Coronaviruses are airborne anyway. This is not. And coronaviruses mutate a lot, and this does not,” he said. “I’m much more concerned about flu than this. Flu can mutate all the time, and it’s already going human to human all over the place, and it’s airborne.”
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“Most infectious disease specialists are much more worried about flu than this, as deadly as this can be,” he added.
“We’re talking apples and oranges, and any comparison you make after that provokes fear.”
Fox News Digital’s Melissa Rudy contributed to this report.
One morning just before Christmas, Michelle stood in a Thrifty-Wash, watching her seven loads of laundry tumble and spin. The machine at the Airbnb had broken and flooded the place. It had been a blessing, in a way — Michelle needed this time alone to think.
The night before, Los Angeles Unified School District officials had hosted a Zoom webinar for parents, in which they had promised to present all the evidence that campus was safe. Michelle had gone in with high hopes, maybe even optimism. Afterward, she called it “the Zoom from hell.”
The officials had opened the meeting by announcing that Pali High’s students would go back to campus at the end of January. Michelle had peered at the screen, squinting to make sense of their color-coded maps, charts and checklists as district officials and their third-party contractors used wonky terms to describe what sounded to Michelle like rudimentary decontamination methods: “visual inspections,” “glove tests,” “subjective evaluations for smoke odor” and the copious use of wet wipes.
The “Environmental Concerns” WhatsApp group began pinging with live commentary. “It’s like they’re all hanging out with my insurance company,” one mother typed. “Transparency my a$$,” wrote another.
During the question-and-answer portion, parents flooded the submission box: Why weren’t the porous ceiling tiles removed? (“We did our best to remove any surface contaminants that we could see visually,” one contractor replied.) Did they realize that lithium had been detected in smoke-damaged homes near the school? (“Lithium, we determined, was not going to be a high-priority metal for us,” another contractor explained.) And why hadn’t they tested for benzene, carbon tetrachloride or perchloroethylene — some of which had been found in other Palisades buildings after the fires?
Michelle had a hunch she knew the answer, but she assumed no official would ever admit it. Then the project manager for one of the contractors came on the screen.
“There are hundreds — literally — of different compounds that could be produced during a fire,” he said, “and there are analytical methods that can be very, very precise in sampling for those.” But the problem, he said, was that it “lacks specificity in what we can actually deal with … ”
Michelle had shaken her head in disbelief. The project manager interrupted himself. “That was the wrong way to put that,” he muttered.
This morning, Michelle had waked to some parents on the “Environmental Concerns” chat talking about putting their kids in virtual learning. Others were hoping to transfer. Michelle was fantasizing about protesting the return to campus, even dreaming up the picket signs: “Lead should only be in pencils,” or maybe, “Test on the school, not on the kids.”
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