Health
Richard Lewis diagnosed with late-onset Parkinson’s disease: ‘Luckily, I got it late in life’
Comic and actor Richard Lewis, 75, just lately introduced in a Twitter video that he was identified with Parkinson’s illness two years in the past.
“I began strolling somewhat stiffly, I used to be shuffling my toes, so I went to a neurologist they usually gave me a mind scan, and I used to be identified with Parkinson’s illness,” he shared within the video.
The “Curb Your Enthusiasm” star appeared optimistic about the truth that he was identified with the central nervous system dysfunction later in life, at 73 years previous.
RICHARD LEWIS REVEALS PARKINSON’S DISEASE DIAGNOSIS: ‘I’M FINISHED WITH STAND-UP’
“Fortunately, I obtained it late in life … I’m on the fitting meds — so I’m cool,” the actor stated.
Late-onset vs. early-onset Parkinson’s
Whereas the vast majority of folks with Parkinson’s illness are identified after age 60, some develop it earlier in life.
When an individual is identified at 50 years previous or youthful, it’s thought-about early-onset Parkinson’s illness, in response to the Parkinson’s Basis.
When it afflicts somebody older than 50, the illness is taken into account late-onset.
What’s comparatively the identical throughout all age teams are early motor signs akin to tremors, stiffness, slowness of motion, fatigue, melancholy, anxiousness, lack of scent and bother sleeping, amongst others.
Early-onset Parkinson’s extra prone to be hereditary
Whereas it’s attainable for somebody to get early-onset Parkinson’s illness even when it doesn’t run within the household, the youthful instances usually tend to be hereditary, in response to Dr. Charalampos Tzoulis, professor of neurology and neurogenetics on the College of Bergen and Haukeland College Hospital in Norway.
“Such causes embody mutations in genes akin to PRKN (Parkin) and PINK1,” the physician advised Fox Information Digital.
About 15% of these with Parkinson’s have a household historical past of the illness, per Johns Hopkins Drugs.
These instances are attributable to genetic mutations within the genes LRRK2, PARK2, PARK7, PINK1 or SNCA.
Outcomes of early-onset Parkinson’s
Actor Michael J. Fox, who’s now 61, was identified with Parkinson’s illness in 1991 at simply 29 years previous (he did not share his prognosis publicly till 1998).
In 2000, he began the Fox Basis for Parkinson’s Analysis, which is devoted to discovering a treatment for the illness by way of funding and analysis of therapies. Fox has additionally written 4 memoirs since his prognosis.
One benefit of getting Parkinson’s early in life is that it tends to progress extra slowly, stated Dr. Tzoulis, who additionally leads analysis on Parkinson’s illness and different neurodegenerative issues.
“Early-onset Parkinson’s typically progresses slower and should have a greater long-term prognosis,” stated the physician.
Youthful sufferers are additionally much less prone to have dementia or cognitive issues.
“However the prognosis is determined by a number of components, akin to whether or not there’s a genetic trigger and what the person’s response is to dopaminergic remedy (medicines that regulate dopamine ranges within the mind) in addition to comorbidity.”
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Youthful sufferers are additionally much less prone to have dementia or cognitive issues, they usually are likely to reside considerably longer than folks with older-onset Parkinson’s, stated Dr. Joel S. Perlmutter, a professor of neurology on the Washington College College of Drugs in St. Louis, Missouri, in a webinar for the American Parkinson Illness Affiliation (APDA).
There are, nonetheless, some drawbacks to getting Parkinson’s earlier in life.
“Youthful sufferers are extra vulnerable to growing levodopa-induced dyskinesias (involuntary actions) in the course of the course of the illness,” Dr. Tzoulis advised Fox Information Digital.
This impact is attributable to the long-term use of levodopa, which is the most typical remedy for managing Parkinson’s motor signs.
“Early-onset Parkinson’s typically progresses slower.”
“This may typically be successfully dealt with by superior remedy choices, akin to deep mind stimulation,” the physician added.
Sufferers with early-onset Parkinson’s are additionally extra prone to develop dystonia, which causes involuntary muscle contractions and adjustments in posture.
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Despair and anxiousness will also be heightened with earlier diagnoses.
“Individuals with young-onset Parkinson’s are likely to have a increased charge of melancholy than older onset Parkinson’s,” stated Dr. Perlmutter.
Life expectancy with Parkinson’s
Parkinson’s is just not in itself a deadly illness, in response to the APDA.
“Most sufferers die with Parkinson’s illness and never from it,” the muse said on its web site.
“The diseases that kill most individuals are the identical as people who kill folks with PD. These are coronary heart situations, stroke and most cancers.”
Because the illness progresses, nonetheless, it might probably make somebody extra vulnerable to accidents and different situations that would grow to be deadly.
For instance, these with Parkinson’s have the next danger of falling.
They may very well be as much as thrice extra prone to expertise falls, per a 2021 examine in Journal of Motion Problems.
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Individuals with the dysfunction additionally face the next hazard of growing pneumonia (lung infections) as a result of problem swallowing.
These with early-onset Parkinson’s are likely to have increased charges of melancholy.
Aspiration pneumonia — which happens when somebody breathes meals or liquid into the airways or lungs with out swallowing — accounts for 70% of deaths in folks with Parkinson’s illness, a 2021 examine printed in Scientific Experiences discovered.
General, nonetheless, these with Parkinson’s can probably reside so long as they’d with out the dysfunction.
“Associated issues” might cut back total life expectancy by only one to 2 years, Healthline said.
Health
Kennedy’s Plan for the Drug Crisis: A Network of ‘Healing Farms’
Though Mr. Kennedy’s embrace of recovery farms may be novel, the concept stretches back almost a century. In 1935, the government opened the United States Narcotic Farm in Lexington, Ky., to research and treat addiction. Over the years, residents included Chet Baker and William S. Burroughs (who portrayed the institution in his novel, “Junkie: Confessions of an Unredeemed Drug Addict”). The program had high relapse rates and was tainted by drug experiments on human subjects. By 1975, as local treatment centers began to proliferate around the country, the program closed.
In America, therapeutic communities for addiction treatment became popular in the 1960s and ’70s. Some, like Synanon, became notorious for cultlike, abusive environments. There are now perhaps 3,000 worldwide, researchers estimate, including one that Mr. Kennedy has also praised — San Patrignano, an Italian program whose centerpiece is a highly regarded bakery, staffed by residents.
“If we do go down the road of large government-funded therapeutic communities, I’d want to see some oversight to ensure they live up to modern standards,” said Dr. Sabet, who is now president of the Foundation for Drug Policy Solutions. “We should get rid of the false dichotomy, too, between these approaches and medications, since we know they can work together for some people.”
Should Mr. Kennedy be confirmed, his authority to establish healing farms would be uncertain. Building federal treatment farms in “depressed rural areas,” as he said in his documentary, presumably on public land, would hit political and legal roadblocks. Fully legalizing and taxing cannabis to pay for the farms would require congressional action.
In the concluding moments of the documentary, Mr. Kennedy invoked Carl Jung, the Swiss psychiatrist whose views on spirituality influenced Alcoholics Anonymous. Dr. Jung, he said, felt that “people who believed in God got better faster and that their recovery was more durable and enduring than people who didn’t.”
Health
Children exposed to higher fluoride levels found to have lower IQs, study reveals
The debate about the benefits and risks of fluoride is ongoing, as RFK Jr. — incoming President Trump’s pick for HHS secretary — pushes to remove it from the U.S. water supply.
“Fluoride is an industrial waste associated with arthritis, bone fractures, bone cancer, IQ loss, neurodevelopmental disorders and thyroid disease,” RFK wrote in a post on X in November.
A new study published in JAMA Pediatrics on Jan. 6 found another correlation between fluoride exposure and children’s IQs.
RFK JR. CALLS FOR REMOVAL OF FLUORIDE FROM DRINKING WATER, SPARKING DEBATE
Study co-author Kyla Taylor, PhD, who is based in North Carolina, noted that fluoridated water has been used “for decades” to reduce dental cavities and improve oral health.
“However, there is concern that pregnant women and children are getting fluoride from many sources, including drinking water, water-added foods and beverages, teas, toothpaste, floss and mouthwash, and that their total fluoride exposure is too high and may affect fetal, infant and child neurodevelopment,” she told Fox News Digital.
The new research, led by scientists at the National Institute of Environmental Health Sciences (NIEHS), analyzed 74 epidemiological studies on children’s IQ and fluoride exposure.
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The studies measured fluoride in drinking water and urine across 10 countries, including Canada, China, Denmark, India, Iran, Mexico, Pakistan, New Zealand, Spain and Taiwan. (None were conducted in the U.S.)
The meta-analysis found a “statistically significant association” between higher fluoride exposure and lower children’s IQ scores, according to Taylor.
“[It showed] that the more fluoride a child is exposed to, the more likely that child’s IQ will be lower than if they were not exposed,” she said.
These results were consistent with six previous meta-analyses, all of which reported the same “statistically significant inverse associations” between fluoride exposure and children’s IQs, Taylor emphasized.
The research found that for every 1mg/L increase in urinary fluoride, there was a 1.63-point decrease in IQ.
‘Safe’ exposure levels
The World Health Organization (WHO) has established 1.5mg/L as the “upper safe limit” of fluoride in drinking water.
“There is concern that pregnant women and children are getting fluoride from many sources.”
Meanwhile, the U.S. Public Health Service recommends a fluoride concentration of 0.7 mg/L in drinking water.
“There was not enough data to determine if 0.7 mg/L of fluoride exposure in drinking water affected children’s IQs,” Taylor noted.
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Higher levels of the chemical can be found in wells and community water serving nearly three million people in the U.S., the researcher noted.
She encouraged pregnant women and parents of small children to be mindful of their total fluoride intake.
“If their water is fluoridated, they may wish to replace tap water with low-fluoride bottled water, like purified water, and limit exposure from other sources, such as dental products or black tea,” she said.
“Parents can use low-fluoride bottled water to mix with powdered infant formula and limit use of fluoridated toothpaste by young children.”
For more Health articles, visit www.foxnews.com/health.
While the research did not intend to address broader public health implications of water fluoridation in the U.S., Taylor suggested that the findings could help inform future research into the impact of fluoride on children’s health.
Dental health expert shares cautions
In response to this study and other previous research, Dr. Ellie Phillips, DDS, an oral health educator based in Austin, Texas, told Fox News Digital that she does not support water fluoridation.
“I join those who vehemently oppose public water fluoridation, and I question why our water supplies are still fluoridated in the 21st century,” she wrote in an email.
“There are non-fluoridated cities and countries where the public enjoy high levels of oral health, which in some cases appear better than those that are fluoridated.”
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Phillips called the fluoride debate “confusing” even among dentists, as the American Dental Association (ADA) advocates for fluoride use for cavity prevention through water fluoridation, toothpaste and mouthwash — “sometimes in high concentrations.”
“[But] biologic (holistic) dentists generally encourage their patients to fear fluoride and avoid its use entirely, even if their teeth are ravaged by tooth decay,” she said.
“Topical fluoride is beneficial, while systemic consumption poses risks.”
Phillips encouraged the public to consider varying fluoride compounds, the effect of different concentrations and the “extreme difference” between applying fluoride topically and ingesting it.
“Topical fluoride is beneficial, while systemic consumption poses risks,” she cautioned.
“Individuals must take charge of their own oral health using natural and informed strategies.”
The study received funding from the National Institute of Environmental Health Sciences (NIEHS), the National Institutes of Health (NIH) and the Intramural Research Program.
Health
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