Health
Red meat could raise dementia risk, researchers claim, yet some doctors have questions
While red meat is a rich source of protein, iron and other nutrients, a recent study linked it to an increased risk of dementia — but some doctors are casting doubt on the claim.
Researchers from the Harvard T.H. Chan School of Public Health and Mass General Brigham found that daily consumption of certain amounts of processed red meats increased dementia risk by 13%, according to a press release.
It was also tied to a 14% higher risk of developing subjective cognitive decline and faster brain aging.
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“The findings did not really surprise us,” lead study author Yuhan Li, a researcher from Harvard T.H. Chan School of Public Health in Boston, told Fox News Digital.
Researchers from the Harvard T.H. Chan School of Public Health and Mass General Brigham found that daily consumption of certain amounts of processed red meats increased dementia risk, but some doctors are casting doubt. (iStock)
“The results are generally in line with our hypothesis, showing that a higher intake of red meat, particularly processed red meat, is associated with an increased risk of developing dementia and worse cognition.”
The increased risk was seen in people who ate at least one-quarter of a serving of unprocessed meats per day, according to the research article. This equates to around one hot dog, two slices of bacon, or one and a half slices of bologna.
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The researchers also suggested that replacing one serving of processed red meat per day with a serving of nuts and legumes could reduce dementia risk by 19% — and that replacing it with fish could reduce the risk by 28%.
The study included 133,771 individuals, 11,173 of whom received a dementia diagnosis over a four-decade span. The data came from the Nurses’ Health Study (NHS) and Health Professionals Follow-Up Study (HPFS), which tracked participants’ dietary choices and health status.
The increased risk was seen in people who ate at least one-quarter of a serving of unprocessed meats per day, which equates to around two slices of bacon, one hot dog, or one and a half slices of bologna. (iStock)
Funded by the National Institutes of Health, the study was published on Jan. 15 in the journal Neurology.
The findings were first presented at the Alzheimer’s Association International Conference (AAIC) earlier in 2024.
Experts react to the findings
“There are many reasons to believe that too much red meat is linked to dementia,” Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News senior medical analyst, told Fox News Digital.
“In the case of processed meat like bacon and ham, the chemicals added may also lead to dementia via inflammation and neuroinflammation,” added Siegel, who was not involved in the new research.
The researchers suggested that replacing one serving of processed red meat per day with a serving of nuts and legumes could reduce dementia risk by 19%. (iStock)
The doctor also warned of red meat potentially leading to weight gain and obesity, which can cause inflammation and in turn raise the risk of dementia.
“Red meat may also lead to heart disease, which increases dementia risk,” Siegel noted.
Theresa Gentile, a registered dietitian nutritionist and spokesperson for the Academy of Nutrition and Dietetics in New York, noted that previous research has found an association between red meat — especially processed red meat — and an increased risk of type 2 diabetes and cardiovascular disease, which are both related to impaired cognitive health.
“There isn’t a single food or ingredient that … has been shown to cause, increase risk, prevent, treat or cure Alzheimer’s or other dementias.”
“This was a large study conducted over a long period of time and was adjusted for confounding factors and still found that, in three different groups, eating more processed red meat was associated with cognitive decline than eating less,” Gentile, who did not work on the study, told Fox News Digital.
Some experts suggested that the risk is linked more to ultraprocessed foods in general rather than specific meats.
“The results are generally in line with our hypothesis, showing that a higher intake of red meat, particularly processed red meat, is associated with an increased risk of developing dementia and worse cognition,” said one of the researchers (not pictured). (iStock)
Heather M. Snyder, Ph.D., senior vice president of medical and scientific relations at the Alzheimer’s Association in Chicago, pointed out that a number of studies have suggested that diets with more ultraprocessed foods are bad for brain health.
“For example, a report at the AAIC 2022 found that people who eat large amounts of ultraprocessed foods have a faster decline in cognition,” Snyder, who was not involved in the new study, told Fox News Digital.
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“More than 20% of daily intake of ultraprocessed foods led to a 28% faster decline in global cognitive scores, including memory and verbal fluency.”
It is “unlikely” that one food will have a “significant beneficial or detrimental effect on a disease as complex as Alzheimer’s,” according to Snyder.
“There isn’t a single food or ingredient that, through rigorous scientific research, has been shown to cause, increase risk, prevent, treat or cure Alzheimer’s or other dementias,” she stated.
Potential study limitations
Siegel noted that the study was observational, which means that “no strict conclusions can be drawn.”
“We still need double-blinded, randomized trials to draw more definite conclusions,” he said.
It is “unlikely” that one food will have a “significant beneficial or detrimental effect on a disease as complex as Alzheimer’s,” one expert stated. (iStock)
Lead study author Yuhan also acknowledged the potential limitations.
“The Nurses’ Health Study enrolled female registered nurses, and the Health Professionals Follow-Up Study enrolled U.S. male health professionals,” she told Fox News Digital.
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“These participants tend to have higher educational attainment and income levels, and therefore, the study’s generalizability may be limited. In addition, because this study is an observational study, residual confounding remains a possibility.”
Dr. Ken Berry, a family physician and diabetes specialist in Tennessee, was not involved in the study but shared his thoughts on “healthy user bias” potentially skewing the results.
“The people who are eating the least amount of processed meat and the least amount of red meat in these studies — they were also exercising every day,” one doctor noted when speaking about the research. (iStock)
“The people who are eating the least amount of processed meat and the least amount of red meat in these studies — they were also exercising every day,” he said in a video posted on his YouTube channel last week.
“They absolutely did not smoke. They did not drink to excess. They were trying their best to live a healthy life.”
“We still need double-blinded, randomized trials to draw more definite conclusions.”
Research has shown that exercising regularly and eating whole, unprocessed foods can decrease the risk of dementia, Berry noted.
“I don’t think any nutrition expert would argue with that,” he said, but added that there is “no evidence whatsoever” that red meat is linked to higher dementia risk.
Healthy dietary tips
Gentile recommended limiting servings of processed red meats like bacon, sausage, hot dogs and deli meats to less than a quarter of a serving per day, and to consider healthier protein alternatives like fish, nuts, legumes and chicken.
“A balanced diet with moderation in terms of protein sources and serving size is key,” Gentile said. “If your diet is heavy in processed red meats, try swapping one of those servings out for beans, fish or chicken.”
One registered dietitian recommended limiting servings of processed red meats and considering protein alternatives like fish, nuts, legumes and chicken. (iStock)
The nutritionist also suggested including brain-boosting foods each day, like fruits, vegetables, whole grains and healthy fats.
The Alzheimer’s Association has long encouraged eating a balanced diet to help prevent Alzheimer’s disease and all other dementia types, Snyder noted.
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“That includes foods that are less processed to ensure that our bodies get the needed nutrients, because they’ve been associated with a lower risk of cognitive decline,” she told Fox News Digital.
“As research continues, we may uncover other dietary patterns that increase or decrease our risk.”
Berry pointed out that while he is a self-described “carnivore,” he is not completely “anti-plant.”
“I’m a proponent of a proper human diet, which ranges from low-carb with vegetables and berries and nuts, to keto with a few berries and vegetables and nuts, to ‘ketovore’ with just a little veg for flavor and garnish, all the way to carnivore,” he said in his video.
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The best diet for any individual should depend on multiple factors, he said, including their overall metabolic health, age, weight, genetics and gut microbiome.
Added Berry, “That’s the proper human diet spectrum.”
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Health
Common eating habit may trigger premature immune system aging, study finds
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Eating too much salt has long been linked to high blood pressure, but new research suggests it could trick the immune system into prematurely aging the blood vessels.
A preclinical study recently published in the Journal of the American Heart Association has identified a biological chain reaction that links a salty diet to cardiovascular decay.
Scientists at the University of South Alabama observed that mice on a high-salt diet experienced rapid deterioration in their blood vessel function.
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After just four weeks of high sodium intake, the small arteries responsible for regulating blood flow lost their ability to relax, according to a press release.
The team found that the cells lining these vessels had entered a state of cellular senescence, a form of premature cellular aging in which cells stop dividing and release a mix of inflammatory signals that can damage surrounding tissue.
Excess salt has long been linked to high blood pressure, but a new study goes deeper into its effects on the cardiovascular system. (iStock)
The researchers tried to replicate this damage by exposing blood vessel cells directly to salt in a laboratory dish, but the cells showed no harmful effects.
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This suggests that salt isn’t directly causing damage to the vascular lining but that the real culprit may be the body’s own defense mechanism, the researchers noted.
Excess salt may trigger the immune system to release a molecule called interleukin-16 (IL-16), which acts as a messenger that instructs blood vessel cells to grow old before their time, according to the study.
Excess salt may trigger the immune system to release a molecule called interleukin-16, which acts as a messenger that instructs blood vessel cells to grow old before their time, according to the study. (iStock)
Once these cells age, they fail to produce nitric oxide, the essential gas that tells arteries to dilate and stay flexible.
To test whether this process could be reversed, the team turned to a class of experimental drugs known as senolytics.
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Using a cancer medication called navitoclax, which selectively clears out aged and dysfunctional cells, the researchers were able to restore nearly normal blood vessel function in the salt-fed mice, the release stated.
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By removing the decaying cells created by the high-salt diet, the drug allowed the remaining healthy tissue to maintain its elasticity and respond correctly to blood flow demands.
Excess salt may trigger the immune system into stopping the cells from dividing, the study suggests. (iStock)
The study did have some limitations. The transition from mouse models to human treatment remains a significant hurdle, the team cautioned.
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Senolytic drugs like navitoclax are still being studied for safety, and the team emphasized that previous trials have shown mixed results regarding their impact on artery plaque.
Additionally, the researchers have not yet confirmed whether the same IL-16 pathway is the primary driver of vascular aging in humans.
Health
Healthy diets spark lung cancer risk in non-smokers as pesticides loom
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Eating a diet high in fruits and vegetables was found to have a surprising link to lung cancer among younger non-smokers, early research suggests.
The observational study, led by Jorge Nieva, M.D., of the USC Norris Comprehensive Cancer Center at Keck Medicine, was presented this month at the American Association for Cancer Research (AACR) annual meeting in San Diego. It has not yet been peer-reviewed.
Researchers looked at dietary, smoking and demographic data for 187 patients who were diagnosed with lung cancer at age 50 or younger.
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They found that among non-smokers, there was a link between healthier-than-average diets – rich in fruits, vegetables and whole grains – and the chance of lung cancer development.
Young lung cancer patients ate more servings of dark green vegetables, legumes and whole grains compared to the average U.S. adult, the researchers found.
Eating a diet high in fruits and vegetables was found to have a surprising link to lung cancer among younger non-smokers, early research suggests. (iStock)
The researchers hypothesized that pesticides applied to conventionally grown produce could be a possible factor in the disease association.
“Commercially produced (non-organic) fruits, vegetables and whole grains are more likely to be associated with a higher residue of pesticides than dairy, meat and many processed foods,” according to Nieva. He also noted that agricultural workers exposed to pesticides tend to have higher rates of lung cancer.
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“There is a large subset of lung cancer patients whose disease is not caused by smoking,” Nieva told Fox News Digital.
The disease is becoming more common in non-smokers 50 and younger, especially women – despite the fact that smoking rates have been falling for decades, the researcher noted.
The researchers hypothesized that pesticides applied to conventionally grown produce could be a possible factor in the disease association. (iStock)
“These patients tend to have eaten much healthier diets before their diagnosis than the average American,” he went on. “We need to support research into understanding why Americans – and women in particular – who no longer smoke very much are still having lung cancer,” he said.
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The study did have some limitations, Nieva acknowledged, primarily that it relied on survey data and was limited by the participants’ memories of their food intake.
“Also, the survey participants were self-selected, and this could have biased the findings,” he told Fox News Digital.
“There is a large subset of lung cancer patients whose disease is not caused by smoking.”
The researchers did not test specific foods for pesticides, relying instead on average pesticide levels for certain types of food. Looking ahead, they plan to test patients’ blood and urine samples to directly measure pesticide levels, Nieva said.
Although the study shows only an association and does not prove that pesticides caused lung cancer, Nieva recommends that people wash their produce before eating and choose organic foods whenever possible.
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“This work represents a critical step toward identifying modifiable environmental factors that may contribute to lung cancer in young adults,” said Nieva. “Our hope is that these insights can guide both public health recommendations and future investigation into lung cancer prevention.”
“It is possible that the increased lung cancer risk could be due to pesticide exposure in whole farmed foods, but is by no means certain,” a doctor said. (AP Photo/Charlie Neibergall)
Dr. Marc Siegel, Fox News senior medical analyst, said the study is “interesting,” but that it “raises far more questions than it answers.”
“It is a small study (around 150) and observational, so no proof,” the doctor, who was not involved in the research, told Fox News Digital.
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“It is possible that the increased lung cancer risk could be due to pesticide exposure in whole farmed foods, but it is by no means certain,” Siegel went on. “How much exposure is needed? How much of it gets into food and in which areas? This requires much further study.”
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Kayla Nichols, communications director for Pesticide Action & Agroecology Network, a distributed global network, said the organization agrees with the study’s conclusion that more research should be done on the rise in lung cancer, particularly in individuals eating diets higher in produce and fiber.
“There is a large subset of lung cancer patients whose disease is not caused by smoking,” the researcher told Fox News Digital. (iStock)
“There is a bounty of existing research that already links pesticide exposure to increased risk of multiple types of cancers,” Nichols, who was also not involved in the study, told Fox News Digital. She called for more research on chronic, low-level exposures to pesticides, as well as more effective policies to protect the public from pesticide residues on food.
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The study was supported by the National Institutes of Health and the National Cancer Institute, as well as industry partners including AstraZeneca and Genentech, among others.
Fox News Digital reached out to several pesticide companies and trade groups for comment.
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